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Journal of Materials Science & Technology 2013年第8期29卷 761-764页

作者： chia ching kee Hanafi Ismail Ahmad Fauzi Mohd Noor School of Materials and Mineral Resources Engineering Engineering CampusUniversiti Sains Malaysia14300 Nibong TebalPenangMalaysia

The syntheses of nanosized carbonated hydroxyapatite （CHA） were performed by comparing dropwise and direct pouring of acetone solution of Ca（NO3）2·4H2O into mixture of （NH4）2HPO4 and NH4HCO3 at room temperature controlled at pH 11. Direct pouring method was later applied to study the increment of carbonate content in syntheses. The as-synthesized powders were characterized by various characterization techniques. The crystallographic results of the produced powders were obtained from X-ray diffraction analysis, whilst the carbonate content in the produced powders was determined by the CHNS/O elemental analyzer. Fourier transform infrared analysis confirmed that the CHA powders formed were B-type. Field emission scanning electron microscopy revealed that the powders were highly agglomerated in nanosized range and hence energy filtered transmission electron microscopy was employed to show elongated particles which decreased with increasing carbonate content.

关键词： Bioceramic Carbonated hydroxyapatite Dropwise Direct pouring

Plasmacytosis mimicking multiple myeloma in angioimmunoblastic T-cell lymphoma:A case report and review of literature

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World Journal of Clinical Cases 2024年第17期12卷 3226-3234页

作者： chia-ching Lin Hsu-Lin Lee Hsin-Yi Chuo Tuo-An Chen Ming-Yueh Liu Li-Mien Chen Division of Cardiovascular Surgery Department of SurgeryKaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Division of Cardiovascular Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Hematology and Oncology Department of Internal MedicineTaichung Armed Forces General HospitalTaichung 411Taiwan Division of Hematology and Oncology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Internal Medicine Taichung Armed-Forces General HospitalTaichung 411Taiwan Department of Pathology Taichung Armed-Forces General HospitalTaichung 411Taiwan Department of Radiation Oncology Taichung Armed-Forces General HospitalTaichung 411Taiwan Department of Radiation Oncology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Angioimmunoblastic T-cell lymphoma(AITL)is a common subtype of peripheral T-cell *** half of patients with AITL may concurrently present with *** numbers of plasma cells in the bone marrow are commonly observed at *** tumors mimic plasma cell myelomas,hindering a conundrum of clinical diagnoses and potentially delaying appropriate *** SUMMARY A 78-year-old woman experienced poor appetite,weight loss of 5 kg,fatigue 2 months before presentation,and shortness of breath 2 d before presentation,but no fever or night *** examination revealed splenomegaly and many palpable masses over the bilateral axillary regions,approximately>2 cm in size,with rubbery consistency and no *** tests revealed anemia and thrombocytopenia,lactate dehydrogenase level of 153 U/L,total protein level of 10.9 g/dL,albumin to globulin ratio of 0.2,and immunoglobulin G level more than the upper limit of 3000 mg/*** free kappa and lambda light chain concentrations were 451 and 614 mg/L,respectively.A pathological examination confirmed the diagnosis of *** initial treatment was the cyclophosphamide,epirubicin,vincristine,and prednisolone *** this treatment,pleural effusion was controlled,and the patient was discharged in a stable condition and followed up in our outpatient *** This report highlights the importance of differentiating reactive plasmacytosis from plasma cell myeloma in patients with hypergammaglobulinemia.A precise diagnosis of AITL requires a comprehensive evaluation,involving clinical,immunophenotypic,and histological findings conducted by a multidisciplinary team to ensure appropriate treatment.

