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Neuroprotective Effects of MIP-15 Peptide from Morchella importuna Against Ischemic-Hypoxic Brain Damage in Rats

Food Science and Human Wellness 2024年

作者： Chuan Xiong Ping Li Qiang Luo chia wei phan Xin Jin Wenli Huang Biotechnology and Nuclear Technology Research Institute， Sichuan Academy of Agricultural Sciences The Second Affiliated Hospital， Chongqing Medical University Department of Anatomy， Faculty of Medicine， Universiti Malaya

Hypoxic-ischemic encephalopathy (HIE) is a prominent cause of neuronal damage and neonatal death， and effective treatment strategies remain limited. In a prior investigation， we purified a novel peptide (designated MIP-15) from the rare mushroom Morchella importuna， demonstrating its notable free radical scavenging activity. Nevertheless， the potential neuroprotective role of MIP-15 in neonatal hypoxic-ischemic brain damage (HIBD) and its underlying mechanism remain elusive. The purpose of this study was to evaluate whether MIP-15 exerts neuroprotective effects by inhibiting the mitochondrial apoptotic pathway after HIBD. A HIBD model in 7-day-old (P7) rats was established by the Rice–Vannucci method to evaluate the effect of MIP-15 on the neurological damage severity and space cognitive ability of rats. Subsequently， an oxygen glucose deprivation/reoxygenation (OGD/R) model was established in rat primary hippocampal neurons to explore the mechanism of MIP-15 action. Both in vivo and in vitro data showed that MIP-15 markedly restored endogenous antioxidative activity， decreased brain water content， and ameliorated pathological abnormalities following HIBD. The spatial cognitive ability and motor function of HIBD rats were also repaired. Moreover， in primary hippocampal neurons after OGD/R， MIP-15 increased cell viability by inhibiting the mitochondrial-dependent apoptosis pathway， as manifested by stabilization of the mitochondrial membrane potential， prevention of the release of cytochrome c， upregulation of Bcl-2/Bax， and reduction in the triggering of caspase proteins. These data indicate that MIP-15 may have the potential to act as a neuroprotective agent.

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Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents

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Food Science and Human Wellness 2023年第4期12卷 1008-1019页

作者： weiyi Chu chia wei phan Seng Joe Lim Abdul Salam Babji Department of Pharmaceutical Life Sciences Faculty of PharmacyUniversiti MalayaKuala Lumpur 50603Malaysia Clinical Investigation Centre University Malaya Medical CentreLembah Pantai Kuala Lumpur 59100Malaysia Mushroom Research Centre Universiti MalayaKuala Lumpur 50603Malaysia Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM BangiSelangor 43600Malaysia Innovation Centre for Confectionery Technology(MANIS) Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM BangiSelangor 43600Malaysia

Neurodegenerative diseases are often associated with the accumulation of oxidative stress and *** bird’s nest(EBN)is a glycoprotein(sialylated mucin glycopeptides)found to be beneficial against neurodegenerative ***,anti-inflammatory,and anti-apoptotic properties of EBN in preserving neuronal cells were widely researched using in vitro and in vivo *** effects of EBN are often linked to its great number of antioxidants and anti-inflammatory *** compounds in EBN,especially sialic acid,add value to neurotrophic potential of EBN and contribute to neuronal repair and *** studies reporting the neuroprotective effects of EBN,their molecular mechanisms,and neuroactive composition were gathered in this review to provide better insights on the neuroprotective effects of EBN.

