检索结果-南通市图书馆

Metabolic memory:mechanisms and diseases

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第3期9卷 1086-1114页

作者： Hao Dong Yuezhang Sun Lulingxiao Nie Aimin Cui Pengfei Zhao Wai Keung leung Qi Wang State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduChina Department of Prosthodontics West China Hospital of StomatologySichuan UniversityChengduChina Periodontology and Implant Dentistry Division Faculty of DentistryThe University of Hong KongHong KongChina

Metabolic diseases and their complications impose health and economic burdens *** from past experimental studies and clinical trials suggests our body may have the ability to remember the past metabolic environment,such as hyperglycemia or hyperlipidemia,thus leading to chronic inflammatory disorders and other diseases even after the elimination of these metabolic *** long-term effects of that aberrant metabolism on the body have been summarized as metabolic memory and are found to assume a crucial role in states of health and *** molecular mechanisms collectively participate in metabolic memory management,resulting in different cellular alterations as well as tissue and organ dysfunctions,culminating in disease progression and even affecting *** elucidation and expansion of the concept of metabolic memory provides more comprehensive insight into pathogenic mechanisms underlying metabolic diseases and complications and promises to be a new target in disease detection and ***,we retrace the history of relevant research on metabolic memory and summarize its salient *** provide a detailed discussion of the mechanisms by which metabolic memory may be involved in disease development at molecular,cellular,and organ levels,with emphasis on the impact of epigenetic ***,we present some of the pivotal findings arguing in favor of targeting metabolic memory to develop therapeutic strategies for metabolic diseases and provide the latest reflections on the consequences of metabolic memory as well as their implications for human health and diseases.

关键词： diseases metabolism alterations

Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science china Mathematics 2024年

作者： Weidong Liu Dennis leung Qiman Shao School of Mathematical Sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne Department of Statistics and Data Science SICM Southern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model, the number of pairwise comparisons can become large even with a moderate number of groups. Motivated by this, we consider a regime with a growing number of groups and prove that, when testing pairwise comparisons, the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries, despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) control. Following Tukey's perspective that the difference between the means of any two groups cannot be exactly zero, our main result provides control over the directional false discovery rate and directional false discovery proportion. A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR control. Our analysis does not rely on conventional assumptions such as normality, variance homogeneity, or a balanced design, thereby offering a theoretical foundation for applications in more general settings.

关键词：

UV-Based Advanced Oxidation Processes for Antibiotic Resistance Control: Efficiency, Influencing Factors, and Energy Consumption

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Engineering 2024年第6期37卷 27-39页

作者： Jiarui Han Wanxin Li Yun Yang Xuanwei Zhang Siyu Bao Xiangru Zhang Tong Zhang Kenneth Mei Yee leung Department of Civil and Environment Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China Department of Civil Engineering The University of Hong KongHong Kong 999077China State Key Laboratory of Marine Pollution and Department of Chemistry City University of Hong KongHong Kong 999077China

Antibiotic resistant bacteria(ARB)with antibiotic resistance genes(ARGs)can reduce or eliminate the effectiveness of antibiotics and thus threaten human *** United Nations Environment Programme considers antibiotic resistance the first of six emerging issues of *** oxidation processes(AOPs)that combine ultraviolet(UV)irradiation and chemical oxidation(primarily chlorine,hydrogen peroxide,and persulfate)have attracted increasing interest as advanced water and wastewater treatment *** integrated technologies have been reported to significantly elevate the efficiencies of ARB inactivation and ARG degradation compared with direct UV irradiation or chemical oxidation alone due to the generation of multiple reactive *** this study,the performance and underlying mechanisms of UV/chlorine,UV/hydrogen peroxide,and UV/persulfate processes for controlling ARB and ARGs were reviewed based on recent *** affecting the process-specific efficiency in controlling ARB and ARGs were discussed,including biotic factors,oxidant dose,UV fluence,pH,and water matrix *** addition,the cost-effectiveness of the UV-based AOPs was evaluated using the concept of electrical energy per *** UV/chlorine process exhibited a higher efficiency with lower energy consumption than other UV-based AOPs in the wastewater matrix,indicating its potential for ARB inactivation and ARG degradation in wastewater *** studies are required to address the trade-off between toxic byproduct formation and the energy efficiency of the UV/chlorine process in real wastewater to facilitate its optimization and application in the control of ARB and ARGs.

