检索结果-南通市图书馆

Pharmacology & Pharmacy 2023年第3期14卷 72-83页

作者： cheyenne m.ffett Katherine J. Kost Austen Thompson Joseph V. Pergolizzi Jr. Tally m. Largent-milnes Robert B. Raffa Todd Vanderah Department of Pharmacology and Comprehensive Pain and Addiction Center University of Arizona Tucson AZ USA NEmA Inc. Naples FL USA Neumentum Inc. Summit NJ USA Enalare Therapeutics Naples FL USA School of Pharmacy Temple University Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA

Benzodiazepines and other benzodiazepine receptor agonists, such as the “Z” drugs, are widely prescribed medications mainly used for treating anxiety and seizures, and for inducing sedation. Unfortunately, despite their popularity, benzodiazepine prescribing often exceeds recommendations and the consequences can be severe. On September 23, 2020, the United States FDA announced a new requirement for a Boxed Warning for benzodiazepines prescribing. Along with this announcement, the FDA stated that relevant information regarding the initiation, continuation, and discontinuation of benzodiazepines is lacking. Here, we describe initial pilot studies intended to investigate the questions 1) can animal models be developed that demonstrate benzodiazepine physical dependence and/or withdrawal symptoms, and 2) determine whether translocator protein (TSPO) plays a role in benzodiazepine dependence and/or withdrawal processes. The former was demonstrated, methodological limitations prevented the latter.

关键词： Benzodiazepine TSPO Rats In Vivo Tests Western-Blot Analysis

用内生长法测定的生物能源作物根生产的长期变化

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2021年第5期14卷 757-770页

作者： cheyenne Lei michael Abraha Jiquan Chen Yahn-Jauh Su Center for Global Change and Earth Observations Michigan State UniversityEast LansingMI 48823USA Department of Geography Environment and Spatial SciencesMichigan State UniversityEast LansingMI 48824USA Great Lakes Bioenergy Research Center Michigan State UniversityEast LansingMI 48824USA W.K.Kellogg Biological Station Michigan State UniversityHickory CornersMI 49060USA

对于土地用途转为种植生物燃料作物后的根系产量,还很少进行过长期的测定。为了评价此前的土地用途对地下生物量积累的影响,我们在“美国休耕保护项目”(Conservation Reserve Program,CPR)下生长了22年的草地(CRP草地)和使用期超过50... 详细信息

对于土地用途转为种植生物燃料作物后的根系产量,还很少进行过长期的测定。为了评价此前的土地用途对地下生物量积累的影响,我们在“美国休耕保护项目”(Conservation Reserve Program,CPR)下生长了22年的草地(CRP草地)和使用期超过50年的农业用地(AGR农地)转为种植生物燃料作物玉米(Zea mays,Corn,C)、柳枝稷(Panicum virgatum,Switchgrass,Sw)和恢复性草原植被(Prairie,Pr)。我们将一块CPR草地维持为对照。我们的假设是土地利用历史和作物类型对根系密度有显著的影响;其中,原CRP草地上种植的多年生作物具有较高的根系生产力,而在原农业用地上种植的玉米的根系生产力最低。通过内生长土芯法对内生长根系生物量进行了原位测定,同时对地上净初级生产力(ANPP)进行了测量。包括气温、生长季长度和降水量在内的辅助测量则被用来考查它们对根系生产量的影响。根系生产力在未转变的CRP草地最高(1716 g m?2 yr?1),而在玉米田中最低(526 g m?2 yr?1)。由CRP草地和AGR农田转变而来的多年生作物种植地在第一年都具有较低的根系生物量和ANPP,但柳枝稷在2011年达到峰值,恢复后的草原植被也在一年后达到峰值。恢复后的草原生态系统稳定性较高(AGR-Pr:4.3±0.11;CRP-Pr:4.1±0.10),而仅种植单一作物的生态系统稳定性都较低。根系生产量与ANPP呈正相关性(R2=0.40)。总体而言,对生物燃料作物大规模种植过程中的根系生物量积累应予以重视,因为这是固碳的一种主要来源。

