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Acid–base Homeostasis and Implications to the Phenotypic Behaviors of Cancer

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Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1133-1148页

作者： Yi Zhou Wennan chang Xiaoyu Lu Jin Wang chi Zhang Ying Xu Cancer Systems Biology Center China–Japan Union HospitalJilin UniversityChangchun 130033China Department of Biochemistry and Molecular Biology and Institute of Bioinformatics University of GeorgiaAthensGA 30602USA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA Department of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47907USA Department of Biohealth Informatics Indiana University–Purdue University IndianapolisIndianapolisIN 46202USA Departments of Chemistry and of Physics and Astronomy Stony Brook UniversityStony BrookNY 11794USA

Acid–base homeostasis is a fundamental property of living cells,and its persistent disruption in human cells can lead to a wide range of *** this study,we conducted a computational modeling analysis of transcriptomic data of 4750 human tissue samples of 9 cancer types in The Cancer Genome Atlas(TCGA)*** on our previous study,we quantitatively estimated the average production rate of OHby cytosolic Fenton reactions,which continuously disrupt the intracellular pH(pHi)*** predictions indicate that all or at least a subset of 43 reprogrammed metabolisms(RMs)are induced to produce net protons(H+)at comparable rates of Fenton reactions to keep the pHi *** then discovered that a number of wellknown phenotypes of cancers,including increased growth rate,metastasis rate,and local immune cell composition,can be naturally explained in terms of the Fenton reaction level and the induced *** study strongly suggests the possibility to have a unified framework for studies of cancerinducing stressors,adaptive metabolic reprogramming,and cancerous *** addition,strong evidence is provided to demonstrate that a popular view that Na+/H+exchangers along with lactic acid exporters and carbonic anhydrases are responsible for the intracellular alkalization and extracellular acidification in cancer may not be justified.

关键词： Acid-basehomeostasis Cancer microenvironment Metabolic reprogramming Fenton reaction Ironmetabolism

Deduction of a meteorological phenology indicator from reconstructed MODIS LST imagery

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Journal of Forestry Research 2020年第6期31卷 2205-2216页

作者： chi Hong Lim Song Hie Jung Nam Shin Kim chang Seok Lee Department of Bio and Environmnetal Technology Graduate SchoolSeoul Women’s UniversitySeoul Republic of Korea Research Team on Ecological and Natural Map National Institute of EcologySeocheon Choongnam Republic of Korea Department of Bio and Environmnetal Technology Seoul Women’s UniversitySeoul Republic of Korea

Phenology is a valuable attribute of vegetation to assess the biological impacts from climate change.A challenge of phenological research is to obtain information on both high temporal resolution and fine spatial scale ***,we constructed an air temperature map based on temporal merging and spatial interpolation algorithms to overcome the cloud-related problem from the MODIS LST ***,we derived the accumulated growing degree days(AGDD)from the constructed mean air temperature map to use as a meteorological ***,we verified the indicator with the seasonal mean air temperature and the green-up date of a Quercus mongolica forest determined from the field-based *** AGDD threshold for each *** forest when the first leaf has unfolded was detected from the EXG trajectory extracted from digital camera images.A comparison between meteorological and MODIS-derived AGDD showed good agreement between *** was also high consistency between DoYs extracted from AGDD and EVI based on curvature K for *** forests of 30 sampling sites throughout South *** results prove that microclimatic factors such as elevation,waterbody,and land-use intensity were faithfully reflected in the reconstructed ***,the results of this study could be applied effectively in areas where microclimatic variation is very severe and for monitoring phenology of undergrowth,which is difficult to detect from reflectance imaging.

关键词： Climate change Digital camera Growing degree days MODIS Phenology Quercus mongolica

Effects of Anomalous Tensor Couplings in B_(s)^(0)-(B-)_(s)^(0) Mixing

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chinese Physics Letters 2012年第3期29卷 67-70页

作者： chang Qin han Lin YANG Ya-Dong Institute of Particle Physics Huazhong Normal UniversityWuhan 430079 Department of Physics Henan Normal UniversityXinxiangHenan 453007 Key Laboratory of Quark&Lepton Physics(Ministry of Education) Huazhong Normal UniversityWuhan 430079

Motivated by the recently observed anomalous large dimuon charge asymmetry in neutral B decays,we study the effects of the anomalous tensor couplings to pursue a possible *** the constraints from the observablesφ_(s)^(J/(φ)(φ,f0),a_(sl)^(s)andΔM_(s),the new physics parameter spaces are severely *** find that the contributions induced by the color-singlet or the color-octet tensor operators are helpful to moderate the anomaly in BOs-(B-)***,the observable aSsl could be enhanced by about two orders of magnitude by the contributionsof color-singlet or color-octet tensor operators with their respective nontrivial new weak phaseφT_(1)=41°±35°orφs=-47°±33°and relevant strength parameters|gT1|=(2.89±1.40)×10^(-2) or|gT8|=(0.79±0.34)×10^(-2).However,due to the fact that the NP contributions are severely suppressed by the recent LHCb measurement forφJ/φ(φ,f0)s,our theoretical result of aSsl is still much smaller than the central value of the experimental data.

