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铁路枢纽区域调机集中调度模式研究

综合运输 2024年第7期46卷 82-88,124页

作者：党湉湉宋瑞迟居尚北京交通大学综合交通运输大数据应用技术交通运输行业重点实验室北京100044

为减少调机及机车组人员,提高运用效率,均衡作业量,在“中心站”模式基础上,提出铁路枢纽区域调机集中调度模式,将调机集中到技术站,由技术站领导指挥调车作业。为最小化调机数及总走行距离,在列车运行图基础上考虑列车运行时间范围及... 详细信息

为减少调机及机车组人员,提高运用效率,均衡作业量,在“中心站”模式基础上,提出铁路枢纽区域调机集中调度模式,将调机集中到技术站,由技术站领导指挥调车作业。为最小化调机数及总走行距离,在列车运行图基础上考虑列车运行时间范围及车站作业时间窗约束,构建多技术站下的区域调机集中作业模型。基于自适应大邻域搜索(Adaptive Large Neighborhood Search,ALNS)及随机邻域下降(Random Variable Neighborhood Descent,RVND),设计两阶段启发式算法求解。对国内某铁路枢纽展开案例分析,结果证明:区域调机集中作业模式技术经济效果显著,可在完成作业的前提下,削减65%的调机及约17%的总走行距离,大幅度缩减调机及机车组人员成本,优化枢纽资源配置,改进调车作业方案,为优化调车作业质量提供参考。

关键词：铁路运输区域调机集中调度模式自适应大邻域搜索调车作业铁路枢纽

Tungsten-based nanocatalysts with different structures for visible light responsive photocatalytic degradation of bisphenol A

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Journal of Environmental Sciences 2024年第5期139卷 569-588页

作者： Hai Bang Truong Thi Thu Loan Doan Nguyen Tien Hoang Nguyen van Tam Minh Kim Nguyen Le Gia Trung Jin Seog Gwag Nguyen Tien Tran Optical Materials Research Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Technology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam The University of Da Nang University of Science and Technology54 Nguyen Luong BangDa NangViet Nam The University of Da Nang University of Science and Education459 Ton Duc Thang St.Lien ChieuDa Nang 550000Viet Nam Institute of Veterinary Science and Technology 31ha zoneTrau QuyGia LamHa Noi 12400Viet Nam Department of Physics Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea Center for Advanced Chemistry Institute of Research and DevelopmentDuy Tan University03 Quang TrungDa Nang 550000Viet Nam Faculty of Natural Sciences Duy Tan University03 Quang TrungDa Nang 550000Viet Nam

Environmental pollution,such as water contamination,is a critical issue that must be absolutely ***,three different morphologies of tungsten-based photocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3)/WS_(2)nanorods)are made using a simple hydrothermal method by changing the solvents(H_(2)O,DMF,aqueous HCl solution).The as-prepared nanocatalysts have excellent thermal stability,large porosity,and high *** results show all materials have good photocatalytic activity in aqueous media,with WO_(3)/WS_(2)nanorods(NRs)having the best activity in the photodegradation of bisphenol A(BPA)under visible-light *** may originate from increased migration of charge carriers and effective prevention of electron–hole recombination in WO_(3)/WS_(2)NRs,whereby this photocatalyst is able to generate more reactive·OH and·O_(2)^(–)species,leading to greater photocatalytic *** 99.6% of BPA is photodegraded within 60 min when using 1.5 g/L WO_(3)/WS_(2)NRs and 5.0 mg/L BPA at pH ***,the optimal conditions(pH,catalyst dosage,initial BPA concentration)for WO_(3)/WS_(2)NRs are also elaborately *** rod-like heterostructures are expressed as potential catalysts with excellent photostability,efficient reusability,and highly active effectivity in different types of *** particular,the removal efficiency of BPA by WO_(3)/WS_(2)NRs reduces by only 1.5% after five recycling runs and even reaches 89.1%in contaminated lake *** study provides promising insights for the nearly complete removal of BPA from wastewater or different water resources,which is advantageous to various applications in environmental remediation.

