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Hierarchical structures hydrogel evaporator and superhydrophilic water collect device for efficient solar steam evaporation

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Nano Research 2021年第4期14卷 1135-1140页

作者： Wenwei Lei Sovann Khan Lie Chen Norihiro Suzuki Chiaki Terashima Kesong Liu Akira Fujishima Mingjie Liu Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China Photocatalysis International Research Center Tokyo University of Science2641 YamazakiNodaChiba 278-8510Japan

Efficient light absorption and trapping are of vital importance for the solar water evaporation by hydrogel-based photothermal conversion materials.Conventional strategies are focused on the development of the composition and structure of the hydrogers internal network.In our point of view,the importance of the surface structure of hydrogel has usually been underestimated or ignored.Here inspired by the excellent absorbance and water transportation ability of biological surface structure,the hierarchical structured hydrogel evaporators(HSEs)increased the light absorption,trapping,water transportation and water-air interface,which is the beneficial photothermal conversion and water evaporation.The HSEs showed a rapid evaporation rate of 1.77 kg·m^(-2)·h^(-1)at about 92%energy efficiency under one sun(1 kW·m^(-2)).Furthermore,the superhydrophilic window device was used in this work to collect the condensed water,which avoids the light-blocking caused by the water mist formed by the small droplets and the problem of the droplets stick on the device dropping back to the bulk water.Integrated with the excellent photothermal conversion hydrogel and superhydrophilic window equipment,this work provides efficient evaporation and desalination of hydrogel-based solar evaporators in practical large-scale applications.

关键词： light-trapping large-scale hierarchical structure hydrogel evaporator solar steam evaporation superhydrophilic window

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Ⅳ期胃癌转化治疗

Science Bulletin 2023年第7期68卷 653-656页

作者：胡灿 Masanori terashima 程向东 Department of Gastric Surgery Zhejiang Cancer HospitalInstitutes of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Key Laboratory of Prevention Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang ProvinceHangzhou 310022China Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer Zhejiang Cancer HospitalHangzhou 310022China Division of Gastric Surgery Shizuoka Cancer CenterShizuoka 411-8777Japan

Gastric cancer(GC)is one of the most common malignant tumors and represents the fourth most common cause of cancer death worldwide.Surgery is the optimal treatment for patients with GC.However,70%–80%of GC patients are diagnosed at locally advanced stages.A large number of clinical studies have shown that no existing treatment has ideal efficacy against advanced unresectable GC with No.16 lymph nodes or distant organ metastasis,and the median survival time of patients is only approximately 10 months.In recent years,conversion therapy has shown great promise.This approach consists mainly of developing reasonable comprehensive treatment programs,including chemotherapy,radiotherapy,and targeted therapy delivered by a multidisciplinary team(MDT),to convert initially unresectable GC to resectable cancer,thus prolonging patients’survival and improving their quality of life.Here,we aim to discuss the treatment strategies,challenges and opportunities of conversion therapy for GC,along with our experience in conversion therapy for patients with advanced GC(Fig.1).

关键词： Surgery Gastric treatment

Numerical analysis on element creation by nuclear transmutation of fission products

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Nuclear Science and Techniques 2015年第1期26卷 113-120页

作者： Atsunori terashima Masaki Ozawa Department of Nuclear Engineering Graduate School of Science and EngineeringTokyo Institute of Technology Research Laboratory for Nuclear Reactors Tokyo Institute of Technology

A burnup calculation was performed to analyze the Apr`es ORIENT process, which aims to create highlyvaluable elements from fission products separated from spent nuclear fuels. The basic idea is to use nuclear transmutation induced by a neutron capture reaction followed by a β-decay, thus changing the atomic number Z of a target element in fission products by 1 unit. LWR(PWR) and FBR(MONJU) were considered as the transmutation devices. High rates of creation were obtained in some cases of platinum group metals(44Ru by FBR,46 Pd by LWR) and rare earth(64Gd by LWR,66 Dy by FBR). Therefore, systems based on LWR and FBR have their own advantages depending on target elements. Furthermore, it was found that creation rates of even Z(= Z + 1) elements from odd Z ones were higher than the opposite cases. This creation rate of an element was interpreted in terms of "average 1-group neutron capture cross section of the corresponding target element σc Z defined in this work. General trends of the creation rate of an even(odd) Z element from the corresponding odd(even) Z one were found to be proportional to the 0.78th(0.63th) power of σc Z, however with noticeable dispersion. The difference in the powers in the above analysis was explained by the difference in the number of stable isotopes caused by the even-odd effect of Z.

