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Nano Research 2017年第7期10卷 2377-2385页

作者： Gang Shi Xin Zhang Jianhua li Haiyan Zhu ying li liping Zhang Caihua Ni lifeng chi The Key Laboratory of Food Colloids and Biotechnology Ministry of Education School of Chemical and Material Engineering Jiangnan University Wuxi 214122 China National Engineering Laboratory for Cereal Fermentation Technology Jiangnan University Wuxi 214122 China Institute of Functional Nano and Soft Materials (FUNSOM) Soochow University Suzhou 215123 China Physikalisches Institut and Center for Nanotechnology (CeNTech) Westfalische Wilhelms-Universitat Munster Munster D-48149 Germany

The traditional single material with two-dimensional （2D） biomimetic moth-eye structures is limited by its narrowband antireflection and single functional capability. To overcome these disadvantages, we exploited wet etching and hydrothermal synthesis coupled with chemical oxidation for fabricating a three- dimensional （3D） biomimetic moth-eye coating with ternary materials （polypyrrole nanoparticles, TiO2 nanorods, and Si micropyramids, i.e., PPy/TiOa/Si-p）. This coating reduced the reflectivity to 〈4% at wavelengths ranging from 200 to 2,300 nm and exhibited remarkable superhydrophilidty with a low water contact angle of 1.8°. Moreover, the composite coating had double p-n heterojunctions, allowing the high-efficiency separation of photogenerated carriers. The photo- current density of PPy/TiO2/Si-p was more than three times higher than that of TiO2/Si-p at a positive potential of 1.5 V. The proposed method provides a means to enhance solar energy conversion.

关键词： biomimetic compositecoating broadband antireflection superhydrophilicity double p-n heterojunctions

富含γ-氨基丁酸红小豆对2型糖尿病小鼠糖脂代谢的调节作用

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食品与发酵工业 2024年第12期50卷 151-158页

作者：姜秀杰许庆鹏张家瑜李莹王杰迟晓星曹冬梅张东杰黑龙江八一农垦大学食品学院黑龙江大庆163319 农业农村部农产品及加工品质量监督检验测试中心黑龙江大庆163319 黑龙江八一农垦大学国家杂粮工程技术研究中心黑龙江大庆163319

2型糖尿病(type 2 diabetes mellitus,T2DM)是世界范围内最普遍代谢性疾病,已成为全球流行的健康问题。豆类为基础的饮食有助于预防和控制T2DM发生及发展。为了研究富含γ-氨基丁酸(γ-aminobutyric acid,GABA)红小豆的健康效应,该研究... 详细信息

2型糖尿病(type 2 diabetes mellitus,T2DM)是世界范围内最普遍代谢性疾病,已成为全球流行的健康问题。豆类为基础的饮食有助于预防和控制T2DM发生及发展。为了研究富含γ-氨基丁酸(γ-aminobutyric acid,GABA)红小豆的健康效应,该研究构建T2DM模型,对富含GABA红小豆膳食干预的小鼠糖脂代谢水平、肝功能相关指标进行分析。结果显示,高剂量富含GABA红小豆组(TF3)对抵抗超重具有一定效果,且可显著降低空腹血糖水平(P<0.05),恢复机体对血糖的调节能力,减轻胰岛素抵抗。与M组相比,各处理组不同程度降低T2DM小鼠血清中总胆固醇、甘油三酯、谷丙转氨酶、谷草转氨酶、尿素和肌酐水平,其中TF3及阳性对照组平衡血糖及调节T2DM小鼠肝肾损伤效果更好,同时可缓解高脂饮食造成的肝脏、胰腺和盲肠组织病理性损伤。表明富含GABA红小豆膳食可改善T2DM小鼠糖脂代谢水平,并可缓解肝脏、胰腺和盲肠组织病理性损伤。该研究为富含GABA功能食品研发及应用提供理论依据。

关键词：红小豆 γ-氨基丁酸 2型糖尿病糖脂代谢调节作用

金属有机框架MIL-101(Fe)用于增强光催化降解含油污水中的原油

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燃料化学学报（中英文） 2024年第4期52卷 607-618页

作者：梁宇宁王宝辉李硕辉迟伟蒙毕明春刘雨萱王一然姚明张天赢陈颖东北石油大学化学与化学工程学院石油与天然气加工重点实验室黑龙江大庆163318 大庆油田生产测试分公司黑龙江大庆163318

利用溶剂热法合成了一种稳定的金属有机框架(MOF)MIL-101(Fe),并作为一种新型光催化剂提高了油田废水中原油的降解性能。通过对反应条件的优化,确定了以下最佳参数:暗反应时间为30 min,光反应时间为30 min,p H值为5.5,催化剂量为150 mg... 详细信息

