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AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo

Genes & Diseases 2022年第4期9卷 1074-1085页

作者： chi heon kim Colleen Oliver Hamid Dar Hicham Drissi Steven M.Presciutti Department of Orthopaedics Emory University School of MedicineAtlantaGA 30329USA Atlanta Veteran Affairs Medical Center DecaturGA 30030USA

Intervertebral disc degeneration is the main contributor to low back pain,now the leading cause of disability *** transfer,either in a therapeutic attempt or in basic research to understand the mechanisms of disc degeneration,is a fascinating and promising tool to manipulate the complex physiology of the *** vectors based on the adeno-associated virus(AAV)have emerged as powerful transgene delivery vehicles yet a systematic investigation into their respective tropism,transduction efficiency,and relative toxicity have not yet been performed in the disc in ***,we used in vivo bioluminescence imaging to systematically compare multiple AAV serotypes,injection volumes,titers,promoters,and luciferase reporters to determine which result in high transduction efficiency of murine nucleus pulposus(NP)cells in *** find that AAV6 using a CAG promoter to drive transgene expression,delivered into the NP of murine caudal discs at a titer of 1011 GC/mL,provides excellent transduction efficiency/kinetics and low toxicity in *** also show,for the first time,that the transduction of NP cells can be significantly boosted in vivo by the use of small cell permeabilization ***,to our knowledge,we are the first to demonstrate the use of optical tissue clearing and three-dimensional lightsheet microscopy in the disc,which was used to visualize fine details of tissue and cell architecture in whole intact discs following AAV6 *** together,these data will contribute to the success of using AAV-mediated gene delivery for basic and translational studies of the IVD.

关键词： Adeno-associated virus Bioluminescence imaging Cell permeabilization peptide Intervertebral disc Lightsheet microscopy Nucleus pulposus transduction Tissue clearing

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Unexpected role of complement component 8 gamma chain in the inflamed brain

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Neural Regeneration Research 2023年第12期18卷 2655-2656页

作者： Jong-heon kim Kyoungho Suk Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation,an intricate inflammatory process occurring in the central nervous system(CNS),plays an important role in host *** cells,including astrocytes and microglia,along with cytokines,chemokines,and the complement system are important components of neuroinflammation.A low level of neuroinflammation is associated with and contributes to various homeostatic and neuroprotective processes,such as removing pathogens or cellular debris and promoting tissue repair after brain injury.

关键词： inflammation protective removing

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Recent Advances in Patterning Strategies for Full‑Color Perovskite Light‑Emitting Diodes

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Nano-Micro Letters 2024年第3期16卷 99-137页

作者： Gwang heon Lee Kiwook kim Yunho kim Jiwoong Yang Moon Kee Choi Graduate School of Semiconductor Materials and Devices Engineering Center for Future Semiconductor Technology(FUST)Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea

Metal halide perovskites have emerged as promising light-emitting materials for next-generation displays owing to their remarkable material characteristics including broad color tunability,pure color emission with remarkably narrow bandwidths,high quantum yield,and solution *** recent advances have pushed the luminance efficiency of monochromic perovskite light-emitting diodes(PeLEDs)to their theoretical limits,their current fabrication using the spincoating process poses limitations for fabrication of full-color *** integrate PeLEDs into full-color display panels,it is crucial to pattern red–green–blue(RGB)perovskite pixels,while mitigating issues such as cross-contamination and reductions in luminous ***,we present state-of-the-art patterning technologies for the development of full-color ***,we highlight recent advances in the development of efficient ***,we discuss various patterning techniques of MPHs(i.e.,photolithography,inkjet printing,electron beam lithography and laserassisted lithography,electrohydrodynamic jet printing,thermal evaporation,and transfer printing)for fabrication of RGB pixelated *** patterning techniques can be classified into two distinct approaches:in situ crystallization patterning using perovskite precursors and patterning of colloidal perovskite *** review highlights advancements and limitations in patterning techniques for PeLEDs,paving the way for integrating PeLEDs into full-color panels.

关键词： Perovskite Light-emitting diode Full-color display High-resolution patterning Electroluminescence

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chinese Medicines Reported to Have Effects on Contact Dermatitis in the Last 20 Years

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chinese Journal of Integrative Medicine 2018年第1期24卷 64-71页

作者： Youngchul Jung Byungju kim Mi heon Ryu Hyungwoo kim School of Korean Medicine Pusan National University School of Dentistry Pusan National University

Contact dermatitis （CD） is one of the most common skin diseases in industrialized countries. chinese medicines （CMs） have been investigated worldwide as complementary and alternative medicines for corticosteroids, which are the first choice for treatment of inflammatory skin diseases owing to their favorable efficacy. This article describes the CMs that have been reported to have anti-dermatitis effects against CD in the last 20 years.

