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Eye Science 2013年第4期28卷 190-194页

作者： wei chi An Li Shuqin Wang Xuefei Zhu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University Department of Ophthalmology the People's Hospital of Hechi The Affiliated Optometry Eye Hospital of Wenzhou Medical Hospital The First Affiliated Hospital of Soochow University

Purpose:To observe the efficacy of combined use of brimonidine and betaxolol in treatment of primary open angle glaucoma(POAG)and ocular ***:A total of 54 patients(90 eyes)with POAG and ocular hypertension were randomly divided into three groups(receiving betaxolol,.brimonidine and combined administration of betaxolol and brimonidine respectively).The administration was given twice daily in all groups(0.5%betaxolol,0.2%brimonidine and 0.5%betaxolol combined with 0.2%brimonidine).The changes in intraocular pressure(IOP)were observed before,and 2,4,6,and 8 weeks after *** addition,the adverse reactions were also recorded ***:.The mean IOPs at all the time points after treatment were significantly reduced compared with pre-treatment levels(P<0.05).Patients receiving brimonidine had a greater reduction in IOP compared with their counterparts in the betaxolol group but the difference was not statistically *** IOP decline was significantly higher in the combined therapy group than in the other two groups(P<0.01).Few cases presented with slight discomfort,.such as sensation of foreign bodies,.ocular irritation,.dizziness,.headache,.fatigue,.and dryness of mouth and *** severe adverse reactions were noted following ***:Combined use of brimonidine and betaxolol is an efficacious treatment of reducing IOP without severe side effects.

关键词：疗效观察青光眼原发性眼压联合用药溴联合治疗行政管理

Origin of abnormal high pressure and its relationship with hydrocarbon accumulation in the Dina 2 Gas Field, Kuqa Depression

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Petroleum Research 2016年第1期1卷 93-102页

作者： Fengqi Zhang Zhenliang Wang Hongli Zhong Yubin Song weiming Liu chi wei School of Earth Sciences and Engineering Xi’an Shiyou UniversityXi’an 710065China Department of Geology Northwest UniversityXi’an 710069China College of Geology&Environment Xi'an University of Science and TechnologyXi'an 710054China Tazhong Exploration&Development Research Management Department Petrochina Tarim Oilfield CompanyKorla 841000China

Based on distribution of formation pressure by indirect estimation and formation testing,this study investigates origin of abnormal high pressure in the Dina 2 Gas Field in the Kuqa Depression in combination with the latest research *** of major overpressure mechanisms to this gas field is estimated,and generation of the abnormal high pressure as well as its relationship with natural gas accumulation is *** compaction,tectonic stress,and overpressure transfer are the major overpressure *** transfer resulted from vertical opening of faults and folding is the most important cause for the *** accumulation and abnormal high pressure generation in the reservoirs of the Dina 2 Gas Field show *** the early oil-gas charge in the Kangcun stage,the reservoirs were generally normal pressure *** the Kuqa deposition stage,rapid deposition caused disequilibrium compaction and led to generation of excess pressure(approximately 5-10 MPa)in the *** the Kuqa Formation denudation stage to the Quaternary,reservoir overpressure was greatly increased to approximately 40-50 MPa as a result of vertical pressure transfer by episodic fault activation,lateral overpressure transfer by folding and horizontal tectonic stress due to intense tectonic *** last stage was the major period of ultra-high pressure generation and gas accumulation in the Dina 2 Gas Field.

关键词： abnormal high pressure overpressure transfer tectonic compression Dina 2 Gas Field Kuqa Depression

High sensitivity C-reactive protein and cardfiac resynchronization therapy in patients with advanced heart failure

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Journal of Geriatric Cardiology 2014年第4期11卷 296-302页

作者： chi CAI wei HUA Li-Gang DING Jing WANG Ke-Ping CHEN Xin-wei YANG Zhi-Min LIU Shu ZHANG Cardiac Arrhythmia Center Fuwai Hospital Beilishi road No. 167 Xicheng district Beijing 100037 China