关键词： Antioxidant Composition Edible bird nest Neurodegenerative disease Neuroprotection Sialylated mucin glycopeptide

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Lipocoacervate,a tunable vesicle for protein delivery

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Nano Research 2024年第10期17卷 9135-9140页

作者： chia-wei Yeh Nathaniel Wright Chelsea Loh Nabeen Chu Yadong Wang Nancy E.and Peter C.Meinig School of Biomedical Engineering Cornell UniversityKimball Hall 290Ithaca 14853USA Human Biology Healthand Society.College of Human EcologyCornell UniversityIthaca 14853USA

Controlled delivery of proteins and other biologics is a growing medium of therapy for diseases previously *** we report a self-assembling,tunable vesicle for the controlled delivery of growth factors and *** made of heparin and a biocompatible polycation,PEAD,forms the core of the vesicle;lipids form the membrane of the *** call this vesicle lipocoacervate(LipCo),which has a high affinity for growth factors and cytokines due to *** is a tunable protein delivery *** vesicle size is controlled through polymer and salt *** functionalization enables potential for targeting capabilities with long-term storage through ***,the controlled delivery of therapeutics also avoids high toxicity to treated cells in *** we report on these key principles of LipCo assembly and design.

关键词： complex coacervate drug delivery protein delivery heparin lipid particle

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New signature of low mass Z'in J/ψdecays

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Chinese Physics C 2024年第8期48卷 1-5页

作者： Chao-Qiang Geng chia-wei Liu Jiabao Zhang School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute of Theoretical Physics University of Chinese Academy of SciencesBeijing 100190China

We explored a new approach to search for a low-mass Z′particle through J/ψdecays by identifying its existence through parity-violating phenomena in the isospin-violating final states ofΛΣ¯^(0)and the corresponding charge conjugated states ofΛΣ¯^(0).Our investigation centered on a generation-independent and leptophobic Z′with mass below 10 *** the present experimental conditions at Beijing Spectrometer III(BESIII)and the anticipated opportunities at the Super Tau Charm Factory(STCF),we conducted Monte-Carlo simulations to predict possible events at both ***,we foresee a substantial enhancement in the precision of the lower limit estimation ofαNP as well as a reduction in statistical uncertainty with upcoming STCF ***,it is essential to highlight that a null result in the measurement ofαNP would impose stringent constraints,requiring the Z′−q−q couplings to be in the order of 10^(−2).

关键词： Z′ parity violation J/ψ

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Can ChatGPT be used to generate scientific hypotheses?

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Journal of Materiomics 2024年第3期10卷 578-584页

作者： Yang Jeong Park Daniel Kaplan Zhichu Ren chia-wei Hsu Changhao Li Haowei Xu Sipei Li Ju Li Department of Nuclear Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02139USA Institute of New Media and Communications Seoul National University1 Gwanak-roGwanak-guSeoul08826Republic of Korea Department of Condensed Matter Physics Weizmann Institute of ScienceRehovot7610001Israel Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02139USA Global Technology Applied Research JPMorgan Chase237 Park AveNew YorkNY10017USA

We investigate whether large language models can perform the creative hypothesis generation that human researchers regularly *** the error rate is high,generative AI seems to be able to effectively structure vast amounts of scientific knowledge and provide interesting and testable *** future scientific enterprise may include synergistic efforts with a swarm of“hypothesis machines”,challenged by automated experimentation and adversarial peer reviews.

关键词： large language models scientific hypothesis generation generative AI GPT-4

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Automatic fovea detection and choroid segmentation for choroidal thickness assessment in optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1763-1771页

作者： Chen Yu Lin Hung Ju Chen Yi Kit Chan wei Ping Hsia Yu Len Huang chia Jen Chang Department of Ophthalmology Taichung Veterans General HospitalTaichung 407TaiwanChina Department of Computer Science Tunghai UniversityTaichung 407TaiwanChina