关键词： Angioimmunoblastic T-cell lymphoma Plasmacytosis Multiple myeloma Lymphoma,Hypergammaglobulinemia Case report

CFD Simulation of a container ship in random waves using a coupled level-set and volume of fluid method

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Journal of Hydrodynamics 2023年第2期35卷 222-231页

作者： Hamn-ching Chen chia-Rong Chen Zachry Department of Civil and Environmental Engineering Texas A&M UniversityCollege StationTexasUSA

The coupled level-set and volume of fluid(CLSVOF)method is an advanced interface-capturing method that has been extended to handle overset grid ***,artificial uneven interface may be observed across block boundaries of different sizes and *** present an improved inter-grid VOF interpolation and mass correction scheme to address the *** demonstrate the capability of the improved CLSVOF method,it is applied to the simulation of a container ship in pitch and heave motions under both head sea and following sea irregular wave *** simulation proves that the improved CLSVOF method is capable of revealing detailed physics difficult to see with other *** phenomena simulated in our work include the extensive greenwater propagation on the ship deck,the breakup of overtopping waves into small droplets,and the formation and collapse of air pockets in sudden bow and stern slamming which cause strong and highly localized impacts on the ship bow,stern,and rudder.

关键词： Computational fluid dynamics(CFD) couple level-set and volume of fluid(CLSVOF)method random waves overset grid system violent free surface flow bow and stern slamming

The fabrication and application of Ni-DNA nanowire-based nanoelectronic devices

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Nano Research 2019年第6期12卷 1293-1300页

作者： Pang-chia Chang chia-Yu Chang Wen-Bin Jian Chiun-Jye Yuan Yu-Chang Chen chia-ching Chang Department of Electrophysics "National Chiao Tung University"Hsinchu 30010TaiwanChina Department of Biological Science and Technology "National Chiao Tung University"Hsinchu 30068TaiwanChina Center for Intelligent Drug Systems and Smart Bio-devices(IDS^2B) "National Chiao Tung University"Hsinchu 30068TaiwanChina Institute of Physics "Academia Sinica"Taipei 11529TaiwanChina

DNA is a self-assembled,double stranded natural molecule that can chelate and align nickel ions between its base *** fabrication of a DNA-guided nickel ion chain (Ni-DNA) device was successful,as indicated by the conducting currents exhibiting a Ni ion redox reaction-driven negative differential resistance effect,a property unique to mem-elements (1).The redox state of nickel ions in the Ni-DNA device is programmable by applying an external bias with different polarities and writing times (2).The multiple states of Ni-DNA-based memristive and memcapacitive systems were characterized (3).As such,the development of Ni-DNA nanowire device-based circuits in the near future is proposed.

关键词： DNA-guided nickel ion chain (Ni-DNA) negative differential resistance (NDR) memristive systemmem capacitive system nanowire

Involvement of P53 and Bax/Bad triggering apoptosis in thioacetamide-induced hepatic epithelial cells

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World Journal of Gastroenterology 2006年第32期12卷 5175-5181页

作者： Li-Hsuen Chen chia-Yu Hsu ching-Feng Weng Institute of Biotechnology National Dong Hwa University HualienTaiwanChina

AIM： Thioacetamide （TAA） has been used in studying liver fibrosis and cirrhosis, however, the mechanisms of TAA-induced apoptosis in liver are still unclear. The hepatic epithelial cell line clone 9 was cultured and treated with TAA to investigate the causes of cell death. METHODS： The cell viability of TAA-induced clone 9 cells was determined using MTT assay. Total cellular GSH in TAA-induced clone 9 cells was measured using a slight modification of the Tietze assay. The activity of caspase 3 in TAA-induced clone 9 cells was monitored by the cleavage of DEVD-p-nitroanaline. TUNEL assay and flow cytometry were applied for the determination of DNA fragmentation and the proportion of apoptosis in TAA- induced clone 9 cells, respectively. The alterations of caspase 3, Bad, Bax and Phospho-P53 contents in TAA- induced clone 9 cells were measured by Western blot. RESULTS： The experimental data indicated that TAA caused rat hepatic epithelial cell line clone 9 cell death in a dose-and time-dependent manner; 60% of the cells died （MTT assay） within 24 h after 100 rag/1 TAA was applied. Apoptotic cell percentage （TUNE1 assay） and caspase 3 activities were highest after 100 rag/1 TAA was added for 8 h. The release of GSH and the elevation in caspase content after TAA treatment resulted in clone 9 cell apoptosis via oxidative stress and a caspasedependent mechanism. The phospho-p53, Bax and Bad protein expressions in clone 9 cells were increased after TAA treatment. CONCLUSION： These results reveal that TAA activates p53, increases caspase 3, Bax and Bad protein contents, perhaps causing the release of cytochrome c from mitochondria and the disintegration of membranes, leading to apoptosis of cells.