关键词： Advanced oxidation processes Ultraviolet/chlorine Ultraviolet/hydrogen peroxide Ultraviolet/persulfate Antibiotic resistant bacteria Antibiotic resistance genes

Combinatorial Optimization of Physics Parameterization Schemes for Typhoon Simulation Based on a Simple Genetic Algorithm(SGA)

在线全文

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2024年第1期38卷 10-26页

作者： Zebin LU Jianjun XU Zhiqiang CHEN Jinyi YANG Jeremy Cheuk-Hin leung Daosheng XU Banglin ZHANG china Meteorological Administration–Guangdong Ocean University Joint Laboratory for Marine Meteorology South China Sea Institute of Marine MeteorologyGuangdong Ocean UniversityZhanjiang 524088 College of Ocean and Meteorology Guangdong Ocean UniversityZhanjiang 524088 Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional Numerical Weather Prediction China Meteorological AdministrationGuangzhou 510640 Shenzhen Institute of Guangdong Ocean University Shenzhen 518120 College of Atmospheric Science Lanzhou UniversityLanzhou 730000

Each physical process in a numerical weather prediction(NWP)system may have many different parameterization *** studies have shown that the performance of different physical parameterization schemes varies with the weather situation to be ***,it is necessary to select a suitable combination of physical parameterization schemes according to the variation of weather ***,it is rather difficult to identify an optimal combination among millions of possible parameterization scheme *** study applied a simple genetic algorithm(SGA)to optimizing the combination of parameterization schemes in NWP models for typhoon *** feasibility of SGA was verified with the simulation of Typhoon Mujigae(2015)by using the Weather Research and Forecasting(WRF)model and Typhoon Higos(2020)by using the Coupled Ocean–Atmosphere–Wave–Sediment Transport(COAWST)modeling *** results show that SGA can efficiently obtain the optimal combination of *** Typhoon Mujigae(2015),the optimal combination can be found from the 1,304,576 possible combinations by running only 488 *** results can be obtained for Typhoon Higos(2020).Compared to the default combination proposed by the COAWST model system,the optimal combination scheme significantly improves the simulation of typhoon track and *** study provides a feasible way to search for the optimal combinations of physical parameterization schemes in WRF and COAWST for more accurate typhoon *** can help provide references for future development of NWP models,and for analyzing the coordination and adaptability of different physical process parameterization schemes under specific weather backgrounds.

关键词： simple genetic algorithm(SGA) combinatorial optimization typhoon forecast numerical weather prediction(NWP)

Genome engineering of the human gut microbiome

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第5期51卷 479-491页

作者： Linggang Zheng Juntao Shen Ruiyue Chen Yucan Hu Wei Zhao Elaine Lai-Han leung Lei Dai Dr Neher's Biophysics Laboratory for Innovative Drug Discovery/State Key Laboratory of Quality Research in chinese Medicine Macao University of Science and TechnologyTaipaMacao 999078China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of chinese Academy of Sciences Beijing 100049China Cancer Center Faculty of Health ScienceUniversity of MacaoMacao 999078China MOE Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China

The human gut microbiome,a complex ecosystem,significantly influences host health,impacting crucial aspects such as metabolism and *** enhance our comprehension and control of the molecular mechanisms orchestrating the intricate interplay between gut commensal bacteria and human health,the exploration of genome engineering for gut microbes is a promising ***,the complexities and diversities inherent in the gut microbiome pose substantial challenges to the development of effective genome engineering tools for human gut *** this comprehensive review,we provide an overview of the current progress and challenges in genome engineering of human gut commensal bacteria,whether executed in vitro or in situ.A specific focus is directed towards the advancements and prospects in cargo DNA delivery and high-throughput ***,we elucidate the immense potential of genome engineering methods to enhance our understanding of the human gut microbiome and engineer the microorganisms to enhance human health.

