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RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew small Jianhuang Xue Huilin Huang Hengyou Weng Rui su Brandon Tan Chao shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith leung Mark Boldin Chun-Wei Chen David Ann Zhijian Qian Xiaolan Deng Jianjun Chen Zhenhua Chen Department of systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate school of Biological sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family Center for Leukemia Research City of HopeDuarteCA 91010USA sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China school of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its process.ng into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the process.ng of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA process.ng,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA process.ng that contributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

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GO-modified flexible polymer nanocomposites fabricated via 3D stereolithography

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Frontiers of Chemical science and Engineering 2019年第4期13卷 736-743页

作者： chi Him Alpha Ts.ng Adilet Zhakeyev Dennis Y.C.leung Jin Xuan school of Environmental sciences and Engineering Sun Yat-Sen UniversityGuangzhou 510006China Department of Mechanical Engineering The University of Hong KongHong KongChina Department of Chemical Engineering Loughborough UniversityLoughboroughLE113TUUK

Graphene oxide(GO)induced enhancement of elastomer properties showed a great deal of potential in recent years,but it is still limited by the barrier of the complicated synthesis ***(sLA),used in fabrication of thermosets and very recently in“flexible”polymers with elastomeric properties,presents itself as simple and user-friendly method for integration of GO into *** this work,it was first time demonstrated that GO loadings can be incorporated into commercial flexible photopolymer resins to successfully fabricate GO/elastomer nanocomposites via readily accessible,consumer-oriented sLA *** material properties of the resulting polymer was characterized and *** mechanical strength,stiffness,and the elongation of the resulting polymer decreased with the addition of *** thermal properties were also adversely affected upon the increase in the GO content based on differential scanning calorimetry and thermogravimetric analysis *** was proposed that the GO agglomerates within the 3D printed composites,can result in significant change in both mechanical and thermal properties of the resulting *** study demonstrated the possibility for the development of the GO/elastomer nanocomposites after the optimization of the GO/“Hexible”photoreactive resin formulation for sLA with suitable annealing process of the composite in future.

关键词： graphene oxide polymer flexible 3D printing stereolithography

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Microwave heating as a universal method to transform confined molecules into armchair graphene nanoribbons

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Nano Research 2023年第7期16卷 10644-10651页

作者： Haoyuan Zhang Yingzhi Chen Kunpeng Tang Ziheng Lin Xuan Li Hongwei Zhang Yifan Zhang chi Ho Wong chi Wah leung Chee leung Mak Yuan Hu Weili Cui Kecheng Cao Lei shi state Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterGuangdong Province Key Lab of Display Material and TechnologySchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China Huzhou Key Laboratory of Environmental Functional Materials and Pollution Control School of EngineeringHuzhou UniversityHuzhou 313000China Department of Industrial and systems Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong 999077China shanghai Key Laboratory of High-resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210China

Armchair graphene nanoribbons(AGNRs)with sub-nanometer width are potential materials for the fabrication of novel nanodevices thanks to their moderate direct band *** are usually synthesized by polymerizing precursor molecules on substrate ***,it is time-consuming and not suitable for large-scale *** can also be grown by transforming precursor molecules inside s.ngle-walled carbon nanotubes(sWCNTs)via furnace annealing,but the obtained AGNRs are normally *** this work,microwave heating is applied for transforming precursor molecules into *** fast heating process allows synthesizing the AGNRs in *** different molecules were successfully transformed into AGNRs,suggesting that it is a universal *** importantly,as demonstrated by Raman spectroscopy,aberrationcorrected high-resolution transmission electron microscopy and theoretical calculations,less twisted AGNRs are synthesized by the microwave heating than the furnace *** results reveal a route for rapid production of AGNRs in large scale,which would benefit future applications in novel AGNRs-based semiconductor devices.

关键词： armchair graphene nanoribbons(AGNRs) microwave heating s.ngle-walled carbon nanotubes(sWCNTs) Raman spectroscopy

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仰卧人体在三轴单向全身振动激励下的振动传递特性

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声学学报 2024年第2期49卷 202-208页

作者：陈晨旭邱毅刘迟郑旭浙江大学能源工程学院杭州310027

研究了人体仰卧姿态下,振动的幅值大小和输入方向对人体头部和胸部振动传递率的影响。分别采用频率范围为0.5~20 Hz,振动幅值为0.2~0.8 m/s^(2)r.m.s.的纵向、横向和垂直单轴随机振动激励,测量了12名男性被试者自振源至头部和胸部的振... 详细信息

