检索结果-南通市图书馆

Cellular & Molecular Immunology 2011年第2期8卷 181-188页

作者： Hong-Ren Yu Hsin-Chun Huang Ho-Chang Kuo Jiunn-Ming Sheen chia-yo ou Te-Yao Hsu Kuender D Yang Department of Pediatrics Chang Gung Memorial Hospital-Kaohsiung Medical CenterGraduate Institute of Clinical Medical ScienceChang Gung University College of MedicineTaiwan Department of Obstetrics Chang Gung Memorial Hospital-Kaohsiung Medical CenterGraduate Institute of Clinical Medical ScienceChang Gung University College of MedicineTaiwan

Understanding the defense mechanisms of the host of an organism is important for infection *** previous studies,we demonstrated that interferon-a(IFN-a),but not IL-12,was produced by human peripheral blood mononuclear cells infected with varicella-zoster virus(VZV).Here,we investigated what kind of cell(s)and which signal molecule(s)are involved in IFN-a *** cell isolation and ELISA,we found that plasmacytoid dendritic cells(pDCs)were responsible for IFN-a production during VZV *** also found that Toll-like receptor 9(TLR9)was involved in VZV-induced IFN-a production because inhibitory CpG oligodeoxynucleotide inhibited IFN-a ***-inactivated VZV-induced IFN-a production was lower than that of active VZV,indicating another TLR9-independent *** studies demonstrated that double-stranded RNA-dependent protein kinase,but not DNA-dependent protein kinase was involved in VZV-induced IFN-a ***,these results suggest that pDCs play an important role in IFN-a production during VZV infection through TLR9-dependent and-independent pathways.

关键词： IFN-a mononuclear cells plasmacytoid dendritic cell TLR9 varicella-zoster virus

Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2249-2258页

作者： Kai Li Zhanpeng Feng Zhiwei Xiong Jun Pan Mingfeng Zhou Weizhao Li Yichao ou Guangsen Wu Mengjie Che Haodong Gong Junjie Peng Xingqin Wang Songtao Qi Junxiang Peng Department of Neurosurgery Institute of Brain DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1 axis.

关键词： arginine vasopressin growth hormone hypothalamo-neurohypophyseal system hypothalamus injury insulin-like growth factor 1 oxytocin regeneration

Clinical Evaluation of the Safety and Efficacy of the Phytomedicine APIVIRINE Based on Aqueous Extracts of Dichrostachys glomerata (Forssk.). Chiov. (D. cinerea) in COVID-19 Patients without Signs of Severity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2023年第6期14卷 302-318页

作者： Daouda ouédraogo Grissoum Tarnagda Jean Claude Romaric Pingdwindé ouédraogo Amed Héma Simon Tiendrebéogo Salfo ouédraogo Geoffroy Gueswindé ouédraogo Lazare Belemnaba Noufou ouédraogo Félix Dit Bondo Kini Zékiba Tarnagda Martial ouédraogo Sylvin ouédraogo Service de Pneumologie/Centre Hospitalier Universitaire Yalgado ouédraogo (CHU-yo) Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouaga-dougou Burkina Faso

Background: Since the appearance of the COVID-19 pandemic, several drugs have also been proposed for the treatment of the COVID-19, but the therapeutic effectiveness of those drugs is not satisfactory. This situation has led to the search for therapeutic solutions based on recipes from traditional medicine. Aims: This study aimed to evaluate the clinical safety, efficacy and tolerability of the phytomedicine APIVIRINE in patients with non-severe COVID-19. Methods: Patients were included following defined criteria and followed on an outpatient basis until recovery in accordance with national guidelines for the management of single cases of COVID-19 in Burkina Faso. Vital signs, anthropometric parameters as well as electrocardiographic, hematological and biochemical examinations were measured on D4, D7, D14 and D21. Adverse events were recorded during maintenance. Results: The present study included 45 patients. The clinical signs present at inclusion were mostly cough (44.44%), asthenia (42.22%), headache (40%), and anosmia (35.55%). Dyspnoea and chest pain were less represented in 05 (11.11%) and 06 (13.33%) patients. Cough, dyspnoea, chest pain, fever, sore throat, headache, and nasal obstruction present at inclusion disappeared before Day 4 of treatment. Anosmia and asthenia disappeared before Day 7. At the inclusion visit (Day 1), CRP, WBC, and blood glucose were abnormal in 15 (33.33%), 13 (28.89%), and 11 (24.44%) patients respectively. In addition, 3 (6.66%) patients had elevated creatinine levels. Transaminases Alanine aminotransferase (ALAT) were elevated in 05 (11.11%) patients while Aspartate aminotransferase (ASAT) was elevated in 04 (8.89%) patients. After 4 days of treatment, the cure rate was 33.33% of patients and 48.89% after 7 days. The cumulative cure rate was 86.67% after 14 days of treatment. Conclusion: No serious side effects or allergic reactions were observed during treatment. No clinical complications were observed and all symptoms present r