Background The data on the prognostic values of high sensitivity C-reactive protein （hsCRP） levels in patients with advanced symp-tomatic heart failure （HF） receiving cardiac resynchronization therapy （CRT） are scarce. The aim of present study was to investigate the association of serum hsCRP levels with left ventricle reverse remodeling after six months of CRT as well as long-term outcome. Methods A total of 232 CRT patients were included. The assessment of hsCRP values, clinical status and echocardiographic data were performed at baseline and after six months of CRT. Long-term follow-up included all-cause mortality and hospitalizations for HF. Results During the mean follow-up periods of 31.3 ± 31.5 months, elevated hsCRP （〉3 mg/L） prior to CRT was associated with a significant 2.39-fold increase （P=0.006） in the risk of death or HF hospitalizations. At 6-month follow-up, patients who responded to CRT showed significant reductions or maintained low in hsCRP levels （–0.5 ± 4.1 mg/L reduction） compared with non-responders （1.7 ± 6.1 mg/L increase, P=0.018）. Com-pared with patients in whom 6-month hsCRP levels were reduced or remained low, patients in whom 6-month hsCRP levels were increased or maintained high experienced a significantly higher risk of subsequent death or HF hospitalizations （Log-rank P〈0.001）. The echocardio-graphic improvement was also better among patients in whom 6-month hsCRP levels were reduced or remained low compared to those in whom 6-month hsCRP levels were raised or maintained high. Conclusions Our findings demonstrated that measurement of baseline and follow-up hsCRP levels may be useful as prognostic markers for timely potential risk stratification and subsequent appropriate treatment strategies in patients with advanced HF undergoing CRT.

关键词： Cardiac resynchronization therapy Clinical outcome Heart failure High sensitivity C-reactive protein

Amniotic membrane transplantation in a patient with impending perforated corneal ulcer caused by Streptococcus mitis: A case report and review of literature

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World Journal of Clinical Cases 2022年第12期10卷 3923-3929页

作者： Fang-chi Hsiao Yaa-Jyuhn James Meir Lung-Kun Yeh Hsin-Yuan Tan ching-Hsi Hsiao David Hui-Kang Ma wei-chi Wu Hung-chi Chen Department of Ophthalmology Chang Gung Memorial HospitalTaoyuan 333423Taiwan Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33305Taiwan Department of Medicine College of MedicineChang Gung UniversityTaoyuan 33305Taiwan Center for Tissue Engineering Chang Gung Memorial HospitalTaoyuan 333423Taiwan

BACKGROUND Streptococcus mitis(***)is an opportunistic pathogen that can lead to severe ocular *** previous reports,penetrating keratoplasty(PK)was usually adopted for the treatment of persistent corneal *** report describes an unusual case of nonhealing descemetocele caused by *** treated by antibiotics plus amniotic membrane transplantation(AMT).CASE SUMMARY A 63-year-old woman presented with a right persistent corneal ulcer that she had suffered from for the past 9 *** culture of a corneal scraping yielded *** right eye descemetocele decreased in diameter from 3 to 0.8 mm after the continuous administration of topical vancomycin and ceftriaxone for 2 *** to the slow healing,AMT was *** corneal erosion healed and gradually became *** visual acuity recovered from initially counting fingers to 100/200 at the last follow-up,67 mo after *** Antibiotics plus AMT may be an effective alternative treatment other than PK to promote epithelializationand to reduce inflammation in the corneas complicated by S. mitis keratitis.

关键词： Persistent corneal ulcer Amniotic membrane transplantation Streptococcus mitis Case report

CD4^+ T cells from behcet patients produce high levels of IL-17

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Eye Science 2011年第2期26卷 65-69页

作者： wei chi Sheng Zhou Peizeng Yang Lina Chen State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthamology Chongqing Eye Institute Chongqing China

