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Family Medicine and Community Health 2017年第3期5卷 215-222页

作者： Lap-Kin Chiang cheuk-wai kam Lorna V.Ng Family Medicine and General Outpatient Department Kwong Wah HospitalHong Kong

Objective:To estimate prevalence of OSA among at risk adult patients in primary care *** test the correlation and agreement between overnight pulse oximetry and polysomnography(PSG).To test the OSA screening performance of overnight pulse *** and Setting:Prospective case series involving adult Chinese patients with risk fac-tors for OSA at a primary care clinic of Hong ***:The prevalence and severity of OSA were established based on overnight pulse oximetry derived oxygen desaturation index(ODI).Screening performance of overnight pulse oxi-metry was compared directly with gold standard diagnostic test ***:Three hundred and five male and 229 female patients were ***(48.3%)was the top presenting *** hundred and twenty five patients(60.9%)were screened positive to have *** hundred and nine patients had performed PSG,the ODI_4 and apnoea-hypopnea index(AHI)had Pearson correlation coefficient 0.71(P<0.001).Bland and Alt-man plot showed good *** designation criteria of ODI_4≥5 events/hr,the sensitivity and specificity for OSA diagnosis are 94.4%and 78.9%***:The prevalence of OSA is 60.9% among adult primary care population who are at risk for *** pulse oximetry shows good performance as a screening tool for the screening of OSA.

关键词： Obstructive sleep apnea overnight pulse oximetry primary care

Characteristics of patients with erectile dysfunction in a family physicianled erectile dysfunction clinic:Retrospective case series

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Family Medicine and Community Health 2017年第1期5卷 85-91页

作者： Lap Kin Chiang cheuk-wai kam Kin-Chung Michael Yau Lorna Ng Family Medicine and General Outpatient Department Kwong Wah HospitalMongkokHong KongChina

Objectives:*** examine the characteristics of patients with erectile dysfunction in a family physician led erectile dysfunction clinic;*** review association of chronic disease spectrum and erectile dysfunction;*** review initial treatment pattern and ***:Retrospective case series ***:All consecutive patients seen in a regional hospital family physician led erectile dysfunction clinic from April 2014 to March *** outcome measures:*** severity of erectile dysfunction,based on International Index of Erectile Function(IIEF-5).*** associated chronic comorbidities of *** patterns and patient ***:One hundred and eighty three patients presented with erectile dysfunction(ED)with mean age 58.7(range 23 to 82)years old were seen during the study *** hundred and twenty seven patients(69.4%)had comorbidity of chronic diseases,including 50.8%had hypertension,38.8%had diabetes mellitus and 33.9%had *** mean body mass index was 25.2 kg/m2,the mean blood pressure was 137.3/79.5 mm Hg(1 mm Hg=0.133 kPa).According to IIEF-5 score,50.3%,30.6%and 18.6%had severe,moderate and mild erectile dysfunction *** average duration of ED before seeking medical help was 3.9 *** 5(PDE5)inhibitors were prescribed to 119 patients(65%),and 57.1%of them achieved good *** nine patients(15.8%)were referred to other specialty for further management,including 27.6%had contraindication for PDE5 ***:High proportion of erectile dysfunction patients had comorbitiy of chronic dis-eases.57.1%of those patients receiving PDE5 inhibitors showed good response.

关键词： Erectile dysfunction chronic diseases family physician

Epidemiological study of hypertensive retinopathy in the primary care setting: Retrospective cross-sectional review of retinal photographs

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Family Medicine and Community Health 2016年第4期4卷 13-21页

作者： Lap-kin Chiang Michael K.C.Yau cheuk-wai kam Lorna V.Ng Benny C.Y.Zee Family Medicine and General Outpatient Department Kwong Wah HospitalHospital AuthorityHong KongChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong KongChina

Objective:The objective is to estimate the prevalence and grading of hypertensive retinopa-thy in the primary care setting;examine the patient characteristics associated with hypertensive retinopathy;and examine the association of hypertensive retinopathy and other hypertension ***:This is a retrospective cross-sectional *** included adult hypertensive patients with available and gradable retinal ***:Two hundred fifty-six male hypertensive patients(34.3%)and 491 female hyper-tensive patients(65.7%)were *** average duration of hypertension was 7.2 years,and 49.8%and 41.2%of patients were taking one or two antihypertensive medications *** 1491 qualified retinal photographs(744 right eye and 747 left eye),24.9%,62.6%,and 12.5%were classified as showing normal,mild,and moderate hypertensive retinopathy *** three commonest retinal signs were generalized or focal arteriolar narrowing(650 cases,43.6%),hard exudates(168 cases,11.3%),and opacity(copper or silver wiring)of the arteriolar wall(166 cases,11.1%).Patients older than 61 years,having hypertension for more than 15 years,or taking three or more antihypertensive medications were significantly associated with hyperten-sive retinopathy(P<0.05).Conclusion:In a primary care clinic in Hong Kong,77.1%of hypertensive patients had hypertensive *** hypertensive retinopathy was the commonest target organ damage for hypertensive patients in a primary care clinic.

