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Biocompatible reduced graphene oxide stimulated BMSCs induce acceleration of bone remodeling and orthodontic tooth movement through promotion on osteoclastogenesis and angiogenesis

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Bioactive materials 2022年第9期7卷 409-425页

作者： Delong jiao Jing Wang Wenting Yu Ke Zhang Ning Zhang Lingyan Cao Xinquan Jiang Yuxing Bai Institute of Dental Research Beijing Stomatological Hospital&School of StomatologyCapital Medical UniversityBeijing100050China department of Orthodontics Beijing Stomatological Hospital&School of StomatologyCapital Medical UniversityBeijing100050China department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai200011China

We has synthesized the biocompatible gelatin reduced graphene oxide(GOG)in previous research,and in this study we would further evaluate its effects on bone remodeling in the aspects of osteoclastogenesis and angiogenesis so as to verify its impact on accelerating orthodontic tooth *** mouse orthodontic tooth movement(OTM)model tests in vivo showed that the tooth movement was accelerated in the GOG local injection group with more osteoclastic bone resorption and neovascularization compared with the PBS injection *** analysis on the degradation of GOG in bone marrow stromal stem cells(BMSCs)illustrated its good biocompatibility in vitro and the accumulation of GOG in spleen after local injection of GOG around the teeth in OTM model in vivo also didn’t influence the survival and life of *** co-culture of BMSCs with hematopoietic stem cells(HSCs)or human umbilical vein endothelial cells(HUVECs)in transwell chamber systems were constructed to test the effects of GOG stimulated BMSCs on osteoclastogenesis and angiogenesis in *** the GOG stimulated BMSCs co-culture in upper chamber of transwell,the HSCs in lower chamber manifested the enhanced ***,the co-culture of GOG stimulated BMSCs with HUVECs showed a promotive effect on the angiogenic ability of *** mechanism analysis on the biofunctions of the GOG stimulated BMSCs illustrated the important regulatory effects of PERK pathway on osteoclastogenesis and *** the results showed the biosecurity of GOG and the biological functions of GOG stimulated BMSCs in accelerating bone remodeling and tooth movement.

关键词： Bone remodeling Reduced graphene oxide Angiogenesis Osteoclastogenesis Orthodontic tooth movement

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3D-printed surface promoting osteogenic differentiation and angiogenetic factor expression of BMSCs on Ti6Al4V implants and early osseointegration in vivo

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Journal of materials science & Technology 2019年第2期35卷 336-343页

作者： Jinkai Zhang Wenhui zhou Hui Wang Kaili Lin Fengshan Chen department of Orthodontics School & Hospital of Stomatology Tongji University shanghai engineering Research Center of Tooth Restoration and Regeneration department of Oral & Cranio-Maxillofacial Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology

Three-dimensional-printed(3 D-P) titanium implants display many advantages, such as design flexibility,higher efficiency, the capability to easily construct complex or customized structures, etc., and is believed to potentially replace traditional implants. However, the biological performance of the 3 D-P titanium surface has not been investigated systematically. Herein, we analyzed the surface characteristics of 3 D-P Ti6 Al4 V implants and evaluated the biological responses of bone marrow derived mesenchymal stromal cells(BMSCs) to the 3 D-P surface in vitro. Moreover, after implantation into the rat femoral condyle for3 and 6 weeks, the osseointegration performance was evaluated. The results showed the 3 D-P Ti6 Al4 V implant presented distinct fluctuant macroscale rough surface and relatively better hydrophilicity which enhanced the adhesion, proliferation, osteogenic differentiation and angiogenetic factor expression of BMSCs. Moreover, the in vivo osseointegration performance was also better than that of the control group at the early stage. The present study suggested the 3 D-P titanium alloy is a promising candidate to be used as implant material.

关键词： Three-dimensional printing Titanium alloy BMSCs Osteogenesis Osseointegration

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Membrane bioreactors for hospital wastewater treatment: recent advancements in membranes and processes

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Frontiers of Chemical science and engineering 2022年第5期16卷 634-660页

作者： Yan Zhao Yangbo Qiu Natalie Mamrol Longfei Ren Xin Li Jiahui Shao xing Yang Bart van der Bruggen department of Chemical engineering KU LeuvenB-3001 LeuvenBelgium School of Environmental science and engineering Shanghai Jiao Tong UniversityShanghai 200240China department of materials science and engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