关键词： APIVIRINE COVID-19 Clinical Study Safety

Ionic Disorders Observed in Infants with Severe Wasting at the Yalgado ouedraogo Teaching Hospital and the Charles de Gaulle Pediatric Teaching Hospital in ouagadougou, Burkina Faso

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Biological Chemistry 2023年第6期13卷 247-255页

作者： Arnaud Kouraogo Fabienne Soudre Caroline yonaba Okengo Faouziatou Yagui Angele Kalmogho Ghislaine Yameogo Alice Kiba Raoul Karfo Ollo Da Emmanuel Zongo Cherileila Thiombiano Fatou Gueye Tall Abdoul Salam ouédraogo Sanata Bamba Georges Anicet ouédraogo Elie Kabré Fla Koueta Jean Sakande Biochemistry Laboratory of Souro Sanou Teaching Hospital Nazi Boni University Bobo-Dioulasso Burkina Faso Health Sciences Training and Research Unit Joseph Ki-Zerbo University Ouagadougou Burkina Faso Department of Pharmaceutical Biochemistry Faculty of Medicine Pharmacy and Dentistry Cheikh Anta Diop University Dakar Senegal

Introduction: A higher risk of death is associated with wasting in children if it is not treated properly. The objective of this study was to investigate the ionic disorders observed in infants suffering from severe wasting at Yalgado ouedraogo Teaching Hospital (yo-TH) and at Charles de Gaulle Pediatric Teaching Hospital (CDG-PTH) in ouagadougou (Burkina Faso). Methods: This was a retrospective study with a descriptive and analytical aim over the period from January 1, 2016 to December 31, 2020. Results: It concerned infants aged 6 to 24 months hospitalized at yo-TH and at CDG-PTH from ouagadougou. We included 271 infants. The mean age of the infants was 14.48 ± 5.44 months with 42.07% which was in the age range of [12 - 18] months. On admission to the hospital, the children had an average weight, height and BMI of 6.22 ± 1.32 kg, 0.73 ± 0.07 m and 11.67 ± 1.53 kg/m2. In urban areas 56.46% of children and the main reasons for consultation were fever (88.19%), vomiting (52.80%) and diarrhea (50.20%). Electrolyte disturbances in emaciated infants affected all 8 parameters of the blood ionogram. However, the major disorders were 65.68% hyponatremia, 55.35% hypobicarbonatemia, 41.33% hypoprotidemia and 32.47% hypokalemia in infants aged 6 to 24 months. We found an association between diarrhea and residence with hypokalemia (p = 0.0000) and hypochloremia (p = 0.010), respectively. Conclusion: Severe acute wasting in infants 6 to 24 months of age remains a concern in the hospital setting. The frequency of biochemical disturbances is also high.

关键词： Severe Wasting Emaciation Infants over 6 - 24 Months Blood Ionogram Burkina Faso

Management of Malaria in Pregnant Women at the Maternity Unit of the University Teaching Hospital Yalgado ouedraogo (UTH-yo) in ouagadougou: About Report on the Quality of Care

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2018年第13期8卷 1337-1344页

作者： ouattara Adama ouédraogo Smaila Lankoandé Bako Coulibaly Natacha ouédraogo Marie Charlemagne ouédraogo Ali Thieba Bonané Blandine Training and Research Unit in Health Sciences (TRU/HS) University Ouaga 1 Pr Joseph KI ZERBO Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The University Teaching Hospital Yalgado Ouedraogo of Ouagadougou (UTH-YO) Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The Bogodogo University Teaching Hospital of Ouagadougou (UTH-B) Ouagadougou Burkina Faso

