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The interaction effects of rocker angle and apex location in rocker shoe design on foot biomechanics and Achilles tendon loading

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Medicine in Novel Technology and Devices 2022年第1期13卷 96-101页

作者： Tony Lin-Wei Chen Duo Wai-chi Wong Yinghu Peng Yan Wang Ivy Kwan-Kei Wong Tsz-Kit lam Wing-Kai lam Ming Zhang Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong The Hong Kong Polytechnic University Shenzhen Research Institute ShenzhenChina Li Ning Sports Science Research Center Li Ning(China)Sports Goods Co.LtdBeijingChina Department of Kinesiology Shenyang Sports InstituteShenyangChina

The influences of rocker shoes on foot biomechanics were controversial because the interaction between two design factors—rocker angle and apex location,was usually *** study investigated the interaction effects of rocker angle and apex location on plantar foot pressure,metatarsophalangeal/ankle angle,and Achilles tendon force during *** participants performed walking trials under six rocker shoe conditions:2 rocker angles(mild and severe)×3 apex locations(distal,standard,and proximal),wherein the plantar foot pressure was measured and the movement data were processed by musculoskeletal modeling to report joint angle and Achilles tendon force.A two-way ANOVA repeated measures was used for *** interaction effects were reported in examinations of forefoot pressure,midfoot pressure,and metatarsophalangeal *** standard apex significantly reduced peak forefoot and midfoot pressures(p=0.008–0.034,Hedges'g=0.75–0.84),which was further decreased by a severe rocker angle(p=0.006,Hedges'g=0.51–0.81).Moving the apex proximally reduced Achilles tendon forces(pchilles tendon *** concluded that apex location was likely the dominant design factor of the rocker sole in influencing foot biomechanics,yet its interactions with rocker angle should be *** configuration of the two features could be varied to possess different therapeutic merits and adapt to specific application purposes.

关键词： Gait Rocker shoe Biomechanics Computer simulation Plantar pressure

Peptidic defective interfering gene nanoparticles against Omicron,Delta SARS-CoV-2 variants and influenza A virus in vivo

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3484-3493页

作者： Hanjun Zhao Chuyuan Zhang Hoiyan lam Xinjie Meng Zheng Peng Man Lung Yeung Jasper Fuk-Woo Chan Kelvin Kai-Wang To Kwok-Yung Yuen State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong Special Administrative RegionChina Department of Infectious Disease and Microbiology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdong ProvinceChina Carol Yu Centre for Infection The University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina

Defective interfering genes(DIGs)are short viral genomes and interfere with wild-type viral ***,we demonstrate that the new designed SARS-CoV-2 DIG(CD3600)can significantly inhibit the replication of SARS-CoV-2 including Alpha,Delta,Kappa and Omicron variants in human HK-2 cells and influenza DIG(PAD4)can significantly inhibit influenza virus replication in human A549 *** dose of influenza DIGs prophylactically protects 90%mice from lethal challenge of A(H1N1)pdm09 virus and CD3600 inhibits SARS-CoV-2 replication in hamster lungs when DIGs are administrated to lungs one day before viral *** further investigate the gene delivery vector in the respiratory tract,a peptidic TAT2-P1&LAH4,which can package genes to form small spherical nanoparticles with high endosomal escape ability,is demonstrated to dramatically increase gene expression in the lung ***2-P1&LAH4,with the dual-functional TAT2-P1(gene-delivery and antiviral),can deliver CD3600 to significantly inhibit the replication of Delta and Omicron SARS-CoV-2 in hamster *** peptide-based nanoparticle system can effectively transfect genes in lungs and deliver DIGs to inhibit SARS-CoV-2 variants and influenza virus in vivo,which provides the new insight into the drug delivery system for gene therapy against respiratory viruses.

