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Successful bailout stenting strategy against rare spontaneous retrograde dissection of partially absorbed magnesium-based resorbable scaffold:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1148-1155页

作者： Zhen-Yu Liao Jer-Young Liou Shen-Chang Lin Huei-Fong hung Che-Ming Chang Lung-ching Chen Su-Kiat Chua Huey-Ming Lo chi-feng hung Division of Cardiology Department of Internal MedicineShin Kong Wu Ho-Su Memorial HospitalTaipei 11101Taiwan Ph.D.Program in Nutrition and Food Science Fu Jen Catholic UniversityNew Taipei 24205Taiwan School of Medicine Fu Jen Catholic UniversityNew Taipei 24205Taiwan MS Program Transdisciplinary Long-Term Care Fu Jen Catholic UniversityNew Taipei 24205Taiwan Ph.D.Program in Pharmaceutical Biotechnology Fu Jen Catholic UniversityNew Taipei 24205Taiwan

BACKGROUND In the development of coronary stent technology,bioresorbable scaffolds are promising milestones in improving the clinical treatment of coronary artery ***“leave nothing behind”motto is the premise of the fourth revolution in percutaneous coronary intervention(PCI).Studies proving the safety and efficacy of the magnesium-based resorbable scaffolds(MgBRSs)include the BIOSOLVE-I and BIOSOLVE-II trials and the latest BIOSOLVE-IV ***,spontaneous retrograde dissection of a partially absorbed MgBRS may still occur,albeit *** SUMMARY We describe an unusual case of coronary artery disease in a patient who had undergone a successful PCI 8 mo earlier,where an MgBRS was implanted into the left anterior descending artery(LAD)and left circumflex artery with drug-coated balloons for a ramus intermedius branch stenosis to achieve the“leave nothing behind”therapeutic intention and was currently presenting with a gradual worsening of chest *** distal edge vascular response,during subsequent attempts with balloon angioplasty was performed ***,spontaneous retrograde dissection of a partially absorbed MgBRS in the LAD *** bailout stenting was performed with revascularization of the entry and exit sites created by spontaneous dissection and complete sealing of the intramural *** patient recovered well and was discharged after 2 d of *** followed up in August 2020(7 mo later),the patient showed uneventful *** Spontaneous retrograde dissection of a partially absorbed MgBRS was successfully treated using bailout sirolimus-eluting coronary stent strategy.

关键词： Coronary artery disease Percutaneous coronary intervention Magnesium Stents Dissection Case report

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Unique anti-angiogenic effects,pharmacological targets and therapeutic mechanisms of chinese herbal medicines for endometriosis

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Genes & Diseases 2024年第5期11卷 63-65页

作者： Bo Liang Rui Dong Sze Wan hung Yiran Li Yuezhen Lin Ling Wu Tao Zhang Gene chi Wai Man Hui Xu Jacqueline Pui Wah Chung chi chiu Wang Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantouGuangdong 515063China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong Kong SARChina

Endometriosis is a common and benign angiogenesisdependent gynecological disorder,which refers to the proliferation and growth of endometrium-like tissues with neovasculature formation outside of the uterus.1 Available medical treatments for endometriosis containing hormonal and non-hormonal treatments had been limited for longterm usage by their side effects.2 Ideal medical treatment for endometriosis with efficacy to relieve symptoms and suppress endometriotic lesion growth and minimal side effects has been longing for decades.3 Angiogenesis is a promising therapeutic target for endometriosis.

关键词： therapeutic endometriosis herbal

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Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho hung Cheung Wong Hoi She Siu Lun Ho Albert chi Yan Chan Chung Mau Lo Tan To Cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

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Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

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Journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan hung Massimiliano Gaetani Yiran Li Zhouyurong Tan Xu Zheng Ruizhe Zhang Yang Ding Gene chi Wai Man Tao Zhang Yi Song Yao Wang Jacqueline Pui Wah Chung Tak Hang Chan Roman A.Zubarev chi chiu Wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical Proteomics Core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&Technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(ProEGCG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral ProEGCG can be effective in preventing and treating ***,1D and 2D Proteome Integral Solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and PX domain containing serine/threonine kinase-like(PXK)as novel binding targets of EGCG and ProEGCG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGCG inhibited protein kinase B(Akt)-mediated angiogenesis,while PXK-ProEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HIF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets ProEGCG EGCG Angiogenesis Treatment Endometriosis

