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High-intensity focused ultrasound strategies for treating prostate cancer

Asian Journal of Andrology 2024年第6期26卷 595-599页

作者： Xiaobo Wu Yupeng Wu chi-Fai Ng chi-hang yee Peter Ka-Fung chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Urology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004China

Prostate cancer (PCa) is a significant health concern globally, necessitating effective treatment options. Typical treatment methods for early stage, particularly localized PCa, encompass radical procedures, such as radical prostatectomy (RP) and radiotherapy (RT), and nonradical focal therapy (FT). FT is a focused approach mainly used for treating small lesions limited to a specific zone of the prostate. Its objective is to achieve cancer control when minimizing damage to benign tissue. High-intensity focused ultrasound (HIFU) is one of the most used modalities in FT for the management of PCa. The progress in HIFU technology showcases continuous advancements, offering clinicians a variety of strategies to cater to diverse patient requirements. The advancements include the development of transrectal and transurethral HIFU machines that offer enhanced treatment distances, magnetic resonance imaging (MRI) fusion capabilities, real-time monitoring, and precise ablation. These improvements contribute to increased treatment effectiveness and better outcomes for patients. This narrative review aims to summarize the use of HIFU technology and its evolution, offering diverse options to clinicians, and explores the safety, effectiveness, and quality of different HIFU strategies, such as whole-gland ablation, hemigland ablation, and focal ablation. We conclude that nonwhole-gland HIFU offers similar cancer control with better short-term functional outcomes and fewer complications compared to whole-gland ablation. Combining HIFU with transurethral resection of the prostate (TURP) improves urinary function and reduces catheterization time. Focal ablation and hemigland ablation show promise in achieving cancer control when preserving continence and potency.

关键词： ablation focal therapy high-intensity focused ultrasound prostate cancer strategy

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Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men

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Asian Journal of Andrology 2019年第5期21卷 468-472页

作者： Jeremy Yuen-Chun Teoh chi-Kwok Chan Maggie Haitian Wang chi-Ho Leung Eddie Shu-Yin Chan Peter Ka-Fung chiu chi-hang yee Hon-Ming Wong Simon See-Ming Hou chi-Fai Ng S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Division of Biostatistics JC School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Division of Urology Department of SurgeryNorth District HospitalHong KongChina Division of Urology Department of SurgeryAlice Ho Miu Ling Nethersole HospitalHong KongChina

It is largely unknown whether lower urinary tract symptoms(LUTS)or acute retention of urine(AROU)is linked to shorter life expectancy in *** conducted a multicenter,retrospective database analysis of patients undergoing transurethral resection of prostate(TURP)to study their *** Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were *** further performed an age-and sex-matched survival analysis with the general population using data from the Census and Statistics Department of the Hong Kong Special Administrative Region(Hong Kong,china).From January 2002 to December 2012,3496 patients undergoing TURP were included in our study,with 1764 patients in the LUTS group and 1732 patients in the AROU *** age,ischemic heart disease,cerebrovascular accident,and AROU were risk factors of *** aged80 *** to the general population,younger patients in the LUTS group appeared to have better survival(80 years,survival was similar with the general population in both the LUTS and AROU *** conclusion,AROU at young age was associated with mortality,while early detection and management of LUTS may improve survival.

关键词： acute retention of urine lower urinary tract symptoms mortality transurethral resection of prostate

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Time trend and characteristics of prostate cancer diagnosed in Hong Kong(china)in the past two decades

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Asian Journal of Andrology 2019年第1期21卷 104-106页

作者： Ho-Fai Wong chi-hang yee Jeremy YC Teoh Samson YS Chan Peter KF chiu Ho-Yuen Cheung Simon SM Hou chi Fai Ng S H.Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong KongChina

Dear Editor, Prostate cancer is an important disease worldwide)In 2015 it was the third most common cancer diagnosed in male in Hong Kong (china) and the incidence of prostate cancer has been rising in the past 15 years. Meanwhile,with increasing public awareness,health education, presentation,and detection of prostate cancer maybe ***, we would like to review how the epidemiology of prostate cancer in Hong Kong (china)had changed in the past two decades.

