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Age-trends in Cognitive Function and Quality of Life: Sex Differences in a Community Population in Taiwan region,china

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International Journal of Mental Health Promotion 2022年第6期24卷 989-998页

作者： Shu-Yu Wu Yu-chi Huang chi-fa hung Liang-Jen Wang Department of Psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung000800TaiwanChina Department of Post-Baccalaureate Medicine National Sun Yat-Sen UniversityKaohsiungTaiwanChina College of Humanities and Social Sciences National Pintung University of Science and TechnologyPingtungTaiwanChina Department of child and Adolescent Psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung000800TaiwanChina

Population aging has developed into a significant area of concern in developed countries, especially in relation to thepreservation of functional independence and the quality of life (QoL). However, information on the contribution ofsex differences in quality of life and cognitive function is scarce. Therefore, this study aimed to investigate potentialdifferences in cognitive function and QoL between males and females. For this study, we recruited 382 healthy subjectsaged 19–79 years from communities in Southern Taiwan region,china. Cognitive function and QoL were assessed using the UCSD Performance-based Skills Assessment, Brief Version (UPSA-B) and World Health Organization Quality ofLife Instruments (WHOQOL-BREF), respectively. The effects of sex, age groups, and interaction of sex and ageon the UPSA-B and WHOQOL-BREF scores were examined. We found that the financial and communicationdomains of the UPSA-B showed declining trends with age in both sexes, although these trends were more obviousin females than in males. In the domain of Physical Capacity, QoL showed an age-increased trend in males, whileQoL in the Environment domain showed an age-increased trend in females. Regarding the relationships betweencognitive function and QoL, we found that the financial skill and communication skill of UPSA-B was positivelycorrelated to the psychological well-being domain of WHOQOL-BREF, in males of age <40 years. In conclusion,our findings demonstrate differential relationships between cognitive function and QoL between males and females,which could serve as a basis for further study between cognitive function and quality of life in communities.

关键词： Psychometrics community age cognition quality of life daily function

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Unique anti-angiogenic effects,pharmacological targets and therapeutic mechanisms of chinese herbal medicines for endometriosis

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Genes & Diseases 2024年第5期11卷 63-65页

作者： Bo Liang Rui Dong Sze Wan hung Yiran Li Yuezhen Lin Ling Wu Tao Zhang Gene chi Wai Man Hui Xu Jacqueline Pui Wah Chung chi chiu Wang Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantouGuangdong 515063China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong Kong SARChina

Endometriosis is a common and benign angiogenesisdependent gynecological disorder,which refers to the proliferation and growth of endometrium-like tissues with neovasculature formation outside of the uterus.1 Available medical treatments for endometriosis containing hormonal and non-hormonal treatments had been limited for longterm usage by their side effects.2 Ideal medical treatment for endometriosis with efficacy to relieve symptoms and suppress endometriotic lesion growth and minimal side effects has been longing for decades.3 Angiogenesis is a promising therapeutic target for endometriosis.

关键词： therapeutic endometriosis herbal

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Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho hung Cheung Wong Hoi She Siu Lun Ho Albert chi Yan Chan Chung Mau Lo Tan To Cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

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Fully Completed Spherical Fuzzy Approach-Based Z Numbers(PHIModel)for Enhanced Group Expert Consensus

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Computers, Materials & Continua 2024年第7期80卷 1655-1675页

作者： Phi-hung Nguyen Research Center of Applied Sciences Faculty of BusinessFPT UniversityHanoi100000Vietnam