关键词： Hypertensive retinopathy retinal photograph primary care

Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu wai Nok Chan Fuda Xie Yigan Zhang Li Liang kam Tong Leung Kwok wai Lo Jun Yu Gary M.K.Tse Wei Kang Ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Department of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of Pediatrics The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease *** an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer *** transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential element is predominantly mediated by metallothioneins(MTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on *** also compile a summary of clinical trials involving zinc *** the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement

Does photobiomodulation require glucose to work effectively?

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Neural Regeneration Research 2024年第5期19卷 945-946页

作者： Jaimie Hoh kam John Mitrofanis UniversitéGrenoble Alpes Fonds de Dotation ClinatecGrenobleFrance University College London Institute of OphthalmologyUK

A main requirement for cells to function normally is the availability of ***,available either direct from circulation or storage,is converted to the essential energy that cells need to drive critical intrinsic *** cells are deprived of glucose,they become dysfunctional and suffer ***,the use of specific wavelengths of light on body tissues,has been shown to promote,through small organelles called mitochondria,the metabolism of glucose to make energy for cells;this energy can be used to improve cell function and *** this perspective,we hypothesize that the availability of glucose is central to the core mechanism of photobiomodulation;that photobiomodulation is at its most efficient in stimulating mitochondrial activity and improving cell function when there is glucose readily available.

关键词： metabolism distress stimulating

Asymptotics for the joint tail probability of bidimensional randomly weighted sums with applications to insurance

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Science China Mathematics 2024年第1期67卷 163-186页

作者： Yang Yang Shaoying Chen kam Chuen Yuen School of Statistics and Data Science Nanjing Audit UniversityNanjing 211815China Department of Statistics and Actuarial Science The University of Hong KongHong Kong 999077China

This paper studies the joint tail behavior of two randomly weighted sums∑_(i=1)^(m)Θ_(i)X_(i)and∑_(j=1)^(n)θ_(j)Y_(j)for some m,n∈N∪{∞},in which the primary random variables{X_(i);i∈N}and{Y_(i);i∈N},respectively,are real-valued,dependent and heavy-tailed,while the random weights{Θi,θi;i∈N}are nonnegative and arbitrarily dependent,but the three sequences{X_(i);i∈N},{Y_(i);i∈N}and{Θ_(i),θ_(i);i∈N}are mutually *** two types of weak dependence assumptions on the heavy-tailed primary random variables and some mild moment conditions on the random weights,we establish some(uniformly)asymptotic formulas for the joint tail probability of the two randomly weighted sums,expressing the insensitivity with respect to the underlying weak dependence *** applications,we consider both discrete-time and continuous-time insurance risk models,and obtain some asymptotic results for ruin probabilities.

关键词： asymptotic joint tail behavior randomly weighted sum heavy-tailed distribution dependence insurance risk model

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Single-pilot operations in commercial flight:Effects on neural activity and visual behaviour under abnormalities and emergencies

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Chinese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinbiao LI Chun-Hsien CHEN kam K.H.NG Xin YUAN Cho Yin YIU Human Factors and Ergonomics Laboratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China School of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With cutting-edge technologies and considering airline human-resource-saving,a single pilot in commercial jets could be technically *** changes in captains’natural behaviours are initially required to comprehend the specific safe human performance envelope for safeguarding single-pilot flight,particularly in high-risk *** paper investigates how captains’performance transforms for fixing emergencies when operating from Dual-Pilot Operations(DPO)to Single-Pilot Operations(SPO)through a physiological-based *** pilots flew an emergency-included flight with/without first officers’*** neural activities and scanning behaviours were recorded using a 32-channel Electroencephalogram(EEG)and glasses-based eye tracker,with the observation and post-experiment questionnaires to evaluate the flight operations and pilots’*** alone,there was a significantly increased cortical activity in h and b waves over the frontal,parietal,and temporal lobes during the more complicated emergencies,and pilots focused less on the primary flight display while spending significantly more time scanning the other *** physiological fluctuating patterns associated with risky operations in SPO were highlighted by cross-correlating multimodal *** experimental-based noteworthy insights may wish to inform commercial SPO measures to lessen the persistent physiological fluctuation,assisting airlines in creating SPO-oriented intelligent flight systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering Single pilot operations Behaviour changes Eye tracker Electroencephalogram

p-wave resonances in the exponential cosine screened Coulomb potential

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Communications in Theoretical Physics 2024年第7期76卷 105-113页

