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β-Octafluorinated tetrakis(ethoxycarbonyl)porphyrin

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chinese Chemical Letters 2015年第5期26卷 529-533页

作者： Hua-Hua Wang Yi-Yu Jiang Mian HR Mahmood Hai-Yang Liu Herman H.Y.Sung Ian D.Williams chi k.chang Department of Chemistry South China University of Technology Department of Chemistry Hong Kong University of Science and Technology Department of Chemistry Michigan State University

Tetrakis（alkoxycarbonyl）porphyrin and its β-octafluoro-substituted derivatives were synthesized via Lindsey method and transformed to their zinc complexes. Single crystal X-ray structures of corresponding Zn（II） porphyrins revealed that β-octafluorination will give more compactness of porphyrin moieties in the crystal structure owing to the hydrogen bonding interactions involving β- fluorine atoms. An unusual six-coordinated Zn（II） was found via intramolecular coordination of oxygen atom of meso-substituents with central Zn（II）.

关键词： Tetraalkyl porphyrin Zinc Ethyl glyoxylate 3 4-Difluoropyrrole

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning chang Liu Yu-chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Situation analytics—at the dawn of a new software engineering paradigm

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Science china(Information Sciences) 2018年第5期61卷 5-18页

作者： Carl k.chang Department of Computer Science Iowa State University

In this paper, I first review the seminal work by Thomas kuhn — The Structure of Scientific Revolutions — and elaborate my view on paradigm shifts in software engineering research and practice as it turns 50 years old in 2018. I then examine major undertakings of the computing profession since early days of modern computing, especially those done by the software engineering community as a whole. I also enumerate anomalies and crises that occurred at various stages, and the attempts to provide solutions by the software engineering professionals in the past five decades. After providing such a background, I direct readers’ attention toward emerging anomalies in software engineering, at a severity level that is causing another software engineering crisis, and suggest a set of criteria for feasible solutions. The main theme of this paper is to advocate that situation analytics, equipped with necessary definitions of essential concepts including situation and intention as parts of a new computational framework, can serve as the foundation for a new software engineering paradigm named the Situation-Centric Paradigm. In this framework, situation is considered a new abstraction for computing and is clearly differentiated from the widely accepted existing abstractions, namely function and object. I argue that the software engineering professionals will inevitably move into this new paradigm, willingly or unwillingly, to empower Human-Embedded Computing(HEC) and End-User Embedded Computing(EUEC), much more than what they have done with traditional humancentered or user-centric computing altogether. In the end, I speculate that an ultimate agile method may be on the rise, and challenge readers to contemplate "what if" hundreds of thousands "end-user developers"emerge into the scene where the boundaries between end users and developers become much more blurred.

关键词： ultimate agile method context intention Internet of things paradigm situation software engineering human-embedded computing

Biotechnology—Updates and New Developments

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Biomedical and Environmental Sciences 2001年第1期14卷 32-39页

作者： SUSHILA k.chang Director CentreforLifeSciences&ChemicalTechnology

Areas of priority for intensive discovery would be the agbiotechnology and biomedical sectors using gene technology as a platform. The use of genetic manipulation in farming and the use of plants as ‘pharma’ factories to manufacture therapeutics would be on the rise. The human genome will continue to have a powerful impact on research and development of human diseases and healthcare. Discovery of genetics and pharmacogenomics will have great impact on drug development and will allow the prediction of the patient's response to various drugs as well as the onset of individualised or ‘designer drugs’. Human stem cells could have their cellular clocks reset by the cloning process, enhancing opportunities to grow young cells, tissues and organs for an aging population. The cellular clock could also be reset by therapeutic cloning. Bioinformatics would be a technology which would be synonymous with biotechnology. The analyses of biotechnology research would be conducted in silico and would involve the exchange of information among sophisticated computer databases. Applications of biotechnology would be even more evident in environmental technology, food development and food processing. In electronics, the use of the specificity of proteins in biochips is underway. In tandem with the explosions in research, regulatory issues, legislation and intellectual property rights will evolve to enhance the climate of discovery and innovation. Public education will have to be continually enhanced as awareness could negate any fear resulting from novel and innovative improvements from biotechnology.