This study aims to establish an expert consensus and enhance the efficacy of decision-making processes by integrating Spherical Fuzzy Sets(SFSs)and Z-Numbers(SFZs).A novel group expert consensus technique,the PHImodel,is developed to address the inherent limitations of both SFSs and the traditional Delphi technique,particularly in uncertain,complex *** such contexts,the accuracy of expert knowledge and the confidence in their judgments are pivotal *** study provides the fundamental operational principles and aggregation operators associated with SFSs and Z-numbers,encompassing weighted geometric and arithmetic operators alongside fully developed operators tailored for SFZs ***,a case study and comparative analysis are conducted to illustrate the practicality and effectiveness of the proposed operators and *** the PHI model with SFZs numbers represents a significant advancement in decision-making frameworks reliant on expert ***,this combination serves as a comprehensive tool for decision-makers,enabling them to achieve heightened levels of consensus while concurrently assessing the reliability of expert *** case study results demonstrate the PHI model’s utility in resolving complex decision-making scenarios,showcasing its ability to improve consensus-building processes and enhance decision ***,the comparative analysis highlights the superiority of the integrated approach over traditional methodologies,underscoring its potential to revolutionize decision-making practices in uncertain environments.

关键词： Spherical fuzzy sets Delphi method Z-numbers expert consensus PHI model uncertainty

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Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

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Journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan hung Massimiliano Gaetani Yiran Li Zhouyurong Tan Xu Zheng Ruizhe Zhang Yang Ding Gene chi Wai Man Tao Zhang Yi Song Yao Wang Jacqueline Pui Wah Chung Tak Hang Chan Roman A.Zubarev chi chiu Wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical Proteomics Core facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&Technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(ProEGCG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral ProEGCG can be effective in preventing and treating ***,1D and 2D Proteome Integral Solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and PX domain containing serine/threonine kinase-like(PXK)as novel binding targets of EGCG and ProEGCG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGCG inhibited protein kinase B(Akt)-mediated angiogenesis,while PXK-ProEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HIF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets ProEGCG EGCG Angiogenesis Treatment Endometriosis

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Identifying Brand Consistency by Product Differentiation Using CNN

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 685-709页

作者： hung-Hsiang Wang chih-Ping Chen Department of Industrial Design National Taipei University of TechnologyTaipeiTaiwan Department of Product Design Ming Chuan UniversityTaoyuanTaiwan

This paper presents a new method of using a convolutional neural network(CNN)in machine learning to identify brand consistency by product appearance *** Experiment 1,we collected fifty mouse devices from the past thirty-five years from a renowned company to build a dataset consisting of product pictures with pre-defined design features of their appearance and *** show that it is a challenge to distinguish periods for the subtle evolution of themouse devices with such traditionalmethods as time series analysis and principal component analysis(PCA).In Experiment 2,we applied deep learning to predict the extent to which the product appearance variation ofmouse devices of various *** investigation collected 6,042 images ofmouse devices and divided theminto the Early Stage and the Late *** show the highest accuracy of 81.4%with the CNNmodel,and the evaluation score of brand style consistency is 0.36,implying that the brand consistency score converted by the CNN accuracy rate is not always perfect in the real *** relationship between product appearance variation,brand style consistency,and evaluation score is beneficial for predicting new product styles and future product style *** addition,the CNN heat maps highlight the critical areas of design features of different styles,providing alternative clues related to the blurred *** study provides insights into practical problems for designers,manufacturers,and marketers in product *** not only contributes to the scientific understanding of design development,but also provides industry professionals with practical tools and methods to improve the design process and maintain brand *** can use these techniques to find features that influence brand ***,capture these features as innovative design elements and maintain core brand values.

关键词： Machine learning product differentiation brand consistency principal component analysis convolutional neural network computer mouse

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Exponentially Bounded C-semigroup and the Cauchy Initial Value Problems in Complete Random Normed Modules

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2195-2212页

作者： Son TA CONG Thang Dang hung Oanh Le THI Department of Mathematics University of ScienceVietnam National University 334 Nguyen TraiThanh XuanHanoiVietnam faculty of Natural Sciences Hong Duc University565 Quang TrungDong VeThanh HoaVietnam

In this paper,the notion of C-semigroup of continuous module homomorphisms on a complete random normal(RN)module is introduced and *** existence and uniqueness of solution to the Cauchy problem with respect to exponen... 详细信息