Objective: To do a report on the quality of the treatment of malaria in pregnant women at University Teaching Hospital Yalgado ouedraogo (UTH-yo) in ouagadougou. Materials and Methods: This was a descriptive cross-sectional study conducted from 29 July to 02 October 2016. The targets were pregnant women and gynecology and obstetrics service care providers. The study used an individual questionnaire administered and clinical parasitological research by the Rapid Diagnostic Test (RDT). Some information was verified in the patient’s prenatal consultation logbook. A total of 351 women and 44 providers participated in the study. The data was captured on a microcomputer and analyzed using Epi info version 7 software. Results: Regarding preventive measures, patients’ responses were correct for long-lasting impregnated mosquito net (LLIN) in 98.8% of cases and for intermittent preventive treatment (IPT) in 96.5% of cases. About providers, they had given a good answer in all cases for using LLIN and taking IPT. Regarding care providers’ knowledge of the clinical signs of malaria, fever was cited in 95.5% of cases for simple malaria and Frankish jaundice in 97.7% of cases for severe malaria. With regard to curative treatment, 77.3% of the care providers surveyed stated that quinine was the reference molecule for the treatment of simple malaria in pregnant women. In terms of the availability of inputs used for malaria management, our survey found no RDTs. Also, the only molecule available was quinine in its compressed and injectable forms. Conclusion: Care Providers’ and patients’ knowledge of malaria in the obstetrics and genecology department is quite satisfactory. However, some shortcomings were noted in the provision of screening and curative and preventive treatment. The elimination of malaria in our country will require joint efforts at all levels.

关键词： Malaria Pregnancy Treatment UTH-yo

Episiotomy: Epidemiological Aspects, Indications and Prognosis in the Bogodogo Health District

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2018年第13期8卷 1354-1363页

作者： ouattara Adama Lankoandé Bako Natacha ouédraogo Smaila Sawadogo yobi Alexis Millogo Traoré Francoise ouédraogo Marie Charlemagne ouédraogo Ali Thieba Bonané Blandine Training and Research Unit in Health Sciences (TRU/HS) University Ouaga 1 Pr Joseph KI ZERBO Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The University Teaching Hospital Yalgado Ouedraogo of Ouagadougou (UTH-YO) Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The Bogodogo University Teaching Hospital of Ouagadougou (UTH-B) Ouagadougou Burkina Faso

Objectives: To study the epidemiological aspects, indications and short and medium term prognosis of episiotomy in the health district of Bogodogo in ouagadougou, Burkina Faso. Materials and Method: It was a descriptive prospective study over 4 months from 1 July 2016 to 30 October 2016. It was conducted in 4 health facilities in the health district of Bogodogo in the city of ouagadougou. The study concerned the patients who gave birth after 28 gestational age (GA) and more, vaginally with episiotomy, in the 4 health facilities and who were reviewed at the appointment of the 9th day and the 3rd month. The data were collected using a questionnaire developed for the purposes of the study, seized with a laptop, then analyzed using the Epi-info software in its 3.5.1 version of the Atlanta C.D.C. Statistical comparisons were made using the Pearson chi-square test, with a significance level of p 0.05. Results: The overall episiotomy rate was 22%. For follow-up, 248 patients were reviewed on the 9th day and 109 patients on the 3rd month. The average age of our patients was 23.1 years. The average number of pregnancies was 1.7 with nulliparous women predominating (60.5% of cases). Excision was associated with episiotomy in 92.3% of cases, with perineal narrowing in 82.5% of patients. The mediolateral episiotomy was the most performed, in 76.6% of patients. Vulvo-perineal stricture was the main indication (75% of cases). The experience during the episiotomy and the evolution following the immediate layer was marked by pain. Dyspareunia was the main difficulty in resuming sexual intercourse. Conclusion: The episiotomy rate in our study was 22%. A program of continuous improvement of the quality of care concerning episiotomy encompassing various actions (audits, training) could reduce the use of episiotomies.

关键词： Episiotomy Epidemiology Bogodogo

Causes of Maternal Mortality According to Reports of Maternal Death Audits in the University Teaching Hospital Bogodogo (UTH-B) from January to December 2017

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2018年第13期8卷 1345-1353页

作者： ouattara Adama ouédraogo Smaila Lankoandé Bako Coulibaly Natacha Kain Dantola Paul Tougma Sanou Aline ouédraogo Marie Charlemagne ouédraogo Ali Thieba Bonané Blandine Training and Research Unit in Health Sciences (TRU/HS) University Ouaga 1 Pr Joseph KI ZERBO Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The University Teaching Hospital Yalgado Ouedraogo of Ouagadougou (UTH-YO) Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The Bogodogo University Teaching Hospital of Ouagadougou (UTH-B) Ouagadougou Burkina Faso

