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Prostate health index can stratify patients with Prostate Imaging Reporting and Data system score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John shung-Lai leung Wai-Kit Ma Brian sze-Ho Ho stacia Tsun-Tsun Chun Rong Na Yongle Zhan chi-Yuen ng chi-Ho Ip Ada Tsui-Lin ng Yiu-Chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data system score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary Hospital and Princess Margaret Hospital,Hong Kong,china)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had Prostate Imaging Reporting and Data system score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had Prostate Imaging Reporting and Data system score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health indexstate health index 25.0-34.9,17.9%in prostate health index 35.0-54.9,and 52.6%in prostate health index≥55.0(Png the patients,26.9%could have avoided a biopsy with a prostate health indexse of a 5.3%risk of miss.ng clinically significant prostate *** health index could be used as an additional risk stratification tool for patients with Prostate Imaging Reporting and Data system score 3 *** could be avoided in patients with low prostate health index,with a small risk of miss.ng clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

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structural insight into palladium-nickel clusters over mordenite zeolite for carbene-insertion reaction

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Frontiers of Chemical science and Engineering 2024年第9期18卷 89-99页

作者： Guangchao Li Ping-Luen Baron Ho Bryan Kit Yue ng Tai-s.ng Wu Pawel Rymarz shik chi Edman Ts.ng Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Chemistry University of OxfordOxford OX13QRUK synchrotron Radiation Research Center Hsinchu 30076China

The advancement of heterogeneous catalysts incorporating metal clusters in the nanometric size range has garnered significant attention due to their extraordinary catalytic activity and *** detailed characterization and understanding of the atomic structure of these metal clusters within catalysts is crucial for elucidating the underlying reaction *** the present study,a distinctive three-atom PdNi cluster,characterized by two Pd atoms at terminal positions and a central Ni atom,was synthesized over mordenite *** presence of atomic PdNi clusters within the eight-membered ring side pocket area was confirmed by multiple advanced analytical techniques,including magic-angle spinning nuclear magnetic resonance spectroscopy,synchrotron X-ray powder diffraction,extended X-ray absorption fine structure spectroscopy,and high-angle annular dark-field scanning transmission electron *** catalytic activity of the confined active species was examined by the carbene-mediated reactions of ethyl-2-diazoacetate to ethyl-2-methoxyacetate as a model *** to the Pd-mordenite and Ni-mordenite,the PdNi-mordenite catalyst incorporates a PdNi cluster,which demonstrates a superior performance,achieving 100%conversion and high selectivity under the same reaction *** study elucidates the potential of constructing bimetallic clusters in zeolites,providing valuable insights for developing new heterogeneous catalysts applicable to a wide range of catalytic processes.

关键词： zeolite metal cluster synchrotron X-ray diffraction carbene-mediated reaction

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A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,china:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan ching-Ho Ko Cindy Yeuk-Lam Hong samuel chi-Hang Yee Jeremy Yuen-Chun Teoh samson Yun-s.ng Chan Ho-Man Tam chi-Kwok Chan chi-Fai ng Peter Ka-Fung chiu sH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(As)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active surveillance(PRIAs)protocol with local adaptation at sH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PsAD)and the presence of the highest ProstateImaging-Reporting and Data system(PI-RADs)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PsAD>0.2 ng ml^(−2)or PI-RADs 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PsAD≤0.2 ng ml−2 and PI-RADs 2 or 3 *** study concludes that As is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PsAD>0.2 ng ml^(−2)and PI-RADs 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

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Quantitative and qualitative subgenomic RNA profiles of sARs-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin ng Grace Lui Lowell Ling Agnes s.Y.leung chit Chow siaw shi Boon Wendy C.s.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David shu Cheong Hui Paul Kay sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club school of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The sARs-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in us.ng sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus sARs-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq subgenomic RNA(sgRNA)

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Efficient Finite Difference WENO scheme for Hyperbolic systems withNon-conservativeProducts

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Communications on Applied Mathematics and Computation 2024年第2期6卷 907-962页

作者： Dinshaw s.Balsara Deepak Bhoriya chi-Wang shu Harish Kumar Physics Department University of Notre DameNotre DameUSA ACMs Department University of Notre DameNotre DameUSA Division of Applied Mathematics Brown UniversityProvidenceUSA Department of Mathematics Indian Institute of TechnologyDelhiIndia