关键词： Photodegradation Bisphenol A Tungsten-based nanocatalyst Structure Nanorod

SPP1 and the risk score model to improve the survival prediction of patients with hepatocellular carcinoma based on multiple algorithms and back propagation neural networks

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BIOCELL 2023年第3期47卷 581-592页

作者： WENLI ZENG FENG LING KAINUO dang QINGJIA chi Nursing Department Renmin Hospital of Wuhan UniversityWuhan430060China Oncology Department Renmin Hospital of Wuhan UniversityWuhan430060China Department of Engineering Structure and Mechanics School of ScienceWuhan University of TechnologyWuhan430070China

Hepatocellular carcinoma(HCC)is associated with poor prognosis and fluctuations in immune *** studies have found that secreted phosphoprotein 1(SPP1)is involved in HCC progression,its independent prognostic value and immune-mediated role remain *** The Cancer Genome Atlas and Gene Expression Omnibus data,we found that low expression of SPP1 is significantly associated with improved survival of HCC patients and that SPP1 expression is correlated with clinical *** and multivariate Cox regression confirmed that SPP1 is an independent prognostic factor of ***,we found that T cell CD4 memory-activated monocytes,M0 macrophages,and resting mast cells showed significant differences in penetration in the high and low SPP1 expression ***,we used the Weighted Gene Co-Expression Network and Least Absolute Shrinkage Sum Selection Operator algorithms to construct a risk score for the 9-immune-related genes *** risk score showed a good ability to identify high and low-risk patients and improved survival *** also used multivariate Cox regression to validate that risk score was significantly correlated with SPP1 and overall ***,the Back-Propagation Neural Network confirmed the reliability of the results of multiple *** conclusion,the findings suggest that SPP1 is an independent marker of HCC survival and immunotherapy.

关键词： SPP1 Hepatocellular carcinoma BPNN Survival Immune cells

Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 1-12页

作者： Nguyen Hoa Binh Quang Vo Luan Nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba Dong Thuy Thi Thu Phan Yen Thi Hoang Creswell Jacob dang Thi Minh Ha Nguyen Lan Huu Shedrawy Jad L?nnroth Knut Nguyen Tuan Dinh van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;P<0.001). This resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

Effect of Freeze-Thaw and Urea in Solubility of GPC3-Csub Protein Expressed in Escherichia coli

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Journal of Biosciences and Medicines 2024年第4期12卷 288-297页

作者： Xuan-Truc Chu-Dao Kim-Tuyen Huynh-Dam dang-Thuc Ngo-Luong Quang-Luan Le Thanh-Thao Vo-Nguyen Department of Medical Biotechnology Biotechnology Center of Ho Chi Minh City Ho Chi Minh City Vietnam

Glypican-3 is a protein encoded by the Glypican-3 gene located on human X chromosome (Xq26), composed of two subunits, a 40 kDa N-terminal subunit, and a 30 kDa C-terminal subunit. Glypican-3 is a currently potential target molecule for liver cancer treatments because of its over-expression and growth effects on hepatocellular carcinoma (HCC). This study examined the expression and purification of a C-terminal subunit of Glypican-3 protein (GPC3-Csub) due to its application in both diagnosis and therapy for hepatocellular carcinoma. The gene encoding for GPC3-Csub was successfully cloned into plasmid pET28a fused with an affinity tag composed of six consecutive histidine residues (His-tag). Recombinant protein GPC3-Csub was expressed in Escherichia coli BL21 (DE3) in the condition of adding 3% ethanol with IPTG induction. GPC3-Csub was extracted using repeated freeze-thaw cycles with lysozyme, and inclusion bodies were solubilized by 8M Urea, SDS 10% in pH 12. His-tag fused GPC3-Csub proteins allowed it to be purified by affinity chromatography method using the Nickel-nitrilotriacetic acid (Ni-NTA) column. High expression of GPC3-Csub was confirmed by Coomassie staining and western-blot. GPC3-Csub could be isolated with a Ni-NTA column and have a purity of about 90%.