Purpose:To investigate the role of interleukin (IL)-17-producing CD4+ T cells in Behcet disease (BD).Methods:Blood samples were drawn from eight BD patients with active uveitis,eight BD patients with inactive uveitis and eight normal controls,*** were prepared from heparinized blood by Ficoll-Hypaque density-gradient *** CD4+ T cells were purified by Human CD4 Microbeads.(MACS).The purity rate of CD4+ T cells was detected using flow *** CD4+ T cells were stimulated with or without anti-CD3 and anti-CD28 antibodies in the presence or absence of recombinant-IL-23 (rIL-23) or recombinant-IL-12 (rIL-12) for 72 *** concentrations of IL-17,IFN-γ and IL-4 in the collected supernatants from CD4+ T cells were measured using a Duoset ELISA Development ***:The results showed that the levels of IL-17 and IFN-γ observed in active BD patients were significantly higher as compared with those in inactive patients and normal *** was no significant difference concerning IL-4 production between BD patients and normal ***-23 significantly augmented the production of IL-17 by CD4+ T cells from both BD patients and normal *** rIL-23 and rIL-12 could increase IFN-γ production by CD4+ T cells from BD patients and normal ***,the effect of rIL-12 was more robust compared with that of *** rIL-23 nor rIL-12 exerted any effect on IL-4 ***:rIL-23 can promote the production of IL-17 by CD4+ T cells in BD *** upregulated IL-17 levels may be related with the intraocular inflammation of Behcet patients.

关键词： CD4 T细胞高水密度梯度离心血液样本白细胞介素流式细胞仪 ELISA

Intraocular lens implantation performed first to protect the posterior capsule in Morgagnian cataracts during phacoemulsification

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International Journal of Ophthalmology(English edition) 2019年第7期12卷 1215-1218页

作者： Xia Hua Yongxiao Dong Ling Wang Zhiqing Li Jianying Du wei chi Xiaoyong Yuan Department of Ophthalmology the Second Hospital of Tianjin Medical University Tianjin 300211China Department of Ophthalmology the First People's Hospital of Xianyang Xianyang 712000 Shaanxi Province China Tianjin Medical University Tianjin 300070China Tianjin Medical University Eye Hospital Tianjin 300384China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 Guangdong ProvinceChina Tianjin Eye Hospital Tianjin Key Laboratory of Ophthalmology and Visual Science Clinical College of Ophthalmology Tianjin Medical University Tianjin 300020 China

This study evaluated the safety of a modified method to implant an intraocular lens (IOL) into the capsular bag immediately after capsulorhexis with a whole or partial nucleus to protect the posterior capsule (PC) during phacoemulsification in a series of 12 Morgagnian cataracts. For 3 cases of hypermature cataracts with smaller and rigid nuclei, after a complete capsulorhexis, an IOL was directly inserted into the capsular bag, which protected the PC during the subsequent phacoemulsification process in the iris plate. For the other 9 cases with larger and softer nuclei, after the nucleus was partially emulsified, the IOL was inserted into the bag. Even with an obvious surge for some cases, the surgeries were uneventful in all 12 cases, with no PC rent or vitreous loss. IOL implantation into the capsular bag with a whole or partial nucleus can provide effective protection for the PC for hypermature cataract during phacoemulsification.

关键词： intraocular lens hypermature cataract Morgagnian cataract phacoemulsification posterior capsule

Is There Excess Liquidity in china？

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china & World Economy 2015年第3期23卷 110-126页

作者： Tie Ying Liu chi wei Su Xu Zhao Jiang Tsangyao Chang Department of Economics Ocean University of China Qingdao China Department of Finance Ocean University of China Qingdao China Department of Finance Feng Chia University Taiwan

In this paper, we developed the recursive unit root tests proposed by Phillips et al. （2013） and used them to identify the beginning and the end of potential excess liquidity in the chinese monetary market during the period from 1992 to 2013. The result indicates that excess liquidity existed from the third quarter of 2002 to 2013. The analysis shows that since 2003, the inflationary pressure of excess liquidity has remained high. We provide evidence supporting the money illusion hypothesis in china. The recursive unit root test is suited to practical implementation with time series and delivers a consistent date-stamping strategy for determining the origination and termination of multiple bubbles. Simulations show that the test significantly improves discriminatory power and leads to distinct power gains.