Discharged hospital wastewater contains various pathogenic microorganisms,antibiotic groups,toxic organic compounds,radioactive elements,and ionic *** contaminants harm the environment and human health causing the spread of ***,effective treatment of hospital wastewater is an urgent task for sustainable ***,with controllable porous and nonporous structures,have been rapidly developed for molecular *** particular,membrane bioreactor(MBR)technology demonstrated high removal efficiency toward organic compounds and low waste sludge *** further enhance the separation efficiency and achieve material recovery from hospital waste streams,novel concepts of MBRs and their applications are rapidly evolved through hybridizing novel membranes(non hydrophilic ultrafiltration/microfiltration)into the MBR units(hybrid MBRs)or the MBR as a pretreatment step and integrating other membrane processes as subsequent secondary purification step(integrated MBR-membrane systems).However,there is a lack of reviews on the latest advancement in MBR technologies for hospital wastewater treatment,and analysis on its major challenges and future *** review started with an overview of main pollutants in common hospital wastewater,followed by an understanding on the key performance indicators/criteria in MBR membranes(i.e.,solute selectivity)and processes(e.g.,fouling).Then,an in-depth analysis was provided into the recent development of hybrid MBR and integrated MBR-membrane system concepts,and applications correlated with wastewater sources,with a particular focus on hospital *** is anticipated that this review will shed light on the knowledge gaps in the field,highlighting the potential contribution of hybrid MBRs and integrated MBRmembrane systems toward global epidemic prevention.

关键词： membrane technology membrane bioreactor hospital wastewater hybrid MBR integrated MBR-membrane system

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Observation of the Hydrogen-Dislocation Interactions in a High-Manganese Steel after Hydrogen Adsorption and Desorption

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Acta Metallurgica Sinica(English Letters) 2023年第7期36卷 1105-1112页

作者： Dayong An Yuhao zhou Yao Xiao Xinxi Liu Xifeng Li Jun Chen department of Plasticity Technology School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200030China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an710072China

Hydrogen embrittlement(HE)poses a significant challenge for the development of high-strength metallic ***,explanations for the observed HE phenomena are still under *** shed light on this issue,here we investigated the hydrogen-defect interaction by comparing the dislocation structure evolution after hydrogen adsorption and desorption in a Fe-28Mn-0.3C(wt%)twinning-induced plasticity steel with an austenitic structure using in situ electron channeling contrast *** results indicate that hydrogen can strongly affect dislocation *** detail,hydrogen can promote the formation of stacking faults with a long dissociation ***,dislocation movements are frequently observed during hydrogen *** required resolved shear stress is considered to be the residual stresses rendered by hydrogen ***,the microstructural heterogeneity could lead to the discrepancy of dislocation activities even within the same materials.

关键词： Hydrogen embrittlement Stacking fault Dislocation movement High-manganese steel Electron channeling contrast imaging(ECCI)

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Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus,persisters and biofilms

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Bioactive materials 2022年第8期7卷 272-289页

作者： Shutao Zhang Xinhua Qu Juyang jiao Haozheng Tang Minqi Wang You Wang Hongtao Yang Weien Yuan Bing Yue department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalShanghai Jiaotong University School of MedicineChina School of Medical science and engineering Beihang UniversityBeijing100191China engineering Research Center of Cell&Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai200240China

Methicillin-resistant Staphylococcus aureus(MRSA),biofilms,and persisters are three major factors leading to recurrent and recalcitrant implant *** antibiotics are still the primary treatment for chronic implant infections in clinical,only few drugs are effective in clearing persisters and formed ***,felodipine,a dihydropyridine calcium channel blocker,was reported for the first time to have antibacterial effects against MRSA,biofilm,and *** after continuous exposure to sub-lethal concentrations of felodipine,bacteria are less likely to develop ***,low doses of felodipine enhances the antibacterial activity of gentamicin by inhibiting the expression of protein associated with aminoglycoside resistance(aacA-aphD).Next,biofilm eradication test and persisters killing assay suggested felodipine has an excellent bactericidal effect against formed biofilms and ***,the result of protein profiling,and quantitative metabonomics analysis indicated felodipine reduce MRSA virulence(agrABC),biofilm formation and TCA ***,molecular docking showed felodipine inhibit the growth of persisters by binding to the H pocket of ClpP protease,which could lead to substantial protein ***,murine infection models suggested felodipine in combination with gentamicin alleviate bacterial burden and inflammatory *** conclusion,low dose of felodipine might be a promising agent for biomaterial delivery to enhance aminoglycosides efficacy against implant infections caused by MRSA,biofilm,and persisters.