AIM:To develop an automated model for subfoveal choroidal thickness(SFCT)detection in optical coherence tomography(OCT)images,addressing manual fovea location and choroidal contour ***:Two procedures were proposed:defining the fovea and segmenting the *** localization from B-scan OCT image sequence with three-dimensional reconstruction(LocBscan-3D)predicted fovea location using central foveal depression features,and fovea localization from two-dimensional en-face OCT(LocEN-2D)used a mask region-based convolutional neural network(Mask R-CNN)model for optic disc detection,and determined the fovea location based on optic disc relative *** segmentation also employed Mask ***:For 53 eyes in 28 healthy subjects,LocBscan-3D’s mean difference between manual and predicted fovea locations was 170.0μm,LocEN-2D yielded 675.9μ***-2D performed better in non-high myopia group(P=0.02).SFCT measurements from Mask R-CNN aligned with manual ***:Our models accurately predict SFCT in OCT ***-3D excels in precise fovea localization even with high ***-2D shows high detection rates but lower accuracy especially in the high myopia *** both models offers a robust SFCT assessment approach,promising efficiency and accuracy for large-scale studies and clinical use.

关键词： subfoveal choroidal thickness optical coherence tomography automatic foveal detection automatic choroid segmentation

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Time-reversal asymmetries in Λ_(b)→Λ(→pπ^(−))ℓ^(+)ℓ^(−)

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Chinese Physics C 2024年第3期48卷 1-14页

作者：耿朝强刘佳韦魏正乙 School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China University of Chinese Academy of Sciences Beijing 100190China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

We study the decays ofΛb→Λ(→pπ^(−))ℓ^(+)ℓ^(−)withℓ=(e,μ,τ).We examine the full angular distributions with polarizedΛb,where the T-odd observables are *** discuss the possible effects of new physics(NP)and find that the T-odd observables are sensitive to them as they vanish in the standard *** attention is given to the interference of(pseudo)scalar operators with(axial)vector operators in polarized Λ_(b)→Λ(→pπ^(−))τ^(+)τ^(−),which are studied for the first *** effects are proportional to the lepton masses and therefore may evade the constraint from Λ_(b)→Λ(→pπ^(−))μ^(+)μ^(−) at the LHCb ***Λ_(b)→Λ(→pπ^(−))τ^(+)τ^(−) is uncontaminated by the charmonia resonance,it provides a clean background to probe *** addition,we show that the experimental central value of K10 in Λ_(b)→Λ(→pπ^(−))μ^(+)μ^(−) at the LHCb can be explained by the NP case,which couples to the right-handed quarks and *** polarization fraction of Λ_(b) at the LHCb is found to be consistent with zero regardless of the NP scenarios.

关键词： time reversal asymmetry angular distribution new physics T-odd correlation

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马来西亚东北部Setiu潟湖1970年以来沉积环境演化及其对ENSO的响应

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海洋学报 2024年第4期46卷 79-89页

作者：赵周平李超骆正骅 NicholasNg chia wei 戴璐同济大学海洋地质国家重点实验室上海200092

马来半岛位于低纬热带地区,厄尔尼诺-南方涛动(El Nino-Southern Oscillation,ENSO)如何影响该区域的气候,尤其是降水仍然存在争议。本文以马来半岛东北部登嘉楼州Setiu潟湖钻孔NTT-3为研究对象,通过分析粒度、总有机碳及总氮含量、C/N... 详细信息

马来半岛位于低纬热带地区,厄尔尼诺-南方涛动(El Nino-Southern Oscillation,ENSO)如何影响该区域的气候,尤其是降水仍然存在争议。本文以马来半岛东北部登嘉楼州Setiu潟湖钻孔NTT-3为研究对象,通过分析粒度、总有机碳及总氮含量、C/N比值和XRF岩心扫描等,探讨该钻孔的沉积环境变化及其对ENSO的响应。研究结果显示,钻孔记录中自1970年前后(84 cm处)出现两种不同的变化趋势。1970年之前钻孔下部沉积物粒度、有机和无机地球化学特征趋势波动明显,沉积速率较低。而1970年以来,潟湖沉积环境总体稳定,沉积物中的有机组分主要来自红树林,同时伴有河流输入的淡水浮游植物的贡献。频谱分析结果显示1970年以来钻孔上部存在明显的ENSO周期变化。强厄尔尼诺现象基本对应低Zr/Rb比值和低Zr/Ti比值,而强拉尼娜(La Nina)现象基本对应高Zr/Rb比值和高Zr/Ti比值。该结论不仅支持了现代观测对马来半岛东部沿海地区气候变化的认识,同时也在地质记录中发现了ENSO变化的直接证据,对全面认识和理解ENSO对亚洲气候变化的影响、区域陆海相互作用过程和环境响应等方面具有重要现实意义。