关键词：裂变产物元素数值分析嬗变快中子增殖反应堆轻水反应堆稳定同位素 LWR

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Ⅳ期胃癌转化治疗（英文）

Science Bulletin 2023年第7期 653-656页

作者：胡灿 Masanori terashima 程向东 Department of Gastric Surgery Zhejiang Cancer Hospital Institutes of Basic Medicine and Cancer(IBMC) Chinese Academy of Sciences Key Laboratory of Prevention Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer Zhejiang Cancer Hospital Division of Gastric Surgery Shizuoka Cancer Center

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Pathological response measured using virtual microscopic slides for gastric cancer patients who underwent neoadjuvant chemotherapy

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World Journal of Gastroenterology 2019年第35期25卷 5334-5343页

作者： Sadayuki Kawai Tadakazu Shimoda Takashi Nakajima Masanori terashima Katsuhiro Omae Nozomu Machida Hirofumi Yasui Division of Gastrointestinal Oncology Shizuoka Cancer Center Sunto-gun 411-8777 Shizuoka Japan Division of Pathology Shizuoka Cancer Center Suntogun 411-8777 Shizuoka Japan Division of Gastric Surgery Shizuoka Cancer Center Nagaizumi 411- 0932 Shizuoka Japan Clinical Research Center Shizuoka Cancer Center Sunto-gun 411-8777 Shizuoka Japan Department of Gastrointestinal Oncology Shizuoka Cancer Center Suntogun 411-8777 Shizuoka Japan

BACKGROUND Although pathological response is a common endpoint used to assess the efficacy of neoadjuvant chemotherapy (NAC) for gastric cancer, the problem of a low rate of concordance from evaluations among pathologists remains unresolved. Moreover, there is no globally accepted consensus regarding the optimal evaluation. A previous study based on a clinical trial suggested that pathological response measured using digitally captured virtual microscopic slides predicted patients’ survival well. However, the pathological concordance rate of this approach and its usefulness in clinical practice were unknown. AIM To investigate the prognostic utility of pathological response measured using digital microscopic slides in clinical practice. METHODS We retrospectively evaluated pathological specimens of gastric cancer patients who underwent NAC followed by surgery and achieved R0 resection between March 2009 and May 2015. Residual tumor area and primary tumor beds were measured in one captured image slide, which contained the largest diameter of the resected specimens. We classified patients with < 10% residual tumor relative to the primary tumorous area as responders, and the rest as non-responders;we then compared overall survival (OS) and relapse-free survival (RFS) between these two groups. Next, we compared the prognostic utility of this method using conventional Japanese criteria. RESULTS Fifty-four patients were evaluated. The concordance rate between two evaluators was 96.2%. Median RFS of 25 responders and 29 non-responders was not reached (NR) vs 18.2 mo [hazard ratio (HR)= 0.35, P = 0.023], and median OS was NR vs 40.7 mo (HR = 0.3, P = 0.016), respectively. This prognostic value was statistically significant even after adjustment for age, eastern cooperative oncology group performance status, macroscopic type, reason for NAC, and T- and Nclassification (HR = 0.23, P = 0.018). This result was also observed even in subgroup analyses for different macroscopic types (Borrmann type 4/non-type 4) and histologica

关键词： Stomach neoplasm Neoadjuvant therapy Drug therapy Pathology Prognostic factor

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Pattern factory

Experimental confirmation of physical metal penetration generation and press casting production considering molten metal's pressure control

2009年

作者： Ayako. terashima

Title translated: 图案工厂175 p. : ill. (chiefly col.) ; 28 cm + 1 CD-ROM.

ISBN: (纸本)9780061885730

Title translated: 图案工厂175 p. : ill. (chiefly col.) ; 28 cm + 1 CD-ROM.

