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Acupuncture for low back pain:a clinical practice guideline from the Hong Kong taskforce of standardized acupuncture practice

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Journal of Traditional chinese Medicine 2022年第1期42卷 140-147页

作者： CHEN Haiyong YEUng Wing-Fai YAng Mingxiao MU Jinglan ZIEA Tat-chi ng Bacon Fung-leung LAO Lixing school of chinese Medicine University of Hong KongHong Kong SARChina school of Nurs.ng Hong Kong Polytechnic UniversityHong Kong SARChina Bendheim Integrative Medicine Center Memorial Sloan Kettering Cancer Center1429 First AvenueNew York 10021USA Department of Anesthesiology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjing210008China chinese Medicine Department Hong Kong Hospital AuthorityHong Kong SARChina Virginia University of Integrative Medicine FairfaxVA 22031USA

OBJECTIVE:To develop a clinical practice guideline to guide the treatment of low back pain by ***:An integrative approach of systematic review of literature,clinical evidence classification,expert opinion surveying,and consensus establishing via a Delphi program was utilized during the developing *** evidence-based practice standards and the personalized features of acupuncture were taken into ***:Based on clinical evidence and expert opinions,we developed a clinical practice guideline for the treatment of low back pain with *** recommendations have a wide coverage spanning from Western Medicine diagnosis and Traditional chinese Medicine syndrome differentiation,to acupuncture treatment procedures,as well as post treatment care for rehabilitation and *** recommendations for acupuncture practice included treatment principles,therapeutic regimens,and operational *** levels of evidence and strength of recommendation were rated for each procedure of ***:A clinical practice guideline for acupuncture treating low back pain was developed based on contemporary clinical evidence and experts'consensus to provide best currently agreeable practice guideline for domestic and international stakeholders.

关键词： acupuncture low back pain diagnosis syndrome differentiation rehabilitation practice guideline

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Absence of enhancement in a lesion does not preclude primary central nervous system T-cell lymphoma:A case report

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World Journal of Clinical Cases 2024年第2期12卷 374-382页

作者： Chan-seop Kim chi-Hoon Choi Kyung sik Yi Yook Kim Jisun Lee Chang Gok Woo Young Hun Jeon Department of Radiology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Radiology Seoul National University HosptialSeoul 03080South Korea

BACKGROUND Primary central nervous system lymphoma(PCNsL)is a non-Hodgkin lymphoma that originates in the central nervous system(CNs)and is exclusively limited to the *** most PCNsLs are diffuse large B-cell lymphomas,primary CNs T-cell lymphomas(PCNsTLs)are *** typically demonstrate some degree of enhancement on contrast-enhanced magnetic resonance imaging(MRI).To the best of our knowledge,non-enhancing PCNsTL has not been reported *** sUMMARY A 69-year-old male presented to the neurology department with complaints of mild cognitive impairment and gradual onset of left lower leg weakness over a span of two *** MRI showed asymmetric T2-hyperintense lesions within the *** enhancement was observed on the contrast-enhanced T1 *** initial diagnosis was neuro-Behçet’s *** high-dose steroid therapy,no alterations in the lesions were identified on initial *** patient’s symptoms deteriorated *** MRI performed one month after the initial scan revealed an increased lesion ***,brain biopsy confirmed the diagnosis of *** patient underwent definitive combined ***,the patient developed bacteremia and died of septic shock approximately three months after *** The absence of enhancement in the lesion did not rule out PCNsTL.A biopsy approach is advisable for pathological confirmation.

关键词： Central nervous system neoplasms Non-Hodgkin Lymphoma T-cell Lymphoma Primary central nervous system lymphoma Primary central nervous system T-cell lymphoma Case report

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Trametinib boosts palbociclib’s efficacy in breast cancer via autophagy inhibition

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Oncology Research 2024年第7期32卷 1197-1207页

作者： AngUO WU JIAO YAN TIng sU chi FEng XIN LOng YIRU PAN RUPEI YE TIAN XIA HANAN LOng JIANMIng WU XIULI XIAO sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaKey Laboratory of Medical Electrophysiology of Ministry of EducationSchool of PharmacySouthwest Medical UniversityLuzhou646000China The Department of Pathology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China The Department of Pathology Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang621000China The Department of Pathology Yongchuan Hospital of Chongqing Medical UniversityChongqing402160China school of Basic Medical sciences Southwest Medical UniversityLuzhou646000China school of Clinical Medical sciences Southwest Medical UniversityLuzhou646000China