Objective: To study causes of maternal mortality according to reports of maternal death audits in the University Teaching Hospital Bogodogo (UTH-B) of ouagadougou, Burkina Faso. Materials and Method: This was a prospective study that took place over a year from 1 January to 31 December 2017.? It concerned maternal deaths that occurred during this period in the obstetrics and gynecology department of the University Teaching Hospital Bogodogo (UTH-B). All maternal deaths were systematically audited by the audit committee;interviews with providers and families were sometimes conducted. The record books of all patients were analyzed by the audit committee;if necessary, interviews were conducted with care providers and families. The main information collected were recorded on individual files, entered and analyzed using the software Epi-info 7. Result: During the study period, we recorded 32 maternal deaths i.e., 587 per 100,000 live births. Deceased women under age 20 were the most numerous, followed by women aged 20 to 24. The death occurred in most cases in the puerperium in 69.80% of cases. Complications of pregnancy were the most incriminated causes in maternal deaths. Bleeding was the leading cause, accounting for 34.3%. They are followed by hypertensive disorders of pregnancy (21.8%) and infections (18.8%). In the contributing factors, resource factors were incriminated in 56.2% of cases, social factors in 43.7% of cases and medical factors in 25.4% of cases. Death was non-preventable in 76.2% of cases compared to 23.8% of preventable deaths. Conclusion: Maternal mortality is a major public health problem at the maternity hospital of the university hospital Yalgado ouedraogo. Hemorrhage is the first cause of death. Hypertensive diseases are more and more worrying. Solutions must be found to improve the practice of audits in the obstetrics and gynecology department of UTH-B.

关键词： Audits Review Maternal Deaths Causes of Maternal Deaths

Quality Control of First Trimester Ultrasound Examinations in the Gynecology and Obstetrics Department of the University Teaching Hospital Yalgado ouedraogo (UTH-yo) of ouagadougou, Burkina Faso

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2018年第13期8卷 1399-1413页

作者： ouattara Adama Nde ouédraogo Nina Astrid Lankoandé Bako Natacha ouédraogo Smaila Nare Amelie Tougma Sanou Aline Sawadogo yobi Alexis Millogo Traoré Francoise ouédraogo Marie Charlemagne ouédraogo Ali Thieba Bonané Blandine Training and Research Unit in Health Sciences (TRU/HS) University Ouaga 1 Pr Joseph KI ZERBO Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The University Teaching Hospital Yalgado Ouedraogo of Ouagadougou (UTH-YO) Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The Bogodogo University Teaching Hospital of Ouagadougou (UTH-B) Ouagadougou Burkina Faso

Objective: To evaluate the quality of first trimester ultrasound examinations in patients consulting in the gynecology and obstetrics department at the University Teaching Hospital Yalgado ouedraogo (UTH-yo) of ouagadougou. Method: our study took place from January 1st to March 31st 2017, in the department of Obstetrics and Gynecology of the University Teaching Hospital Yalgado ouedraogo of ouagadougou. This was a descriptive study on the records of the first trimester ultrasound of pregnancy, with analysis of the iconography. We used the criteria of the Technical Committee of Fetal Echography (TCFE) of France to analyse all the ultrasound reports brought by the patients. Results: Two hundred reports were collected in three months. In terms of ultrasound identification, only 2 reports out of 200 mentioned the brand and date of first circulation and 4 specified the type of device. The study of the quality of the appointment showed that only 52% of the ultrasounds had been performed at the right time, between 11SA - 14SA of amenorrhea. For the nuchal translucency quality, we rated by the Herman score, 41.67% of the scores were of “unacceptable” quality and only 58.33% were of “acceptable” quality we did not achieve “excellent” quality. The analysis of the biparietal diameter (BIP) cuts revealed that 1/4 only anatomical cuts had been well made. Analysis of the cranio caudal length (CCL) cuts showed that only 14.58% of the CCLs had been well done. Elements of early morphology had been explored to less than 5%. Conclusion: The results revealed the acceptable quality of the NC measurements, but a small proportion of NC achieved. The quality of the ultrasound, morphological analysis and biometrics period is not very acceptable.

关键词： Ultrasonography First Trimester Reports UTH-yo

Quality Control of Second Trimester Ultrasound Examinations in the Gynecology and Obstetrics Department of the University Teaching Hospital Yalgado ouedraogo (UTH-yo) of ouagadougou, Burkina Faso

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2018年第13期8卷 1324-1336页

作者： ouattara Adama Nde ouédraogo Nina Astrid Lankoandé Bako Natacha ouédraogo Smaila Bayala René-Philippe Yi Dia Tougma Sanou Aline Sawadogo yobi Alexis Millogo Traoré Francoise ouédraogo Marie Charlemagne ouédraogo Ali Thieba Bonané Blandine Training and Research Unit in Health Sciences (TRU/HS) University Ouaga 1 Pr Joseph KI ZERBO Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The University Teaching Hospital Yalgado Ouedraogo of Ouagadougou (UTH-YO) Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The Bogodogo University Teaching Hospital of Ouagadougou (UTH-B) Ouagadougou Burkina Faso

