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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang liu Yu-chi liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Time Decay Rate of Solutions Toward the Viscous Shock Waves under Periodic Perturbations for the Scalar Conservation Law with Nonlinear Viscosity

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Acta Mathematicae Applicatae Sinica 2023年第1期39卷 28-48页

作者： Ye-chi liu Academy of Mathmatics and Systems Science Chinese Academy of SciencesBeijing 100190China

In this paper,it is proved that the weak solution to the Cauchy problem for the scalar viscous conservation law,with nonlinear viscosity,different far field states and periodic perturbations,not only exists globally in time,but also converges towards the viscous shock wave of the corresponding Riemann problem as time goes to ***,the decay rate is *** proof is given by a technical energy method.

关键词： viscous conservation law asymptotic behavior time decay rate viscous shock wave periodic perturbation

CFD analysis of a transfer matrix of exhaust muffler with mean flow and prediction of exhaust noise

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第9期13卷 709-716页

作者： Lian-yun liu Zhi-yong HAO chi liu Department of Energy Engineering Zhejiang UniversityHangzhou 310027China

A multi-dimensional computational fluid dynamics(CFD) approach was proposed in this study aiming to calculate the transfer matrix of an engine exhaust muffler in the conditions with and without mean *** CFD model of the muffler with absorptive material defined as porous zone was calibrated with the measured noise reduction without mean flow,and was further employed to study the effect of the mean flow on the acoustic performance of the ***,the exhaust acoustical source was derived from the calculated transfer matrices of six different additional acoustic loads obtained by the proposed CFD approach as well as the measured tail noise based on a multiload least squares ***,the exhaust noise was predicted based on Thevenin's *** proposed CFD approach was suggested to be able to predict the acoustic performance of a complex muffler considering mean flow(without and with mean flow) and heat transfer,and provide reasonable results of the exhaust noise.

关键词： Computational fluid dynamics (CFD) Transfer matrix Mean flow Acoustical source Exhaust noise

Three-Dimensional Collapse Analysis for a Shallow Cavity in Layered Strata Based on Upper Bound Theorem

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Computer Modeling in Engineering & Sciences 2020年第7期124卷 375-391页

作者： Hongtao Wang Ping liu Lige Wang chi liu Xin Zhang Luyao liu School of Civil Engineering Shandong Jianzhu UniversityJinanChina Key Laboratory of Building Structural Retrofitting and Underground Space Engineering(Shandong Jianzhu University) Ministry of EducationJinanChina Department of Chemical and Biological Engineering University of SheffieldSheffieldUK State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhanChina Jinan Rail Transit Group Co. Ltd.JinanChina

Layered rock strata are observed to be common during the excavation of tunnels or cavities,and may significantly affect the deformation and failure characteristics of surrounding rock masses due to various complex forms and mechanical *** this paper,we propose a three-dimensional axisymmetric velocity field for roof collapse of shallow cavities in multi rock layers,by considering the influences of roof cross-section shapes,supporting pressure,ground overload,*** internal energy dissipation rate and work rates of external forces corresponding to the velocity field are computed by employing the Hoek-Brown strength criterion and its associated flow ***,the equations of the collapse surfaces and the corresponding weight of collapsing rock masses are derived on the basis of upper bound ***,we validate the proposed method by comparing the results of numerical calculations and existing research *** change laws of the collapse range under varying parameters are obtained for the presence of rectangular and spherical *** also find that the three-dimensional mechanism is relatively safer for engineering designing actually,compared with the traditional two-dimensional *** these conclusions may provide workable guidelines for the support design of shallow cavities in layered rock strata practically.