关键词： Setiu潟湖沉积记录频谱分析 ENSO

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Force-position collaborative optimization of rope-driven snake manipulator for capturing non-cooperative space targets

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Chinese Journal of Aeronautics 2024年第9期37卷 369-384页

作者： Xiaofeng LI Jian TIAN Cheng wei Xibin CAO School of Astronautics Harbin Institute of TechnologyHarbin 150001China Beijing Instiuteof Spacecraft System Engineering China Academy of Space TechnolgyBeijing 100094Chia

With the rapid development of space activities,non-cooperative space targets increase swiftly,such as failed satellites and upper stages,threating normal spacecrafts *** there are some problems in the capture process,such as excessive collision and fast tumbling of targets,manipulator with redundant Degrees of Freedom(DOFs)can be used to improve the compliance and therefore solve these *** Rope-Driven Snake Manipulator(RDSM)is a combina-tion of hyper-redundant DOFs and better compliance,and therefore it is suitable for capturing *** this paper,a snake manipulator mechanism is designed,and the complete kinematic model and system dynamic model considering RDSM,target and contact is ***,to obtain the configuration of joint with hyper-redundant DOFs,an improved motion dexterity index is pro-posed as the joint motion optimization ***,the force-position collaborative optimization index is designed to adjust active stiffness,and the impedance control method based on the modified index is used to capture the space ***,the proposed force-position collaborative opti-mization method is verified by virtual prototype *** results demonstrate that based on the proposed method,the collision force is reduced by about 25%compared to normal impe-dance control,showing higher safety.

关键词： Capturing non-cooperative spacetargets Rope-driven snakemanipu-lator Force-position collaborative optimization Redundant degrees of free-dom Active stiffness adjustment

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Behcet's disease-related panuveitis following COVID-19 vaccination:A case report

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World Journal of Radiology 2024年第9期16卷 460-465页

作者： Rou-Ting Lin Pei-Kang Liu chia-wei Chang Kai-Chun Cheng Kuo-Jen Chen Yo-Chen Chang School of Medicine College of MedicineChung Shan Medical UniversityTaichung 40201Taiwan Department of Clinical Education and Training Kaohsiung Medical University HospitalKaohsiung 80756Taiwan Department of Ophthalmology School of MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiung 80737Taiwan Department of Ophthalmology Kaohsiung Medical University HospitalKaohsiung 80756Taiwan Department of Ophthalmology Kaohsiung Municipal Siaogang HospitalKaohsiung Medical UniversityKaohsiung 81201Taiwan

BACKGROUND Behcet's disease(BD)is an inflammatory disorder known for various symptoms,including oral and genital ulcers and ocular ***,a severe eye condition,is rare as the first sign of *** SUMMARY We present an unusual case of a 30-year-old man who developed panuveitis after receiving the mRNA-based coronavirus disease 2019(COVID-19)vaccine(Moderna).Laboratory tests ruled out infections,but he had a positive HLA-B51 result and a history of genital ulcer and oral ulcers,leading to a BD *** with corticosteroids improved his ***,he had another episode of panuveitis after the second mRNA vaccine dose,which also responded to *** This case highlights the rare onset of BD following mRNA COVID-19 vaccination,suggesting a potential link between these vaccines and BD's eye symptoms,emphasizing the importance of quick treatment in similar cases.

关键词： Behcet’s disease mRNA COVID-19 vaccine Ocular inflammation Panuveitis Case report

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