Objective: To evaluate the quality of second trimester ultrasound examinations in patients consulting in the gynecology and obstetrics department at the University Teaching Hospital Yalgado ouedraogo (UTH-yo) of ouagadougou. Method: our study took place from January 1st to March 31st 2017, in the department of Obstetrics and Gynecology of the University Teaching Hospital Yalgado ouedraogo of ouagadougou. This was a descriptive study on the records of the second trimester ultrasound of pregnancy, with analysis of the iconography. We used the criteria of the Technical Committee of Fetal Echography (TCFE) of France to analyse all the ultrasound reports brought by the patients. Results: Three hundred ultrasound reports were collected over three months. It revealed that, in terms of patient identification, 100% of the reports bore the surname and first name of the pregnant woman;88% and 94.67% of the ultrasound scans bore the surname and first name of the ultrasound specialist respectively. Only 2% presented the brand and type of ultrasound scanner. The study of the quality of the appointment showed that 52% of the ultrasounds had been performed at the right time, between 20 Gestational Age (GA) and 25 GA. For the quality of the iconography, referring to the recommendations of the Technical Committee of Fetal Echography (TCFE) of France and taking into account the data confirmed by the literature, we found that the quality was slightly acceptable either respectively for biometric and morphological sections. Conclusion: The quality of the ultrasound reports of the second trimester ultrasounds in patients consulting in the obstetrics and gynecology department of the University Hospital Yalgado ouEDRAOGO was not totally satisfactory.

关键词： Ultrasonography Second Trimester Reports UTH-yo

Particularities of Pregnancy and Childbirth among Adolescents’ Girls in the University Teaching Hospital Yalgado ouedraogo (UTH-yo) in ouagadougou, Burkina Faso

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2018年第13期8卷 1389-1398页

作者： ouattara Adama ouédraogo Smaila Lankoandé Bako Natacha Tossou Arséne Serge Tougma Sanou Aline Sawadogo yobi Alexis Millogo Traoré Francoise ouédraogo Marie Charlemagne ouédraogo Ali Thieba Bonané Blandine Training and Research Unit in Health Sciences (TRU/HS) University Ouaga 1 Pr Joseph KI ZERBO Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The University Teaching Hospital Yalgado Ouedraogo of Ouagadougou (UTH-YO) Ouagadougou Burkina Faso Department of Gynecology and Obstetrics The Bogodogo University Teaching Hospital of Ouagadougou (UTH-B) Ouagadougou Burkina Faso

Objectives: To study the particularities of pregnancy and childbirth among adolescent girls at the University Teaching Hospital Yalgado ouedraogo (UTH-yo) of ouagadougou. Patients and Method: This was a comparative, descriptive and analytical cross-sectional study conducted over a 6-month period on 138 adolescent girls and 276 adults who gave birth in the obstetrics and gynecology department of the University Teaching Hospital Yalgado ouedraogo (UTH-yo) in ouagadougou during the study period from May 1 to October 30, 2017. The statistical analysis had used the Chi square test and the strength of the association was appreciated by the Odds Ratio (OR). The significance threshold was set at 5%. Results: Adolescent girls had an average age of 17.04 ± 0.72 years and 64.49% were married. The majority came from urban areas and was educated. Housewives were more represented with 73.2% and 65.94% of adolescent girls were of low socio-economic status. Concerning the level of education, 48 (34.7%) were out of school, 57 (41.3%) had primary level, 32 (23.2%) secondary level and 1 (0.7%) higher level. Primigravida was the most numerous and only 39 adolescent girls used a contraceptive method. Malaria (p = 0.0247), preeclampsia (p = 0.0008) and anaemia (p = 0.0002) dominated pathologies during pregnancy in adolescent girls. The pelvis was borderline in 10.8% of adolescent girls. For newborns, teenage girls had a lower weight and an Apgar score of less than 7 higher. Perinatal mortality was higher (p = 0.0269). Postpartum outcomes were marked by complications with endometritis type (p = 0.0315) and higher maternal mortality (p = 0.0049). Conclusion: The teenagers’ pregnancy experience is marked by high maternal and perinatal morbidity and mortality. The promotion of contraception among adolescents should help to resolve this unpleasant situation.

关键词： Teen Pregnancy UTH-yo Burkina Faso