关键词： influenza vivo Delta

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基于HBP编码结构的MVC快速算法

电子与信息学报 2011年第8期33卷 1955-1962页

作者：邓智玭贾克斌陈锐霖伏长虹萧允治北京工业大学电子信息与控制工程学院北京100124 香港理工大学电子资讯工程系

针对MVC系统中运算量最大的矢量预测部分——单向搜索和双向搜索,该文提出一种快速算法。根据多视点视频的序列相关性,采用立体-运动约束模型在运动域和视差域进行联合迭代单向搜索,设计可信度因子来自适应地调整修正搜索窗口,同步搜索... 详细信息

针对MVC系统中运算量最大的矢量预测部分——单向搜索和双向搜索,该文提出一种快速算法。根据多视点视频的序列相关性,采用立体-运动约束模型在运动域和视差域进行联合迭代单向搜索,设计可信度因子来自适应地调整修正搜索窗口,同步搜索得到运动和视差矢量。此外,通过分析双向预测宏块的特性,提出一种双向搜索提前中止算法。实验结果证明该文算法的有效性,能在保持编码质量的同时极大减少算法复杂度。

关键词：多视点视频编码 JMVC 视差估计双向预测

Effects of resistance training on cardiovascular health in non-obese active adolescents

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World Journal of Clinical Pediatrics 2016年第3期5卷 293-300页

作者： Clare Chung-Wah Yu Alison Mary McManus Hung-Kwan So Ping Chook Chun-Ting Au Albert Martin Li Jack Tat-chi Kam Raymond chi-Hung So Christopher Wai-Kei lam Iris Hiu-Shuen Chan Rita Yn-Tz Sung Department of Health and Physical Education the Education University of Hong Kong Institute of Human Performance the University of Hong Kong Centre for Heart Lung and Vascular HealthSchool of Health and Exercise SciencesUniversity of British Columbia Department of Paediatrics the Chinese University of Hong Kong Hong Kong Sports Institute Faculty of Health Sciences and University Hospital Macao University of Science and Technology Department of Chemical Pathology Prince of Wales Hospitalthe Chinese University of Hong Kong

AIM:To determine the benefits of a 10-wk resistance training programme on cardiovascular health in nonobese and active ***:This is a pragmatic randomised controlled *** study was carried out in a Hong Kong Government secondary ***-eight lean and active boys and girls were randomised to either the resistance training group or the control *** in the resistance training group received in-school 10-wk supervised resistance training twice per week,with each session lasting 70 *** outcome measures taken before and after training included brachial endothelial dependent flow-mediated dilation,body composition,fasting serum lipids,fasting glucose and insulin,high sensitive C-reactive protein,24-h ambulatory blood pressure and aerobic ***:The only training related change was in endothelial dependent flow-mediated dilation which increased from 8.5%to 9.8%.A main effect of time and an interaction(Pchildren.

关键词： Strength training children Cardiometabolic risk factors Endothelial function School-based training program High sensitive C-reactive protein 24-h ambulatory blood pressure Aerobic fitness

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人尿中柯铁宁含量的气相色谱-质谱测定法

中华劳动卫生职业病杂志 2006年第1期24卷 39-41页

作者：曹民张奕伦江朝强林大庆郑家强张维森广州市职业病防治院职业卫生检测中心 510620 香港大学医学院社会医学系英国伯明翰大学公共卫生与流行病学研究所

目的建立利用气相色谱-质谱(GC-MS)联用技术准确测定人尿中柯铁宁含量的方法。方法用β-葡萄糖苷酸酶水解共轭存在的三羟基柯铁宁(THOC)及柯铁宁(COT),以n-丁基乙酸及二氯甲烷混合液(2:1)萃取尿中的柯铁宁成分。应用HP-5MS交联石英毛细... 详细信息

