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An Efficient Second-Order Convergent Scheme for One-Side Space Fractional Diffusion Equations with Variable Coefficients

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Communications on Applied Mathematics and Computation 2020年第2期2卷 215-239页

作者： Xue-lei lin pin Lyu Michael KNg Hai-Wei Sun Seakweng Vong Department of Mathematics Hong Kong Baptist UniversityHong KongChina School of Economic Mathematics Southwestern University of Finance and EconomicsChengdu 611130China Department of Mathematics The University of Hong KongHong KongChina Department of Mathematics University of MacaoMacaoChina

In this paper,a second-order fnite-diference scheme is investigated for time-dependent space fractional difusion equations with variable *** the presented scheme,the Crank-Nicolson temporal discretization and a second-order weighted-and-shifted Grünwald-Letnikov spatial discretization are ***,the unconditional stability and the second-order convergence in time and space of the proposed scheme are established under some conditions on the variable ***,a Toeplitz preconditioner is proposed for linear systems arising from the proposed *** condition number of the preconditioned matrix is proven to be bounded by a constant independent of the discretization step-sizes,so that the Krylov subspace solver for the preconditioned linear systems converges *** results are reported to show the convergence rate and the efciency of the proposed scheme.

关键词： One-side space fractional difusion equation Variable difusion coefcients Stability and convergence High-order fnite-diference scheme Preconditioner

Anti-oxidant and anti-inflammatory effects of hydrogenrich water alleviate ethanol-induced fatty liver in mice

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World Journal of Gastroenterology 2017年第27期23卷 4920-4934页

作者： Ching-pin lin Wen-Chen Chuang Fung-Jou Lu Chih-Yen Chen Institute of Biochemistry Microbiology and ImmunologyChung Shan Medical University Division of Gastroenterology Department of Internal MedicineChung Shan Medical University Hospital Institute of Medicine Chung Shan Medical University Division of Gastroenterology and Hepatology Department of MedicineTaipei Veterans General Hospital Faculty of Medicine National Yang-Ming University School of Medicine

AIM To investigate the effects of hydrogen-rich water(HRW) treatment on prevention of ethanol(Et OH)-induced early fatty liver in *** In vitro reduction of hydrogen peroxide by HRW was determined with a chemiluminescence system. Female mice were randomly divided into five groups: control,Et OH,Et OH + silymarin,Et OH + HRW and Et OH + silymarin + HRW. Each group was fed a Lieber-De Carli liquid diet containing Et OH or isocaloric maltose dextrin(control diet). Silymarin was used as a positive control to compare HRW efficacy against chronic Et OH-induced hepatotoxicity. HRW was freshly prepared and given at a dosage of 1.2 m L/mouse trice daily. Blood and liver tissue were collected after chronic-binge liquid-diet feeding for 12 *** The in vitro study showed that HRW directly scavenged hydrogen peroxide. The in vivo study showed that HRW increased expression of acyl ghrelin,which was correlated with food intake. HRW treatment significantly reduced Et OH-induced increases in serum alanine aminotransferase,aspartate aminotransferase,triglycerol and total cholesterol levels,hepatic lipid accumulation and inflammatory cytokines,including tumor necrosis factor-alpha(TNF-α) and interleukin(IL)-6. HRW attenuated malondialdehyde level,restored glutathione depletion and increased superoxide dismutase,glutathione peroxidase and catalase activities in the liver. Moreover,HRW reduced TNF-α and IL-6 levels but increased IL-10 and IL-22 *** HRW protects against chronic Et OH-induced liver injury,possibly by inducing acyl ghrelin to suppress the pro-inflammatory cytokines TNF-α and IL-6 and induce IL-10 and IL-22,thus activating antioxidant enzymes against oxidative stress.

关键词： Hydrogen Chronic plus binge Et OH feeding Antioxidant Protective cytokine Acyl ghrelin Female mice

Optimization Design and Finite Element Analysis of Core Cutter

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Journal of China University of Mining and Technology 2007年第3期17卷 399-402页

作者： CAO pin-lu YIN Kun PENG Jian-ming LIU Jian-lin College of Construction Engineering Jilin University Changchun Jilin 130026 China Key Laboratory of Geo-exploration Instrumentation Ministry of Eduction Changchun Jilin 130026 China

The hydro-hammer sampler is a new type of sampler compared with traditional ones. An important part of this new offshore sampler is that the structure of the core cutter has a significant effect on penetration and core recovery. In our experiments, a commercial finite element code with a capability of simulating large-strain frictional contact between two or more solid bodies is used to simulate the core cutter-soil interaction. The effects of the cutting edge shape, the diameter and the edge angle on penetration are analyzed by non-liner transient dynamic analysis using a finite element method （FEM）. Simulation results show that the cutter shape clearly has an effect on the penetration and core recovery. In addition, the penetration of the sampler increases with an increase in the inside diameter of the cutter, but decreases with an increase in the cutting angle. Based on these analyses, an optimum structure of the core cutter is designed and tested in the north margin of the Dalian gulf. Experiment results show that the penetration rate is about 16.5 m/h in silty clay and 15.4 m/h in cohesive clay, while the recovery is 68% and 83.3% resoectively.