利用溶剂热法合成了一种稳定的金属有机框架(MOF)MIL-101(Fe),并作为一种新型光催化剂提高了油田废水中原油的降解性能。通过对反应条件的优化,确定了以下最佳参数:暗反应时间为30 min,光反应时间为30 min,p H值为5.5,催化剂量为150 mg/L,反应温度为303.15 K。在这些反应条件下,去除率达到了94.73%。本研究是铁基MOFs在油田废水光催化降解中的应用。MIL-101(Fe)在温和的酸性条件下表现出良好的稳定性,并且可以有效地循环利用。这些发现为利用MIL-101(Fe)作为一种很有前途的工业应用材料,通过光催化降解从受油污染的水中去除原油提供了有价值的见解。

关键词： MIL-101(Fe) MOF 光催化溶剂热油田废水降解

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血液透析患者口渴症状管理的最佳证据总结

中国血液净化 2024年第9期23卷 716-720页

作者：姜海龙李唱盖莹耿小婷张池李淑英承德医学院护理学院承德067000 承德医学院附属医院护理部承德067020 承德医学院附属医院手术室承德067020

目的评价总结血液透析患者口渴症状管理的最佳证据,为临床实践提供循证证据。方法系统检索国内外计算机决策支持系统、指南网站、数据库、相关专业协会网站中与血液透析患者口渴症状管理的相关文献,检索时限为建库至2023年11月。采用AG... 详细信息

目的评价总结血液透析患者口渴症状管理的最佳证据,为临床实践提供循证证据。方法系统检索国内外计算机决策支持系统、指南网站、数据库、相关专业协会网站中与血液透析患者口渴症状管理的相关文献,检索时限为建库至2023年11月。采用AGREEⅡ、JBI及CASE评价工具对纳入的文献进行质量评价,对符合要求的文献进行证据总结和归纳。结果最终共纳入12篇文献,包括指南1篇、证据总结1篇、系统评价3篇、随机对照试验7篇。结论本研究对血液透析患者口渴症状管理的最佳证据进行总结,为医护人员在临床实践过程中提供科学依据。

关键词：血液透析口渴证据总结循证护理学

3D Crystal Plasticity Finite Element Modeling of the Tensile Deformation of Polycrystalline Ferritic Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2017年第1期30卷 79-88页

作者： chi Zhang li-Wen Zhang Wen-Fei Shen ying-Nan Xia Yu-Tan Yan School of Materials Science and Engineering Dalian University of TechnologyDalian 116024China

A mesoscale model of plastic deformation of ferritic stainless steels （FSSs） is formulated by combining a crystal plasticity finite element model with 3D cellular automaton algorithm. The actual grain orientations of FSS cold rolling and annealing sheet have been detected by electron backscatter diffraction and selected to be assigned to the polycrystal model. The simulation results have been validated by comparing the calculated true stress-strain response with the experimental one. For the lack of considering the interactions of dislocations with impurities, there are no upper and lower yield points in the simulation stress-strain curves. However, the calculated yield strength and the stress-strain response after yielding agree well with the real material. The local stress and strain fields show inhomogeneous at mesoscale. The plastic deformations of the grains with typical orientations have been characterized. The analysis reveals that the grains with fiber texture show higher thickness reduction ratio as compared to others. The deformation behaviors of the grains in polycrystal are not only related to the orientations but also to the interactions from adjacent grains.

关键词： Ferritic steels Crystallographic orientation Polycrystal plasticity modeling Cellular automaton

Solidification behavior and rheo-diecasting microstructure of A356 aluminum alloy prepared by self-inoculation method

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china Foundry 2017年第1期14卷 1-9页

作者： Ming li Yuan-dong li Xiao-feng Huang chi Cao ying Ma State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou 730050China Key Laboratory of Non-ferrous Metal Alloys and Processing Ministry of EducationLanzhou University of TechnologyLanzhou 730050China

Semisolid slurry of A356 aluminum alloy was prepared by self-inoculation method, and the microstructure and solidification behavior during rheo-diecasting process were investigated. The results indicate that the semisolid slurry of A356 aluminum alloy can be prepared by self-inoculation method at 600℃. Primary a-AI particles with fine and spherical morphologies are uniformly distributed when the isothermal holding time of slurry is 3 min. liquid phase segregation occurs during rheo-diecasting process of semisolid slurry and the primary particles （α1） show obvious plastic deformation in the area of high stress and low cooling rate. A small amount of dendrites resulting from the relatively low temperature of the shot chamber at the initial stage of secondary solidification are fragmented as they pass through the in-gate during the mould filling process. The amount of dendrite fragments decreases with the increase of filling distance. During the solidification process of the remaining liquid, the nucleation rate of secondary particles （α2） increases with the increase of cooling rate, and the content of Si in secondary particles （α2） are larger than primary particles （α1）. With the increase of cooling rate, the content of Si in secondary particles （α2） gradually increases. The morphologies of eutectic Si in different parts of die casting are noticeably different. The low cooling rate in the first filling positions leads to coarse eutectic structures, while the high cooling rate in the post filling positions promotes small and compact eutectic structures.

