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A HYBRID POLYMER GEL AND ITS STATIC NONERGODICITY

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chinese Journal of Polymer science 2002年第3期20卷 269-274页

作者： Yue Zhao chi wu the open laboratory of bond selective chemistry department of chemical physics, university of science and technology of china hefei 230026 china department of chemistry the chinese university of hong kong shatin, N.T., hong kong china Univ Sci & Technol china Dept Phys Chem Open Lab Bond Select Chem Hefei 230026 Peoples R China chinese Univ hong kong Dept Chem Shatin Hong Kong Peoples R China

We used a thermally reversible hybrid gel made of billions of physically jam-packed swollen thermally sensitivepoly(N-isopropyl-acrylamide) chemical microgels. Laser light scattering study on a series of such hybrid gels formed atdifferent gelling rates and temperatures revealed that the position-dependence of the scattering speckle pattern(staticnonergodicity) came from large voids formed during the sol-gel transition. With a proper preparation, such a nonergodicitycould be completely removed, indicating that the static nonergodicity generally observed in a gel is not indinsic, but comesfrom the clustering "island" structure formed during the gelation process.

关键词： Polymer gel Nonergodicity Dynamic light scattering

Interaction of glucose oxidase with PMMA-BSA nanoparticles

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Interaction of glucose oxidase with PMMA-BSA nanoparticles

A one-step procedure for facile, selective synthesis of protected d-glucopyranosides with free 2-C hydroxyl group starting from peracetylated β-D-glucopyranose

第六届全国化学生物学学术会议

作者： Chuanxin He,~1 Jianhong Liu,~(2,*) Qianling Zhang,Guangzhao Zhang~1 and chi wu~3 1.The hefei National laboratory for Physical sciences at Microscale and department of chemical physics,university of science and technology of china,hefei,Anhui 230026,china, 2.School of chemistry and chemical Engineering,Shenzhen university,Shenzhen,Guangdong 518060,china, 3.department of chemistry,The chinese university of hong kong,shatin,N.T.,hong kong

＜正＞The development of biosensors,especially enzymed-based biosensors,has attracted much attention,which often involves the immobilization of enzymes on some proper surfaces and coverts chemical information into an electronic signal.A better understanding and control of the complicate enzyme interaction with different surfaces is always needed for the

关键词： glucose oxidase interaction adsorption nanoparticles

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cnki会议

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chinese Journal of chemistry 1996年第2期14卷 190-192页

作者： LIU,Mei-Zheng FAN,hong-Ni GUO,Zhong-wu HUI,Yong-ZhengNational laboratory of Bio-Organic and Natural Product chemistry,Shanghai Institute of Organic chemistry,chinese Academy of sciences,Shanghai 200033,china National laboratory of Bio-Organic and Natural Product chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China [?]On leave from department of chemistry Jiangxi Normal University Nanchang Jiangxi 330027 China.

An important field in carbohydrate chemistry is to look for regioselective re-actions of saccharides to simplify the chemical synthesis of oligosaccharides. Oneof such efforts nowadays is directed to the convenient pr... 详细信息

关键词： One-step reaction protected D-glucopyranosides with free 2-hydroxyl group

Enones from aldehydes and alkenes by carbene-catalyzed dehydrogenative couplings

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chinese chemical Letters 2024年第9期35卷 150-154页

作者： Kun Tang Fen Su Shijie Pan Fengfei Lu Zhongfu Luo Fengrui Che Xingxing wu Yonggui Robin chi National Key laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang 550025China School of chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore

Enones are widely explored in synthetic chemistry as fundamental building blocks for a wide range of reactions and exhibit intriguing biological activities that are pivotal for drug *** development of synthetic strategies for highly efficient preparation of enones thereby receives intense attention,in particular through the transition metal-catalyzed coupling ***,we describe a carbene-catalyzed cross dehydrogenative coupling(CDC)reaction that enables effective assembly of simple aldehydes and alkenes to afford a diverse set of enone ***,the in situ generated aryl radical is pivotal to“activate”the alkene by forming an allyl radical through intermolecular hydrogen atom transfer(HAT)pathway and thus forging the carbon-carbon bond formation with aldehyde as the acyl ***,our method represents the first example on the enone synthesis through coupling of“non-functionalized”aldehydes and alkenes as coupling partners,and offers a distinct organocatalytic pathway to the transition metal-catalyzed coupling transformations.

关键词： Enones Cross dehydrogenative coupling N-Heterocyclic carbene Aryl radical Hydrogen atom transfer

Fouling-release Property of Water-filled Porous Elastomers

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chinese Journal of chemical physics 2012年第3期25卷 330-334,374页

作者： Lai-yong Xie Fei hong Chuan-xin He Jian-hong Liu chi wu hefei National laboratory for Physical sciences at Microscale Department of Chemical PhysicsUniversity of Science and Technology of China Hefei 230025 China School of chemistry and chemical Engineering Shenzhen University Shenzhen 518060 China department of chemistry The Chinese University of Hong Kong Hong Kong

Since the fouling-releasing ability of silicone elastomers increased as their modulus decreases, we designed and prepared composites with embedded tiny NaC1 crytals that were soluble after their immersion in water, resulting in water-filled porous elastomers. The scanning electron microscope images confirmed such a designed water-filling porous structure. The existence of many micro-drops of water in these specially designed elastomers decreased the shear storage modulus and increased the loss factors. The decrease of shear modulus plays a leading role here and is directly related to a lower critical peeling-off stress of a pseudo-barnacle on them. Therefore, such a novel preparation with cheap salts instead of an expensive silicone provides a better way to make fouling-release paints with a lower modulus, a lower critical peeling-off stress and a better fouling-release property without a significant decrease of the cross-linking density.

