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Antimicrobial potential of Terminalia chebula Retz. fruit extracts against ear pathogens

World Journal of Otorhinolaryngology 2012年第2期2卷 8-13页

作者： chetan Sharma Kamal R Aneja Ramkrashan Kasera Ashish Aneja Department of Microbiology Kurukshetra UniversityKurukshetra 136119HaryanaIndia Department of Biotechnology Pune UniversityPune 411007India University Health Center Kurukshetra UniversityKurukshetra 136119HaryanaIndia

AIM： To evaluate the antimicrobial potential of Terminalia chebula （ T. chebula） extracts against pathogens causing otitis externa and compare it with ear ***： Four different extracts, methanol, ethanol, acetone and aqueous （hot and cold） extracts, from the T. chebula were tested for their antimicrobial activity through the agar well diffusion method and minimum inhibitory concentration （MIC）/minimum bactericidal concentration （MBC） values were determined through the macrodilution broth method against six different microorganism, five bacterial （one gram positive and four gram negative） and one ***： Organic and aqueous fruit extracts displayed activity against all fve tested bacterial ear pathogens with a maximum zone of inhibition of 31.6 mm against Staphylococcus aureus , followed by Acinetobacter sp. （24.6 mm）, Pseudomonas aeruginosa （23.6 mm）, Proteus mirabilis （21 mm） and Escherichia coli （19.3mm）. Of the four solvents evaluated, acetonic fruit extract of T. chebula was found to be best. The MIC values ranged between 0.78 mg/mL and 50 mg/mL for the different bacterial ear pathogens and MBC values ranged between 1.56 mg/mL and 50 mg/mL. The acetonic fruit extract showed larger inhibition zones compared to the herbal ear drops, Kan pip with lowest MIC of 0.78 mg/mL and MBC of 1.56 mg/***： Acetonic extract of T. chebula fruit may be used to treat otitis externa. However, more detailed studies, such as in vivo testing and pharmacokinetics properties, are needed to determine its therapeutic potential.

关键词： Otitis externa Terminalia chebula Anti-microbial activity Minimum inhibitory concentration Mi-nimum bactericidal concentration Organic and aqueous extracts

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Post-Traumatic Long Segment Small Bowel Stricture <br/>—A Diagnostic Dilemma

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Surgical Science 2014年第11期5卷 508-511页

作者： Kirti Katherine Kabeer Sugumaran Manoj Karthik chetan Anand Nilakantan Ananthakrishnan Department of General Surgery Mahatma Gandhi Medical College and Research Institute Pondicherry India

Delayed post-traumatic small bowel stricture is rare and differentiation from other more common causes of small intestinal stricture is difficult. Presentation may be delayed up to years after the injury. Very often the findings mimic those of other causes of long segment strictures such as tuberculosis, Crohn’s disease, lymphoma etc. This study analyzes two cases of post-traumatic small bowel stricture, with different presentations and different therapeutic challenges. The literature on this condition is not well recognized and will be reviewed. Resection and reconstruction are diagnostic and therapeutic in patients who present with post-traumatic small bowel stricture, as inflammatory and neoplastic causes cannot be ruled out without histological diagnosis.

关键词： Bowel Stricture Post-Traumatic Bowel Pathology Delayed Small Bowel Stricture

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Building and evaluating an artificial intelligence algorithm:A practical guide for practicing oncologists

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Artificial Intelligence in Cancer 2022年第3期3卷 42-53页

作者： Anupama Ramachandran Deeksha Bhalla Krithika Rangarajan Raja Pramanik Subhashis Banerjee chetan Arora Department of Radiology All India Institute of Medical SciencesNew Delhi 110029India Department of Radiology All India Institute of Medical Sciences New DelhiNew Delhi 110029India School of Information Technology Indian Institute of TechnologyDelhi 110016India Department of Medical Oncology Dr.B.R.A.Institute Rotary Cancer HospitalAll India Institute of Medical SciencesNew Delhi 110029India chetan Arora Department of Computer ScienceIndian Institute of TechnologyDelhi 110016India