Breast cancer,a predominant global health issue,requires ongoing exploration of new therapeutic ***(PAL),a well-known cyclin-dependent kinase(CDK)inhibitor,plays a critical role in breast cancer *** its efﬁcacy is recognized,the interplay between PAL and cellular autophagy,particularly in the context of the RAF/MEK/ERK signaling pathway,remains insufﬁciently *** study investigates PAL’s inhibitory effects on breast cancer us.ng both in vitro(MCF7 and MDA-MB-468 cells)and in vivo(tumor-bearing nude mice)*** at elucidating the impact of PAL on autophagic processes and exploring the potential of combining it with trametinib(TRA),an MEK inhibitor,our research seeks to address the challenge of PAL-induced drug ***ﬁndings reveal that PAL signiﬁcantly decreases the viability of MCF7 and MDA-MB-468 cells and reduces tumor size in mice while showing minimal cytotoxicity in MCF10A ***,PAL also induces protective autophagy,potentially leading to drug resistance via the RAF/MEK/ERK pathway *** TRA effectively neutralized this autophagy,enhancing PAL’s anti-tumor efﬁcacy.A combination of PAL and TRA synergistically reduced cell viability and proliferation,and in vivo studies showed notable tumor size *** conclusion,the PAL and TRA combination emerges as a promis.ng strategy for overcoming PAL-induced resistance,offering a new horizon in breast cancer treatment.

关键词： Palbociclib Trametinib Protective autophagy RAF/MEK/ERK MCF7 MDA-MB-468

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Novel Batch Polishing Method of Ceramic Cutting Inserts for Reducing Tool Wear

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chinese Journal of Mechanical Engineering 2024年第4期 87-96页

作者： Rui Gao Chunjin Wang Yee Man Loh Xiaoliang Liang Chen Jiang chi Fai Cheung state Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic University College of Mechanical Engineering University of Shanghai for Science and Technology

Ceramic cutting inserts are a type of cutting tool commonly used in high-speed metal cutting ***, the wear of these inserts caused by friction between the workpiece and cutting inserts limits their overall effectiveness. In order to improve the tool life and reduce wear, this study introduces an emerging method called magnetic field-assisted batch polishing(MABP) for simultaneously polishing multiple ceramic cutting inserts. several polishing experiments were conducted under different conditions, and the wear characteristics were clarified by cutting s136H steel. The results showed that after 15 min of polishing, the surface roughness at the flank face,edge, and nose of the inserts was reduced to below 2.5 nm, 6.25 nm, and 45.8 nm, respectively. Furthermore, the nose radii of the inserts did not change significantly, and there were no significant changes in the weight percentage of elements before and after polishing. Additionally, the tool life of the batch polished inserts was found to be up to 1.75 times longer than that of unpolished inserts. These findings suggest that the MABP method is an effective way to mass polish ceramic cutting inserts, resulting in significantly reduced tool wear. Furthermore, this novel method offers new possibilities for polishing other tools.

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Auxiliary ligand-induced assembly of atomically precise silver clusters

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science china Chemistry 2024年

作者： Yeqin Feng Xuemeng Jing Fangyu Fu Mengyun Zhao Manzhou chi Hongjin Lü Guoyu Yang MOE Key Laboratory of Cluster science Beijing Key Laboratory of Photoelectroic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical Engineering Beijing Institute of Technology

Establishing the correlation between inter-cluster assembly and auxiliary ligands at the atomic level is crucial for the development of metal cluster *** this work,we report the successful preparation and characterization of three Ag clusters,discrete 0-D Ag51s6Cl3（iPrs）21（TsO）15CH3CN(0-D Ag51,iPrs-=isopropanethiolate,TsO-=toluenesulfonate),1-D {Ag38s4（iPrs）18（PhCOO）12}_n(1-D Ag38,PHCOO-=benzoate),and 2-D {Ag20（sO4）Cl2（iPrs）10（NO3）6}_n(2-D Ag20),us.ng a delicate auxiliary-ligand-induced *** analyses reveal that the types of auxiliary ligands can readily affect the structure and dimensionality of resulting Ag *** addition of different surface auxiliary ligands from TsO-to PhCOO-and then to NO3-leads to the formation of 0-D Ag51to 1-D Ag38and then to 2-D Ag20clusters under otherwise identical reaction conditions,*** resulting Ag clusters exhibited structure-related optical/luminescence properties and distinct bathochromic shifts as revealed by the temperature-dependent luminescence and s.ngle-crystal X-ray diffraction studies.