关键词： semisolid self-inoculation method secondary solidification dendrite fragments primary particles eutectic structure

Effects of N-acetylcysteine on Clara cells in rats with cigarette smoke exposure

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chinese Medical Journal 2010年第4期123卷 412-417页

作者： liAO Ji-ping chi Chun-hua li Hai-chao TANG Xiu-ying Department of Respiratory Medicine Peking University First Hospital Beijing 100034 China Department of Pathology Peking University First Hospital Beijing 100034 China

Background The number of Clara cells and the Clara cell 16-kDa protein （CC16） levels of the lung decrease in patients with chronic obstructive pulmonary disease （COPD）. N-acetylcysteine （NAC） is a powerful antioxidant and can reduce the frequency of acute exacerbations of COPD. But the exact mechanism is unclear. The present study was designed to investigate the effects of NAC on Clara cells in rats with cigarette smoke exposure. Methods Eighteen adult male Wistar rats were randomly divided into 3 groups, 12 exposed to cigarette smoke （CS） thrice a day, 10 cigarettes for 30 minutes each time for 1 week, without （CS group） or with （CS＋NAC group） oral intake of NAC 80 mg·kg^-1·d^-1, and another 6 rats exposed to fresh air （control group）. Clara cells were observed by an electron microscope. The mRNA expression of CC16 and CC16 protein in lungs were determined by reverse transcription polymerase chain reaction （RT-PCR） and immunohistochemistry respectively. The glutathion （GSH） level in plasma and lung tissue were tested by fluorimetry assay. Results Compared with the controls, the pathologic score of small airways significantly increased in the CS exposed rats （20.3±14.7 vs. 53.7±11.5, P 〈0.05）. The Clara cell particles in cytoplasm decreased in the CS group （P 〈0.05）. The percentage of CC16-positive cells in bronchioles in the CS group （27.8±4.3 and 29.5±2.4 in terminal bronchioles and respiratory bronchioles, respectively） significantly decreased as compared with the control group （37.1±3.8 and 43.8±5.8 in terminal bronchioles and respiratory bronchioles, respectively）（P 〈0.05）. No significant difference was observed in GSH level （（181±26） nmol/L in the control group vs. （170±18） nmol/L in the CS group） between the two groups. After treatment with NAC, the pathologic score of small airways （24.1±17.5） decreased （P 〈0.05）. Clara cell particles in cytoplasm of Clara cells increased and GSH level in plasma （（213±40） nmol/L vs. （170±18） nmol/L in the CS group） increase

关键词： tobacco smoke pollution Clara cells N-acetylcysteine glutathion

Trends in insulin resistance:insights into mechanisms and therapeutic strategy

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2762-2786页

作者： Mengwei li Xiaowei chi ying Wang Sarra Setrerrahmane Wenwei Xie Hanmei Xu The Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation of Jiangsu Province China Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines Ministry of EducationChina Pharmaceutical UniversityNanjing 210009China Development Center for Medical Science&Technology National Health Commission of the People’s Republic of china 100044 BeijingChina NANJING ANJI BIOTECHNOLOGY CO.LTD Nanjing 210033China

The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic *** is a key peptide hormone and mediates the systemic glucose metabolism in different *** resistance(IR)is a disordered biological response for insulin stimulation through the disruption of different molecular pathways in target *** conditions and genetic factors have been implicated in *** genetic and biochemical studies suggest that the dysregulated metabolic mediators released by adipose tissue including adipokines,cytokines,chemokines,excess lipids and toxic lipid metabolites promote IR in other *** is associated with several groups of abnormal syndromes that include obesity,diabetes,metabolic dysfunction-associated fatty liver disease(MAFLD),cardiovascular disease,polycystic ovary syndrome(PCOS),and other *** no medication is specifically approved to treat IR,we summarized the lifestyle changes and pharmacological medications that have been used as efficient intervention to improve insulin ***,the systematic discussion of complex mechanism will help to identify potential new targets and treat the closely associated metabolic syndrome of IR.