关键词： Non-model gut commensals Genomeediting reagents Cargo delivery High-throughput genome engineering

An improved pulse coupled neural networks model for semantic IoT

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第3期10卷 557-567页

作者： Rong Ma Zhen Zhang Yide Ma Xiping Hu Edith C.H.Ngai Victor C.M.leung School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China School of Medical Technology Beijing Institute of TechnologyBeijing100081China Department of Electrical and Electronic Engineer The University of Hong KongHong Kong 999077China College of Computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Electrical and Computer Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada

In recent years,the Internet of Things(IoT)has gradually developed applications such as collecting sensory data and building intelligent services,which has led to an explosion in mobile data ***,with the rapid development of artificial intelligence,semantic communication has attracted great attention as a new communication ***,for IoT devices,however,processing image information efficiently in real time is an essential task for the rapid transmission of semantic *** the increase of model parameters in deep learning methods,the model inference time in sensor devices continues to *** contrast,the Pulse Coupled Neural Network(PCNN)has fewer parameters,making it more suitable for processing real-time scene tasks such as image segmentation,which lays the foundation for real-time,effective,and accurate image ***,the parameters of PCNN are determined by trial and error,which limits its *** overcome this limitation,an Improved Pulse Coupled Neural Networks(IPCNN)model is proposed in this *** IPCNN constructs the connection between the static properties of the input image and the dynamic properties of the neurons,and all its parameters are set adaptively,which avoids the inconvenience of manual setting in traditional methods and improves the adaptability of parameters to different types of *** segmentation results demonstrate the validity and efficiency of the proposed self-adaptive parameter setting method of IPCNN on the gray images and natural images from the Matlab and Berkeley Segmentation *** IPCNN method achieves a better segmentation result without training,providing a new solution for the real-time transmission of image semantic information.

关键词： Internet of things(IoT) Semantic information Real-time application Improved pulse coupled neural network Image segmentation

Impact of effective stress on permeability for carbonate fractured-vuggy rocks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 942-960页

作者： Ke Sun Huiqing Liu Juliana Y.leung Jing Wang Yabin Feng Renjie Liu Zhijiang Kang Yun Zhang State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China School of Mining&Petroleum Engineering University of AlbertaEdmontonT6G 1H9Canada SINOPEC Petroleum Exploration and Production Research Institute Beijing100083China

To gain insight into the flow mechanisms and stress sensitivity for fractured-vuggy reservoirs,several core models with different structural characteristics were designed and fabricated to investigate the impact of effective stress on permeability for carbonate fractured-vuggy rocks(CFVR).It shows that the permeability performance curves under different pore and confining pressures(*** stress conditions)for the fractured core models and the vuggy core models have similar change *** ranges of permeability variation are significantly wider at high pore pressures,indicating that permeability reduction is the most significant during the early stage of development for fractured-vuggy *** each obtained effective stress coefficient for permeability(ESCP)varies with the changes in confining pressure and pore pressure,the effective stresses for permeability of four representative CFVR show obvious nonlinear characteristics,and the variation ranges of ESCP are all between 0 and ***,a comprehensive ESCP mathematical model considering triple media,including matrix pores,fractures,and dissolved vugs,was *** is proved theoretically that the ESCP of CFVR generally varies between 0 and ***,the regression results showed that the power model ranked highest among the four empirical models mainly applied in stress sensitivity characterization,followed by the logarithmic model,exponential model,and binomial *** concept of“permeability decline rate”was introduced to better evaluate the stress sensitivity performance for CFVR,in which the one-fracture rock is the strongest,followed by the fracture-vug rock and two-horizontalfracture rock;the through-hole rock is the *** general,this study provides a theoretical basis to guide the design of development and adjustment programs for carbonate fractured-vuggy reservoirs.