研究了人体仰卧姿态下,振动的幅值大小和输入方向对人体头部和胸部振动传递率的影响。分别采用频率范围为0.5~20 Hz,振动幅值为0.2~0.8 m/s^(2)r.m.s.的纵向、横向和垂直单轴随机振动激励,测量了12名男性被试者自振源至头部和胸部的振动传递特性。结果表明,人体头部和胸部振动传递率的共振频率在纵向方向上大约为4 Hz,在横向方向上大约为2.4 Hz,而在垂直方向上头部和胸部传递率的共振频率并不相同。在纵向激励下,仰卧人体各部位振动传递率随振幅变化而表现出的非线性特征最为明显。

关键词：仰卧人体全身振动传递率非线性

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预测抓握力和振动传递的手-臂系统生物动力学模型

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声学学报 2024年第2期49卷 194-201页

作者：王遵铭邱毅郑旭刘迟浙江大学能源工程学院杭州310027

针对手-臂的振动问题,提出了一种手-臂混合模型来计算不同抓握力下叉车方向盘传递给手-臂的振动。该模型由肩膀、上臂、前臂和手组成,通过具有刚度和阻尼的关节连接。手部模型包含手掌和五个手指,每个手指的远端、近端和掌指端通过旋转... 详细信息

针对手-臂的振动问题,提出了一种手-臂混合模型来计算不同抓握力下叉车方向盘传递给手-臂的振动。该模型由肩膀、上臂、前臂和手组成,通过具有刚度和阻尼的关节连接。手部模型包含手掌和五个手指,每个手指的远端、近端和掌指端通过旋转关节相互连接,在手指关节上施加力矩来模拟抓握手柄时的主动肌肉力。通过调整模型材料参数以匹配手和手臂在抓握手柄时的接触压力和振动。将标定后的模型应用于某叉车方向盘对手臂系统振动传递率进行预测,结果表明所建立的考虑抓握力和手与手柄接触条件的模型能够预测车辆驾驶员手臂系统的振动传递。

关键词：手-臂生物动力学模型振动传递率接触压力抓握力

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高通量蛋白质结构生物信息学进展

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生物化学与生物物理进展 2024年第9期51卷 1989-1999页

作者：祝云篪陆祖宏东南大学生物科学与医学工程学院数字医学工程全国重点实验室南京211189

本文总结了高通量蛋白质结构生物信息学的最新进展,包括结构数据管理、工具软件开发和结构数据挖掘三个主要方面。结构数据管理方面,得益于类AlphaFold系统的发展,蛋白质结构数据量实现爆发式增长,直接促进了压缩技术的升级,也吸引了研... 详细信息

本文总结了高通量蛋白质结构生物信息学的最新进展,包括结构数据管理、工具软件开发和结构数据挖掘三个主要方面。结构数据管理方面,得益于类AlphaFold系统的发展,蛋白质结构数据量实现爆发式增长,直接促进了压缩技术的升级,也吸引了研究者对结构数据管理的关注。工具软件开发方面,以Foldseek为代表的新算法实现了高速的结构比对,突破了结构分析的通量瓶颈,此外深度学习模型的大量应用从多个方面改进了基于结构的蛋白质功能注释。结构数据挖掘方面,研究者以组学思维处理结构大数据,在持续的探索中提炼分析要素、优化方法,并在新工具的帮助下推动着结构数据挖掘的进阶。随着高通量方法的发展,结构生物信息学有望在生命科学中发挥更重要的作用。

关键词：蛋白质结构生物信息学高通量类AlphaFold系统结构蛋白质组学

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Dual-functional additive of cesium ion for achieving ultrahigh efficiency of persistent phosphorescence in existing polymer-based materials

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science china Chemistry 2024年

作者： Yao Liu Jinzheng Chen Yiling Miao Kaimin Zhang Faxu Lin Huahua Huang Lina Zhang Zhan Yang Yi Zhang Zhenguo chi Zhiyong Yang Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education Guangdong Engineering Technology Research Center for High-performance Organic and Polymer Photoelectric Functional Films Guangdong Basic Research Center of Excellence (GBRCE) for Functional Molecular Engineering School of Chemistry Sun Yat-sen University school of Materials science and Engineering Sun Yat-sen University College of Materials science and Engineering Hebei University of Engineering school of Environmental and Chemical Engineering Wuyi UniversityJiangmen

Despite great achievements obtained for polymer-based room-temperature phosphorescence（RTP） materials, the limited efficiencies of persistent RTP still hinder their development. Herein, a simple and universal strategy of us.ng the dual-functional additive of Cs+was presented, which could simultaneously enhance the efficiency（Φp） and maintain the long lifetime（τp） of RTP in existing polymer-based systems with various phosphors and polymers. Among them, the commercial emitter（TpB）-doped polyvinyl alcohol（PVA）/Cs2CO3system possessed an extremely high Φpup to 75.5% and still maintained a long τpof 2.13 s, by introducing the heavy-atom effect and an extra network of ionic bonding through the Cs+additive. Additionally, the temperature resistance of RTP in TpB@PVA/Cs+film could also be improved to 85℃. More satisfactorily, the efficiency of F?rster resonance energy transfer（FRET） from RTP to near-infrared（NIR） was also remarkably enhanced in the multi-component systems. This work provides a simple and universal strategy for developing polymer systems with high RTP performance.