关键词： Aminoglycosides Felodipine Persisters Methicillin-resistant Staphylococcus aureus Implant infection

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Light-emitting self-assembled metallacages

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National science Review 2021年第6期8卷 94-111页

作者： Jun Zhao Zhixuan zhou Guangfeng Li Peter J.Stang Xuzhou Yan School of Chemistry and Chemical engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong University department of Chemistry University of Utah

Coordination-driven self-assembly of metallacages has garnered significant interest because of their 3 D layout and cavity-cored nature. The well-defined, highly tunable metallacage structures render them particularly attractive for investigating the properties of luminophores, as well as for inducing novel photophysical characters that enable widespread applications. In this review, we summarize the recent advances in synthetic methodologies for light-emitting metallacages, and highlight some representative applications of these metallacages. In particular, we focus on the favorable photophysical properties—including high luminescence efficiency in various physical states, good modularity in photophysical properties and stimulus responsiveness—that have resulted from incorporating ligands displaying aggregation-induced emission(AIE) into metallacages. These features show that the synergy between carrying out coordination-driven self-assembly and using luminophores with novel photophysical characteristics like AIE could stimulate the development of supramolecular luminophores for applications in fields as diverse as sensing, biomedicine and catalysis.

关键词： supramolecular coordination complexes coordination-driven self-assembly aggregation-induced emission metallacages organometallic materials

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A 3D-bioprinted scaffold with doxycycline-controlled BMP2-expressing cells for inducing bone regeneration and inhibiting bacterial infection

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Bioactive materials 2021年第5期6卷 1318-1329页

作者： Minqi Wang Hanjun Li Yiqi Yang Kai Yuan Feng zhou Haibei Liu Qinghui zhou Shengbing Yang Tingting Tang shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai200011China shanghai Graphic Design Information Co.Ltd Shanghai200011China

Large bone defects face a high risk of pathogen exposure due to open wounds,which leads to high infection rates and delayed bone *** promote successful repair of infectious bone defects,fabrication of a scaffold with dual functions of osteo-induction and bacterial inhibition is *** study describes creation of an engineered progenitor cell line(C3H10T1/2)capable of doxycycline(DOX)-mediated release of bone morphogenetic protein-2(BMP2).Three-dimensional bioprinting technology enabled creation of scaffolds,comprising polycaprolactone/mesoporous bioactive glass/DOX and bioink,containing these engineered *** vivo and in vitro experiments confirmed that the scaffold could actively secrete BMP2 to significantly promote osteoblast differentiation and induce ectopic bone ***,the scaffold exhibited broad-spectrum antibacterial capacity,thereby ensuring the survival of embedded engineered cells when facing high risk of *** findings demonstrated the efficacy of this bioprinted scaffold to release BMP2 in a controlled manner and prevent the occurrence of infection;thus,showing its potential for repairing infectious bone defects.

关键词： 3D bioprinting Genetic engineering Bone repair Antibacterial activity Infectious bone defect

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Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

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Bioactive materials 2023年第7期25卷 239-255页

作者： Zeqian Xu Xuanyu Qi Minyue Bao Tian zhou Junfeng Shi Zhiyan Xu Mingliang zhou Aldo R.Boccaccini Kai Zheng Xinquan Jiang department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011People’s Republic of China College of Stomatology Shanghai Jiao Tong UniversityNo.639 Zhizaoju RoadShanghai200011People’s Republic of China National Center for Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China National Clinical Research Center for Oral Diseases No.639 Zhizaoju RoadShanghai200011People’s Republic of China shanghai Key Laboratory of Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China shanghai engineering Research Center of Advanced Dental Technology and materials No.639 Zhizaoju RoadShanghai200011People’s Republic of China department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200023People’s Republic of China Institute of Biomaterials University of Erlangen-NurembergCauerstrasse 691058ErlangenGermany Jiangsu Province engineering Research Center of Stomatological Translational Medicine Nanjing Medical UniversityNanjing210029People’s Republic of China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing210029People’s Republic of China

TypeⅡdiabetes mellitus(TIIDM)remains a challenging clinical issue for both dentists and *** virtue of persistent hyperglycemia and altered host metabolism,the pathologic diabetic micromilieu with chronic inflammation,advanced glycation end products accumulation,and attenuated biomineralization severely impairs bone regeneration *** to“remodel”the pathologic diabetic micromilieu,we 3D-printed bioscaffolds composed of Sr-containing mesoporous bioactive glass nanoparticles(Sr-MBGNs)and gelatin methacrylate(GelMA).Sr-MBGNs act as a biomineralization precursor embedded in the GelMA-simulated extracellular matrix and release Sr,Ca,and Si ions enhancing osteogenic,angiogenic,and immunomodulatory *** addition to angiogenic and anti-inflammatory outcomes,this innovative design reveals that the nanocomposites can modulate extracellular matrix reconstruction and simulate biomineralization by activating lysyl oxidase to form healthy enzymatic crosslinked collagen,promoting cell focal adhesion,modulating osteoblast differentiation,and boosting the release of OCN,the noncollagenous proteins(intrafibrillar mineralization dependent),and thus orchestrating osteogenesis through the Kindlin-2/PTH1R/OCN *** 3D-printed bioscaffold provides a multifunctional biomineralization-inspired system that remodels the“barren”diabetic microenvironment and sheds light on the new bone regeneration approaches for TIIDM.