关键词： contact dermatitis herbal chinese medicine

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Collagen fleece(Tachosil®)for treating testis torsion:A case report

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World Journal of Clinical Cases 2023年第18期11卷 4306-4312页

作者： Ki Min kim Jae heon kim Department of Urology Soonchunhayng University Seoul HospitalSeoul 04410South Korea

BACKGROUND Testicular torsion is an emergent disease in urology,and there has been discussion of the treatment of testicular *** decompression has been established as a critical treatment for testicular compartment syndrome(TCS),which occurs after detorsion in a patient who is diagnosed with testis *** now,testicular fasciotomy and incision of tunica albuginea with tunica vaginalis flap(TVF)graft have been suggested for decompression,and some studies about the efficacy of TVF were ***,this method is time consuming and needs meticulous technique,so other methods such as orchio-septopexy are *** objective of this clinical case report was to propose new surgical method using collagen fleece(Tachosil®)instead of tunica vagina *** SUMMARY A 5-year-old boy with scrotal pain visited our hospital 24 h after symptom *** history taking,physical examination,and scrotum ultrasonography,he was diagnosed with testis *** surgery was performed after *** the incision of scrotum and fasciotomy,we covered his tunica albuginea with collagen fleece called Tachosil®instead of covering with *** Short-term follow-up showed normal blood flow in testis without a *** is the first case report of using Tachosil®in testicular torsion surgery,and its advantages were already reported in other surgeries like Peyronie’s *** case suggests this new technique is an appropriate method because of its advantages including its cost-effective and time-saving *** main limitation is the short follow-up,so more studies are needed to provide a high level of evidence about its efficacy and safety.

关键词： Testicular torsion Testicular compartment syndrome Collagen fleece Tachosil® Case report

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Genome-Wide Analysis and Molecular Characterization of Heat Shock Transcription Factor Family in Glycine max

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Journal of Genetics and Genomics 2013年第3期40卷 127-135页

作者： Eunsook Chung Kyoung-Mi kim Jai-heon Lee BK21 Center for Silver-Bio Industrialization College of Natural Resources and Life Science Dong-A University

Heat shock transcription factors （Hsfs） play an essential role on the increased tolerance against heat stress by regulating the expression of heat-responsive genes. In this study, a genome-wide analysis was performed to identify all of the soybean （Glycine max） GmHsfgenes based on the latest soybean genome sequence. Chromosomal location, protein domain, motif organization, and phylogenetic relationships of 26 non-redundant GmHsf genes were analyzed compared with AtHsfs （Arabidopsis thaliana Hsfs）. According to their structural features, the predicted members were divided into the previously defined classes A-C, as described for AtHsfs. Transcript levels and subcellular localization of five GmHsfs responsive to abiotic stresses were analyzed by real-time RT-PCR. These results provide a fundamental clue for understanding the complexity of the soybean GmHsfgene family and cloning the functional genes in future studies.

关键词： Abiotic stress Arabidopsis thaliana Expression patterns Glycine max Heat shock transcription factor Phylogenetic analysis

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Asymmetry-aware load balancing for parallel applications in single-ISA multi-core systems

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第6期13卷 413-427页

作者： Eunsung kim Hyeonsang EOM heon Y. YEOM School of Computer Science and Engineering Seoul National University Seoul 151-744 Korea

Contemporary operating systems for single-ISA （instruction set architecture） multi-core systems attempt to distribute tasks equally among all the CPUs. This approach works relatively well when there is no difference in CPU capability. However, there are cases in which CPU capability differs from one another. For instance, static capability asymmetry results from the advent of new asymmetric hardware, and dynamic capability asymmetry comes from the operating system （OS） outside noise caused from networking or I/O handling. These asymmetries can make it hard for the OS scheduler to evenly distribute the tasks, resulting in less efficient load balancing. In this paper, we propose a user-level load balaneer for parallel applications, called the ＇capability balancer＇, which recognizes the difference of CPU capability and makes subtasks share the entire CPU capability fairly. The balancer can coexist with the existing kemel-level load balancer without detrimenting the behavior of the kernel balancer. The capability balancer can fairly distribute CPU capability to tasks with very little overhead. For real workloads like the NAS Parallel Benchmark （NPB）, we have accomplished speedups of up to 9.8% and 8.5% in dynamic and static asymmetries, respectively. We have also experienced speedups of 13.3% for dynamic asymmetry and 24.1% for static asymmetry in a competitive environment. The impacts of our task selection policies, FIFO （first in, first out） and cache, were compared. The use of the cache policy led to a speedup of 5.3% in overall execution time and a decrease of 4.7% in the overall cache miss count, compared with the FIFO policy, which is used by default.

关键词： Scheduler Load balancing Capability asymmetry OS noise Multi-core

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Quantification of Tc-99m-ethyl cysteinate dimer brain single photon emission computed tomography images using statistical probabilistic brain atlas in depressive end-stage renal disease patients:Correlation with disease severity and symptom factors

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Neural Regeneration Research 2012年第27期7卷 2151-2159页

作者： Heeyoung kim In Joo kim Seong-Jang kim Sang heon Song Kyoungjune Pak Keunyoung kim Department of Nuclear Medicine Pusan National University HospitalBusanRepublic of Korea Biomedical Research Institute Pusan NationalBusanRepublic of Korea Department of Internal Medicine Pusan National University HospitalBusanRepublic of Korea