The use of machine learning and deep learning has enabled many applications,previously thought of as being *** all medical fields,cancer care is arguably the most significantly impacted,with precision medicine now truly being a *** effect of these technologies,loosely known as artificial intelligence,is particularly striking in fields involving images(such as radiology and pathology)and fields involving large amounts of data(such as genomics).Practicing oncologists are often confronted with new technologies claiming to predict response to therapy or predict the genomic make-up of *** these new claims and technologies requires a deep understanding of the *** this review,we provide an overview of the basis of deep *** describe various common tasks and their data requirements so that oncologists could be equipped to start such projects,as well as evaluate algorithms presented to them.

关键词： Artificial intelligence Precision medicine Radiomics Deep learning

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Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies

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Journal of Molecular Cell Biology 2021年第4期13卷 282-294页

作者： Maarten C.Hardenberg Tessa Sinnige Sam Casford Samuel T.Dada chetan Poudel Elizabeth A.Robinson Monika Fuxreiter Clemens F.Kaminksi Gabriele S.Kaminski Schierle Ellen A.A.Nollen Christopher M.Dobson Michele Vendruscolo Centre for Misfolding Diseases Department of ChemistryUniversity of CambridgeCambridge CB21EWUK Department of Chemical Engineering and Biotechnology University of CambridgeCambridge CB3 OASUK MTA-DE Laboratory of Protein Dynamics Department of Biochemistry and Molecular BiologyUniversity of DebrecenHungary European Research Institute for the Biology of Aging University Medical Center GroningenUniversity of GroningenGroningen 9713 AVThe Netherlands Present address Bijvoet Centre for Biomolecular Research Department of ChemistryUtrecht UniversityUtrecht 3584 CHThe Netherlands

Misfoldedα-synudein is a major component of Lewy bodies,which are a hallmark of Parkinson's disease(PD).A large body of evidence shows thatα-synuclein can aggregate into amyloid fibrils,but the relationship between a-synuclein self-assembly and Lewy body formation remains ***,we show,both in vitro and in a Caenorhabditis elegans model of PD,thatα-synuclein undergoes liquid-liquid phase separation by forming a liquid droplet state,which converts into an amyloid-rich hydrogel with Lewy-body-like *** maturation process towards the amyloid state is delayed in the presence of model synaptic vesicles in *** together,these results suggest that the formation of Lewy bodies may be linked to the arrested maturation ofα-synuclein condensates in the presence of lipids and other cellular components.

关键词： α-synuclein,liquid-liquid phase separation,Parkinson's disease

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番石榴汁和番石榴粉加工工艺的优化

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热带农业工程 2003年第2期28卷 33-38页

作者： chetan A CHOPDA 喻孟君

对番石榴原浆进行酶处理可以优化产率和澄清度 ,处理时首先测定最具影响力的浓度 ,然后改变培养时间和温度。应用PectinexUltraSP L○R酶进行处理的最佳条件为 :酶液浓度 70 0ppm ,5 0℃作用 1 5h。应用超滤法 (分子量在 4 0～ 6 0kDa)... 详细信息

对番石榴原浆进行酶处理可以优化产率和澄清度 ,处理时首先测定最具影响力的浓度 ,然后改变培养时间和温度。应用PectinexUltraSP L○R酶进行处理的最佳条件为 :酶液浓度 70 0ppm ,5 0℃作用 1 5h。应用超滤法 (分子量在 4 0～ 6 0kDa)得到的澄清番石榴汁的澄清度比板框压滤法得到的要高 ,前者为 89 6 % ,后者为 82 8% ;但板框压滤法得到的可溶性固形物和抗坏血酸 (Vc)含量要高些。用冷冻干燥、喷雾干燥和隧道式干燥法处理番石榴果汁得到番石榴果汁粉。冷冻干燥得到的产品质量最好 ,但喷雾干燥得到的产品稳定且更经济。感观评定专家组评定由无菌番石榴原浆制得的混汁等级最高 ;用巴氏灭菌、澄清蜜汁饮料 ,冷冻干燥后的番石榴原浆粉或果汁粉制得的果汁并无显著差别。