作者： Yuan-Cheng Wang Li Guang Jiao Aihua Liu Yew kam Ho Stephan Fritzsche College of Physical Science and Technology Shenyang Normal UniversityShenyang 110034China College of Physics Jilin UniversityChangchun 130012China Helmholtz-Institut Jena D-07743 JenaGermany GSI Helmholtzzentrum fur Schwerionenforschung GmbH D-64291 DarmstadtGermany Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China Institute of Atomic and Molecular Sciences Academia SinicaTaipei 10617TaiwanChina

We perform benchmark calculations of the p-wave resonances in the exponentially cosine screened Coulomb potential using the uniform complex-scaling generalized pseudo-spectral *** present results show significant improvement in calculation accuracy compared to previous predictions and correct the misidentification of resonance electron configuration in previous *** is found that the resonance states approximately follow an n^(2)-scaling law which is similar to the bound *** birth of a new resonance would distort the trajectory of an adjacent higher-lying resonance.

关键词： complex-scaling method shape resonance generalized pseudospectral method exponential cosine screened Coulomb potential

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World Journal of Clinical Cases 2024年第1期12卷 176-179页

作者： Hsin-Chia Angela Lin kam-Fai Lee Tzu Hao Huang Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalChiayi 613Taiwan

BACKGROUND Gastric IgG4-related disease(IgG4-RD)is rarely encountered in clinical practice,and especially more so among pediatric *** our knowledge,this is the first report of IgG4-RD presenting as a calcifying gastric mass in a *** describe how this entity was difficult to differentiate from a gastrointestinal stromal tumor(GIST)imaging-based ***,this case highlights the importance of considering IgG4-RD in the differential diagnosis of gastric tumor before performing surgical resection,especially to distinguish it from malignancy to avoid unnecessary *** SUMMARY The patient suffered from epigastric pain for several *** and computed tomography scan revealed a submucosal *** diagnoses included GIST,leiomyoma,teratoma,and mucinous ***,laparoscopic proximal gastrectomy allowed for the definitive diagnosis of IgG4-related stomach *** We emphasize the importance of considering IgG4-RD in the differential diagnosis of gastric submucosal tumors before performing surgical resection.

关键词： IgG4-related disease Gastrointestinal stromal tumor Child Pediatric Case report

Assessing the Applicability of Multi-Source Precipitation Products over the Chinese Mainland and Its Seven Regions

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Journal of Tropical Meteorology 2024年第3期30卷 275-288页

作者： TIAN Wei WU Yun-long LIN Chen ZHANG Jing-guo LIM kam SIAN Kenny Thiam Choy School of Computer and Software Nanjing University of Information Science&TechnologyNanjing 210044 China School of Atmospheric Science and Remote Sensing Wuxi UniversityWuxiJiangsu 214105 China

Satellite-based and reanalysis precipitation products provide valuable information for various ***,their performance varies widely across regions due to different data sources and production *** paper evaluated the daily performance of four precipitation products(MSWEP,ERA5,PERSIANN,and TRMM)for seven regions of the Chinese mainland,using observations from 2462 ground stations across the country as a *** used four statistical and four classification indicators to describe their spatial and temporal accuracy,and capability to detect precipitation events while analyzing their *** results show that according to the precipitation char-acteristics and accuracy of different types of precipitation products over the Chinese mainland,MSWEP was the most suitable product over the Chinese mainland,having the lowest root mean square error and mean absolute error,along with the highest coefficient of *** was followed by TRMM and ERA5,whereas PERSIANN lagged behind in terms of *** terms of different regions,MSWEP still performed well,especially in North China and East *** accuracy of the four precipitation products was relatively low in the summer months,and they all overestimated in the northwest *** other months,MSWEP and TRMM were better than PERSIANN and *** four precipitation products had good detection performance over the Chinese mainland,with probability of detection above ***,with the increase of precipitation threshold,the detection capability of the four products decreased,and MSWEP and ERA5 had good detection capability for moderate ***’s detection capability for heavy rain and rainstorms was better than that of the other three products,and PERSIANN’s detection capability for moderate rain,heavy rain and rainstorms was relatively poor,with a large deviation.

关键词： precipitation product MSWEP TRMM ERA5 PERSIANN