关键词： Biomineralization TypeⅡDiabetes mellitus 3D printing Sr-containing mesoporous bioactive glass nanoparticles Enzymatic cross-links

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Ultra-high strength yet superplasticity in a hetero-grain-sized nanocrystalline Au nanowire

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Journal of materials science & Technology 2022年第6期101卷 95-106页

作者： Libo Fu Deli Kong Chengpeng Yang jiao Teng Yan Lu Yizhong Guo Guo Yang Xin Yan Pan Liu Mingwei Chen Ze Zhang Lihua Wang Xiaodong Han Beijing Key Lab of Microstructure and Properties of Advanced materials Beijing University of TechnologyBeijing 100124China department of Material Physics and Chemistry University of Science and Technology BeijingBeijing 100083China School of Mechanical engineering and Automation Beihang UniversityBeijing 100191China School of materials science and engineering Shanghai Jiao Tong UniversityShanghai 200240China department of materials science and engineering Johns Hopkins UniversityBaltimoreMD 21218United States School of materials science and engineering Zhejiang UniversityHangzhou 310027China

Nanocrystalline metals often display a high strength up to the gigapascal level,yet they suffer from poor *** studies have shown that the development of hetero-sized grains can efficiently overcome the strength-ductility trade-off of nanocrystalline ***,whether this strategy can lead to the fabrication of nanocrystalline nanowires exhibiting both high strength and superplasticity is unclear,similar to the atomistic deformation *** this paper,we show that ultra-small nanocrystalline Au nanowires comprising grains in both the Hall–Petch and inverse Hall–Petch grain-size regions can exhibit extremely high uniform elongation(236%)and high strength(2.34 gigapascals)at room *** situ atomic-scale observations revealed that the plastic deformation underwent two *** the first stage,the super-elongation ability originated from the intergrain plasticity of small grains via mechanisms such as grain boundary migration and grain *** intergrain plasticity caused the grains in the heterogeneous-structured nanowires to grow very *** the second stage,the superelongation ability originated from intragrain plasticity accompanied by the diffusion of surface *** results show that the hetero-grain-sized nanocrystalline nanowires,comprising grains with sizes both in the strongest Hall–Petch effect region and the inverse Hall–Petch effect region,were simultaneously ultrastrong and *** displayed neither a strength-ductility trade-off nor plastic instability.

关键词： In situ Mechanical property Metallic nanowires Transmission electron microscopy Plastic deformation

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Bidirectional differentiation of BMSCs induced by a biomimetic procallus based on a gelatin-reduced graphene oxide reinforced hydrogel for rapid bone regeneration

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Bioactive materials 2021年第7期6卷 2011-2028页

作者： Delong jiao Ao Zheng Yang Liu Xiangkai Zhang Xiao Wang Jiannan Wu Wenjun She Kaige Lv Lingyan Cao Xinquan Jiang department of Prosthodontics Shanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyNational Clinical Research Center for Oral DiseasesShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineChina The State Key Laboratory of Bioreactor engineering East China University of Science and Technology130 Meilong RoadShanghai 200237China

Developmental engineering strategy needs the biomimetic composites that can integrate the progenitor cells,biomaterial matrices and bioactive signals to mimic the natural bone healing process for faster healing and reconstruction of segmental bone *** prepared the gelatin-reduced graphene oxide(GOG)and constructed the composites that mimicked the procallus by combining the GOG with the photo-crosslinked gelatin *** biological effects of the GOG-reinforced composites could induce the bi-differentiation of bone marrow stromal cells(BMSCs)for rapid bone *** proper ratio of GOG in the composites regulated the composites’mechanical properties to a suitable range for the adhesion and proliferation of ***,the GOG-mediated bidirectional differentiation of BMSCs,including osteogenesis and angiogenesis,could be activated through Erk1/2 and AKT *** methyl vanillate(MV)delivered by GOG also contributed to the bioactive signals of the biomimetic procallus through priming the osteogenesis of *** the repair of the calvarial defect in vivo,the initial hypoxic condition due to GOG in the composites gradually transformed into a well-vasculature robust situation with the bi-differentiation of BMSCs,which mimicked the process of bone healing resulting in the rapid bone *** an inorganic constituent,GOG reinforced the organic photo-crosslinked gelatin hydrogel to form a double-phase biomimetic procallus,which provided the porous extracellular matrix microenvironment and bioactive signals for the bi-directional differentiation of *** show a promised application of the bio-reduced graphene oxide in biomedicine with a developmental engineering strategy.

关键词： Biomimetic procallus Bio-reduced graphene oxide Photo-crosslinked gelatin hydrogel Methyl vanillate Developmental engineering

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