This study adapted a statistical probabilistic anatomical map of the brain for single photon emission computed tomography images of depressive end-stage renal disease patients. This research aimed to investigate the relationship between symptom clusters, disease severity, and cerebral blood flow. Twenty-seven patients （16 males, 11 females） with stages 4 and 5 end-stage renal disease were enrolled, along with 25 healthy controls. All patients underwent depressive mood assessment and brain single photon emission computed tomography. The statistical probabilistic anatomical map images were used to calculate the brain single photon emission computed tomography counts. Asymmetric index was acquired and Pearson correlation analysis was performed to analyze the correlation between symptom factors, severity, and regional cerebral blood flow. The depression factors of the Hamilton Depression Rating Scale showed a negative correlation with cerebral blood flow in the left amygdale. The insomnia factor showed negative correlations with cerebral blood flow in the left amygdala, right superior frontal gyrus, right middle frontal gyrus, and left middle frontal gyrus. The anxiety factor showed a positive correlation with cerebral glucose metabolism in the cerebellar vermis and a negative correlation with cerebral glucose metabolism in the left globus pailidus, right inferior frontal gyrus, both temporal poles, and left parahippocampus. The overall depression severity （total scores of Hamilton Depression Rating Scale） was negatively correlated with the statistical probabilistic anatomical map results in the left amygdala and right inferior frontal gyrus. In conclusion, our results demonstrated that the disease severity and extent of cerebral blood flow quantified by a probabilistic brain atlas was related to various brain areas in terms of the overall severity and symptom factors in end-stage renal disease patients.

关键词： single photon emission computed tomography end-stage renal disease depression statisticalprobabilistic brain atlas disease severity cerebral blood flow symptom brain neural regeneration

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Hydrodynamic optimization of a triswach

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Journal of Hydrodynamics 2014年第6期26卷 856-864页

作者： YANG chi HUANG Fuxin kim Hyunyul School of Physics Astronomy and Computational Sciences George Mason University NAVATEK South KingstownRI 02879USA

A new methodology for hydrodynamic optimization of a Tri SWACH is developed, which considers not only the positions of the side hulls but also the shape of the side hulls. In order to account for the strong near-field interference effects between closely-spaced multihulls, an integrated hydrodynamic computational tool that consists of a potential-flow based simple CFD tool and an Euler/RANS/Navier-Stokes based advanced CFD tool has been further developed and integrated into a practical multiobjective hydrodynamic optimization tool. The other components of this hydrodynamic optimization tool consist of a hull shape representation and modification module and an optimization module. This enhanced multi-objective hydrodynamic optimization tool has been applied to the hydrodynamic design optimization of the Tri SWACH for reduced drag by optimizing the side hulls only. A new methodology is developed to optimize side hull forms so that the Tri SWACH has a minimal drag for a wide speed range and for various side hull positions. Two sets of the side hulls are developed and used for the design of two optimal Tri SWACH models. Model tests are carried out for two optimal Tri SWACH models at Webb Institute for validations. Substantial drag reductions have been obtained for a wide range of speed.

关键词： hydrodynamics optimization drag reduction CFD trimaran surface modification

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Selectively patterned TiO2 nanorods as electron transport pathway for high performance perovskite solar cells

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Nano Research 2019年第3期12卷 601-606页

作者： Daihong Huh KyoungSuk Oh Minjin kim Hak-Jong Choi Dong Suk kim heon Lee Department of Materials Science and Engineering Korea University Anam-ro 145 Sungbuk-Gu Seoul 136-701 Republic cf Korea KIER-UNIST Advanced Center for Energy Korea Institute of Energy Research (KIER) UNIST-Gil 50 Eonyang-eup Ulju-gun Ulsan 689-851 Republic of Korea Department of Electrical and Systems Engineering University of Pennsylvania Philadelphia Pennsylvania 19104 USA

Organic-inorganic hybrid perovskite solar cells (PSCs) are attracting tremendous attention for new-generation photovoltaic devices because of their excellent power conversion efficiency and simple fabrication process. One of the various approaches to increase the efficiency of PSCs is to change the material or structure of the carrier transport layer. Here, optically long and electrically short structural concept is proposed to enhance the characteristics of a PSC by employing selectively grown single crystalline TiO2 nanorods. The approach has the merit of increasing the electro n-hole separati on effectively and en ables a thicker active layer to be coated without electrical loss by using TiO2 nano rods as an electr on pathway. Moreover, selectively grow n TiO2 nano rods in crease the optical path of the in cide nt light via scatteri ng effects and en able a smooth coati ng of the active layer. Nano imprint lithography and hydrothermal growth were employed to fabricate selectively grow n TiO2 nanorod substrates. The fabricated solar cell exhibits an efficiency of 19.86% with a current density, open-circuit voltage, and fill factor of 23.13 mA/cm^2, 1.120 V, and 76.69%, respectively. Time-resolved photoluminescence, ultraviolet-visible (UV-Vis) spectroscopy, and the incident phot on to current efficiency (IPCE) an alysis were conducted to understand the factors resp on sible for the improvement in characteristics of the fabricated PSCs.

关键词： perovskite solar cells patter ned T1O2 nanorods nanoimprint lithography

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