关键词： Shallow cavity three-dimensional collapse layered rock strata upper

Screening of protease-producing marine yeasts for production of the bioactive peptides

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Acta Oceanologica Sinica 2008年第2期27卷 116-125页

作者： NI Xiumei chi Zhenming liu Zhiqiang YUE Lixi UNESCO chinese Center of Marine Biotechnology Ocean University of China Qingdao 266003 China

Over 400 yeast strains from seawater and sediments were obtained, but only five strains named HN2 -3, N13d, N13C, Mb5 and HN3 - 2 among them could form clear zones around their colonies on the double plates with 2.0% casein. Peptides in the hydrolysate produced by the proteases from strains HN2 -3 and N13d had higher angiotensin I-converting-enzyme （ACE）-inhibitory activity. The two marine yeast strains were identified to be Aureobasidium pullulans according to the results of routine yeast identification and molecular methods. After purification of the proteases from the two marine yeast strains, it was found that the optimal pH for them was both 9.0, both of them were serine alkaline protease. However, the optimal temperature for the protease from the strain HN2 -3 was 52℃ while that from strain N13d was 48℃. ACE-inhibitory activity of the peptides in the hydrolysate of shrimp protein produced by the purified protease from the strain HN2 -3 was the highest while antioxidant activity in the hydrolysate of spirulina protein produced by the purified protease from the strain N13d was the highest.

关键词： marine yeasts alkaline protease bioactive peptide ACE inhibitory activity antioxidant activity

Adsorption and diffusion of F_2 molecules on pristine graphene

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chinese Physics B 2018年第10期27卷 525-530页

作者： Yong Yang Fu-chi liu Yoshiyuki Kawazoe College of Physics and Technology Guangxi Normal UniversityGuilin 541004China Key Laboratory of Materials Physics Institute of Solid State PhysicsChinese Academy of SciencesHefei 230031China New Industry Creation Hatchery Center（NICHe） Tohoku University6-6-4 AobaAramakiAoba-kuSendaiMiyagi 980-8579Japan Department of Physics and Nanotechnology SRM Institute of Science and TechnologyKattankulathurm603203TNIndia

The adsorption and diffusion of F2 molecules on pristine graphene are studied by using first-principles *** the diffusion of F2 from molecular state in gas phase to the dissociative adsorption state on graphene surface, a kinetic barrier is identified, which explains the inertness of graphene in molecular F2 at room temperature, and its reactivity with F2 at higher temperatures. Study of the diffusion of F2 molecules on graphene surface determines the energy barrier along the optimal diffusion pathway, which conduces to the understanding of the high stability of fluorographene.

关键词： adsorption diffusion F2 molecule graphene first-principles calculations

Effect of Seawater Stress on Physiological and Biochemical Responses of Five Jerusalem Artichoke Ecotypes

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Pedosphere 2009年第2期19卷 208-216页

作者： LONG Xiao-Hua chi Jin-He liu Ling LI Qing liu Zhao-Pu College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 China

Three treatments consisting of 0%,15%,and 30%seawater were investigated to analyse the ecotypic variabilities among five populations of Jerusalem artichoke(Helianthus tuberosus)regarding their responses to seawater stress under a hydroponic culture *** were done 2,4,and 6 days after *** 15%and 30%seawater treatments reduced the growth rates of roots and shoots of *** *** activities of superoxide dismutase, peroxidase,and catalase majored in the leaves were stimulated under the seawater *** electrolyte leakage and malondialdehyde contents of the leaves were also stimulated owing to seawater *** contents of proline and soluble- sugars in the leaves increased significantly with increasing seawater *** concentrations of Na+,K+,and Cl-in the aerial parts and roots increased with an increase in the seawater concentration throughout the experimental *** were ecotypic differences among the five populations of *** as evidenced by the analyses of the above items in both aerial parts and roots under seawater *** magnitude of the ecotypic variance components indicated that a substantial proportion of the total variation for these physiological and biochemical responses were owing to ecotype,indicating the possibility of improvement through hybridization and selection.