关键词： Food Technology Agriculture Biotechnology Databases Factual Genetic Engineering Human Genome Project Humans Information Services Public Opinion Public Policy

Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-chi Hsu Lin Chen Yitian Qian key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis

Intermediate polaronic charge transport in organic crystals from a many-body first-principles approach

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npj Computational Materials 2022年第1期8卷 630-637页

作者： Benjamin k.chang Jin-Jian Zhou Nien-En Lee Marco Bernardi Department of Applied Physics and Materials Science California Institute of TechnologyPasadenaCA91125USA

Charge transport in organic molecular crystals (OMCs) is conventionally categorized into two limiting regimes − band transport,characterized by weak electron-phonon (e-ph) interactions,and charge hopping due to localized polarons formed by strong e-ph ***,between these two limiting cases there is a less well understood intermediate regime where polarons are present but transport does not occur via *** we show a many-body first-principles approach that can accurately predict the carrier mobility in this intermediate regime and shed light on its microscopic *** approach combines a finite-temperature cumulant method to describe strong e-ph interactions with Green-kubo transport *** apply this parameter-free framework to naphthalene crystal,demonstrating electron mobility predictions within a factor of 1.5−2 of experiment between 100 and 300 *** analysis reveals the formation of a broad polaron satellite peak in the electron spectral function and the failure of the Boltzmann equation in the intermediate regime.

关键词： polaron charge limiting

Sporadic E responds to the 2022 Tonga volcano eruptions recorded by the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 20-28页

作者： YangYi Sun Tao Yu Jin Wang chi Long School of Geophysics and Geomatics China University of Geosciences(Wuhan)Wuhan 430047China School of Physics and Electronic Science Guizhou Normal UniversityGuizhou 550001China

In this study,ionosonde observations over Fuke(19.5°N,109.1°E),Wuhan(30.5°N,114.4°E),and Mohe(53.5°N,122.3°E)were analyzed to demonstrate the responses of the sporadic E()to the severe atmospheric disturbances caused by the Tonga volcanic eruptions on January 15,*** most prominent signature was the disappearance of the layer after~10:00 UT over Wuhan and Fuke,which was attributed to the vertical drift caused by the *** occurred intermittently after 13:00 UT following the arrival of the tropospheric Lamb *** examine the causal mechanism for the intermittence,we also included data of horizontal winds in the mesosphere and lower thermosphere region recorded by the meteor radars at Wuhan and Mohe in this *** wind disturbances with periods of~20 hours contributed to the formation of the layer in the nighttime on January 15.

关键词： sporadic E Tonga eruptions neutral wind disturbances

Egg-spot matching in common cuckoo parasitism of the oriental reed warbler: effects of host nest availability and egg rejection

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chinese Birds 2016年第4期7卷 199-209页

作者： Donglai Li Yanan Ruan Ying Wang Alan k.chang Dongmei Wan Zhengwang Zhang Provincial key Laboratory of Animal Resource and Epidemic Disease Prevention College of Life Sciences Liaoning University Ministry of Education key Laboratory for Biodiversity Science and Ecological Engineering College of Life Sciences Beijing Normal University

Background: The success of cuckoo parasitism is thought to depend largely on the extent of egg matching between cuckoo and host eggs, since poor-matching cuckoo egg would lead to more frequent egg rejection by the host. In this study, we investigated how egg-spot matching between the Common Cuckoo(Cuculus canorus) and its host, the Oriental Reed Warbler(Acrocephalus orientalis) is affected by the local parasitism rate, nest availability in breeding synchronization and egg ***: We used the paired design of parasitized and their nearest non-parasitized nests where breeding occurred simultaneously to compare egg-spot matching. The image analysis was used to compare four eggshell pattern variables, namely spot size, density, coverage on the different areas of egg surface, and the distribution on the whole egg surface. Egg recognition experiments were conducted to test the effect of egg spots on egg rejection by the ***: Our results show that much better matching in almost all spot parameters tested on the side of the egg and the spot distribution on the whole egg occurred in parasitized nests than in non-parasitized nests. Matching of spot density between cuckoo and host eggs in parasitized nests increased with the synchronization between temporal availability of nests and the egg-laying period of female cuckoos. Egg recognition experiments in which the warbler eggs were deliberately painted with extra spots led to a significantly higher egg rejection rate(78.3%) than of unpainted ***: Our data suggest that both the high temporal encounter rate between cuckoo and warbler nests as well as the high egg rejection ability of the host are important factors for egg-spot matching of the cuckoos.

关键词： Brood parasite Cuckoo Egg mimicry Egg matching Spot pattern Egg rejection Parasitism rate Oriental Reed Warbler

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long chi State key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles