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chinese Journal of Chemistry 1990年第4期8卷 333-339页

作者： XIA, chi-Zhong ZHOU, Pei-Wen ding, Jing-Fan The Institute of Molecular Science, Department of Chemistry,Shanxi University, Taiyuan, 030006

Four 1, 2, 3-trisubstituted imidazolinium iodides which were used as 5,10-^+CPh-THF model (7-10) at formic acid oxidation level were synthesized. The benzylidyne group (phenyl- substituted one carbon unit)transfer reactions from these compounds to Grignard reagent were in- vestigated, and the reactions of these compounds with KBH_4 and NaOH were also studied.

关键词： Synthesis of l-methyl-2-phenyl-3-aryl imidazoliniumiodide and benzylildyne Tetrahydrofolate coenzyme models I phenyl-substitutef one carbon unit)transfer reactions

Characterization of acid-and pepsin-soluble collagens from spines and skulls of skipjack tuna(Katsuwonus pelamis)

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chinese Journal of Natural Medicines 2014年第9期12卷 712-720页

作者： YU Di chi Chang-Feng WANG Bin ding Guo-Fang LI Zhong-Rui Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products School of Food and PharmacyZhejiang Ocean University

Acid-soluble collagen(ASC) and pepsin-soluble collagen(PSC) from the spine(ASC-SP and PSC-SP) and skull(ASC-SK and PSC-SK) of the skipjack tuna, Katsuwonus pelamis, were successfully isolated and characterized. The yields of ASC-SP, PSC-SP, ASC-SK and PSC-SK were(2.47 ± 0.39)%,(5.62 ± 0.82)%,(3.57 ± 0.40)%, and(6.71 ± 0.81)%, respectively, on the basis of dry weight. The four collagens contained Gly(330.2-339.1 residues/1 000 residues) as the major amino acid, and their imino acid contents were between 168.8 and 178.2 residues/1 000 residues. Amino acid composition, SDS-PAGE, and FTIR investigations confirmed that ASC-SP and ASC-SK were mainly composed of type I collagen, and had higher contents of high-molecular weight cross-links than those of PSC-SK and PSC-SP. The FTIR investigation also certified all the collagens had triple helical structure. The denaturation temperatures of ASC-SK, PSC-SK, ASC-SP, and PSC-SP were 17.8, 16.6, 17.6, and 16.5 °C, respectively. All isolated collagens were soluble at acidic pH(1-5) and lost their solubilities when the NaCl concentration was above 2%(W/V). The isolated collagens from the spines and skulls of skipjack tuna could serve as an alternative source of collagens for further application in food, cosmetic, biomedical, and pharmaceutical industries.

关键词： solubility imino viscosity residues collagen helical amide biomedical chains pharmaceutical

Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives

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chinese Chemical Letters 2015年第10期26卷 1307-1310页

作者： chi-Yu Sun Yang-Sheng Li Ai-Long Shi Ya-Fei Li Rui-Fang Cao Huai-Wei ding Qing-Qing Yin Li-Juan Zhang Hua-Chuan Zheng Hong-Rui Song Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education Shenyang Pharmaceutical University The First Affiliated Hospital of Liaoning Medical University

A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound 10 c showed promising inhibition of hedgehog（Hh） signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10 c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization.

关键词： Aryl cycloaliphatic amine Antiproliferative activity Hedgehog signaling

基于地理探测器的中国陆地生态系统土壤有机碳空间异质性影响因子分析

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生态环境学报 2021年第1期30卷 19-28页

作者：丁倩张弛中国科学院新疆生态与地理研究所/荒漠与绿洲生态国家重点实验室新疆乌鲁木齐830011 中国科学院大学北京100049 中国科学院中亚生态与环境研究中心新疆乌鲁木齐830011

中国陆地生态系统土壤有机碳库对全球生态系统碳平衡具有显著影响。为揭示土壤碳库空间分布的潜在主控因子并为今后建立碳库空间分布模型提供依据,利用地理探测器对中国陆地生态系统表层土壤(0—20 cm)有机碳密度的影响因子(气温、降水... 详细信息

中国陆地生态系统土壤有机碳库对全球生态系统碳平衡具有显著影响。为揭示土壤碳库空间分布的潜在主控因子并为今后建立碳库空间分布模型提供依据,利用地理探测器对中国陆地生态系统表层土壤(0—20 cm)有机碳密度的影响因子(气温、降水量、DEM、NDVI、陆地生态系统类型、人口密度)进行空间分异性探测和定量归因。结果表明:自然因素是全国和区域尺度陆地生态系统表层土壤有机碳密度的主要因素,而人为因素影响较小。全国尺度各影响因子按解释程度大小排序分别为:温度(0.22)>NDVI(0.16)>DEM(0.12)>陆地生态系统类型(0.09)>降水量(0.06)>人口密度(0.04);自然因素中的气候因素是中国陆地生态系统表层土壤有机碳密度空间分异性的主要影响因子,温度与降水量交互作用的解释程度为0.37,其中温度的作用尤为重要;气温因子与土壤有机碳密度在相对寒冷的地区(均温<15℃)呈负相关,但在更热的地区则呈正相关,意味着生态系统碳平衡对未来气候变暖可能表现出异质性的响应特征;强烈的因子互作效应表明,中国陆地生态系统表层土壤有机碳空间分异性是由多种因子共同作用影响而非单一因素决定;中国六大分区(东北、华北、华东、西北、中南、西南)陆地生态系统表层土壤有机碳密度的各影响因子解释程度存在差异,体现出土壤有机碳密度的主控因子的空间异质性。

关键词：土壤有机碳影响因子空间异质性地理探测器陆地生态系统

An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoY-2 variants

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Signal Transduction and Targeted Therapy 2022年第3期7卷 780-789页

作者： Xiaojing chi Xinhui Zhang Shengnan Pan Yanying Yu Yujin Shi Tianli Lin Huarui Duan Xiuying Liu Wenfang Chen Xuehua Yang Lan Chen Xiaoqian Dong Lili Ren Qiang ding Jianwei Wang Wei Yang NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical College100176 BeijingChina School of Medicine Tsinghua University100084 BeijingChina

The wide transmission and host adaptation of SARS-CoV-2 have led to the rapid accumulation of mutations,posing significant challenges to the effectiveness of vaccines and therapeutic *** several neutralizing antibodies were authorized for emergency clinical use,convalescent patients derived natural antibodies are vulnerable to SARS-CoV-2 Spike mutation.

关键词： neutral antibodies clinical

Induction of Apoptosis in the Immature Mouse Testes by a Mixture of Melamine and Cyanuric Acid

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Journal of Integrative Agriculture 2012年第12期11卷 2058-2066页

作者： YOU Hua ZHU Jin-feng SHE Rui-ping CHANG Ling-ling SHI Rui-han ding Ye chi Li-juan LIU Bin YUE Zhuo TIAN Ji-jing MAO Jing-jing SU Li-fang Key Laboratory of Zoonosis Ministry of Agriculture/Department of Veterinary Pathology College of Veterinary Medicine China Agricultural University china Animal Disease Control Center National Animal Husbandry Service

The toxicity of melamine has attracted much attention since the recent outbreaks of renal injury in pets and infants. Previous studies indicated that melamine by itself had low toxicity, whereas a mixture of melamine and cyanuric acid （M＋CA） could cause serious renal damage. At present, most researches on the toxicity of M＋CA are focused on the kidney. However, little is known about the adverse effects of this mixture on the reproductive system. In the present study, the toxicity of M＋CA to testes was investigated. Immature male mice were orally dosed with 0, 0.6, 3, and 15 mg kg-1 d-1 of a 1：1 M＋CA for 28 d. Pathological changes occurred in germ cells, such as loose arrangement, reduced numbers and karyopyknosis, indicating that this mixture was toxic to spermatogenesis. Compared with the control group, the TUNEL- positive germ cells increased significantly and the ratio of Bcl-2 to Bax, total antioxidant capacity and superoxide dismutase activity decreased significantly in the 3 and 15 mg kg-1 d- M＋CA treated group, while the activities of caspase-3, caspase- 8 and caspase-9 remained unchanged. The results suggest that M＋CA can induce apoptosis in the mice testes. The downregulation of Bcl-2/Bax and oxidative stress may play a pivotal role in the induction of apoptosis by M＋CA in mice testes.

关键词： melamine/cyanuric acid mixture testes injury caspase-independent apoptosis

Quantile Regression Based on Semi-Competing Risks Data

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Open Journal of Statistics 2013年第1期3卷 12-26页

作者： Jin-Jian Hsieh A. Adam ding Weijing Wang Yu-Lin chi Department of Mathematics National Chung Cheng University Chia-Yi Chinese Taipei Department of Mathematics Northeastern University Boston USA. Institute of Statistics National Chiao-Tung University Hsin-Chu Chinese Taipei

This paper considers quantile regression analysis based on semi-competing risks data in which a non-terminal event may be dependently censored by a terminal event. The major interest is the covariate effects on the quantile of the non-terminal event time. Dependent censoring is handled by assuming that the joint distribution of the two event times follows a parametric copula model with unspecified marginal distributions. The technique of inverse probability weighting (IPW) is adopted to adjust for the selection bias. Large-sample properties of the proposed estimator are derived and a model diagnostic procedure is developed to check the adequacy of the model assumption. Simulation results show that the proposed estimator performs well. For illustrative purposes, our method is applied to analyze the bone marrow transplant data in [1].

关键词： Copula Model Dependent Censoring Quantile Regression Semi-Competing Risks Data

Pressure-and temperature-dependent luminescence from Tm^(3+) ions doped in GdYTaO_(4)

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chinese Physics B 2022年第1期31卷 497-503页

作者： Peng-Yu Zhou Xiu-Ming Dou Bao-Quan Sun Ren-Qin Dou Qing-Li Zhang Bao Liu Pu-Geng Hou Kai-Lin chi Kun ding School of Science Northeast Electric Power UniversityJilin 132012China State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Key Laboratory of Photonic Devices and Materials Anhui Institute of Optics and Fine MechanicsChinese Academy of SciencesHefei 230031China

Luminescent properties of Tm^(3+)-doped GdYTaO_(4) are studied for exploring their potential applications in temperature and pressure *** main emission peaks from ^(3)H_(4)→^(3)H_(6) transition of Tm^(3+)are *** ratio between the two peaks evolves exponentially with temperature and has a highest sensitivity of 0.014 K^(−1) at 32 *** energy difference between the two peaks increases linearly with pressure increasing at a rate of 0.38 meV/*** ratio between the two peaks and their emission lifetimes are also analyzed for discussing the pressure-induced variation of the sample ***,Raman spectra recorded under high pressures indicate an isostructural phase transition of GdYTaO_(4) occurring at 4.46 GPa.

关键词： rare-earth tantalate photoluminescence high pressure Raman

Effect of Carbon on the Paramagnetic-Antiferromagnetic Transition and γ→εMartensitic Transformation of Fe-24Mn Alloys

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Journal of Materials Science & Technology 2000年第3期16卷 297-301页

作者： Xing LU, Zuoxiang QIN, Yansheng ZHANG, Xingyu WANG and Fengxian LI (Department of Materials Science & Engineering, Dalian Railway Institute, Dalian 116028, china) Bingzhe ding and Zhuangqi HU (State Key Laboratory for RSA, Institute of Metal Research, chi Department of Materials Science and Engineering Dalian Railway Institute Dalian 116028 China State Key Laboratory for RSA Institute of Metal Research Chinese Academy of Science Shenyang 110015 China

The effect of C content (0.014-0.39 wt pct) on the paramagnetic-antiferromagnetic transition and γ→ε martensitic transformation of Fe-24Mn alloys has been investigated by the resistivity, dilation, tensile properties measurement and microstructure examination. The results have shown that C decreases T_N; increases the thermal expansion coefficients both above and below the T_N; increases the resistivity above the T_N and antiferromagnetic scattering resistivity below T_N. It strongly depresses the γ→ε martensitic transformation and reduces the M_s of Fe-24Mn alloys. Moreover, it increases the lattice parameter of austenite, enhances the tensile ductility, but almost does not affect the tensile strength. With increasing C content from 0.014 to 0.19 wt pct, the yield strength of Fe-24Mn alloy decreases obviously arising from the decreasing of preexisting ε martensite. but it increases from 0.19 to 0.39 wt pct C due to the solution hardening of C.

关键词： Mn Effect of Carbon on the Paramagnetic-Antiferromagnetic Transition and Martensitic Transformation of Fe-24Mn Alloys Fe

Association of renal function with cardiac reverse remodeling and long-term outcome in heart failure patients following cardiac resynchronization therapy

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chinese Medical Journal 2014年第23期127卷 4036-4042页

作者： Cai chi Hua Wei ding Ligang Wang Jing Chen Keping Yang Xinwei Liu Zhimin Zhang Shu Centre of Arrhythmia Diagnosis and Treatment Fuwai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China

Background Renal insufficiency （RI） is significantly associated with clinical prognosis in patients with heart failure （HF）,but direct evidences on the relation between renal function and clinical outcome in patients receiving cardiac resynchronization therapy （CRT） are *** aim of the current study was to systematically evaluate the association of baseline and 6-month renal function with cardiac reverse remodeling and long-term outcome after *** We retrospectively evaluated 190 consecutive patients who underwent CRT at Fuwai Hospital from January 2008 to April *** function tests,echocardiographic measurement,and clinical parameters at baseline and after 6 months of CRT were *** endpoint events included all-cause mortality,cardiac transplantation,and unplanned hospitalizations for *** At baseline,compared with normal renal function or mild RI （estimated glomerular filtration rate （eGFR）〉-60 ml·min-1·1.73 m-2）,moderate-to-severe RI （eGFR 〈60 ml·min-1·1.73 m-2） exerted a negative influence on cardiac reverse remodeling *** 6-month follow-up,114 （60.0%） patients were classified as responders and showed significant renal function improvement,whereas renal function deteriorated in non-responders and subsequently 41 （25.6%） patients developed worsening renal function （WRF）.During the mean follow-up of （24.3±17.1） months,both patients with baseline eGFR 〈60 ml·min^-1·1.73 m^-2 and those with WRF experienced worse event-free survival （P 〈0.01,respectively）.Conclusions：This analysis identified that baseline eGFR as well as WRF after CRT were found to be independent determinants of the combined endpoints of all-cause mortality and HF-related hospitalizations in CRT recipients.

关键词： heart failure renal insufficiency cardiac resynchronization therapy clinical outcome