关键词： prostate cancer Time trend

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A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,china:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan ching-Ho Ko Cindy Yeuk-Lam Hong Samuel chi-hang yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam chi-Kwok Chan chi-Fai Ng Peter Ka-Fung chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman yee hang Ethan Ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

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Prognostic factors for acute central retinal artery occlusion treated with hyperbaric oxygen:The Hong Kong study report number five

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World Journal of Methodology 2025年第2期15卷 117-124页

作者： Sunny chi Lik Au Steffi Shing yee Chong Department of Ophthalmology Tung Wah Eastern HospitalHong Kong 999077China Department of Ophthalmology Pamela Youde Nethersole Eastern HospitalHong Kong 999077China

BACKGROUND Central retinal artery occlusion(CRAO)is a potentially blinding disease,and hyperbaric oxygen therapy(HBOT)is becoming increasingly popular with the support of scientific *** the presence of various acute management measures,there is no clear evidence on the gold standard treatment for *** To identify factors and imaging parameters associated with good visual outcome,which guide ophthalmologists in the triage of CRAO patients for *** Patients who suffered from CRAO and had a symptom onset≤6 h were recruited for a course of HBOT in a tertiary hospital after failing bedside *** demographics,onset time,CRAO eye parameters,and past medical history were prospectively *** outcomes after HBOT were also *** A total of 26 patients were included;the female-to-male ratio was 1:1.6,and the mean age was 67.5 years±13.3 years(range 44–89 years).The mean duration of follow-up and mean visual acuity(VA)improvement were 10.0 mo±5.3 mo and 0.48 logarithm of minimal angle of resolution(logMAR)±0.57 logMAR(approx-imately 9 letters in ETDRS)(P=0.0001,Z=-3.67),*** 1 mm zone of central macular thickness(CMT)on optical coherence tomography was not associated with VA changes(P=0.119);however,the 1-to-3 mm circular rim of CMT was fairly associated(P=0.02,Spearman's coefficient=0.45).Complete retinal perfusion time during fundus fluorescein angiography(FFA)was mode-rately associated(P=0.01,Spearman's coefficient=0.58)with visual outcome.

关键词： Central retinal artery occlusion Fundus fluorescein angiography Hyperbaric oxygen therapy Optical coherence tomography Stroke

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Novel Batch Polishing Method of Ceramic Cutting Inserts for Reducing Tool Wear

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chinese Journal of Mechanical Engineering 2024年第4期37卷 74-83页

作者： Rui Gao Chunjin Wang yee Man Loh Xiaoliang Liang Chen Jiang chi Fai Cheung State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China College of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China

Ceramic cutting inserts are a type of cutting tool commonly used in high-speed metal cutting ***,the wear of these inserts caused by friction between the workpiece and cutting inserts limits their overall *** order to improve the tool life and reduce wear,this study introduces an emerging method called magnetic field-assisted batch polishing(MABP)for simultaneously polishing multiple ceramic cutting *** polishing experiments were conducted under different conditions,and the wear characteristics were clarified by cutting S136H *** results showed that after 15 min of polishing,the surface roughness at the flank face,edge,and nose of the inserts was reduced to below 2.5 nm,6.25 nm,and 45.8 nm,***,the nose radii of the inserts did not change significantly,and there were no significant changes in the weight percentage of elements before and after ***,the tool life of the batch polished inserts was found to be up to 1.75 times longer than that of unpolished *** findings suggest that the MABP method is an effective way to mass polish ceramic cutting inserts,resulting in significantly reduced tool ***,this novel method offers new possibilities for polishing other tools.

关键词： Polishing Finishing Magnetic field-assisted Tool wear Ultra-precision machining

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A Plant SMALL RNA-BINDING PROTEIN 1 Family Mediates Cell-to-Cell Trafficking of RNAi Signals

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Molecular Plant 2020年第2期13卷 321-335页

作者： Yan Yan Byung-Kook Ham yee hang Chong Shyi-Dong Yeh William J.Lucas Department of Plant Biology College of Biological SciencesUniversity of CaliforniaDavisCA 95616USA Department of Plant Pathology National Chung-Hsing UniversityTaichung Present address:Global Institute for Food Security University of SaskatchewanSaskatoonSK S7N 4J8Canada Present address:Department of Biology University of Saskatchewan112 Science PlaceSaskatoonSK S7N 5E2Canada