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数字媒介时代我国回应权制度的构建与完善

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新闻界 2024年第5期 68-77页

作者：谢宜璋张弛华东政法大学知识产权学院上海200050

数字技术的更迭对媒体形态的影响内嵌着对公民人格权益的新威胁。作为公众应对侵权报道以自我维权的必要法治配套措施,各国回应权制度紧随媒介形态的变革而呈现出扩张的趋势。相比之下,我国回应权制度仍停留在纸媒时代且近乎被虚置为“... 详细信息

数字技术的更迭对媒体形态的影响内嵌着对公民人格权益的新威胁。作为公众应对侵权报道以自我维权的必要法治配套措施,各国回应权制度紧随媒介形态的变革而呈现出扩张的趋势。相比之下,我国回应权制度仍停留在纸媒时代且近乎被虚置为“僵尸条款”,从而导致被报道者法律自救措施的缺位。数字媒介时代下,有必要对我国回应权制度进行完善以发挥其制度功能。我国《民法典》对人格权采取独立成编的立法模式为回应权的引入提供了解释空间,依据回应权的权利特性与功能价值,更适宜将回应权定位为《民法典》中的人格权请求权而非侵权请求权,以《民法典》第1028条与第995条为制度依据,并在此定位基础上对回应权的权利主体、回应对象、行权期限、行权效果及救济途径作进一步安排。

关键词：数字媒介回应权新闻自由民法典人格权请求权

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Magnetic activity of the spotted dwarf AP149 in the α Persei open cluster

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Research in Astronomy and Astrophysics 2010年第3期10卷 253-265页

作者： Xiang-s.ng Fang sheng-Hong Gu sze-leung Cheung Ho-Keung Hui chi-Tai Kwok Kam-Cheung leung National Astronomical Observatories / Yunnan Observatory Chinese Academy of Sciences Kunming 650011 China Graduate University of chinese Academy of sciences Beijing 100049 China Ho Koon Nature Education cum Astronomical Centre Sik Sik Yuen Hong Kong China Hong Kong Astronomical society Hong Kong China

The simultaneous photometric and spectroscopic observations of the spotted G dwarf AP149 in the young open cluster α Persei are analyzed here. We reconstruct the observed light curves with a two-starspot model by means of a light curve modeling technique, and find that the active regions shift oppositely along longitude on a time scale of one day. Combining with the observational data obtained by other groups, we discuss the evolution of spotted regions in the photosphere, and find that its starspots evolve not only on a short time scale but also on a long time scale. The pure chromospheric emissions for Ca IIHK and Hβ lines are derived by us.ng the spectral subtraction technique. The variation of Ca IIHK lines＇ excess emission is spatially correlated to the starspot regions. There is no clear rotational modulation for the Hβ line＇s excess emission, probably due to the contamination of prominence emission.

关键词： stars: activity -- stars: late-type -- stars: spots -- stars: individual AP149

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海上丝路典籍翻译的互文性路径探赜——以柔克义译文为例

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中国外语 2024年第2期21卷 90-96页

作者：迟帅卞建华青岛大学

海上丝路典籍记载了古代海上丝绸之路沿线国家的地理位置、社会制度、民风民俗、气候物产及各国交往历史,是古代海上丝绸之路的“百科全书”。海上丝路典籍时间跨度长,内容多有连续性、统一性与传承性,呈现出较强的互文性关联。文章从... 详细信息

海上丝路典籍记载了古代海上丝绸之路沿线国家的地理位置、社会制度、民风民俗、气候物产及各国交往历史,是古代海上丝绸之路的“百科全书”。海上丝路典籍时间跨度长,内容多有连续性、统一性与传承性,呈现出较强的互文性关联。文章从互文性视角出发,聚焦美国近代知名“学者型外交官”柔克义的海上丝路典籍系列译文,探讨其英译的互文性路径。研究发现,柔克义博览海上丝路典籍,借助互文本解读源语文本并建构译语文本,在译文中塑造了兼具知识广度与深度的互文性景观。其译文与翻译路径可为当下海上丝路典籍外译与海上丝路文化对外传播提供一定借鉴与反思。

关键词：海上丝路典籍海外译介互文性柔克义

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