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Fully Completed Spherical Fuzzy Approach-Based Z Numbers(PHIModel)for Enhanced Group Expert Consensus

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Computers, Materials & Continua 2024年第7期80卷 1655-1675页

作者： Phi-hung Nguyen Research Center of Applied Sciences Faculty of BusinessFPT UniversityHanoi100000Vietnam

This study aims to establish an expert consensus and enhance the efficacy of decision-making processes by integrating Spherical Fuzzy Sets(SFSs)and Z-Numbers(SFZs).A novel group expert consensus technique,the PHImodel,is developed to address the inherent limitations of both SFSs and the traditional Delphi technique,particularly in uncertain,complex *** such contexts,the accuracy of expert knowledge and the confidence in their judgments are pivotal *** study provides the fundamental operational principles and aggregation operators associated with SFSs and Z-numbers,encompassing weighted geometric and arithmetic operators alongside fully developed operators tailored for SFZs ***,a case study and comparative analysis are conducted to illustrate the practicality and effectiveness of the proposed operators and *** the PHI model with SFZs numbers represents a significant advancement in decision-making frameworks reliant on expert ***,this combination serves as a comprehensive tool for decision-makers,enabling them to achieve heightened levels of consensus while concurrently assessing the reliability of expert *** case study results demonstrate the PHI model’s utility in resolving complex decision-making scenarios,showcasing its ability to improve consensus-building processes and enhance decision ***,the comparative analysis highlights the superiority of the integrated approach over traditional methodologies,underscoring its potential to revolutionize decision-making practices in uncertain environments.

关键词： Spherical fuzzy sets Delphi method Z-numbers expert consensus PHI model uncertainty

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Green tea polyphenol （-）-Epigallocatechin-3-gallate Inhibits Rat Vascular Smooth Muscle Cell Adhesion and Migration on laminin

Green tea polyphenol （-）-Epigallocatechin-3-gallate Inhibi...

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第十五届国际药理学大会

作者： Wen - Bin Wu chi - feng hung Yu-Yuan Huang.School of Medicine Fu - Jen Catholic Univeristy.Dept of Life Science Fu - Jen Catholic University

＜正＞ Smooth Muscle Cells （SMCs） play an important role in the development of atherosclerosis and restenosis after angioplasty and coronary bypass grafting. （-） -Epigallocatechin-3-gallate （EGCG） has been shown to have antiproliferaliveactivity on SMCs through the inhibition of PDGFR activation. However,little attention has been paid on its effect on SMC *** the present study,the effect of EGCG on rat aortic SMC （A10 SMC） adhesion and migration was *** demonstrated that A10 SMC adhesion to collagen and laminin was inhibited by EGCG but not by （+）-catechin. Our results showed that EGCG not only binds directly to laminin but also affects SMC’s binding *** analysis showed that betal integrin expression on SMCs and SMC adhesion to immobilized integrin betal antibody were both reduced by EGCG treatment. In *** treatment also inhibited spontaneous and PDGF - induced SMC migration toward laminin. Taken together, we provided here the first evidence that EGCG can affect SMC adhesion and migration on laminin. possibly acting through binding to laminin and reducing the interaction between betal integrin and laminin.

关键词： adhesion smooth muscle cell EGCG

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Identifying Brand Consistency by Product Differentiation Using CNN

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 685-709页

作者： hung-Hsiang Wang chih-Ping Chen Department of Industrial Design National Taipei University of TechnologyTaipeiTaiwan Department of Product Design Ming Chuan UniversityTaoyuanTaiwan