Higher order finite difference weighted essentially non-oscillatory(WENO)schemes have been constructed for conservation *** multidimensional problems,they offer a high order accuracy at a fraction of the cost of a finite volume WENO or DG scheme of the comparable *** makes them quite attractive for several science and engineering ***,to the best of our knowledge,such schemes have not been extended to non-linear hyperbolic systems with non-conservative *** this paper,we perform such an extension which improves the domain of the applicability of such *** extension is carried out by writing the scheme in fluctuation *** use the HLLI Riemann solver of Dumbser and Balsara(***.304:275-319,2016)as a building block for carrying out this *** of the use of an HLL building block,the resulting scheme has a proper supersonic *** use of anti-diffusive fluxes ensures that stationary discontinuities can be preserved by the scheme,thus expanding its domain of the *** new finite difference WENO formulation uses the same WENO reconstruction that was used in classical versions,making it very easy for users to transition over to the present *** conservation laws,the new finite difference WENO is shown to perform as well as the classical version of finite difference WENO,with two major advantages:(i)It can capture jumps in stationary linearly degenerate wave families exactly.(i)It only requires the reconstruction to be applied *** examples from hyperbolic PDE systems with non-conservative products are shown which indicate that the scheme works and achieves its design order of the accuracy for smooth multidimensional *** Riemann problems and several novel multidimensional problems that are drawn from compressible Baer-Nunziato multiphase flow,multiphase debris flow and twolayer shallow water equations are also shown to document the robustness of the *** some

关键词： Hyperbolic PDEs Numerical schemes Non-conservative products stiff source terms Finite difference WENO

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Cell-free biocatalysis coupled with photo-catalysis and electro-catalysis: Efficient CO2-to-chemical conversion

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Green Energy & Environment 2024年第9期9卷 1366-1383页

作者： Junzhu Yang chi-Kit sou Yuan Lu Key Laboratory of Industrial Biocatalysis Ministry of Education Tsinghua University Department of Chemical Engineering Tsinghua University

The increas.ng atmospheric carbon dioxide （CO2） concentration has exposed a series of crises in the earth's ecological *** to effectively fix and convert carbon dioxide into products with added value has attracted the attention of many ***-free enzyme catalytic system coupled with electrical and light have been a promis.ng attempt in the field of biological carbon fixation in recent *** this review,the research progresses of photoenzyme catalysis,electroenzyme catalysis and photo-electroenzyme catalysis for converting carbon dioxide into chemical products in cell-free systems are systematically *** focus on reviewing and comparing various coupling methods and principles of photoenzyme catalysis and electroenzyme catalysis in cell-free systems,especially the materials used in the construction of the coupling system,and analyze and point out the characteristics and possible problems of different coupling ***,we discuss the major challenges and prospects of coupling physical signals and cell-free enzymatic catalytic systems in the field of CO2fixation,suggesting possible strategies to improve the carbon sequestration capacity of such systems.

关键词： CO 2 fixation Cell-free system Enzyme Photoenzyme catalysis Electroenzyme catalysis

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A systematic Analysis of Early Life Exposure to the chinese Famine(1959-1961)and the Health of Older Adults-china,2008-2023

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china CDC weekly 2024年第11期6卷 203-207,I0001-I0003页

作者： chi shen Xi Chen school of Public Policy and Administration Xi’an Jiaotong UniversityXi’an CityShaanxi ProvinceChina Department of Health Policy and Management Yale School of Public HealthNew HavenCTU.S Department of Economics Yale UniversityNew HavenCTU.S

What is already known about this topic?There is mounting evidence indicating that the aging process initiates during early life stages,with in utero the individual’s environment playing a significant ***,it is crucial to comprehend the enduring effects of early life circumstances on health in old *** is added by this report?In this study,we conducted a meta-analysis to examine the effects of the chinese Famine(1959–1961)on the health of older *** also explored potential mechanisms underlying these *** are the implications for public health practice?The complex interplay between early life circumstances,multiple health-related sectors,and healthy aging necessitates a comprehensive life-course approach and strategic interventions to enhance public health in an aging society.

关键词： life aging mount

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Honeycomb-like biochar framework coupled with Fe_(3)O_(4)/Fes nanoparticles as efficient heterogeneous Fenton catalyst for phenol degradation

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Journal of Environmental sciences 2024年第2期136卷 390-399页

作者： Aihua Cheng Yi He Xiaohe Liu chi He Department of Environmental Engineering College of Geology and EnvironmentXi’an University of Science and TechnologyXi’an 710054China state Key Laboratory of Multiphase Flow in Power Engineering School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an 710049China National Engineering Laboratory for VOCs Pollution Control Material and Technology University of Chinese Academy of SciencesBeijing 101408China

Achieving an efficient and stable heterogeneous Fenton reaction over a wide pH range is of great significance for wastewater ***,a pollen-derived biochar catalyst with a unique honeycomb-like structure,coupled with the dispersion of magnetic Fe_(3)O_(4)/Fes(Fe/s)nanoparticles,was synthesized by simple impregnation precursor,followed by *** prepared Fe/s-biochar catalyst demonstrated outstanding phenol degradation efficiency across a wide pH range,with 98%of which eliminated even under neutral conditions(pH 7.0).The high catalytic activity was due to the multilevel porous structure of pollenderived biochar provided enough active sites and allowed for better electron transfer,then increases oxidation ability to promote the ***,the acid microenvironment formed by sO_(4)^(2-)group from Fe/s composite extended the pH range for Fenton reaction,and s^(2-)facilitated the conversion of≡Fe^(3+)to≡Fe^(2+),resulting in remarkable degradation ***,biochar can effectively promote cycling stability by limiting Fe *** work may provide a general strategy for designing 3D framework biochar-based Fe/s catalysts with excellent performance for heterogeneous Fenton reactions.

关键词： Biomass Biochar Fenton reaction Fe_(3)O_(4)/Fes(Fe/s) Phenol degradation

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An impact sensitivity assessment method of spacecraft based on virtual exterior wall

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Defence Technology（防务技术） 2024年第1期31卷 142-157页

作者： Runqiang chi Yuyan Liu Diqi Hu Baojun Pang Hypervelocity Impact Research Center Harbin Institute Of TechnologyHarbin150080China

The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit *** impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational *** method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the *** Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh *** influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and *** results of this method were compared with those of s3DE(survivability of spacecraft in space Debris Environment),BUMPER,MDPANTO,EsABAsE2/Debris to verify the feasibility of the *** PchiP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size *** relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft.

关键词： sensitivity OD/M spacecraft Virtual exterior wall

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spatiotemporal variations of sand hydraulic conductivity by microbial application methods

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 268-278页

作者： Viroon Kamchoom Thiti Khattiwong Treesukon Treebupachatsakul suraparb Keawsawasvong Anthony Kwan leung Excellent Centre for Green and sustainable Infrastructure Department of Civil EngineeringSchool of EngineeringKing Mongkut’s Institute of Technology Ladkrabang(KMITL)Bangkok10520Thailand Department of Biomedical Engineering School of EngineeringKing Mongkut’s Institute of Technology Ladkrabang(KMITL)Bangkok10520Thailand Department of Civil Engineering Thammasat School of EngineeringThammasat UniversityPrathumthani10200Thailand Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology(HKUST)Hong KongChina

The spatiotemporal distributions of microbes in soil by different methods could affect the efficacy of the microbes to reduce the soil hydraulic *** this study,the specimens of bio-mediated sands were prepared us.ng three different methods,***,mixing,and pouring a given microbial so-lution onto compacted sand *** hydraulic conductivity was measured by constant-head tests,while any soil microstructural changes due to addition of the microbes were observed by scan-ning electron microscope(sEM)and mercury intrusion porosimetry(MIP)*** amount of dextran concentration produced by microbes in each type of specimen was quantified by a *** show that dextran production increased exponentially after 5-7 d of microbial settling with the supply of culture *** injection and mixing methods resulted in a similar amount and uniform dis-tribution of dextran in the *** pouring method,however,produced a nonuniform distri-bution,with a higher concentration near the specimen *** the supply of culture medium discontinued,the dextran content near the surface produced by the pouring method decreased dramatically due to high competition for nutrients with foreign *** dextran concentration was negatively and correlated with hydraulic conductivity of bio-mediated soils exponentially,due to the clogging of large soil pores by *** hydraulic conductivity of the injection and mixing cases did not change significantly when the supply of culture medium was absent.

关键词： Bio-mediated soil Dextran Hydraulic conductivity Leuconostoc mesenteroides Microbial application Microstructure

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