关键词： solution tensor operators

Experimental and Numerical Study on Vibration of the Full-Revolving Propulsion Ship Stern

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china Ocean Engineering 2015年第1期29卷 33-48页

作者：刘长卿车驰东沈小寒 State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong University

In order to solve the severe vibration problems of an ocean engineering ship with a full-revolving propulsion system, the navigation tests, including forced vibration response test and modal test, are carded out in its stem. It is concluded from the comparison of the time-domain waveform and spectrum from different measurement points that three main factors lead to a high-level stern vibration. Firstly, the specific dynamic stiffness of a water tank is relatively small compared with its neighbor hold, which makes it act like a vibration isolator preventing vibrational energy transmitting to the main hold. Secondly, there exists high-density local modes in the working frequency range of the main engine and thus the local resonance occurs. Thirdly, the abnormal engagement of gears caused by the large deflection of the shaft bearing due to its low mounting rigidity leads to violent extra impulse excitations at high speeds. Then the modification against the dynamic defects is given by simply improving the specific stiffness of the water tanks. And the effect is validated by the FEM calculation. Some important experience is obtained with the problems being solved, which is useful in the design of ships with the same propulsion system. It is also believed that the dynamic consideration is as important as the static analysis for the ships, and that most of the vibration problems may be avoided with a proper acoustic design.

关键词： full-revolving propulsion stern vibration navigation test modal identification acoustic design

Sensitivity improvement by Vernier effect in microwave photonic filter based on F-P fiber ring

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Optoelectronics Letters 2025年

作者： LIN Rui ZhanG Ailing chang Pengxiang PAN Honggang WANG Minghe WANG Bo Engineering Research Center of Optoelectronic Devices & Communication Technology， Ministry of Education， Tianjin Key Laboratory of Film Electronic and Communication Devices， School of Electrical and Electronic Engineering， Tianjin University of Technology

A high sensitivity fiber optic temperature sensor based on Vernier effect in microwave photonic filter based on two paralleled F-P (Fabry-Perot) fiber ring is proposed and experimentally verified. Sensitivity is improved through the Vernier effect， which is caused by two parallel F-P fiber rings with approximate lengths. Temperature interrogation is achieved by monitoring the notch frequency of the superimposed frequency response curve. The temperature sensitivity of -484.514kHz/℃ is achieved in experiment， which is 57 times of the sensor without Vernier effect. The improved sensitivity and simple structure make it have wide potential applications in temperature monitoring of power systems.

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Simulation Might change Your Results: A Comparison of Context-Aware System Input Validation in Simulated and Physical Environments

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Journal of Computer Science & Technology 2022年第1期37卷 83-105页

作者： Jin-chi Chen Yi Qin Hui-Yan Wang chang Xu State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China

Context-aware systems(***)integrate cyber and physical space to provide adaptive functionalities in response to changes in *** context-aware systems is challenging due to the uncertain running ***,many input validation approaches have been proposed to protect context-aware systems from uncertainty and keep them executing ***,in contrast to context-aware systems'prevailing in physical environments,most of those academic solutions(83%)are purely evaluated in simulated *** this article,we study whether this evaluation setting could lead to biased *** build a testing platform,RM-Testing,based on DJI RoboMaster robot car,to conduct the physical-environment based *** select three up-to-date input validation approaches,and compare their performance in the simulated environment and in the physical *** experimental results show that all three approaches'performance in simulated environments(improving task success rate by 82%compared with the system without the support of input validation)does differ from their performance in a physical environment(improving the task success rate by 50%).We also recognize three factors(scenario setting,physical platform and environmental model)that affect the performance of input validation approaches,based on an execution model of the context-aware system.

关键词： context-aware system input validation self-driving car testing infrastructure

Effects of Homogeneous Plasma on Strong Gravitational Lensing of Kerr Black Holes

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chinese Physics Letters 2017年第9期34卷 24-28页

作者： chang-Qing Liu chi-Kun Ding Ji-Liang Jing Department of Physics Hunan University of Humanities Science and Technology Loudi 417000 Department of Physics and Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of Education Hunan Normal University Changsha 410081

Considering the Kerr black hole surrounded by a homogeneous unmagnetized plasma medium, we study the strong gravitational lensing on the equatorial plane of the Kerr black hole. It is found that the presence of the uniform plasma can increase the photon-sphere radius r_{／rm ps}, the coefficients ／bar{a} and ／bar{b}, the angular position of the relativistic images （／theta_{／infty}）, the deflection angle ／alpha（／theta） and the angular separation s. However, the relative magnitude r_{／rm m} decreases in the presence of the uniform plasma medium. It is also shown that the impact of the uniform plasma on the effect of strong gravitational lensing becomes smaller as the spin of the Kerr black hole increases in the prograde orbit （a〉0）. In particular, for the extreme black hole （a=0.5）, the effect of strong gravitational lensing in the homogeneous plasma medium is the same as the case in vacuum for the prograde orbit.