关键词： bubbles excess liquidity generalized sup augmented Dickey-Fuller test money illusion sup augmented Dickey-Fuller test

Optimization of Bearing Locations for Maximizing First Mode Natural Frequency of Motorized Spindle-Bearing Systems Using a Genetic Algorithm

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Applied Mathematics 2014年第14期5卷 2137-2152页

作者： chi-wei Lin Department of Industrial Engineering and Systems Management Feng Chia University Taichung Taiwan

This paper has developed a genetic algorithm (GA) optimization approach to search for the optimal locations to install bearings on the motorized spindle shaft to maximize its first-mode natural frequency (FMNF). First, a finite element method (FEM) dynamic model of the spindle-bearing system is formulated, and by solving the eigenvalue problem derived from the equations of motion, the natural frequencies of the spindle system can be acquired. Next, the mathematical model is built, which includes the objective function to maximize FMNF and the constraints to limit the locations of the bearings with respect to the geometrical boundaries of the segments they located and the spacings between adjacent bearings. Then, the Sequential Decoding Process (SDP) GA is designed to accommodate the dependent characteristics of the constraints in the mathematical model. To verify the proposed SDP-GA optimization approach, a four-bearing installation optimazation problem of an illustrative spindle system is investigated. The results show that the SDP-GA provides well convergence for the optimization searching process. By applying design of experiments and analysis of variance, the optimal values of GA parameters are determined under a certain number restriction in executing the eigenvalue calculation subroutine. A linear regression equation is derived also to estimate necessary calculation efforts with respect to the specific quality of the optimization solution. From the results of this illustrative example, we can conclude that the proposed SDP-GA optimization approach is effective and efficient.

关键词： Optimal Design Motorized Spindle System Design Finite Element Method Genetic Algorithm First Mode Natural Frequency

Perioperative topical ascorbic acid for the prevention of phacoemulsification-related corneal endothelial damage:Two case reports and review of literature

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World Journal of Clinical Cases 2019年第5期7卷 642-649页

作者： chia-Yi Lee Hung-Ta Chen Yi-Jen Hsueh Hung-chi Chen chieh-Cheng Huang Yaa-Jyuhn James Meir Chao-Min Cheng wei-chi Wu Department of Ophthalmology Show Chwan Memorial Hospital Department of Optometry College of Medicine and Life Science Chung Hwa University of Medical Technology Department of Internal Medicine Taipei City Hospital-Heping Branch Department of Ophthalmology Chang Gung Memorial Hospital Center for Tissue Engineering Chang Gung Memorial Hospital Department of Medicine College of Medicine Chang Gung University Institute of Biomedical Engineering National Tsing Hua University Department of Biomedical Sciences College of Medicine Chang Gung University

BACKGROUND The current case report describes successful phacoemulsification with the aid of perioperative topical ascorbic acid(AA) in two patients with corneal endothelial disorders to prevent postoperative corneal endothelial *** SUMMARY Two eyes of two patients underwent phacoemulsification with pre-existing corneal endothelial disorders including Fuchs corneal endothelial dystrophy(Patient 1) and endotheliitis(Patient 2). Topical AA was applied to both patients at least one month before and after with a frequency of four times per day. After the surgery, both eyes improved best-corrected visual acuity(BCVA) and there was limited human corneal endothelial cell loss without signs of corneal endothelial decompensation, such as deteriorated BCVA or persistent corneal edema during the follow-up of at least two *** Perioperative administration of topical AA may be an alternative therapy to the triple procedure in patients expecting to undergo cataract surgery.

关键词： Ascorbic acid Fuchs corneal endothelial dystrophy Endotheliitis Human corneal endothelial cell Phacoemulsification Case report

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健康指数的构建方法

中华疾病控制杂志 2022年第10期26卷 1146-1151页

作者：迟蔚蔚山东健康医疗大数据管理中心济南250002

当前在健康指数构建方面存在的瓶颈,一方面是缺乏构建健康指数的一般性、普适性的理论模型或理论范式;二是缺乏全栈式健康指数技术流程,致使健康指数转化应用难以实现规模化、权威化适时发布。为此,本文在已构建的健康指数的普适性概念... 详细信息

当前在健康指数构建方面存在的瓶颈,一方面是缺乏构建健康指数的一般性、普适性的理论模型或理论范式;二是缺乏全栈式健康指数技术流程,致使健康指数转化应用难以实现规模化、权威化适时发布。为此,本文在已构建的健康指数的普适性概念模型及理论范式指导下,制定了贯穿“数据平台→数据采集→健康测量→理论模型→循证指标→指标体系→加权综合→指数可视化→指数发布→转化服务”的全栈式健康指数技术流程,实现了健康指数转化应用的规模化、权威化适时发布和服务。

关键词：健康指数理论模型和范式全栈式健康指数流程