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Inhibition of protein kinases by anticancer DNA intercalator, 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline

Acta Pharmaceutica sinica B 2017年第3期7卷 303-310页

作者： HeggoduG.Rohitkumar chethan s.kumar Hulihalli N.Kiran kumar Gopal M.Advi Rao Department of Biochemistry Davangere UniversityShivagangotriTholahunaseDavangere 577002India ss Institute of Medical sciences and Research Centre JnanashankaraDavangere 577005India

Targeting protein kinases(PKs) has been a promising strategy in treating cancer, as PKs are key regulators of cell survival and proliferation. Here in this study, we studied the ability of pyrimido[4',5':4,5]thieno(2,3-b)quinolines(PTQ) to inhibit different PKs by performing computational docking and in vitro screening. Docking studies revealed that 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline(BPTQ) has a higher order of interaction with the kinase receptors than other PTQ *** vitro screening confirms that BPTQ inhibits VEGFR1 and CHK2, with the IC_(50) values of 0.54 and1.70 mmol/L, respectively. Further, cytotoxicity of BPTQ was measured by trypan blue assay. Treatment with BPTQ decreased the proliferation of HL-60 cells with an IC_(50) value of 12 mmol/L and induces apoptosis, as explicated by the fall in the mitochondrial membrane potential, annexin V labeling and increased expression of caspase-3. Taken together, these data suggest that BPTQ possess ability to inhibit PKs and to induce cell death in human promyelocytic leukemia cells.

关键词： DNA intercalator Molecular docking Kinase inhibitor Anticancer drugs Apoptosis Chemotherapy

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Preoperative estimation of humerus intramedullary nail length using clinical landmarks

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中华创伤杂志:英文版 2023年第5期26卷 256-260页

作者： Atmananda s.Hegde chethan B.shetty Nitin Joseph Prajwal Mane samarth Thakkar Department of Orthopedics Kasturba Medical College MangaloreManipal Academy of Higher EducationKarnatakaIndia

Purpose:Intramedullary interlocking nailing is one of the accepted methods of treating humerus diaphyseal *** nail length and diameter are of paramount importance to achieve a stable fracture *** the nail length can be as challenging in certain cases as it is *** study aims to provide an easy-to-use formula utilizing clinical measurements from contra lateral arm to accurately estimate humeral nail ***:This descriptive cross-sectional study was conducted at 3 tertiary care hospitals in Mangalore,*** above the age of 18 years coming to the outpatient department with elbow,shoulder or arm complaints requiring radiological investigation from July 2021 to July 2022 were *** with fractures or dislocations of upper limbs,malunited or non-united fractures of upper limbs,congenital or developmental deformities and patients with open growth plates were ***'variables(like age and gender),radiological humerus length and contralateral arm clinical measurements were *** independent samples t-test was used for univariate analysis,and linear regression analysis was done to estimate the desired nail length using the clinical measurement of the humerus(cm)in both genders *** significance level was set at pstudy included 204 participants of which 108 were male and 96 were *** formula for predicting humeral nail length in males is(-2.029)+(0.883×clinical measurement).The formula for females is 1.862+(0.741×clinical measurement).A simplified formula to determine humeral nail length is 0.9 clinical length-2 cm(in males)and 0.7×clinical length+2 cm(in females).Conclusion:To improve the stability of fixation with intramedullary nails it is imperative to select the appropriate nail *** have been studies that devised reliable methods of determining nail lengths in the tibia and femur using preoperative clinical measurements.A similar clinical met

关键词： Humerus nailing Nail length Preoperative measurement Intramedullary interlockingnail

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A comparative analysis of distal locked and unlocked long proximal femoral nail antirotation (PFNA-II) in the fixation of stable intertrochanteric fractures

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Chinese Journal of Traumatology 2023年第2期26卷 111-115页

作者： Atmananda Hegde Vikrant Khanna Prajwal Mane chethan shetty Nitin Joseph Department of Orthopaedics Kasturba Medical CollegeMangaloreManipal Academy of Higher Education(MAHE)ManipalKarnatakaIndia Department of Trauma Kalyani HospitalGurugramIndia Department of Community Medicine Kasturba Medical CollegeMangaloreManipal Academy of Higher Education(MAHE)ManipalKarnatakaIndia

