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Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第47期19卷 8880-8886页

作者： chia-chi hsu Hsin-Chen Lee Yau-Huei Wei Institute of Pharmacology School of MedicineNational Yang-Ming University Department of Biochemistry and Molecular Biology National Yang-Ming University Department of Medicine Mackay Medical College

Hepatocellular carcinoma(HCC)is one of the most common malignancies and is ranked third in mortality among cancer-related *** are intracellular organelles that are responsible for energy metabolism and cellular homeostasis,and mitochondrial dysfunction has been regarded as a hallmark of *** the past decades,several types of mitochondrial DNA(mtDNA)alterations have been identified in human cancers,including ***,the role of these mtDNA alterations in cancer progression is *** this review,we summarize the recent findings on the somatic mtDNA alterations identified in HCC and their relationships with the clinicopathological features of *** advances in understanding the potential roles of somatic mtDNA alterations in the progression of HCC are also *** suggest that somatic mtDNA mutations and a decrease in the mtDNA copy number are common events in HCC and that a mitochondrial dysfunction-activated signaling cascade may play an important role in the progression of *** of the retrograde signaling pathways in HCC and the quest for strategies to block some of these pathways will be instrumental for the development of novel treatments for this and other malignancies.

关键词： Hepatocellular carcinoma Somatic mitochondrial DNA mutations Mitochondrial dysfunction

Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-chi hsu Lin Chen Yitian Qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis

Thickness bound for nonlocal wide-field-of-view metalenses

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Light(Science & Applications) 2022年第12期11卷 3018-3027页

作者： Shiyu Li chia Wei hsu Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA

Metalenses—flat lenses made with optical metasurfaces—promise to enable thinner,cheaper,and better imaging *** a sufficient angular field of view(FOV)is crucial toward that goal and requires a tailored incidentangle-dependent ***,we show that there is an intrinsic trade-off between achieving a desired broad-angle response and reducing the thickness of the *** the memory effect in disordered media,this thickness bound originates from the Fourier transform duality between space and *** can write down the transmission matrix describing the desired angle-dependent response,convert it to the spatial basis where its degree of nonlocality can be quantified through a lateral spreading,and determine the minimal device thickness based on such a required lateral *** approach is *** applied to wide-FOV lenses,it predicts the minimal thickness as a function of the FOV,lens diameter,and numerical *** bound is tight,as some inverse-designed multi-layer metasurfaces can approach the minimal thickness we *** work offers guidance for the design of nonlocal metasurfaces,proposes a new framework for establishing bounds,and reveals the relation between angular diversity and spatial footprint in multi-channel systems.

关键词： desired angular field

What role do emission trading schemes,energy innovation,and technology transfer play in sustainable recovery?A perspective from BRICS economies

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Geoscience Frontiers 2024年第4期15卷 505-517页

作者： YunQian Zhang ching-chi hsu School of Finance Fuzhou University of International Studies and TradeFuzhou 350202China City University of Macao Avenida Padre Tomás Pereira TaipaMacaoChina Carbon Economy Research Center Fuzhou University of International Studies and TradeFuzhou 350202China

To ensure long-run sustainability,it is imperative to achieve the goal of zero-carbon emissions without compromising economic *** whether BRICS economies,which are an attractive set of countries due to their rapid economic growth and high emissions,can shift towards sustainability with the support of policy measures,is a question which needs to be *** article investigates the impact of emission trading schemes,energy innovation,technology transfer,population growth,and inflation on the economic performance of BRICS economies(2001-2020).The outcomes of the CS-ARDL and PMG estimators reveal that carbon taxes,carbon finance,energy innovation,technology transfer,population growth,and inflation have positive effects on economic *** light of the evidence,policy insights are recommended to achieve a win-win situation for economic and environmental performance.

关键词： Emission trading schemes Carbon taxes Carbon finance Energy innovation Technology transfer Economic performance

A family of explicit algorithms for general pseudodynamic testing

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Earthquake Engineering and Engineering Vibration 2011年第1期10卷 51-64页

作者： Shuenn-Yih Chang chi-Wei hsu Department of Civil Engineering Taipei University of Technology (NTUT) NTUT Box 2653

A new family of explicit pseudodynamic algorithms is proposed for general pseudodynamic testing. One particular subfamily seems very promising for use in general pseudodynamic testing since the stability problem for a structure does not need to be considered. This is because this subfamily is unconditionally stable for any instantaneous stiffness softening system, linear elastic system and instantaneous stiffness hardening system that might occur in the pseudodynamic testing of a real structure. In addition, it also offers good accuracy when compared to a general second-order accurate method for both linear elastic and nonlinear systems.

关键词： pseudodynamic test explicit method unconditional stability dominant mode structural dynamics instantaneous degree of nonlinearity

Comparison of capability of time integration methods in capturing dynamic loading

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Earthquake Engineering and Engineering Vibration 2010年第3期9卷 409-423页

作者： Shuenn-Yih Chang chi-Wei hsu Department of Civil Engineering Taipei University of Technology

Numerical properties of the time integration method proposed by the first author of this paper in 2007 are the same as those of the constant average acceleration method （AAM） for linear elastic systems, except that the capability to capture dynamic loading was not explored. It was found that there were different quadrature equations to predict the next step displacement increment. A modified quadrature equation of this method was derived so that the equation to determine the next step displacement was numerically equivalent to the equation used in the constant AAM. It was verified that the original form of this method, in general, had a better capability to capture dynamic loadings than the constant AAM. This excellent property, in addition to computational efficiency, will help to make this method competitive with general secondorder accurate integration methods.