关键词： Repetitive patterns (Decorative arts) Pictorial works.

来源：畅想之星图书光盘版（南... 评论

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China Foundry 2012年第1期9卷 84-90页

作者： Ryosuke Tasaki Yoshiyuki Noda Kunihiro Hashimoto Kazuhiko terashima Department of Mechanical Engineering Toyohashi University of Technology Sintokogio Ltd.

This paper presents a technique for controlling the pressure of a molten metal when using a new type of iron casting method called sand mold press casting to realize high productivity and obtain high-quality products.The past test results using this method showed a casting yield of 90% to 95%,while conventional methods only show a casting yield of 60% to 70%.Although the press casting method does not require a sprue cup or runner channel casting defects such as metal penetration are often caused by the high pressure in the high-velocity pressing part of this casting process.Therefore,we proposed a pressure control method with a mathematical model of molten metal pressure,and with it we achieved experimental confirmation of the successful production of brake drums at different pressing temperatures.Results show that the proposed pressing control method can realize sound,penetration-free casting production.However,the theoretical analysis and design of this pressing process had not previously been studied sufficiently,and therefore this paper presents the theoretical design algorithm for the process as well as its experimental confirmation.

关键词： press casting pressure control metal penetration sand mould

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Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review

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Cancer Drug Resistance 2021年第4期4卷 946-964页

作者： Shogo Ozawa Toshitaka Miura Jun terashima Wataru Habano Division of Pharmacodynamics and Molecular Genetics School of PharmacyIwate Medical UniversityYahabaIwate 0283694Japan

Treatment with pharmacological drugs for colorectal cancer(CRC)remains unsatisfactory.A major cause of failure in pharmacotherapy is the resistance of colon cancer cells to the drugs,creating an urgent issue.In this review,we summarize previous studies on the resistance of CRC cells to irinotecan and discuss possible reasons for refractoriness.Our review presents the following five major causes of irinotecan resistance in human CRC:(1)cellular irinotecan resistance is induced mainly through the increased expression of the drug efflux transporter,ABCG2;(2)cellular irinotecan resistance is also induced in association with a nuclear receptor,pregnane/steroid X receptor(PXR/SXR),which is enriched in the CYP3A4 gene enhancer region in CRC cells by exposing the cells to SN-38;(3)irinotecan-resistant cells possess either reduced DNA topoisomerase I(Top1)expression at both the mRNA and protein levels or Top1 missense mutations;(4)alterations in the tumor microenvironment lead to drug resistance through intercellular vesicle-mediated transmission of miRNAs;and(5)CRC stem cells are the most difficult targets to successfully treat CRC.In the clinical setting,CRC gradually develops resistance to initially effective irinotecan-based therapy.To solve this problem,several clinical trials,such as irinotecan plus cetuximab vs.cetuximab monotherapy,have been conducted.Another clinical trial on irinotecan plus guadecitabine,a DNA-methyltransferase inhibitor,has also been conducted.

关键词： Drug resistance colorectal cancer anti-cancer drugs irinotecan ABCG2 DNA topoisomerase I cancer stem cells epigenetics

二氧化钛光催化技术应用于室内甲醛降解的研究进展

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化学研究 2016年第4期27卷 502-513页

作者：刘山虎许庆峰邢瑞敏中田一弥寺岛千晶藤嶋昭河南大学化学化工学院河南开封475004 東京理科大学総合研究機構光触媒国際研究中心

随着人们健康意识的不断提升,室内空气中甲醛气体的净化引起了研究者广泛的关注.本文简要介绍了甲醛的危害以及来源;综述了国内室内建材、空气净化器研究中与二氧化钛光催化技术降解甲醛相关的专利,最后对本研究领域存在的问题以及未来... 详细信息

随着人们健康意识的不断提升,室内空气中甲醛气体的净化引起了研究者广泛的关注.本文简要介绍了甲醛的危害以及来源;综述了国内室内建材、空气净化器研究中与二氧化钛光催化技术降解甲醛相关的专利,最后对本研究领域存在的问题以及未来的研究方向进行了总结和展望.

关键词：室内甲醛 TiO2 光催化

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