关键词：番石榴汁番石榴粉加工工艺优化产率澄清度酶处理

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Do Changes Occur in Hemodynamic Parameters, Hemogram, Renal Function and Serum Electrolytes during Percutaneous Nephrolithotomy? Its Correlation with Irrigation Fluid and Intravenous Fluid

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Open Journal of Urology 2022年第1期12卷 57-68页

作者： chetan R. Kulkarni Subodh R. Shivde Jaydeep A. Date Rohan S. Valsangkar Department of Urology and Transplant Services Deenanath Mangeshkar Hospital and Research Centre Pune Maharashtra India

Introduction: Percutaneous nephrolithotomy (PCNL) is a standard minimally invasive urological procedure for the treatment of large renal calculi. It is also associated with complications arising from absorption of irrigation fluid and intravenous fluid injection. We evaluated the changes occurring in vital and blood parameters during PCNL using 0.9% normal saline (NS) as an irrigation fluid. Materials and Methods: We prospectively studied 71 patients who underwent PCNL in our hospital between 2016 and 2018. NS (0.9%) was used as irrigation fluid in all patients. Changes in hemodynamics, hemogram, renal function tests and serum electrolytes were noted and assessed for significance using paired t-test. These changes were correlated with ASA grade, BMI, total operating time, total irrigation fluid used and total intravenous fluid used using Pearson’s correlation test. Results: A significant fall in serum creatinine was present (1.30 ± 0.96 vs. 1.24 ± 0.93) along with a rise in eGFR (85.39 ± 24.10 vs. 90.18 ± 22.58). A significant rise in serum potassium (4.34 ± 0.45 vs. 4.5 ± 0.56) and chloride levels (104.79 ± 3.51 vs. 106.69 ± 3.14) post-operatively was noted. A significant rise in pulse rate (80.84 ± 10.13 vs. 87.76 ± 13.12) and systolic blood pressure (127.67 ± 15.90 vs. 136.88 ± 19.56) post-operatively was noted. There was no significant change noted in hemoglobin, PCV, platelets and serum sodium levels. Total operating time and irrigation fluid volume showed a positive correlation with changes in eGFR, serum chloride, post-operative pulse rate and blood pressure values. Intravenous fluids volume correlated positively with changes in serum potassium, chloride, post-operative pulse rate and blood pressure values. Conclusion: High amount of irrigation fluid absorption can cause early post-operative changes in patients’ hemodynamics and blood indices. Overzealous hydration during PCNL with potassium

关键词： Percutaneous Nephrolithotomy Hemodynamic Parameters Hemogram Renal Function and Serum Electrolytes

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Common underlying diseases do not contribute in determining the causes of sudden unexplained death

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Chinese Medical Journal 2013年第5期126卷 870-874页

作者： TIAN Zhao-xing LV Yan-yu chetan Rai Nugessur YAN Wei ZHAO Wen-kui KONG Li-li ZHENG Ya-an Department of Emergency Medicine Peking University Third Hospital Beijing 100191 China Department of Gastroenterology and Hepatology Peking University Third Hospital Beijing 100191 China Department of Respiratory Disease Peking University Third Hospital Beijing 100191 China Capital Institute of Pediatrics Beijing 100020 China