In plants,RNA interference(RNAi)plays a pivotal role in growth and development,and responses to environmental inputs,including pathogen *** intercellular and systemic trafficking of small interfering RNA(siRNA)/microRNA(miRNA)is a central component in this regulatory ***,little is known with regards to the molecular agents involved in the movement of these si/*** address this situation,we employed a biochemical approach to identify and characterize a conserved SMALL RNA-BINDING PROTEIN 1(SRBP1)family that mediates non-cell-autonomous small RNA(sRNA)*** Arabidopsis,AtSRBP1 is a glycine-rich(GR)RNA-binding protein,also known as AtGRP7,which we show binds single-stranded siRNA.A viral vector,Zucchini yellow mosaic virus(ZYMV),was employed to functionally characterized the AtSRBP1-4(AtGRP7/2/4/8)RNA recognition motif and GR ***-based studies revealed the GR domain as being necessary and sufficient for SRBP1 cell-to-cell *** together,our findings provide a foundation for future research into the mechanism and function of mobile sRNA signaling agents in plants.

关键词： RNAi small RNA-binding protein family small RNA movement non-cell-autonomous protein glycinerich protein

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An Investigation of Effect of Stand-Off Distance on the Material Removal Characteristics and Surface Generation in Fluid Jet Polishing

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Nanomanufacturing and Metrology 2020年第2期3卷 112-122页

作者： Chun Jin Wang chi Fai Cheung Lai Ting Ho yee Man Loh State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Fluid jet polishing(FJP)is a versatile polishing process that has many advantages compared to other polishing ***-off distance(SOD)is one of the key parameters in flu id jet polishi ***,relatively little research work has been carried out to investigate its effect of SOD on material removal characteristics and surface generation in *** this paper,a systematic investigation of the effect of SOD on the tool influence function and surface topography in FJP was *** were designed for FJP two kinds of materials corresponding to ductile and brittle *** are nickel copper(NiCu)alloy and BK7 optical glass,*** this study,the SOD was varied from 2 to 35 *** and discussions were made on its effect on the shape of TIF,material removal rate,and surface *** is interesting to note that the TIF shape becomes a Gaussian-like shape with large SOD both on NiCu and BK7,which provides a novel way to optimize the TIF in *** variation of the material removal rate and surface roughness versus SOD on NiCu and BK7 were also determined from the experimental ***,the surface topography of NiCu and BK7 were characterized from the results measured from the white light interferometer and scan electron *** outcome of the study provides a better understanding of the material removal characteristics and surface generation mechanism in FJP.

关键词： Fluid jet polishing Material removal characteristics Stand-off distance Tool influence function Surface generation Ultra-precision machining

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Modelling for registration of remotely sensed imagery when reference control points contain error

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Science china Earth Sciences 2006年第7期49卷 739-746页

作者： Leung yee The Department of Geography and Resource Management The Chinese University of Hong Kong Shatin Hong Kong China

Reference control points (RCPs) used in establishing the regression model in the regis-tration or geometric correction of remote sensing images are generally assumed to be “perfect”. That is, the RCPs, as explanatory variables in the regression equation, are accurate and the coordinates of their locations have no errors. Thus ordinary least squares (OLS) estimator has been applied exten-sively to the registration or geometric correction of remotely sensed data. However, this assumption is often invalid in practice because RCPs always contain errors. Moreover, the errors are actually one of the main sources which lower the accuracy of geometric correction of an uncorrected image. Under this situation, the OLS estimator is biased. It cannot handle explanatory variables with errors and cannot propagate appropriately errors from the RCPs to the corrected image. Therefore, it is essential to develop new feasible methods to overcome such a problem. This paper introduces a consistent adjusted least squares (CALS) estimator and proposes relaxed consistent adjusted least squares (RCALS) estimator, with the latter being more general and flexible, for geometric correction or regis-tration. These estimators have good capability in correcting errors contained in the RCPs, and in propagating appropriately errors of the RCPs to the corrected image with and without prior information. The objective of the CALS and proposed RCALS estimators is to improve the accuracy of measure-ment value by weakening the measurement errors. The conceptual arguments are substantiated by a real remotely sensed data. Compared to the OLS estimator, the CALS and RCALS estimators give a superior overall performance in estimating the regression coefficients and variance of measurement errors.

关键词： error modelling, registration, ordinary least squares, relaxed consistent adjusted least squares, remote sensing images.

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