检索结果-南通市图书馆

World Journal of Psychiatry 2021年第7期11卷 316-324页

作者： Alfredo bellon Kieuhanh Nguyen Department of Psychiatry and Behavioral Health Penn State Hershey Medical CenterHersheyPA 17033United States Department of Penn State College of Medicine Penn State Hershey Medical CenterHersheyPA 17033United States

Patients with schizophrenia(SCZ)are at high risk of cardiovascular disease(CVD)due to an inherited predisposition,a sedentary life style and the use of antipsychotic *** approaches have been taken to minimize this risk but results continue to be unsatisfactory.A potential alternative is prescribing selective serotonin reuptake inhibitors(SSRIs).SSRIs decrease platelet aggregation and reduce the risk of coronary heart disease in patients with *** therefore aim to investigate whether there is evidence that supports the use of SSRIs to reduce the risk for CVD in SCZ.A review of the literature revealed five published reports relating to the impact of SSRIs on CV risk in *** trials assessed the influence on metabolic parameters of fluvoxamine when combined with *** of those studies found improvements with *** the other two reports,one indicates SSRIs as a group caused minimal but statistically significant increments in total cholesterol,low-density lipoprotein and *** second report suggests that when SSRIs are combined with antipsychotics,the metabolic impact depends on the antipsychotic *** there are promising results,no conclusions can be made currently on whether SSRIs increase or decrease CV risk in *** studies are needed to resolve this matter.

关键词： Antidepressants Metabolic syndrome Cholesterol Psychotic disorders Antipsychotics Body weight

Tackling the epigenome in the pluripotent stem cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2008年第7期35卷 403-412页

作者： chia-Lin Wei Genome Technology and Biology Group Genome Institute of Singapore 138672 Singapore

Embryonic stem cells are unique in their abilities of self-renewal and to differentiate into many, if not all, cellular lineages. Transcriptional regulation, epigenetic modifications and chromatin structures are the key modulators in controlling such pluripotency nature of embryonic stem cell genomes, particularly in the developmental decisions and the maintenance of cell fates. Among them, epigenetic regulation of gene expression is mediated partly by covalent modifications of core histone proteins including methylation, phosphorylation and acetylation. Moreover, the chromatins in stem cell genome appear as a highly organized structure containing distinct functional domains. Recent rapid progress of new technologies enables us to take a global, unbiased and comprehensive view of the epigenetic modifications and chromatin structures that contribute to gene expression regulation and cell identity during diverse developmental stages. Here, we summarized the latest advances made by high throughput approaches in profiling epigenetic modifications and chromatin conformations, with an emphasis on genome-wide analysis of histone modifications and their implications in pluripotency nature of embryonic stem cells.

关键词： epigenetics histone modification ChiP-chip ChIP-PET embryonic stem cell

在线全文

学校读者我要写书评

暂无评论

香港中学文凭考试等级预测研究

中国考试 2024年第2期 33-39+101页

作者：许嘉凌萧伟乐席小明香港考试及评核局

为研究香港中学文凭考试（简称文凭试）等级预测结果，以过往文凭试结果作为依据，通过标准化程序，对2020—2023年共计146 180名考生根据其校内评核成绩进行文凭试等级预测；并采用问卷调查法，基于各参与学校组织架构、教师的工作经... 详细信息

为研究香港中学文凭考试（简称文凭试）等级预测结果，以过往文凭试结果作为依据，通过标准化程序，对2020—2023年共计146 180名考生根据其校内评核成绩进行文凭试等级预测；并采用问卷调查法，基于各参与学校组织架构、教师的工作经验、公开考试阅卷经验及专业发展活动等，运用多层线性模型探讨学校属性与校内评核的关系。结果显示：中文、英文、数学、通识教育4门核心科目等级预测结果具有较高的准确度，其中英文预测结果最佳，其余3科预测结果类似；选修科目则因每年选考人数少导致文凭试成绩变化大，进而影响预测结果；多层线性模型分析显示，不同学校属性对于不同科目的校内评核具有不同的预测效果。

关键词：香港中学文凭考试等级预测校内评核标准参照测验

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

香港地区中学文凭考试等级预测研究

中国考试 2024年第2期 33-39,101页

作者：许嘉凌萧伟乐席小明香港考试及评核局中国香港999077

为研究香港地区中学文凭考试(简称文凭试)等级预测结果,以过往文凭试结果作为依据,通过标准化程序,对2020—2023年共计146180名考生根据其校内评核成绩进行文凭试等级预测;并采用问卷调查法,基于各参与学校组织架构、教师的工作经验、... 详细信息

为研究香港地区中学文凭考试(简称文凭试)等级预测结果,以过往文凭试结果作为依据,通过标准化程序,对2020—2023年共计146180名考生根据其校内评核成绩进行文凭试等级预测;并采用问卷调查法,基于各参与学校组织架构、教师的工作经验、公开考试阅卷经验及专业发展活动等,运用多层线性模型探讨学校属性与校内评核的关系。结果显示:中文、英文、数学、通识教育4门核心科目等级预测结果具有较高的准确度,其中英文预测结果最佳,其余3科预测结果类似;选修科目则因每年选考人数少导致文凭试成绩变化大,进而影响预测结果;多层线性模型分析显示,不同学校属性对于不同科目的校内评核具有不同的预测效果。

关键词：香港地区中学文凭考试等级预测校内评核标准参照测验

Observer Design —— A Survey

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Automation and computing 2015年第1期12卷 50-61页

作者： chia-Chi Tsui Staten Island USA

This paper surveys the results of observer design for linear time-invariant(L-T-I) deterministic irreducible open-loop systems(OLS), the most basic type of OLS. An observer estimates Kxx(t) signal where K is a constant and x(t) is the state vector of the OLS. Thus, an observer can be used as a feedback controller that implements state feedback control(SFC) or Kxx(t)-control,and observer design is therefore utterly important in all feedback control designs of state space theory. In this survey, the observer design results are divided into three categories and for three respective main purposes. The first category of observers estimate signal Kxx(t) only with a given K, and this survey has four conclusions: 1) Function observer that estimates Kxx(t) directly is more general than state observer that estimates x(t), and may be designed with order lower than that of state observer, and the additional design objective is to minimize observer order; 2) The function observer design problem has already been simplified to the solving of a single set of linear equations only while seeking the lowest possible number of rows of the solution matrix, and an apparently most effective and general algorithm of solving such a problem can guarantee unified upper and lower bounds of the observer order; 3) Because such a single set of linear equations is the simplest possible theoretical formulation of the design problem and such theoretical observer order bounds are the lowest possible, and because the general, simple, and explicit theoretical formula for the function observer order itself do not exist, the theoretical part of this design problem is solved; 4) Because the function observer order is generically near its upper bound, further improvement on the computational design algorithm so that the corresponding observer order can be further reduced,is generically not worthwhile. The second category of observers further realize the loop transfer function and robustness properties of t

关键词： Low order function observer robust output feedback observer synthesized design principle faults and time-delays

On Variance and Covariance for Bounded Linear Operators

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2001年第4期17卷 657-668页

作者： chia Shiang LIN Department of Mathematics Bishop's University Lennoxville P. Q. J1M 1Z7. Canada

In this paper we initiate a study of covariance and variance for two operators on a Hilbert space. proving that the c-v (covariance-variance) inequality holds, which is equivalent to the Cauchy- Schwarz inequality. As for applications of the c-v inequality we provc uniformly the Bernstein-type inequalities and equalities. and show the generalized Heinz-Kato-Furuta-type inequalities and equalities. from which a generalization and sharpening of Reid’s inequlality is obtained. We show that every operator can be expressed as a p-hyponormal-type, and a hyponormal-type operator. Finally, some new characterizations of the Furuta inequality are given.

关键词： Covariance-variance inequality Bernstein inequality Reid’s inequality Furuta inequality Lowner-Heinz formula

Chow’s Theorem for Semi-abelian Varieties and Bounds for Splitting Fields of Algebraic Tori

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2019年第9期35卷 1453-1463页

作者： chia Fu YU Institute of Mathematics Academia Sinica & NCTS Astronomy Mathematics Building

A theorem of Chow concerns homomorphisms of two abelian varieties under a primary field extension base change. In this paper, we generalize Chow’s theorem to semi-abelian *** contributes to different proofs of a well-known result that every algebraic torus splits over a finite separable field extension. We also obtain the best bound for the degrees of splitting fields of tori.

关键词： Algebraic tori splitting fields semi-abelian varieties inverse Galois problem

The fabrication and application of Ni-DNA nanowire-based nanoelectronic devices

在线全文

学校读者我要写书评

暂无评论

Nano Research 2019年第6期12卷 1293-1300页

作者： Pang-chia Chang chia-Yu Chang Wen-Bin Jian Chiun-Jye Yuan Yu-Chang Chen chia-Ching Chang Department of Electrophysics "National Chiao Tung University"Hsinchu 30010TaiwanChina Department of Biological Science and Technology "National Chiao Tung University"Hsinchu 30068TaiwanChina Center for Intelligent Drug Systems and Smart Bio-devices(IDS^2B) "National Chiao Tung University"Hsinchu 30068TaiwanChina Institute of Physics "Academia Sinica"Taipei 11529TaiwanChina

DNA is a self-assembled,double stranded natural molecule that can chelate and align nickel ions between its base *** fabrication of a DNA-guided nickel ion chain (Ni-DNA) device was successful,as indicated by the conducting currents exhibiting a Ni ion redox reaction-driven negative differential resistance effect,a property unique to mem-elements (1).The redox state of nickel ions in the Ni-DNA device is programmable by applying an external bias with different polarities and writing times (2).The multiple states of Ni-DNA-based memristive and memcapacitive systems were characterized (3).As such,the development of Ni-DNA nanowire device-based circuits in the near future is proposed.

关键词： DNA-guided nickel ion chain (Ni-DNA) negative differential resistance (NDR) memristive systemmem capacitive system nanowire

Novel roles of Skp2 E3 ligase in cellular senescence,cancer progression,and metastasis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

癌症 2012年第4期31卷 169-177页

作者： chia-Hsin Chan Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

S-phase kinase-associated protein 2 (Skp2) belongs to the F-box protein *** is a component of the SCF E3 ubiquitin ligase ***2 has been shown to regulate cellular proliferation by targeting several cell cycle-regulated proteins for ubiquitination and degradation,including cyclin-dependent kinase inhibitor ***2 has also been demonstrated to display an oncogenic function since its overexpression has been observed in many human *** review discusses the recent discoveries on the novel roles of Skp2 in regulating cellular senescence,cancer progression,and metastasis,as well as the therapeutic potential of targeting Skp2 for human cancer treatment.

关键词： Skp2 p53 RhoA cellular senescence metastasis cancer therapy

Lithium Salt of NH_2-substituted Graphene Nanoribbon with Twofold Donor-acceptor Framework: Large Nonlinear Optical Property

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2011年第3期27卷 512-515页

作者： SUN chia-chung State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical Chemistry Jilin University

Based on graphene, a new class of second-order nonlinear optical（NLO） material, the lithium salt of NH2-substituted graphene nanoribbon with the twofold donor（D）/acceptor（A） mode, was reported. Eight stable 2Li-2NH2-GNR lithium salts, especially cis lithium salts, display considerably large β0 values. The combination of NH2-substituting and cis Li-doping makes β0 greatly increased from 0（GNR） to 1.2×105―2.9×105 a.u.（cis-2Li- 2NH2-GNRs）. Our largest β0 value（2.9×105 a.u.） for cis-2Li-1,3-2NH2-AGNR is comparable to the record value of 1.7×105 a.u. for a long donor-acceptor polyene.

关键词： First hyperpolarizability Nonlinear optical material Twofold donor-acceptor mode