Background Underlying diseases have a statistically significant positive correlation to sudden death. However, sudden unexplained death （SUD） is different from sudden death, as there is no clinical evidence to support the sudden death due to the original underlying disease, nor a lethal pathological basis to be found during autopsy. In addition, SUD are more common in young, previously healthy individuals, usually without any signs of disease, with no positive lesions found after autopsy. Therefore, a causal relationship between SUD and the underlying disease needs to be further explored. This study aimed to explore the role that common underlying diseases play in patients with SUD and to reveal the correlation between them. Methods The medical records, history and case information of 208 patients with SUD were collected for the survey. All these SUD occurred in the emergency room of Peking University Third Hospital from January 2006 to December 2009. The patients were stratified by with and without common underlying diseases. To examine possible associations between the underlying diseases and the cause of unexplained sudden death, the chi-squared and Fisher＇s exact tests were used. Results Among the 208 patients, 65 were diagnosed with common underlying diseases while 143 were not. Within these two groups, there were 45 patients for whom the clear cause of death was determined. However, there were no statistically significant differences or strong associations （x2=1.238, P 〉0.05） between the 11 patients with （16.90%） and 34 without （23.78%） common underlying disease among these 45 patients. We also found that occurrence of the common underlying diseases, such as neurological system, cardiovascular and pulmonary system diseases, are not statistically significant （P 〉0.05） in the diagnosis of the SUD. Conclusion Common underlying diseases make no obvious contributions to SUD and are not useful in diagnosing the underlying reasons for death.

关键词： sudden unexplained death common underlying diseases death causes

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姑且糊弄——索尼公司新掌门人出手谨慎的改革措施表明,他正在两个方面孤注一掷

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当代外语研究 2005年第11期 18-20,32页

作者： chetan Parikh 陶庆

走马上任仅三个月,霍华德·斯特林格爵士——这位原先负责索尼公司美国业务的美籍威尔士裔的传媒业高层管理者——就宣布了他的新策略。然而,对于9月22日出台的计划,分析人士表示失望。对此, 霍华德爵士不得不为自己辩解。他指出,在日... 详细信息

走马上任仅三个月,霍华德·斯特林格爵士——这位原先负责索尼公司美国业务的美籍威尔士裔的传媒业高层管理者——就宣布了他的新策略。然而,对于9月22日出台的计划,分析人士表示失望。对此, 霍华德爵士不得不为自己辩解。他指出,在日本这样一个崇尚共识、回避交锋的社会环境中。

关键词：索尼公司电子产品游戏机改革措施理性化为自己辩解社会环境传媒业高层管理者经营方法

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亚洲面临核心通胀率上升的挑战

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海外经济评论 2008年第25期 21-25页

作者： chetan Ahya Qing Wang

【摩根士丹利5月29日】近几个月，我们一直担心日本之外亚洲地区（AXJ）的核心通胀率出现周期性上升。现在看来，这种担忧正在成为现实。2008年4月，AXJ的总体通胀率达到7．5％，达到9年半以来的高点；扣除石油和食品价格的核心通胀率... 详细信息

【摩根士丹利5月29日】近几个月，我们一直担心日本之外亚洲地区（AXJ）的核心通胀率出现周期性上升。现在看来，这种担忧正在成为现实。2008年4月，AXJ的总体通胀率达到7．5％，达到9年半以来的高点；扣除石油和食品价格的核心通胀率也达到了3．8％。另一方面，以GDP为权重，AXJ地区政策利率的加权平均值为6．75％，3月期国债收益率的加权平均值为4．95％。

关键词：亚洲地区通胀率加权平均值摩根士丹利国债收益率食品价格地区政策 GDP

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亚洲投资滑坡深度有限，但复苏前景暗淡

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海外经济评论 2009年第23期 24-26页

作者： chetan hhya Sumeet Kariwala

【摩根士丹利5月7日】危机前的资本支出增长极为强劲近年来，日本之外亚洲（AXJ）地区的固定资本总投资（GFCF）出现了大幅增长，据我们估算，2001—2008年间，AXJ经济体的GFCF由9200亿美元（占GDP的28．5％）猛增至2．9万亿美元。本轮... 详细信息

【摩根士丹利5月7日】危机前的资本支出增长极为强劲近年来，日本之外亚洲（AXJ）地区的固定资本总投资（GFCF）出现了大幅增长，据我们估算，2001—2008年间，AXJ经济体的GFCF由9200亿美元（占GDP的28．5％）猛增至2．9万亿美元。本轮周期之中，GFCF从谷底到峰顶的升幅远超过上世纪90年代中期那轮周期的升幅。

关键词：总投资亚洲有限滑坡摩根士丹利资本支出固定资本 90年代

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