关键词： Glypican-3 Affinity Chromatography Inclusion Body Liver Cancer

Identification of zinc-binding peptides in ADAM17-inhibiting whey protein hydrolysates using IMAC-Zn^(2+) coupled with shotgun peptidomics

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Food Production, Processing and Nutrition 2021年第1期3卷 70-79页

作者： M.chinonye Udechukwu chi dang chibuike C.Udenigwe Department of Plant Foodand Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNova Scotia B2N 5E3Canada Department of Chemistry and Biomolecular Sciences Faculty of ScienceUniversity of OttawaOttawaOntario K1N 6N5Canada School of Nutrition Sciences Faculty of Health SciencesUniversity of OttawaOttawaOntario K1H 8M5Canada

Food components possessing zinc ligands can be used to inhibit zinc-dependent *** this study,zinc-binding peptides were derived from whey protein hydrolysates,and their ultrafiltration(>1 and<1 kDa)fractions,produced with Esperase(WPH-Esp),Everlase and *** metal affinity chromatography(IMAC-Zn^(2+))increased the zinc-binding capacity of the peptide fraction(83%)when compared to WPH-Esp(23%)and its<1 kDa fraction(40%).The increased zinc-binding capacity of the sample increased the inhibitory activity against the zinc-dependent“a disintegrin and metalloproteinase 17”.LC-MS/MS analysis using a shotgun peptidomics approach resulted in the identification of 24 peptides originating from bovineβ-lactoglobulin,α-lactalbumin,serum albumin,β-casein,κ-casein,osteopontin-k,and folate receptor-αin the *** identified peptides contained different combinations of the strong zinc-binding group of residues,His+Cys,Asp+Glu and Phe+Tyr,although Cys residues were absent in the *** silico predictions showed that the IMAC-Zn^(2+)peptides were ***,the peptides possessed poor drug-like and pharmacokinetic properties;this was possibly due to their long chain lengths(5–19 residues).Taken together,this work provided an array of food peptide-based zinc ligands for further investigation of structure-function relationships and development of nutraceuticals against inflammatory and other zinc-related diseases.

关键词： Zinc Zinc ligands Food protein Bioactive peptides Immobilized metal affinity chromatography Ultrafiltration ADAM17 Peptidomics Bioinformatics

Blood glucose-lowering activity of protocatechuic acid is mediated by inhibiting a-glucosidase

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Food Science and Human Wellness 2024年第3期13卷 1212-1219页

作者： Huafang Ding Shouhe Huang Chui Yiu Chook Erika Kwek chi Yan Kaying Ma Jianhui Liu Hanyue Zhu Zhenyu Chen Food&Nutritional Sciences Programme School of Life SciencesThe Chinese University of Hong KongHong Kong 999077China

α-Glucosidase inhibitors are effective in controlling postprandial hyperglycemia,which play crucial roles in the management of type 2 *** acid(PCA)is one of phenolic acids existing not only in various plant foods but also as a major microbial metabolite of dietary anthocyanins in the large *** present study investigated the inhibitory mechanism of PCA on a-glucosidase in vitro and examined its effect on postprandial blood glucose levels in *** from in vitro experiments demonstrated that PCA was a mix-type inhibitor of *** by hydrogen bonds and van der Waals interactions,PCA reversibly bound withα-glucosidase to form a stable a-glucosidase-PCA complex in a spontaneous *** computational simulation found that PCA could insert into the active cavity of a-glucosidase and establish hydrogen bonds with catalytic amino acid *** binding aroused the steric hindrance for substrates to enter active sites and caused the structural changes of interacted catalytic amino acid *** also exhibited postprandial hypoglycemic capacity in diabetic *** study may provide the theoretical basis for the application of PCA as an active ingredient of functional foods in dietary management of diabetes.