目的建立利用气相色谱-质谱(GC-MS)联用技术准确测定人尿中柯铁宁含量的方法。方法用β-葡萄糖苷酸酶水解共轭存在的三羟基柯铁宁(THOC)及柯铁宁(COT),以n-丁基乙酸及二氯甲烷混合液(2:1)萃取尿中的柯铁宁成分。应用HP-5MS交联石英毛细管柱进行分离,用GCMS 测定其含量。结果该方法检出限为0．02μg/L,回收率>90％,平均相对标准偏差为4．30％。结论 GC-MS法可以准确测定人尿中柯铁宁含量,满足痕量分析的要求,并具有背景值少、快速、准确可靠等特点,已应用于广州生物库老年人队列大样品量的人尿中柯铁宁的研究。

关键词：环境污染,吸烟柯铁宁气-质量光谱测定法

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广州工厂职工健康自评和吸烟者戒烟意愿研究

中华劳动卫生职业病杂志 2008年第12期26卷 733-737页

作者：张维森江朝强林大庆孔聪肖吕武郑家强广州市职业病防治院职业卫生评价检测中心 510620 广州市职业病防治院分子流行病学研究中心 510620 广州市职业病防治院职业健康监护中心 510620 香港大学公共卫生学院社会医学系英国伯明翰大学公共卫生与流行病学系

目的调查工厂职工的健康状况和戒烟意愿，为开展控烟工作提供科学依据。方法采用横断面调查方法对668名广州不同工作类型工厂职工的吸烟行为、自评健康状况和戒烟意愿进行问卷调查，吸烟者尼古丁依赖性用FTND问卷进行调查，自评健康和... 详细信息

目的调查工厂职工的健康状况和戒烟意愿，为开展控烟工作提供科学依据。方法采用横断面调查方法对668名广州不同工作类型工厂职工的吸烟行为、自评健康状况和戒烟意愿进行问卷调查，吸烟者尼古丁依赖性用FTND问卷进行调查，自评健康和戒烟难度与某些因素的关系用logistic回归模型分析。结果（1）男性工人吸烟者348人，吸烟率为65．0％；女性工人吸烟者4人，吸烟率为3．0％。与朋友或其他吸烟者在一起、在家或休闲时以及饭后吸烟最常见，占男性经常吸烟者的90．6％。（2）男性经常吸烟和戒烟者自评健康状况比普通同龄人差者占10．7％，高于偶吸和从不吸烟者（5．1％），调整年龄和文化程度后，OR值为2．22（95％CI 1．08～4．59）。（3）男性经常吸烟者想过戒烟的占50．5％，其中自评健康状况比同龄人差、差不多和好者分别占73．3％、50．0％和37．2％，差异有统计学意义（P=-0．009）。自评戒烟难度≤30分、31～60分和60分以上的分别占26．9％、24．9％和48．2％，自评戒烟难度（≤30分和〉30分）比数比随周围同事吸烟人数和尼古丁依赖性的增加而增大。结论男性职工经常吸烟或戒烟者自评健康较偶吸或从不吸烟者差，自评健康较差者多数想过戒烟，戒烟难度主要与周围同事吸烟和尼古丁依赖有关。

关键词：吸烟烟草对健康的危害戒烟

The role of 5 -lipoxygenase in the tumorigenesis promoted by cigarette smoke

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The role of 5 -lipoxygenase in the tumorigenesis promoted by...

An Innovative Antiseptic, Antiperspirant and Deodourant Diaper for the Older and Frail Older People Suffering from Urinary Incontinence

第六届全国药理学教学学术会议

作者： YE Yi - Ni, Liu Edgar Shiu - lam, SHIN Vivian - Yvonne, CHO chi - Hin Department of Pharmacology, The University of Hong Kong, Hong Kong, china

AIM: 5-lipoxygenase (5-LOX) is an enzyme that converts arachidonic acid to 5-s-HETE, and several studies have suggested a link between 5 - s - HETE formation and carcinogenesis in various organ. Our previous study shows that passive cigarettesmoking promoted inflammation - associated adenoma formation in colon. The purpose of the present study was to investigate the possible involvement of 5 - LOX in the tumorigenesis enhanced by cigarette smoke. METHODS: In vivo study, male balb/c mice were allocated into 4 groups: control, cigarette smoke (CS), dextran sulfate sodium (DSS)