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“俄罗斯诗学欧美化”——北境时期布罗茨基的诗学演进与经典化历程

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外国文学研究 2024年第2期46卷 165-176页

作者：张驰浙江大学外国语学院

1964—1965年间,布罗茨基北境乡村的流放经历以及随之发生的诗学变法,是影响其一生艺术创作与精神世界的关键转型,其中最为核心的嬗变机制是“俄罗斯诗学欧美化”尝试。在流放地的异质文化空间内,布罗茨基通过对欧美抒情诗资源的嫁接,... 详细信息

1964—1965年间,布罗茨基北境乡村的流放经历以及随之发生的诗学变法,是影响其一生艺术创作与精神世界的关键转型,其中最为核心的嬗变机制是“俄罗斯诗学欧美化”尝试。在流放地的异质文化空间内,布罗茨基通过对欧美抒情诗资源的嫁接,处理了本国文学传统和异国诗学资源之间的复杂关系,打破了俄罗斯诗歌在文化上和形式上经典完善的自洽体系,使其具有全新的音乐性、隐喻性和智慧性。借由在“彼得堡文本”符码系统中融入的盛期现代主义和客体化诗学,诗人改变了民族语言的当代表现形式,拓宽了俄罗斯诗歌的心理和思维界线,这一诗歌经典化理路让布罗茨基逐渐完成了从地方性诗人逐渐到世界级诗人的蜕变。表面上看,这次诗学转型是布罗茨基个人创作论与文体学意义上的变构,实质上是俄罗斯诗歌内在生长机制的一次自我更新。

关键词：布罗茨基北境时期诗学转型经典化俄裔美国文学

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scientific objectives and payload configuration of the Chang'E-7 mission

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National science Review 2024年第2期11卷 285-300页

作者： chi Wang Yingzhuo Jia Changbin Xue Yangting Lin Jianzhong Liu Xiaohui Fu Lin Xu Yun Huang Yufen Zhao Yigang Xu Rui Gao Yong Wei Yuhua Tang Dengyun Yu Yongliao Zou state Key Laboratory of space Weather National Space Science Center Chinese Academy of Sciences National space science Center Chinese Academy of Sciences Institute of Geology and Geophysics Chinese Academy of Sciences Institute of Geochemistry Chinese Academy of Sciences shandong Provincial Key Laboratory of Optical Astronomy and solar-Terrestrial Environment School of Space Science and Physics Institute of Space SciencesShandong University Institute of Drug Discovery Technology Ningbo University state Key Laboratory of Isotope Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences school of Earth science and Engineering Sun Yat-sen University Lunar Exploration and space Engineering Center china Aerospace science and Technology Corporation

As the cornerstone mission of the fourth phase of the chinese Lunar Exploration Program, Chang'E-7(CE-7) was officially approved, and implementation started in 2022, including a main probe and a communication relay satellite. The main probe, consisting of an orbiter, a lander, a rover and a mini-flying probe, is scheduled to be launched in 2026. The lander will land on shackleton crater's illuminated rim near the lunar south pole, along with the rover and mini-flying probe. The relay satellite(named Queqiao-2) will be launched in February 2024 as an independent mission to support relay communication during scientific exploration undertaken by Chang'E-4, the upcoming Chang'E-6 in 2024 and subsequent lunar *** CE-7 mission is mainly aimed at scientific and resource exploration of the lunar south pole. We present CE-7's scientific objectives, the scientific payloads configuration and the main functions for each scientific payload with its key technical specifications.