关键词： Thioacetamide, Phospho-p53 Caspase 3,Apoptosis Bax, Bad

Recognition of Film Type Using HSV Features on Deep-Learning Neural Networks

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Journal of Electronic Science and Technology 2020年第1期18卷 31-41页

作者： ching-Ta Lu Jia-An Lin chia-Yi Chang chia-Hua Liu Ling-Ling Wang Kun-Fu Tseng Department of Information Communication Asia UniversityTaichung 41354 the Department of Digital Media Design Asia UniversityTaichung 41354 School of Electronics and Communication Engineering Quanzhou University of Information EngineeringQuanzhou 362000

The number of films is numerous and the film contents are complex over the Internet and multimedia sources. It is time consuming for a viewer to select a favorite film. This paper presents an automatic recognition system of film types. Initially, a film is firstly sampled as frame sequences. The color space, including hue, saturation,and brightness value(HSV), is analyzed for each sampled frame by computing the deviation and mean of HSV for each film. These features are utilized as inputs to a deep-learning neural network(DNN) for the recognition of film types. One hundred films are utilized to train and validate the model parameters of DNN. In the testing phase, a film is recognized as one of the five categories, including action, comedy, horror thriller, romance, and science fiction, by the trained DNN. The experimental results reveal that the film types can be effectively recognized by the proposed approach, enabling the viewer to select an interesting film accurately and quickly.

关键词： Deep-learning film type recognition hue,saturation,and brightness value(HSV)analysis neural networks video classification

Bedform development and its effect on bed stabilization and sediment transport based on a flume experiment with non-uniform sediment

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International Journal of Sediment Research 2017年第3期32卷 305-312页

作者： Su-Chin Chen chia-Ning Yang ching-Ying Tsou Department of Soil and Water Conservation National Chung Hsing University Sinotech Engineering Consultants LTD. Department of Agricultural and Environmental Engineering Faculty of Agriculture and Life Science Hirosaki University

Non-uniform sediment deposited in a confined, steep mountain channel can alter the bed surface composition. This study evaluates the contribution of geometric and resistance parameters to bed stabilization and the reduction in sediment transport. Flume experiments were done under various hydraulic conditions with non-uniform bed material and no sediment supply from upstream. Results indicate that flume channels respond in a sequence of coarsening and with the formation of bedformroughness features such as rapids, cascades, and steps. A bedform development coefficient is introduced and is shown to increase(i.e. vertical sinuosity develops) in response to increasing shear stress during the organization process. The bedform development coefficient also is positively correlated with the critical Shields number and Manning’s roughness coefficient, suggesting the evolution of flow resistance with increasing bedform development. The sediment transport rate decreases with increasing bed shear stress and bedform development, further illustrating the effect of bed stabilization. An empirical sediment transport model for an equilibrium condition is proposed that uses the bedform development coefficient, relative particle submergence(i.e. the ratio of mean water depth and maximum sediment diameter), modified bed slope, and discharge. The model suggests bedform development can play a primary role in reducing sediment transport(increasing bed stabilization). The model is an extension of Lane’s(1955) relation specifically adapted for mountain streams. These results explain the significance of bedform development in heightening flow resistance, stabilizing the bed, and reducing sediment transport in coarse, steep channels.