关键词： hydro-hammer sampler finite element analysis core cutter-soil interaction optimum design

基于第一性原理和热力学计算的TiAl-Nb金属间化合物稳定性和相关系研究

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原子与分子物理学报 2025年第5期42卷 151-162页

作者：汪文洋徐勇田彬甘信柱王志刚梁永锋林均品山东建筑大学材料科学与工程学院济南250101 北京科技大学新金属材料国家重点实验室北京100083

采用基于广义梯度近似密度泛函理论的第一性原理计算和相图计算方法,研究了TiAl-Nb合金中γ、α_(2)、O_(2)和ωo相的热力学和力学性质以及相转变关系.研究表明,第一性原理计算得到的化合物相的参数是准确的,且分析结果与相图计算结果... 详细信息

采用基于广义梯度近似密度泛函理论的第一性原理计算和相图计算方法,研究了TiAl-Nb合金中γ、α_(2)、O_(2)和ωo相的热力学和力学性质以及相转变关系.研究表明,第一性原理计算得到的化合物相的参数是准确的,且分析结果与相图计算结果相一致.四个化合物相都是能够稳定存在的相.通过热力学和力学性质的分析,发现α_(2)相更容易转变为O_(2)相,并且在一定条件下可以通过相变反应生成ωo相.而γ相更容易转变为ωo相,但无法生成O_(2)相.

关键词： TiAl合金第一性原理相图声子谱及态密度热力学性质

Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites

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World Journal of Gastroenterology 2016年第12期22卷 3363-3371页

作者： Chao Chen Ren-pin Chen Hai-Hua lin Wen-You Zhang Xie-lin Huang Zhi-Ming Huang Department of Gastroenterology the First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 Zhejiang Province China Ren-Ji College of Wenzhou Medical University Wenzhou 325000 Zhejiang Province China

AIM: To investigate the role of tolvaptan in regulating aquaporin(AQP)-2 expression and fecal water content in cirrhotic rats with ***: Cirrhosis with ascites was induced in rats by repetitive dorsal injection of CCl4 for 14 wk. In total, 84 cirrhotic rats with ascites divided into three groups(vehicle, 3 mg/kg and 5 mg/kg tolvaptan), and then further divided into five subgroups(days 1, 2, 3, 4, and 5). Blood samples were obtained to measure vasopressin and sodium concentrations. Rats were killed and colonic mucosa was scraped for analysis of protein expression and AQP-2 transcriptional level. The whole layer was fixed for hematoxylin&eosin(HE) staining and feces were collected for determination of fecal water content. CONCLUSION: Compared with vehicle, vasopressin decreased significantly in the tolvaptan groups from day 2 to a similar level in each treatment group. AQP-2 showed significant upregulation in cirrhotic rats with ascites compared with an untreated control group(100% ± 22.9% vs 22.2% ± 10.23%, P line at day 4 at the latest in both treatment groups, and did not correspond to the change in AQP-2 expression. HE staining of the colonic mucosa showed no mucosal damage related to ***: Upregulation of AQP-2 in the distal colon is found in cirrhotic rats with ascites. Tolvaptan inhibits its expression and may decrease water reabsorption and induce diarrhea.

关键词： Tolvaptan Aquaporin-2 Cirrhosis Ascites

The role of magmatism in the thinning and breakup of the South China Sea continental margin

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National Science Review 2019年第5期6卷 871-876页

作者： Zhen Sun Jian lin Ning Qiu Zhimin Jian pin Xian Wang Xiong Pang Jinyun Zheng Benduo Zhu CAS Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of Sciences Innovation Academy of South China Sea Ecology and Environmental Engineering Chinese Academy of Sciences Department of Geology and Geophysics Woods Hole Oceanographic Institution School of Ocean and Earth Science Tongji University East South China Sea Petroleum Research Institute Shenzhen branch of China National Offshore Oil Corporation Guangzhou Marine Geological Survey Ministry of Natural Resources

INTRODUCTION Magmatism plays a key role in the process of continental margin breakup and ocean *** in the extremely magma-poor Iberia and Newfoundland margin, studies of field outcrops have shown that syn-rift magmati... 详细信息

关键词： SCS The role of magmatism in the thinning and breakup of the South China Sea continental margin China

Efficient circularly polarized photoluminescence and electroluminescence of chiral spiro-skeleton-based thermally activated delayed fluorescence molecules

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Science China Chemistry 2022年第7期65卷 1347-1355页

作者： Yi-pin Zhang Shi-Quan Song Meng-Xi Mao Cheng-Hui Li You-Xuan Zheng Jing-lin Zuo State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China MaAnShan High-Tech Research Institute of Nanjing University Maanshan 238200China