关键词： antioxidative enzyme Helianthus tuberosus inorganic and organic solutes seawater stress

Production of 5-Hydroxymethylfurfural and Furfural from Lignocellulosic Biomass in Water-Tetrahydrofuran Media with Sodium Bisulfate

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chinese Journal of Chemical Physics 2015年第5期28卷 -页

作者： Ning Shi Qi-ying liu Tie-jun Wang Qi Zhang Long-long Ma chi-liu Cai CAS Key Laboratory of Renewable Energy4 Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640 ChinaSchool of Chemical Engineering Guizhou Institute of Technology Guiyang 550003 China CAS Key Laboratory of Renewable Energy4 Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640 China

5-Hydroxymethylfurfural (HMF) and furfural (FF), two bio-based platform chemicals, were produced from various raw lignocellulosic materials (corncob, corn stover, wheat straw, rice straw and sugarcane bagasse) in a water-tetrahydrofuran media by using NaHSO4 as catalyst. The influences of reaction temperature (160–200 °C), reaction time (30–120 min), solvent volume ratio, feedstock concentration (2.4wt%–11.1wt%) and catalyst dosage were studied. The highest HMF and FF yields obtained from corncob were 47mol% and 56mol% under condition of 190 °C, 90 min, 10/1 of THF/H2O. Besides, the lignin in the raw biomass was also depolymerized into organosolv lignin.

关键词： 5-Hydroxymethylfurfural Furfural Lignocellulosic biomass Hydrolysis Dehydration Tetrahydrofuran Sodium bisulfate

Corneal neuromediator profiles following laser refractive surgery

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Neural Regeneration Research 2021年第11期16卷 2177-2183页

作者： Lily Wei Yun Yang Jodhbir S.Mehta Yu-chi liu Yong Loo Lin School of Medicine National University of SingaporeSingapore Tissue Engineering and Cell Therapy Group Singapore Eye Research InstituteSingapore Department of Cornea and External Eye Disease Singapore National Eye CentreSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Laser refractive surgery is one of the most commonly performed procedures *** laser refractive surgery,Femtosecond Laser in Situ Keratomileusis and Refractive Lenticule Extraction have emerged as promising alternatives to microkeratome Laser in Situ Keratomileusis and Photorefractive *** laser refractive surgery,the corneal nerves,epithelial and stromal cells release neuromediators,including neurotrophins,neuropeptides and ***,nerve growth factor,substance P,calcitonin gene-related peptide and various cytokines are important mediators of neurogenic inflammation and corneal nerve *** in neuromediator profiles and ocular surface parameters following laser refractive surgery are attributed to the surgical techniques and the severity of tissue insult *** this review,we will discuss the(1)Functions of neuromediators and their physiological and clinical significance;(2)Changes in the neuromediators following various laser refractive surgeries;(3)Correlation between neuromediators,ocular surface health and corneal nerve status;and(4)Future directions,including the use of neuromediators as potential biomarkers for ocular surface health following laser refractive surgery,and as adjuncts to aid in corneal regeneration after laser refractive surgery.

关键词： cornea corneal nerves dry eye femtosecond laser laser in situ keratomileusis neuromediator refractive surgery small incision lenticule extraction

Chemical Composition Effect on Microstructures and Mechanical Properties in Friction Stir Additive Manufacturing

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Acta Metallurgica Sinica(English Letters) 2022年第9期35卷 1494-1508页

作者： Jian-Yu Li Shi-Ning Kong chi-Kun liu Bin-Bin Wang Zhao Zhang State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalian116024China

The variation of chemical compositions can affect the mechanical property of friction stir additive manufacturing(FSAM).Quantitative characterization of the relationship between the chemical composition and the mechanical property of FSAM components is key to control the quality of FSAM *** effect of chemical composition on the mechanical property of 6 xxx series aluminum alloy FSAM joint was studied by both experimental and numerical methods.A moving heat source model was established to simulate the heat transfer in FSAM *** average grain size was calculated by Monte Carlo model,and the precipitate evolution model was used to calculate the hardness and constitutive stress-strain *** validity of the numerical model was verified by *** indicate that the hardness and yield stress of 6 xxx series aluminum alloy FSAW joint can be enhanced by increasing silicon or magnesium *** increasing the content of magnesium(silicon),the volume fraction and the mean radius of MgSi can be increased when the content of silicon(magnesium) is *** the decrease in volume fraction,the average grain size can be *** changing the weight percentage of magnesium and silicon in different layers,the hardness and yield stress along the build direction can be controlled.

关键词： Friction stir additive manufacturing Chemical composition Mechanical property Microstructure Numerical model