关键词： Chang’ E-7 scientific objectives scientific payloads

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一九二二年中共领导的浦东日华纱厂罢工——以与上海华界当局的关系为中心

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中共党史研究 2024年第3期 67-76页

作者：徐迟同济大学马克思主义学院博士后流动站

1922年浦东日华纱厂的三次罢工,是由成立初期的中国共产党领导,兼具经济、政治双重斗争目标的工人运动。罢工期间,浦东纺织工会在中国劳动组合书记部领导下,多次与上海华界当局及日华纱厂厂方进行交涉和谈判。三次罢工声震沪上,浦东纺... 详细信息

1922年浦东日华纱厂的三次罢工,是由成立初期的中国共产党领导,兼具经济、政治双重斗争目标的工人运动。罢工期间,浦东纺织工会在中国劳动组合书记部领导下,多次与上海华界当局及日华纱厂厂方进行交涉和谈判。三次罢工声震沪上,浦东纺织工会亦在一段时期内获得小范围发展,与中共对上海华界当局内部非制度性因素的认识与利用是分不开的,具体体现在华界当局治理体系尚不健全、官员依据人情社会的行为逻辑处置罢工,以及地方社会政治生态复杂、政令不能统一这三个方面。

关键词：日华纱厂中国劳动组合书记部工人运动浦东纺织工会

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Efficient C-N coupling in electrocatalytic urea generation on copper carbonate hydroxide electrocatalysts

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Journal of Energy Chemistry 2024年第6期93卷 289-298,I0008页

作者： Yinuo Wang Yian Wang Qinglan Zhao Hongming Xu shangqian Zhu Fei Yang Ernest P.Delmo Xiaoyi Qiu chi s.ng Juhee Jang Tiehuai Li Ping Gao MDanny Gu Minhua shao Advanced Materials Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400GuangdongChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Materials science and Engineering Southern University of Science and Technology of Chin11088 Xueyuan BoulevardShenzhen 518055GuangdongChina Energy Institute and Chinese National Engineering Research Center for Control&Treatment of Heavy Metal PollutionThe Hong Kong University of Science and TechnologyKowloonHong KongChina Department of Chemistry City University of Hong KongTat Chee AvenueKowloonHong KongChina

Urea generation through electrochemical CO_(2) and NO_(3)~-co-reduction reaction(CO_(2)NO_(3)RR)is still limited by either the low selectivity or yield rate of ***,we report copper carbonate hydroxide(Cu_2(OH)_2CO_(3))as an efficient CO_(2)NO_(3)RR electrocatalyst with an impressive urea Faradaic efficiency of45.2%±2.1%and a high yield rate of 1564.5±145.2μg h~(-1)mg_(cat)~(-1).More importantly,H_(2) evolution is fully inhibited on this electrocatalyst over a wide potential range between-0.3 and-0.8 V versus reversible hydrogen *** thermodynamic simulation reveals that the first C-N coupling follows a unique pathway on Cu_2(OH)_2CO_(3) by combining the two intermediates,~*COOH and~**** work demonstrates that high selectivity and yield rate of urea can be simultaneously achieved on simple Cu-based electrocatalysts in CO_(2)NO_(3)RR,and provide guidance for rational design of more advanced catalysts.

关键词： Copper carbonate hydroxide Co-reduction Urea generation C-N coupling DFT calculation

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高丽对宋朝认知轨迹与宋丽关系的变迁

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江汉论坛 2024年第3期 114-119页

作者：张弛上海政法学院政府管理学院上海201701

高丽王朝虽然在地理上与两宋并不接壤,但它在宋朝建立后不久便与之建立了朝贡关系。然而,受辽、金等北方少数民族政权先后兴起的影响,宋丽关系发展十分微妙。高丽对宋的认识经历了一个从统治合法性的来源,到抗辽的潜在盟友,再到汲取先... 详细信息

高丽王朝虽然在地理上与两宋并不接壤,但它在宋朝建立后不久便与之建立了朝贡关系。然而,受辽、金等北方少数民族政权先后兴起的影响,宋丽关系发展十分微妙。高丽对宋的认识经历了一个从统治合法性的来源,到抗辽的潜在盟友,再到汲取先进经济文化的对象的复杂过程,宋丽关系也因之“三立三绝”。高丽对宋的认知之所以数度变化,背后有其国内政局变动、宋朝对丽政策以及东亚地缘格局演进等变数的影响。不过确定的是,高丽对宋文化上的认同与向往,支撑着高丽在相对困难的条件下依然不断寻求与宋建立联系,使宋丽关系断断续续地维持了二百余年。高丽基于对宋认知的变化而及时调整对外政策的举措不仅维护了本国的安全与利益,促进了宋丽之间的贸易繁荣和文化互鉴,而且给后世韩国务实外交思想的确立积累了宝贵的历史经验。

关键词：高丽宋朝认知宋丽关系三立三绝

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