关键词：生物燃料作物生态系统玉米内生长土芯法根系生物量恢复后的草原柳枝稷

Evaluation of a chitosan-polyethylene glycol paste as a local antibiotic delivery device

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界骨科杂志：英文版 2017年第2期8卷 130-141页

作者： cheyenne S Rhodes Christopher m Alexander Joel m Berretta Harry S Courtney Karen E Beenken mark S Smeltzer Joel D Bumgardner Warren O Haggard J Amber Jennings Department of Biomedical Engineering University of Memphis Department of medicine University of Tennessee Health Science CenterVeterans Affairs Medical Center Department of microbiology and Immunology University of Arkansas for Medical Sciences

AIm To investigate the efficacy of a chitosan/polyethylene glycol blended paste as a local antibiotic delivery device, particularly in musculoskeletal *** Acidic(A) chitosan sponges and neutralized(N) chitosan/polyethylene glycol(PEG) blended sponges were combined in ratios of 3A:2N, 1A:1N, and 2A:3N; then hydrated with phosphate buffered saline to form a chitosan/PEG paste(CPP). Both in vitro and in vivo studies were conducted to determine the potential CPP has as a local antibiotic delivery device. In vitro biocompatibility was assessed by the cytotoxic response of fibroblast cells exposed to the experimental groups. Degradation rate was measured as the change in dry mass due to lysozyme based degradation over a 10-d period. The antibiotic elution profiles and eluate activity of CPP were evaluated over a 72-h period. To assess the in vivo antimicrobial efficacy of the CPP, antibiotic-loaded paste samples were exposed to subcutaneously implanted murine catheters inoculated with Staphylococcus aureus. material properties of the experimental paste groups were evaluated by testing the ejection force from a syringe, as well as the adhesion to representative musculoskeletal tissue *** The highly acidic CPP group, 3A:2N, displayed significantly lower cell viability than the control sponge group. The equally distributed group, 1A:1N, and the highly neutral group, 2A:3N, displayed similar cell viability to the control sponge group and are deemed biocompatible. The degradation studies revealed CPP is more readily degradable than the chitosan sponge control group. The antibiotic activity studies indicated the CPP groups released antibiotics at a constant rate and remained above the minimum inhibitory concentrations of the respective test bacteria for a longer time period than the control chitosan sponges, as well as displaying a minimized burst release. The in vivo functional model resulted in complete bacterial infection prevention in all catheters tr

关键词： Chitosan Polyethylene glycol Paste Local antibiotic delivery Biofilm Bacterial infection

The FDA mandate to Reassess Benzodiazepines: Alprazolam Induces a Positive Conditioned Place-Preference in male Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosciences and medicines 2021年第3期9卷 1-8页

作者： cheyenne m.ffett Katherine J. Kost Austen Thompson michael H. Ossipov Joseph V. Pergolizzi Junior Sumiyo Umeda-Raffa Robert B. Raffa Tally m. Largent-milnes Todd Vanderah Department of Pharmacology and Comprehensive Pain and Addiction Center University of Arizona Tucson AZ USA Department of Pharmacology and Comprehensive Pain and Addiction Center University of Arizona Tucson AZ USA Neumentum Inc. Morristown NJ USA Enalare Therapeutics Naples FL USA Pharmaceutical Sciences (Form. Faculty) Hokkaido University of Science Hokkaido Japan Temple University School of Pharmacy (Prof Em.) Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA

On September 23, 2020, in order “To address the serious risks of abuse, addiction, physical dependence, and withdrawal reactions, the U.S. Food and Drug Administration (FDA) is requiring the Boxed Warning be updated for all benzodiazepine medicines”. With this announcement, the FDA proclaimed that much more needs to be known about the initiation, continuation, and discontinuation of these widely-used drugs. Unfortunately, relevant information is lacking, since for many years, there has been a notable sparsity in the funding and conduct of basic and clinical research on these drugs. In order to begin to fill the void, it is valuable to (re)examine animal models. We here describe a model of conditioned place-preference (CPP) for rats and for the first time, to our knowledge, show that the representative benzodiazepine alprazolam induces positive place-preference in male rats.