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来源： cnki会议评论

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Advances in Aging Research 2017年第2期6卷 29-37页

作者： Elaine Wat Alex W. L. Lin Cyrus Mak Ivan lam Clara Bik-San Lau Frency Sau-Fun Ng Patrick chi-Leung Hui Ping-Chung Leung Institute of chinese Medicine The Chinese University of Hong Kong Hong Kong Partner State Key Laboratory of Phytochemistry and Plant Resources in West china The Chinese University of Hong Kong Hong Kong Institute of Textiles and Clothing The Hong Kong Polytechnic University Hong Kong Neighbourhood Advice-Action Council Harmony Manor Hong Kong

Background: Urinary Incontinence is a common symptom among the older and frail older people. Apart from affecting the quality of life and skin complications, the demand on assistance could be too high for any sufferer. While conservative means of treatment do not work, special incontinence apparel could be a good compromise. Objective: To create an absorbent, antiseptic, antiperspirant and deodourant diaper for the older and dependent people suffering from urinary incontinence. Material and Methods: Antiperspirant and antiseptic medicinal materials have been reported in Traditional chinese Medicine and two herbs were screened out to provide the required effects. A combination of Fraxini Cortex, Calamine and Zinc oxide made in powder forms was impregnated into a pocket of the diaper. Laboratory tests were performed to confirm the antiseptic, antiperspirant and deodourant effects of the materials. A self-control clinical trial on the diaper was organized in an elderly home. Results: Antibacterial effects against Staphylococcus, E. coli and Candida were proven. Antiperspirant effects were confirmed using acetylcholinesterase inhibitor testings. Volunteers using the Sudoscan machine further demonstrated the weak antiperspirant effects of the herbs. A pilot study on 31 dependent diaper users gave positive feedbacks of more comfort, less leakage, odour and better skin conditions. The overall satisfaction reached 79%. Conclusion: A special diaper with antiseptic, antiperspirant and deodourant effects could be created with inexpensive herbal powder impregnated and could be recommended to the older and frail older people with urinary incontinence.

关键词： Urinary Incontinence Older And Frail Older Toilet Assistance Rehabilitation Adult Diaper

Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma

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Cancer Communications 2023年第8期43卷 951-955页

作者： Hoi-Hin Kwok Huiyu Li Jiashuang Yang Junyang Deng Nerissa Chui-Mei Lee Timmy Wing-Kuk Au Alva Ko-Yung Sit Michael Kuan-Yew Hsin Stephanie Kwai-Yee Ma LydiaWai-Ting Cheung Luc Girard Junya Fujimoto Ignacio Ivan Wistuba Boning Gao John Dorrance Minna David chi-Leung lam Department of Medicine Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong SARP.R.China Nancy B.and Jake L.Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical CenterDallasTexasUSA Cardiothoracic Surgical Department Queen Mary HospitalHong Kong SARP.R.China School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARP.R.China Department of Translational Molecular Pathology Division of Pathology/Lab MedicineUniversity of Texas MD Anderson Cancer CenterHoustonTexasUSA

Dear Editor,Non-small cell lung carcinoma(NSCLC)accounts for more than 85%of all lung cancers[1].Lung adenocarcinomas(ADCs)arising from never-smokers have been frequently found to be associated with oncogenic driver mutations,including anaplastic lymphoma kinase(ALK)*** microtubule-associated protein-like 4(EML4)is the most common fusion partner of the ALK gene[2].Tyrosine kinase inhibitors(TKIs)are currently the first-line treatment for advanced EML4-ALKrearranged lung ADC.

关键词： lung adenocarcinoma Lung