This paper presents a new method of using a convolutional neural network(CNN)in machine learning to identify brand consistency by product appearance *** Experiment 1,we collected fifty mouse devices from the past thirty-five years from a renowned company to build a dataset consisting of product pictures with pre-defined design features of their appearance and *** show that it is a challenge to distinguish periods for the subtle evolution of themouse devices with such traditionalmethods as time series analysis and principal component analysis(PCA).In Experiment 2,we applied deep learning to predict the extent to which the product appearance variation ofmouse devices of various *** investigation collected 6,042 images ofmouse devices and divided theminto the Early Stage and the Late *** show the highest accuracy of 81.4%with the CNNmodel,and the evaluation score of brand style consistency is 0.36,implying that the brand consistency score converted by the CNN accuracy rate is not always perfect in the real *** relationship between product appearance variation,brand style consistency,and evaluation score is beneficial for predicting new product styles and future product style *** addition,the CNN heat maps highlight the critical areas of design features of different styles,providing alternative clues related to the blurred *** study provides insights into practical problems for designers,manufacturers,and marketers in product *** not only contributes to the scientific understanding of design development,but also provides industry professionals with practical tools and methods to improve the design process and maintain brand *** can use these techniques to find features that influence brand ***,capture these features as innovative design elements and maintain core brand values.

关键词： Machine learning product differentiation brand consistency principal component analysis convolutional neural network computer mouse

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Exponentially Bounded C-semigroup and the Cauchy Initial Value Problems in Complete Random Normed Modules

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2195-2212页

作者： Son TA CONG Thang Dang hung Oanh Le THI Department of Mathematics University of ScienceVietnam National University 334 Nguyen TraiThanh XuanHanoiVietnam Faculty of Natural Sciences Hong Duc University565 Quang TrungDong VeThanh HoaVietnam

In this paper,the notion of C-semigroup of continuous module homomorphisms on a complete random normal(RN)module is introduced and *** existence and uniqueness of solution to the Cauchy problem with respect to exponen... 详细信息

关键词： C-semigroup Cauchy problem random normed modules L^(0)-Lipschitz

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高度取向磷酸锆/环氧树脂纳米复合涂层的防腐蚀性能

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高分子材料科学与工程 2024年第4期40卷 72-78页

作者：雷凡冯民生李涛 hung-Jue Sue 李姜成都大学机械工程学院四川成都610106 Polymer Technology Center Department of Materials Science and EngineeringTexas A&M UniversityCollege StationTX 77843-3123USA 高分子材料工程国家重点实验室(四川大学)四川大学高分子研究所四川成都610065

针对金属防腐蚀的需求,采用简单的喷涂法在金属基底上制备了高度取向磷酸锆/环氧树脂纳米复合涂层。利用透射电镜和X射线衍射分析探究了复合涂层中磷酸锆纳米粒子的分散形貌,采用电化学交流阻抗谱和动电位极化曲线等测试评价了复合涂层... 详细信息

针对金属防腐蚀的需求,采用简单的喷涂法在金属基底上制备了高度取向磷酸锆/环氧树脂纳米复合涂层。利用透射电镜和X射线衍射分析探究了复合涂层中磷酸锆纳米粒子的分散形貌,采用电化学交流阻抗谱和动电位极化曲线等测试评价了复合涂层的防腐蚀性能和其作用机理。结果表明,高度取向的磷酸锆纳米粒子可有效地增加水、氧气、电解液的扩散路径,改善涂层的防腐蚀性能。此外,该绝缘涂层也可进一步阻止腐蚀介质的迁移,增加涂层电阻,显著提高环氧树脂涂层对金属基底的长期防护性能。

关键词：环氧树脂磷酸锆高度取向防腐蚀性能

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Data-Driven Modeling of Partially Observed Biological Systems

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Communications on Applied Mathematics and Computation 2024年第1期6卷 739-754页

作者： Wei-hung Su ching-Shan Chou Dongbin Xiu Department of Mathematics The Ohio State UniversityColumbusOH43221USA

We present a numerical approach for modeling unknown dynamical systems using partially observed data,with a focus on biological systems with(relatively)complex dynamical *** an extension of the recently developed deep neural network(DNN)learning methods,our approach is particularly suitable for practical situations when(i)measurement data are available for only a subset of the state variables,and(ii)the system parameters cannot be observed or measured at *** demonstrate that,with a properly designed DNN structure with memory terms,effective DNN models can be learned from such partially observed data containing hidden *** learned DNN model serves as an accurate predictive tool for system *** a few representative biological problems,we demonstrate that such DNN models can capture qualitative dynamical behavior changes in the system,such as bifurcations,even when the parameters controlling such behavior changes are completely unknown throughout not only the model learning process but also the system prediction *** learned DNN model effectively creates a“closed”model involving only the observables when such a closed-form model does not exist mathematically.

关键词： Deep neural network(DNN) Governing equation discovery Biological system Partial observation

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