Chiral thermally activated delayed fluorescence(TADF) molecules showing circularly polarized luminescence(CPL) have great potential in 3D displays. However, the relationships among CPL property, device performance and molecule structure are still not clear. In this article, we develop a strategy to promote dissymmetry factors without sacrifice in device performance and study the impact of molecule structures towards CPL property. Three novel TADF enantiomers are synthesized and studied.(R/S)-SCN with diminutive cyano group as an acceptor shows dissymmetry factor |gPL| ≈ 1.4×10^(-3) and noticeable organic light-emitting diode(OLED) performances with a maximum external quantum efficiency(EQEmax) of 23.0%. For(R/S)-SPHCN, the prolonged electron withdrawing group benzonitrile enhances |gPL| up to 3.6×10^(-3) with decreased device EQEmaxof 15.4%. By further replacing benzonitrile with(trifluoromethyl)pyridine, the enantiomers of(R/S)-SCFPY show similar |gPL| factors of 3.5×10^(-3) and device EQE_(max)up to 23.3%, which represents the highest efficiency among sprio-type TADF materials based OLEDs. Furthermore, the OLEDs also show obvious circularly polarized electroluminescence with gELfactors of-1.4/1.8×10^(-3),-3.6/3.6×10^(-3) and-3.7/3.6×10^(-3), respectively. These results indecate by delicate functional group engineering, high g factor can be achieved while maintaining decent device performances. Besides,(R/S)-SCFPY represents an impressive TADF emitter, which shows promoted g factor and recorded high device EQE_(max)among similar molecules.

关键词： chiral spiro-skeleton thermally activated delayed fluorescence circularly polarized photoluminescence circularly polarized electroluminescence dissymmetry factor

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Growth rate and composition of directionally solidified intermetallic TiAl–Nb alloys with different solidification conditions

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Rare Metals 2016年第1期35卷 54-64页

作者： Li-Wei Zhang Jun-pin lin Xiang-Jun Xu Jian-ping He Xian-Fei Ding Xiao-Ou Jin State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Materials and Chemistry School Zhongyuan University of Technology National Center for Materials Service Safety University of Science and Technology Beijing School of Architecture and Engineering Heilongjiang University

Intermetallic Ti-xAl-8Nb（x = 41,43,45,47,49;at%） alloys were solidified unidirectionally upwards with a constant temperature gradient of G=3.8 K·mm^（-1）at wide range of growth rates of v=10-400 μm·s^（-1）using a Bridgman directional solidification（DS） *** parameters including the primary dendrite arm spacing（λ_1）,secondary dendrite arm spacing（λ_2）,dendrite tip radius（R） and mushy zone depth（d） were measured *** values of λ_1,λ_2,R and d decrease as the growth rate increases for a given composition（x）.The values of λ_1,λ_2,R and v increase with the increase in x value,while the value of d firstly increases and then decreases with the increase in x value for a given *** relationships between λ_1,λ_2 and R were analyzed by the linear *** average growth rate exponent of λ_1 is 0.29,which is in accordance with the previous experimental observations,and that of λ_2 is close to the previous experimental results,while those of R and d are lower than the results in other alloy *** addition,theoretical models for λ_1,λ_2 and R were compared with the experimental observations,and a comparison of the present experimental results with the theoretical models and previous experimental results was also made.

关键词： TiAl-Nb alloys Intermetallic Directionalsolidification Microstructural parameters Soluteconcentration

A phase Ⅰ study of Hemay022, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor in Chinese patients with HER2-positive advanced breast cancer

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Chinese Journal of Cancer Research 2024年第1期36卷 46-54页

作者： pin Zhang lin Wang Yueying Zhen Zhihong Wang Hesheng Zhang Richard Jones Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin Hemay Pharmaceutical Co. LTDTianjin 300308China

Objective: Hemay022 is a novel small-molecule and an irreversible tyrosine kinase inhibitor with the target of epidermal growth factor receptor(EGFR)/human epidermal growth factor receptor 2(HER2), which demonstrated anti-tumor activity in preclinical studies. This first-in-human study evaluated the safety, pharmacokinetics,tolerability and preliminary anti-tumor activity of Hemay022 in HER2-positive advanced breast cancer ***: Heavily pretreated patients with HER2-positive advanced breast cancer were assigned to eight dose cohorts in a 3+3 dose-escalation pattern at doses of 50-600 mg QD and 300 mg BID. Eligible patients were given a single dose of Hemay022 on d 1 in week 0, followed by once daily continuous doses for four weeks in 28-day *** samples were obtained on d 1 and d 28. Clinical responses were assessed every eight ***: Twenty-eight patients with advanced breast cancer were treated with Hemay022. The most frequently reported drug-related adverse events were diarrhoea(85.7%), vomiting(28.6%), nausea(25.0%) and decreased appetite(17.9%). No grade 4 drug-related adverse events were reported. At 50-600 mg doses, steady state areas under the concentration-time curve and peak concentrations increased with doses. One patient achieved complete response(CR), and three achieved partial response(PR). The objective response rate(ORR) and disease control rate(DCR) were 14.3% and 46.4% in 28 patients, respectively. The median progression-free survival(PFS) was3.98 ***: Hemay022 at the dose of 500 mg once daily was well tolerated. The pharmacokinetic properties and encouraging anti-tumor activities of Hemay022 in advanced breast cancer patients warranted further evaluation of Hemay022 for treating breast cancer patients in the current phase Ⅲ trial(No. NCT05122494).

关键词： Advanced breast cancer HER2-positive Hemay022 first-in-human trial