关键词： Effects of Homogeneous Plasma on Strong Gravitational Lensing of Kerr Black Holes

Comparison of presentation and impact on quality of life of gastroesophageal reflux disease between young and old adults in a chinese population

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World Journal of Gastroenterology 2011年第41期17卷 4614-4618页

作者： Shou-Wu Lee chia-Ming chang chi-Sen chang Ai-Wen Kao Ming-chih Chou Institute of Medicine Chung Shan Medical University Division of Gastroenterology Department of Internal MedicineTaichung Veterans General Hospital Department of Medicine Chung Shan Medical University Institute of Gerontology National Cheng Kang University Division of Geriatrics Department of Internal MedicineNational Cheng Kang University Hospital Division of Gastroenterology Department of Internal MedicineNational Cheng Kang University Hospital

AIM:To compare the presentation and impact on qual-ity of life of gastroesophageal reflux disease(GERD)in old and young age ***:Data from adult patients with GERD di-agnosed by endoscopic and symptomic characteristics were collected between January and November *** criteria included combined peptic ulcers,ma-lignancy,prior surgery,antacid medication for more than 2 mo,and *** patients were assigned to the elderly group if they were 65 years or older,or the younger group if they were under 65 *** had completed the GERD impact scale,the chinese GERD questionnaire,and the SF-36 *** from other cases without endoscopic f ind-ings or symptoms were collected and these subjects comprised the control group in our ***:There were 111 patients with GERD and 44 normal cases:78(70.3%)and 33 patients(29.7%)were in the younger and elderly groups,*** were more female patients(60.3%)in the younger group,and more males(72.7%)in the elderly *** younger cases had more severe and fre-quent typical symptoms than the elderly ***-nif icantly more impairment of daily activities was noted in the younger patients compared with the elderly group,except for physical ***:Elderly patients with GERD were pre-dominantly male with rare presentation of typical symp-toms,and had less impaired quality of life compared with younger patients in a chinese population.

关键词： Gastroesophageal reflux disease Quality oflife Age factors

结肠支架联合外科手术治疗急性梗阻性结直肠癌的效果

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中国医学创新 2025年第1期22卷 25-30页

作者：迟宝欣常志恒韩熙渊党彤汤泊夫王觅柱刘璐内蒙古科技大学包头医学院研究生院内蒙古包头014040 呼和浩特市第一医院消化内科内蒙古呼和浩特010020 内蒙古科技大学包头医学院第二附属医院普外科内蒙古包头014030 内蒙古科技大学包头医学院第二附属医院消化内科内蒙古包头014030

目的:对比内镜下结肠支架置入作为手术过渡联合外科手术与单纯外科手术两种方式治疗急性梗阻性结直肠癌的临床效果,探讨结肠支架在治疗急性梗阻性结直肠癌的有效性和安全性。方法:本文为回顾性研究,选择2020年1月—2023年9月就诊于内蒙... 详细信息

目的:对比内镜下结肠支架置入作为手术过渡联合外科手术与单纯外科手术两种方式治疗急性梗阻性结直肠癌的临床效果,探讨结肠支架在治疗急性梗阻性结直肠癌的有效性和安全性。方法:本文为回顾性研究,选择2020年1月—2023年9月就诊于内蒙古科技大学包头医学院第二附属医院因急性梗阻性结直肠癌接受结肠支架置入后进行择期手术的50例患者(支架组),并对技术成功率、临床成功率及支架相关并发症进行了观察,并与同期急性梗阻性结直肠癌行外科手术的50例患者(外科组)比较,观察腹腔镜手术率、手术用时、术后肠道恢复时间、肿瘤一期切除吻合率、术后并发症发生率及住院花费等指标。结果:支架组技术成功率和临床成功率分别为100%和96%。与外科组相比,支架组患者在腹腔镜手术率、一期切除吻合率方面有明显优势(P<0.05);同时,支架组在手术用时、术中出血量、术后肠道恢复时间及手术相关并发症发生率上均显著优于外科组(P<0.05)。支架组患者住院花费高于外科组患者(P<0.05)。结论:结肠支架置入术是急性梗阻性结直肠癌安全和可靠的治疗手段。与外科手术相比,支架置入术作为择期手术的过渡治疗有助于提高急性梗阻性结直肠癌患者选择腹腔镜微创手术的可能性,同时缩短手术时间,降低患者术后并发症的风险,提高了一期切除吻合率,虽住院费用较高,但也为患者治疗提供了一种新的选择。

关键词：急性梗阻性结直肠癌结肠支架并发症