关键词： Fouling-release Porous silicone elastomer Soluble salt Pseudo-barnacle ad-hesion NaCl Micro-drop of water

Preparation of true solutions of monomeric amyloidogenic protein/peptide:A critical prerequisite for aggregation kinetic study

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维普期刊数据库

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science china chemistry 2012年第1期55卷 118-124页

作者： DIAO Shu ZHAO hong WANG WeiMao wu chi department of chemistry The Chinese University of Hong Kong Hong Kong China The hefei National laboratory of Physical science at Microscale department of chemical physics The University of Science and Technology of China Hefei 230022 China

Our dynamic laser light scattering(LLS) study shows that the current widely used protocols of dissolving amyloidogenic protein/peptide do not really result in a true solution;namely,there always exist a trace amount of interchain aggregates,which greatly affect the association kinetics,partially explaining why different kinetics were reported even for a solution with identical protein and ***,using a combination of the conventional dissolution procedure and our newly developed ultra-filtration method,we have developed a novel protocol to prepare a true solution of amyloidogenic protein/peptide without any interchain *** resultant solutions remain in their monomeric state for at least one week,which is vitally important for further study of the very initial stage of the interchain association under the physiological conditions because more and more evidence suggests that it is those small oligomers rather than large fabric aggregates that are *** addition,this study shows that combining static and dynamic LLS can lead to more physical and microscopic information about the protein association instead of only the size distribution.

关键词： amyloidogenic protein/peptide laser light scattering monomer ultra-filtration

Preparation of true solutions of monomeric amyloidogenic protein/peptide:A critical prerequisite for aggregation kinetic study

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中国科学：化学 2012年第2期42卷 229-230页

关键词：聚合动力学淀粉样蛋白多肽单体关联动力学动态激光光散射正解制备

A stable Co(Ⅱ)-based metal-organic framework with dual-functional pyrazolate-carboxylate ligand:Construction and CO_(2) selective adsorption and fixation

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chinese chemical Letters 2021年第2期32卷 918-922页

作者： Guangrui Si Xiangjing kong Tao He Wei wu Linhua Xie Jianrong Li Beijing Key laboratory for Green Catalysis and Separation and department of Environmental chemical Engineering Beijing University of TechnologyBeijing 100124China

By taking the functional adva ntages of both pyrazolate and carboxylate ligands,a unique dual-functional pyrazolate-carboxylate ligand acid,4-(3,6-di(pyrazol-4-yl)-9-carbazol-9-yl)benzoic acid(H3PCBA) was designed and *** it,a new Co(Ⅱ)-based metal-organic framework(MOF),Co_(3)(PCBA)_(2)(H_(2)O)_(2)(BUT-75) has been *** revealed a(3,6)-connected net based on the 6-connected linear trinuclear metal node,and showed good chemical stability in a wide pH range from 3 to 12 at room temperature,as well as in boiling *** to the presence of rich exposed Co(Ⅱ) sites in pores,BUT-75 presented high selective CO_(2) adsorption capacity over N2 at 298 ***,it demonstrated fine catalytic performance for the cycloaddition of CO_(2) with epoxides into cyclic carbonates under ambient *** work has not only enriched the MOF community through integrating diverse functio nalities into one ligand but also contributed a versatile platform for CO_(2) fixation,thereby pushing MOF chemistry forward by stability enhancement and application expansion.

关键词： Metal-organic framework(MOF) Pyrazolate-carboxylate ligand Construction CO_(2)selective adsorption CO_(2)fixation

Recent advances in chemical protein synthesis:method developments and biological applications

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science china chemistry 2024年第4期67卷 1060-1096页

作者： Suwei Dong Ji-Shen Zheng Yiming Li Huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun Guo Chunmao He honggang Hu Xuechen Li Yanmei Li Zigang Li Man Pan Shan Tang Changlin Tian Ping Wang Bian wu Chuanliu wu Junfeng Zhao Lei Liu State Key laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Division of Life sciences and Medicine University of Science and Technology of ChinaHefei 230027China School of Food and Biological Engineering Engineering Research Center of Bio-processMinistry of EducationHefei University of TechnologyHefei 230009China School of chemistry and chemical Engineering Nanjing UniversityNanjing 210023China State Key laboratory of Elemento-Organic chemistry Nankai UniversityTianjin 300071China department of chemistry Tsinghua UniversityBeijing 100084China Institute of Health sciences Anhui UniversityHefei 230601China College of chemistry Central China Normal UniversityWuhan 430079China School of chemistry and chemical Engineering South China University of TechnologyGuangzhou 510640China School of Medicine or Institute of Translational Medicine Shanghai UniversityShanghai 200444China department of chemistry The University of Hong KongHong Kong 999077China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of chemistry and chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Life sciences University of Science and Technology of ChinaHefei 230026China department of chemical Biology Shanghai Jiao Tong UniversityShanghai 200240China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China department of chemistry Xiamen UniversityXiamen 361005China School of Pharmaceutical science Guangzhou Medical UniversityGuangzhou 511436China

The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and *** protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image *** review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic ***,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse *** applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further ***,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis.

关键词： chemical protein synthesis solid-phase peptide synthesis ligation reactions post-translational modifications mirror-image proteins peptide drugs