关键词： equations of motion quadrature equation constant average acceleration method integration methods

Changes in Surface Energy Partitioning in china over the Past Three Decades

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Advances in Atmospheric Sciences 2017年第5期34卷 635-649页

作者： Yitian QIAN Pang-chi hsu chi-Han CHENG Key Laboratory of Meteorological Disaster of Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of lnformation Science and Technology Nanjing Jiangsu 210044 China Applied Hydrometeorological Research Institute Nanjing University of Information Science and Technology Nanjing Jiangsu 210044 China

Surface energy balance and the partitioning of sensible heat flux(SHF) and latent heat flux(LHF) play key roles in land–atmosphere feedback. However,the lack of long-term observations of surface energy fluxes,not to mention spatially extensive ones,limits our understanding of how the surface energy distribution has responded to a warming climate over recent decades(1979–2009) at the national scale in china. Using four state-of-the-art reanalysis products with long-term surface energy outputs,we identified robust changes in surface energy partitioning,defined by the Bowen ratio(BR = SHF/LHF),over different climate regimes in china. Over the past three decades,the net radiation showed an increasing trend over almost the whole of china. The increase in available radiative energy flux,however,was balanced by differential partitioning of surface turbulent fluxes,determined by local hydrological conditions. In semi-arid areas,such as Northeast china,the radiative energy was transferred largely into SHF. A severe deficiency in near-surface and soil moistures led to a significant decreasing trend in LHF. The combined effect of increased SHF and decreased LHF resulted in significant upward trends in the BR and surface warming over Northeast china. In contrast,in the wet monsoon regions,such as southern china,increased downward net radiation favored a rise in LHF rather than in SHF,leading to a significant decreasing trend in the BR. Meanwhile,the increased LHF partly cancelled out the surface warming. The warming trend in southern china was smaller than that in Northeast china. In addition to impacts on heat-related events,the changes in the BR also reflected recent cases of extreme drought in china. Our results indicate that information regarding the BR may be valuable for drought monitoring,especially in regions prone to such conditions.

关键词： surface energy partitioning Bowen ratio climate change long-term trend

Untangling the relationship between power outage and population activity recovery in disasters

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Resilient Cities and Structures 2024年第3期3卷 53-64页

作者： chia-Wei hsu Ali Mostafavi Urban Resilience.AI Lab Zachry Department of Civil&Environmental Engineering 3136TAMUCollege StationTX77843USA

Despite recognition of the relationship between infrastructure resilience and community recovery,very limited empirical evidence exists regarding the extent to which the disruptions in and restoration of infrastructure ser-vices contribute to the speed of community *** address this gap,this study investigates the relationship between community and infrastructure systems in the context of hurricane impacts,focusing on the recovery dy-namics of population activity and power infrastructure *** observational data were utilized to analyze the extent of impact,recovery duration,and recovery types of both systems in the aftermath of Hurricane *** study reveals three key ***,power outage duration positively correlates with outage extent until a certain impact threshold is *** this threshold,restoration time remains relatively stable re-gardless of outage *** finding underscores the need to strengthen power infrastructure,particularly in extreme weather conditions,to minimize outage restoration ***,power was fully restored in 70% of affected areas before population activity levels *** finding suggests the role infrastructure function-ality plays in post-disaster community *** power restoration did not equate to rapid population activity recovery due to other possible factors such as transportation,housing damage,and business ***,if power outages last beyond two weeks,community activity resumes before complete power restoration,indicating adaptability in prolonged outage *** implies the capacity of communities to adapt to on-going power outages and continue daily life *** findings offer valuable empirical insights into the interaction between human activities and infrastructure systems,such as power outages,during extreme weather *** also enhance our empirical understanding of how infrastructure resilience influences community recov

关键词： Infrastructure resilience Community recovery Power outage Human mobility Location-based data Weather hazard

Modulation of the Intraseasonal Variability of Pacific-Japan Pattern by ENSO

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Journal of Meteorological Research 2020年第3期34卷 546-558页

作者： Ying LI Fei LIU Pang-chi hsu Earth System Modeling and Climate Dynamics Research Center Nanjing University of Information Science&TechnologyNanjing 210044

This study investigates how the El Nino-Southern Oscillation(ENSO)modulates the intraseasonal variability(ISV)of Pacific-Japan(PJ)teleconnection *** PJ index during boreal summer is constructed from the empirical orthogonal function(EOF)of the 850-hPa zonal wind(U850)*** periods of the PJ index are found during El Nino and La Nina *** ISV of the PJ pattern is significant during 10-25 days for both types of summers,it peaks on Days 30 and 60 in El Nino and La Nina summers *** El Nino summers,the 30-day ISV of PJ pattern is related to the northwestward propagating intraseasonal oscillation(ISO)over the western North Pacific(WNP),which is originated from the tropical Indian Ocean(IO).During La Nina summers,the 60-day ISV of PJ pattern is related to the northeastward propagating ISO from the tropical *** low-frequency ISV modes in both El Nino and La Nina summers are closely related to the boreal summer ISO(BSISO),and the high-frequency ISV modes over WNP are related to the quasi-biweekly *** underlying mechanisms for these different evolutions are also discussed.

关键词： Pacific–Japan(PJ)pattern El Nino–Southern Oscillation(ENSO) intraseasonal variability(ISV) intraseasonal oscillation(ISO) intraseasonal timescale low-frequency ISV mode boreal summer ISO