关键词： Benzodiazepines Conditioned Place-Preference Alprazolam Reinforcement Affective State

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2021年第5期12卷 100-108页

作者： cheyenne m.ffett Katherine J. Kost Austen Thompson michael H. Ossipov Joseph V. Pergolizzi Jr. Sumiyo Umeda-Raffa Robert B. Raffa Tally m. Largent-milnes Todd Vanderah Department of Pharmacology and Comprehensive Pain and Addiction Center University of Arizona Tucson AZ USA NEmA Inc. Naples FL USA Neumentum Inc. Morristown NJ USA Enalare Therapeutics Naples FL USA Pharmaceutical Sciences (Form. Faculty) Hokkaido University of Science Hokkaido Japan School of Pharmacy (Prof Em.) Temple University Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA

The benzodiazepines were introduced into medical practice during the 1960s. At the time, they represented a safer alternative to extant therapies used for anxiety, such as the barbiturates. However, on September 23, 2020, the United States FDA indicated that more is needed to be known about the initiation, continuation, and discontinuation of the use of these widely-used drugs with publication of the announcement “to address the serious risks of abuse, addiction, physical dependence, and withdrawal reactions, the U.S. Food and Drug Administration (FDA) is requiring the Boxed Warning be updated for all benzodiazepine medicines.” Because for many years, there has been a sparsity of research on these drugs, relevant information is unfortunately lacking at this critical time. It is therefore valuable to (re)establish animal models and begin to collect relevant data. We here use a model of conditioned place mal;font-family:Verdan

关键词： Benzodiazepine Conditioned Placepreference Alprazolam Female Rats

Relationships of milk production of beef cows to postweaning gain of their calves

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationships of milk production of beef cows to postweaning...

ⅩⅪ International Grassland Congress and the Ⅷ International Rangeland Congress

作者： m.A.Brown USDA-ARS Grazinglands Research Laboratory7207 W.CheyenneEl RenoOK 73036USA

＜正＞Introduction In the U.S.,live beef production is segmented into cow-calf,stocker/backgrounder,and feedlot *** in beef production systems depends on proper relationships between each of these *** milk yield accounts for over 50%of the variation in calf weaning weight,cow-calf producers depend on higher milk production in their cow herds to produce calves that are heavier at ***,higher levels of milk yield in the cow and the corresponding greater milk

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

伊森伯格管理学院商业创新中心

当代建筑 2020年第2期 122-127页

作者：无 Yu Inamoto Pauline Lavie-Luong Hung Kai Liao Alice Cladet Amina Blacksher Barbara Stallone cheyenne Vandevoorde Daniel Kidd Davide maggio Deborah Campbell Denys Kozak Derek Wong Domenic Schmid Douglass Alligood Elena Bresciani Emily mohr Fabian Lorenz Francesca Portesine Ibrahim Salman Jan Leenknegt Justyna mydlak Kai-Uwe Bergmann Ku Hun Chung Linda Halim Lucas Hong manon Otto maria Eugenia Dominguez mustafa Khan Nicolas Gustin Pei Pei Yang Peter Lee Seoyoung Shin Simon Lee Terrence Chew Tianqi Zhang Yixin Li BIG建筑事务所不详

位于马萨诸塞州艾摩斯特市的商业创新中心外墙为覆铜设计,极具现代艺术之感。该建筑为伊森伯格管理学院(全美排名前30的公立商学院)增加了7万***(约为0.6万m2)的超协作研究与社交空间。此次扩建和部分翻新使得伊森伯格管理学院的既有空... 详细信息

位于马萨诸塞州艾摩斯特市的商业创新中心外墙为覆铜设计,极具现代艺术之感。该建筑为伊森伯格管理学院(全美排名前30的公立商学院)增加了7万***(约为0.6万m2)的超协作研究与社交空间。此次扩建和部分翻新使得伊森伯格管理学院的既有空间几乎扩大了一倍,不仅能够满足该学院在过去十年间的快速发展需求,同时也为学院150多名教职人员和5000名本科、硕士及博士生引进了新的设施。

关键词：商业创新教职人员马萨诸塞州协作研究外墙社交空间伊森商学院