关键词： Protocatechuic acid α-Glucosidase Postprandial hyperglycemia Inhibition mechanism

基于子阵正交的MIMO雷达LFM信号部分相关波形设计方法

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火控雷达技术 2024年第3期53卷 39-43页

作者：池政刚党腾飞王伟于贵龙西安电子工程研究所西安710100

MIMO雷达是雷达体制的一种扩展,具有多个发射和接收天线,各发射天线可以发射不同信号,这使得MIMO雷达具有波形分集的优势。MIMO雷达的波形分集优势,使得雷达系统具有更高的发射自由度,可以针对不同的工作场景和需求,灵活地设计发射能量... 详细信息

MIMO雷达是雷达体制的一种扩展,具有多个发射和接收天线,各发射天线可以发射不同信号,这使得MIMO雷达具有波形分集的优势。MIMO雷达的波形分集优势,使得雷达系统具有更高的发射自由度,可以针对不同的工作场景和需求,灵活地设计发射能量覆盖图,也可以根据环境信息及时调整发射波形。因此,MIMO雷达波形优化设计技术是一个重要的研究领域。根据信号形式的不同可以分为相位编码信号和LFM信号两大类,由于相位编码信号的多普勒容忍性较差,LFM信号更适合用于高速目标的跟踪与检测。其中基于LFM信号的部分相关波形具有更高的能量利用率,但传统方法设计得到部分相关波形的脉冲综合结果的主瓣相对于信号带宽决定的脉冲宽度有较大展宽,在目标检测时会严重影响目标的距离分辨性能。针对这一问题,本文提出了一种基于子阵正交的LFM信号部分相关波形设计方法。该方法通过对信号带宽和初相的联合优化,提高了信号的自由度,设计得到波形的脉冲综合结果的主瓣基本没有展宽,且旁瓣峰值较低,有效地提高了雷达对于目标的检测能力。

关键词： MIMO雷达部分相关波形子阵正交波形设计

加减归脾汤治疗甲基丙二酸尿症认知障碍心脾两虚患儿的临床疗效观察

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中华中医药杂志 2024年第8期39卷 4478-4482页

作者：陆相朋彭琰琰郑宏党伟利张弛冯斌冯刚马丙祥河北中医药大学石家庄050091 郑州市中心医院郑州450007 河南中医药大学第一附属医院郑州450000

目的:观察加减归脾汤治疗甲基丙二酸尿症(MMA)心脾两虚证认知障碍患儿的临床疗效。方法:采用随机、双盲、安慰剂对照的观察试验设计,将65例MMA心脾两虚证认知障碍患儿随机分为试验组(32例)和对照组(33例)。两组患儿均给予西医基础治疗... 详细信息

目的:观察加减归脾汤治疗甲基丙二酸尿症(MMA)心脾两虚证认知障碍患儿的临床疗效。方法:采用随机、双盲、安慰剂对照的观察试验设计,将65例MMA心脾两虚证认知障碍患儿随机分为试验组(32例)和对照组(33例)。两组患儿均给予西医基础治疗及认知功能训练,在此基础上试验组给予加减归脾汤颗粒治疗,对照组给予模拟剂颗粒治疗,疗程共12周。在治疗前后采用Griffiths神经认知发育量表(GDS-C)及婴儿-初中生社会生活能力量表(S-M)对患儿认知功能进行评估比较。结果:治疗后两组患儿GDS-C量表总发育商及S-M量表标准分评分均有提升,其中试验组患儿GDS-C量表各分领域包括个人社会、听力与言语、手眼协调、操作表现评分及总发育商高于对照组(P<0.05,P<0.01);试验组S-M量表评分在独立生活、作业操作、交往、集体管理、自我管理评分及标准分高于对照组(P<0.05,P<0.01)。治疗前后未发现明显不良反应。结论:加减归脾汤可有效地改善MMA心脾两虚证患儿的认知功能,提高患儿生活质量。

关键词：甲基丙二酸尿症儿童认知障碍归脾汤临床研究