关键词： C-semigroup Cauchy problem random normed modules L^(0)-Lipschitz

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Data-Driven Modeling of Partially Observed Biological Systems

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Communications on Applied Mathematics and Computation 2024年第1期6卷 739-754页

作者： Wei-hung Su ching-Shan Chou Dongbin Xiu Department of Mathematics The Ohio State UniversityColumbusOH43221USA

We present a numerical approach for modeling unknown dynamical systems using partially observed data,with a focus on biological systems with(relatively)complex dynamical *** an extension of the recently developed deep neural network(DNN)learning methods,our approach is particularly suitable for practical situations when(i)measurement data are available for only a subset of the state variables,and(ii)the system parameters cannot be observed or measured at *** demonstrate that,with a properly designed DNN structure with memory terms,effective DNN models can be learned from such partially observed data containing hidden *** learned DNN model serves as an accurate predictive tool for system *** a few representative biological problems,we demonstrate that such DNN models can capture qualitative dynamical behavior changes in the system,such as bifurcations,even when the parameters controlling such behavior changes are completely unknown throughout not only the model learning process but also the system prediction *** learned DNN model effectively creates a“closed”model involving only the observables when such a closed-form model does not exist mathematically.

关键词： Deep neural network(DNN) Governing equation discovery Biological system Partial observation

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Hard Paternalism and Confucian familism

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Fudan Journal of the Humanities and Social Sciences 2024年第3期17卷 455-478页

作者： Andrew Tsz Wan hung Division of Social Sciences Humanities and DesignCollege of Professional and Continuing EducationThe Hong Kong Polytechnic University9 Hoi Ting RoadYau Ma TeiKowloonHong KongChina

In this paper,I criticize Joel Feinberg's argument of soft paternalism,which stands against hard paternalism,as being *** assessing one's voluntariness is very difficult and controversial,paternalistic measures would be preferable to be implemented by hard paternalism rather than soft paternalism.I then examine four usual criticisms of hard paternalism from the perspective of utilitarianism and the principle of autonomy.I argue that these criticisms are unsound and unfounded,and I defend hard paternalism from the perspective of Confucian familism.I argue that as one's life and identity are inseparable from one's family,“self-regarding”actions,traditionally understood,do not only affect the self,but also one's family ***,paternalistic measures to protect individuals from self-harming are also aimed to protect their family members which are indeed compatible with Mill's harm principle.

关键词： Paternalism Feinberg John S.Mill-Confucian familism Autonomy:Voluntariness

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Study of relationship between motion of mechanisms in gas operated weapon and its shock absorber

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Defence Technology（防务技术） 2024年第3期33卷 42-54页

作者： Jiri Balla Roman Vitek Dung Nguyen Van Zbynek Krist hung Nguyen Van Department of Weapons and Ammunition University of Defence BrnoCzech Republic Department of Weapons Le Quy Don Technical UniversityHanoiViet Nam Department of Design and Special Engineering Alexander Dubcek University of TrencinSlovakia

The article deals with the motion of the breech block carrier and the weapon casing of an automatic weapon mounted on a flexible carriage and the base of the *** works,which did not consider the dynamic properties of the base of the weapon,did not allow to reconcile the calculated and experimental results of the weapon casing displacement when shooting from firing *** the analysis of the motion of individual parts,the methods of mathematical modelling and firing experiments using a high-speed camera were *** show the best accord with experiment when modelling the system with 4 degrees of *** oscillation of the system regarding the movement of the breech block carrier and the weapon casing was investigated under changed conditions of rate of fire,the use of a muzzle brake and different types of shock *** velocities and displacements of the weapon casing and the breech block carrier at different values of the impulse of the gases to the breech block carrier were determined.

关键词： Shock absorber Gas-operated weapon Force-impulse diagram Recoil system Breech block carrier

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