关键词： metabolism stimulation diagnosis

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基于国家药品抽检的川牛膝质量问题及建议

中国药学杂志 2024年第3期59卷 275-280页

作者：高必兴齐景梁李倩耿昭钟恋高驰邓曦王颖包小红杨蕾苟琰四川省药品检验研究院国家药品监督管理局中成药质量评价重点实验室成都611731

目的基于2022年国家药品抽检工作,分析市场上不同厂家川牛膝质量差异,分析问题并提出建议,为川牛膝的质量监管及标准提高提供依据。方法针对所抽取川牛膝样品按照相应标准进行检测,出具检验报告书。针对检验中所发现的质量问题、标准... 详细信息

目的基于2022年国家药品抽检工作,分析市场上不同厂家川牛膝质量差异,分析问题并提出建议,为川牛膝的质量监管及标准提高提供依据。方法针对所抽取川牛膝样品按照相应标准进行检测,出具检验报告书。针对检验中所发现的质量问题、标准问题及前期调研发现的相关问题进行有针对性的探索性研究,进行质量评价分析,发现问题,提出建议。结果共抽取川牛膝样品334批。标准检验,2批样品性状不合格,存在用麻牛膝充当川牛膝使用的情况,同时发现标准收载含量测定方法过于复杂,且限度过低。探索性研究,27批川牛膝检出麻牛膝特有成分牛膝皂苷Ⅰ,7批超出规定限度,存在麻牛膝混用的情况;270批川牛膝检出植物生长调节剂(多效唑)。114批重金属及有害元素镉(Cd)检测超出限度。最后提升了川牛膝质量标准、建立了补充检验方法、提出风险警示。结论通过此次全国抽检发现川牛膝饮片和标准中的相关问题,提示需完善标准并加强川牛膝的质量监管。

关键词：川牛膝麻牛膝国家药品抽检质量分析多效性

胶西北大泽山岩体地球化学、锆石U-Pb年代学及Lu-Hf同位素特征

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地质科学 2024年第1期59卷 21-37页

作者：李增胜张晨西迟乃杰单伟刘传娥马祥县解玉凤申颖王秀凤山东省地质科学研究院自然资源部金矿成矿过程与资源利用重点实验室山东省金属矿产成矿地质过程与综合利用重点实验室济南250013 山东省地质矿产勘查开发局八〇一水文地质工程地质大队济南250014 潍坊市建筑设计研究院有限责任公司山东潍坊261041

胶东金矿集区是我国最重要的金矿集区,大规模金成矿作用发生于125~110 Ma。本文选择了与成矿作用同期的早白垩世晚期大泽山岩体为研究对象,通过详细的岩相学、岩石地球化学、锆石LA-ICP-MS U-Pb年代学研究,识别出中粒二长花岗岩和细粒... 详细信息

胶东金矿集区是我国最重要的金矿集区,大规模金成矿作用发生于125~110 Ma。本文选择了与成矿作用同期的早白垩世晚期大泽山岩体为研究对象,通过详细的岩相学、岩石地球化学、锆石LA-ICP-MS U-Pb年代学研究,识别出中粒二长花岗岩和细粒二长花岗岩两种主要的侵入岩类型,它们具有相似的岩相学和岩石地球化学特征,呈现同源岩浆演化特征。定年结果表明,中粒二长花岗岩中锆石U-Pb年龄分别为119.8±0.8 Ma和119.3±0.9 Ma,细粒二长花岗岩中锆石U-Pb年龄分别为109.2±0.7 Ma和109.9±0.7 Ma。岩石地球化学研究表明,二长花岗岩具有高的全碱(K_(2)O+Na_(2)O=8.14%~8.72%),高的Al_(2)O_(3)(12.42%~15.32%),属过铝质高钾钙碱性系列,轻稀土(LREE)富集、重稀土(HREE)相对亏损(LREE/HREE=8.46~18.87),具明显的稀土元素分馏((La/Yb)_(N)=8.52~24.08)和较强的Eu负异常(δEu=0.33~0.58)。大泽山岩体锆石ε_(Hf)(t)值为-26.4~-16.2,亏损地幔二阶段模式年龄(T_(DM2))为2812~2173 Ma,物源主要是古元古代和新太古代陆壳的部分熔融,有少量幔源物质的加入。大泽山岩体成岩期与胶东金矿的主成矿期一致,暗示岩浆活动与金成矿具有统一的地球动力学背景。

关键词：地球化学锆石U-Pb年龄 Lu-Hf同位素大泽山岩体胶西北