关键词： Effective stress Permeability Carbonate fractured-vuggy rocks Structure characteristics Stress sensitivity

Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第7期30卷 714-726页

作者： Pui-Yin leung Wenjing Chen Anissa N Sari Poojitha Sitaram Pui-Kei Wu Susan Tsai Jong-In Park Department of Biochemistry Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Pancreatic cancer is a leading cause of cancer-related *** activity of the epidermal growth factor receptor(EGFR)is often observed in pancreatic cancer,and the small molecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug ***,erlotinib alone is ineffective and should be combined with other drugs to improve therapeutic *** previously showed that certain receptor tyrosine kinase inhibitors can increase mitochondrial membrane potential(Δψm),facilitate tumor cell uptake ofΔψm-sensitive agents,disrupt mitochondrial homeostasis,and subsequently trigger tumor cell *** has not been tested for this *** To determine whether erlotinib can elevateΔψm and increase tumor cell uptake ofΔψm-sensitive agents,subsequently triggering tumor cell ***Δψm-sensitive fluorescent dye was used to determine how erlotinib affectsΔψm in pancreatic adenocarcinoma(PDAC)cell *** viability of conventional and patient-derived primary PDAC cell lines in 2D-and 3D cultures was measured after treating cells sequentially with erlotinib and mitochondria-targeted ubiquinone(MitoQ),aΔψm-sensitive *** synergy between erlotinib and MitoQ was then analyzed using SynergyFinder *** preclinical efficacy of the twodrug combination was determined using immune-compromised nude mice bearing PDAC cell line *** Erlotinib elevatedΔψm in PDAC cells,facilitating tumor cell uptake and mitochondrial enrichment ofΔψm-sensitive *** triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatment potentiated low doses of *** suggested that these drugs synergistically induced tumor cell *** with in vitro data,erlotinib and MitoQ combination suppressed human PDAC cell line xenografts in mice more effectively than single treatments of each *** Our findings suggest tha

关键词： Pancreatic cancer Erlotinib Mitochondria-targeted ubiquinone Mitochondria Combination therapy

Outcomes and satisfaction of patients with orthopaedic implants left in-situ for more than three years： a retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Medical Journal 2011年第15期124卷 2297-2300页

作者： Aaran Heng-chi leung Jeffrey Shen Andraay Hon-chi leung Yuk-wah Hung Anna HW Mok Wing-Hoi Cheung Kwok-Sui leung Department of Orthopaedics and Traumatology The Chinese University of Hong Kong Shatin New Territories Hong Kong China Specialty Registrar Trauma and Orthopaedics West of Scotland Region NHS Scotland United Kingdom

Background There are no clear guidelines on implant removal. Few have assessed the long-term outcomes of patients with implants left in-situ, or removed. Therefore, removal of implants after fracture fixation remains controversial. Methods In this retrospective study, we reviewed 53 patients with implant for fracture fixation in-situ for more than 3 years. All patients were younger than 60 years. Quality of life of each patient was assessed with the chinese （Hong Kong） validated Short Form-36 and the pain was assessed with visual analogue scale （VAS）. All patients were clinically examined and plain radiographs were taken. Results The total SF-36 score of the patients was not statistically different from the Hong Kong norm （P 〉0.05）. Mean score of VAS was 2.08. Thirty-three patients （62.3%） reported limited range of movement, 9 patients （17%） complained of cosmetic problems, and 10 patients （18.9%） complained of weakness. Clinically, 82.6% of patients had no scarring, 84.7% of patients had full range of movement and all had no tenderness on assessment. Radiologically, no abnormality was detected except for one patient with known avascular necrosis of the femoral head after screw fixation. Conclusion As most patients were clinically and radiologically normal with quality of life scores comparable to the norm, removal of implants is not advisable as a routine practice.

关键词： fracture fixation implant removal quality of life visual analogue scale refracture