关键词： Bedform development Bed stabilization Sediment transport Non-uniform bed

Designing a Secure and Scalable Data Sharing Mechanism Using Decentralized Identifiers(DID)

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 809-822页

作者： Iuon-Chang Lin I-Ling Yeh ching-Chun Chang Jui-Chuan Liu Chin-Chen Chang Department of Management Information Systems National Chung Hsing UniversityTaichung402TaiwanChina Information and Communication Security Research Center Feng Chia UniversityTaichung407TaiwanChina Department of Information Engineering and Computer Science Feng Chia UniversityTaichung407TaiwanChina

Centralized storage and identity identification methods pose many risks,including hacker attacks,data misuse,and single points of ***,existing centralized identity management methods face interoperability issues and rely on a single identity provider,leaving users without control over their ***,this paper proposes a mechanism for identity identification and data sharing based on decentralized *** scheme utilizes blockchain technology to store the identifiers and data hashed on the chain to ensure permanent identity recognition and data *** is stored on InterPlanetary File System(IPFS)to avoid the risk of single points of failure and to enhance data persistence and *** the same time,compliance with World Wide Web Consortium(W3C)standards for decentralized identifiers and verifiable credentials increases the mechanism’s scalability and interoperability.

关键词： Self-sovereign identity decentralized identifier blockchain

Genetic variation and potential coinfection of Wolbachia among widespread Asian citrus psyllid (Diaphorina citri Kuwayama) populations

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Insect Science 2019年第4期26卷 671-682页

作者： chia-ching Chu Mark Hoffmann W. Evan Braswell Kirsten S. Pelz-Stelinski Department of Entomology and Nematology University of Florida Gainesville Florida USA Citrus Research and Education Center University of Florida Lake Alfred Florida USA 3Department of Horticultural Sciences North Carolina State University Raleigh North Carolina USA Center for Plant Health Science and Technology USDA APHIS Edinburg Texas USA

Wolbachia can profoundly influence the survival, reproduction, and defenses of insect hosts. These interactions could potentially be harnessed for managing pests or insecttransmitted diseases. Diaphorina citri Kuwayama is a phloem-feeding pest capable of transmitting the putative causal agent of citrus greening, Candidatus Liberibacter asiaticus (CLas). Like many insects, D. citri is also infected with Wolbachia (wDi). Recent studies indicate that the relative abundance of wDi could be associated with the abundance of CLas, and that wDi may contribute to regulating expression of phage lytic cycle genes in CLas, suggesting the need for better understanding of wDi biology in general. This study investigated the genetic diversity of wDi among D. citri in populations spanning eleven countries and two U.S. territories. Six Wolbachia genes, wsp, ***, gatB, and hep A, were sequenced and compared across samples. Two prevalent wDi strains were identified across the samples, and screening of clone libraries revealed possible coinfection of wDi strains in specific populations. D. citri mitochondrial cytochrome oxidase subunit I gene (mtCOI) were more divergent between D. citri populations that were infected with different wDi strains or had different infection statuses (single infection vs. coinfection). While we could not eliminate the possibility that maternal transmission may contribute to such patterns, it is also possible that wDi may induce cytoplasmic incompatibility in their host. These fin dings should contribute to the understanding of wDi population ecology, which may facilitate manipulation of this endosymbiont for management of citrus greening disease worldwide.

关键词： bacteria genetic diversity Huanglongbing plant disease superinfection vertically transmitted endosymbionts

Moderating Mechanism in the Relationship between Social Isolation and Mental Health among College Students during High-Risk Period of COVID-19 Transmission in Hubei, China

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International Journal of Mental Health Promotion 2023年第2期25卷 193-206页

作者： Dong Yang chia ching Tu Zhengyan Guo Xiao Dai chia Feng Tu International College Krirk UniversityBangkok10220Thailand Chinese International College Dhurakij Pundit UniversityBangkok10210Thailand Wei Gong Memorial Hospital Toufen CityMiaoli County351011Taiwan

This study explored the effect of perceived social isolation on the mental health of college students during the high-risk period of COVID-19 transmission in Hubei,China and the role of social support from online friends in alleviating this *** questionnaire responses of 213 college students from four universities in Hubei were *** and structural models were constructed using structural equation *** findings revealed that perceived social isolation while under home quarantine was a negative predictor of the mental health of college students in *** social support from online friends may lead to a relatively strong relationship between perceived social isolation and mental health in these college students,whereas high social support from online friends may lead to a relatively weak relationship between perceived social isolation and mental health.

关键词： Social isolation social support mental health moderator Hubei