Purpose:Long proximal femoral nail anti-rotation (PFNA-II) is a preferred implant in recent years for fixation of pertrochanteric fractures,especially in osteoporotic *** purpose of this study is to prospectively investigate the effect of distal locking in long PFNA-II fixation of stable intertrochanteric ***:A total of 58 patients with isolated stable intertrochanteric fractures and treated in our hospital during the study period of 2017–2019 by distal locked or unlocked long PFNA-II fixation were included in this *** who had multiple injuries or open fractures were *** were 40 female and 18 male patients,with 33 affecting the left side and 25 the right *** them,31 belonged to the distal locked group (group A) and 27 to the unlocked group (group B).surgical procedures and implants used in both groups were similar except for the distal locking of the *** data (age,gender,fracture side,etc.) showed no significant difference between two groups (allp > 0.05).The intraoperative parameters like operative time,radiation exposure and follow-up parameters like functional and radiological outcomes were recorded and *** tests like the independent samplest-test Fischer’’s exact and Chi-square test were used to analyze ***:The distribution of the fractures according to AO/OTA classification and 31A1.2 type of intertrochanteric fractures were most common in our *** the included fractures united and the average functional outcome in both groups were good and comparable at the end of one *** operative time (mL,107.1 ± 12.6vs.77.0 ± 12.0,p sure (s,78.6 ± 11.0vs.40.3 ± 9.3,p significantly less among the patients in group *** consolidation,three months after the operative procedures,was seen in a significantly greater proportion of patients in group B (92.6%vs.67.7%,p = 0.025).Hardware irritation because of distal locking bolt was excl

关键词： Intertrochanteric fractures Hip fractures Proximal femoral nail Distal locked Unlocked intramedullary nail Intramedullary nail

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Nonlinear Thermal Buoyancy on Ferromagnetic Liquid stream Over a Radiated Elastic surface with Non Fourier Heat Flux

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Computer Modeling in Engineering & sciences 2021年第2期126卷 599-616页

作者： T.K.sreelakshmi Abraham Annamma A.s.chethan M.Krishna Murthy C.s.K.Raju Department of Mathematics BMS Institute of Technology and ManagementBengaluru560064India Department of Mathematics School of Applied SciencesREVA UniversityBengaluru560064India Department of Mathematics GITAM School of ScienceGITAM Deemed to be UniversityBengaluru562163India

The current article discusses the heat transfer characteristics of ferromagnetic liquid over an elastic surface with the thermal radiation and non-Fourier heat *** most of the existing studies,the heat flux is considered as constant,but whereas we incorporated the non-Fourier flux to get the exact performance of the ***,we excluded the PWT and PHF cases to control the boundary layer of the *** governing equations related to our contemplate are changed into non-linear ordinary differential equations(ODE’s)by utilizing appropriate similarity changes,which are at the point enlightened by Runge–Kutta based shooting *** equations are broken down concerning boundary conditions and to be explained prescribed wall temperature(PWT)and prescribed heat flux(PHF)*** impacts of diverse non-dimensional physical parameters on velocity and temperature profiles are laid out ***,the assortment of skin friction and local Nusselt number for both PWT and PHF cases for various assessments of non-dimensional parameters have been sorted *** the wrap-up of the examination,we suspect that the friction factor coefficient is higher in the PWT case compared to the PHF *** result helps to conclude that the flux conditions are useful for cooling applications.

关键词： Ferromagnetic liquid nonlinear thermal buoyancy non-Fourier heat flux radiated elastic surface

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Parental attitudes towards influenza vaccination for children in south India

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World Journal of Pediatrics 2017年第1期13卷 84-90页

作者： chethan Ramprasad Rajeev Zachariah Mark steinhoff Anna simon University of Miami Miller school of Medicine MiamiFloridaUSA Christian Medical College VelloreTamil NaduIndia Cincinnati Children's Hospital Medical Center CincinnatiOhioUSA Christian Medical College VelloreTamil NaduIndia

Background:The rate of influenza vaccination is low for children in *** purpose of this study is to assess parental attitudes towards influenza vaccination in south ***:Participants were parents who brought their children to the Well Baby Clinic of Christian Medical College Hospital,Vellore,India for routine *** answered questions by written survey while waiting for their children’s vaccination.

关键词： doctor recommendation influenza immunization parental attitudes vaccination

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