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Anti-arthritis activity of roots of Hemidesmus indicus ***.(Anantmul)in rats

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Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 130-135页

作者： Alka Mehta Neeraj K Sethiya chetan Mehta GB Shah Pharmacy Department Faculty of Technology and Engineering KalabhavanThe M.S.University of BarodaVadodara 390002(Gujarat)India Radiology Department SSG Hospital and Medical CollegeVadodara-390001(Gujarat)India KBIPER Gandhinagar-382023(Gujarat).India

Objective:To investigate the protective effects of hydroalcoholic and its fractions from roots of Hemidesmus indicus on arthritis in in vitro models of ***:Preliminary phytochemical analysis and thin-layer chromoatography were performed to analyze constituents of hydroalcoholic extract and its three fraction namely ethyl acetate fraction,chloroform fraction and residual fraction of mot of Hemidesmus *** rats models were established by Complete Freund’s *** parameters including paw edema,body weight,arthritic index,erythrocyte sedimentation rate,serum rheumatoid factor,serum C-reactive protein,serum nitrite level,and histopathology of synovial joints were *** was taken as positive ***:Rats treated with hydroalcoholic extract(450 mg/kg,p.o.),ethyl acetate (75 mg/kg,p.o.),chloroform(60 mg/kg,p.o) and residual fractions(270 mg/kg,p.o.),showed significant decrease in physical and biochemical parameters compared with arthritic model rats. Hydroalcoholic extract and its ethyl acetate fraction of Hemidesmus indicus showed significantly higher anti-arthritic activity than chloroform and residual *** analysis demonstrated that both of hydroalcoholic extract and its ethyl acetate fraction had comparable anti-arthritic activity with ***:The present study suggests that Hemidesmus indicus has protective activity against arthritis and the activity might be attributed to presence of terpenoid in hydroalcoholic extract,as well as in ethyl acetate fraction.

关键词： Arthritic Index Hemidesmus indicus Anti-inflammatory Phenolic Terpenoids

Experimental investigation of a high aspect ratio,low speed contra-rotating fan stage with complex inflow distortion

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Propulsion and Power Research 2014年第2期3卷 68-81页

作者： chetan Mistry A.M.Pradeepn Department of Aerospace Engineering Indian Institute of TechnologyBombayMaharashtra 400076India

This paper focuses on the response of a high aspect ratio,low speed contra-rotating fan with complex inflow *** total pressure at the inlet is artificially distorted by means of two different sets of screens with different porosities to generate a hub-strong complex distortion and a tip-strong complex *** flow analyses were conducted for the design speed of rotor-1 in combination with off design speeds of rotor-2 both for the design and the peak pressure mass flow *** order to understand the extent of inlet distortion,the distortion sector was rotated circumferentially at intervals of 151 to cover the entire *** measurements of total pressure,static pressure,velocity components and flow angles were carried out at the inlet of the first rotor,between the two rotors and at the exit of the second rotor using three seven hole *** study reveals a few interesting aspects on the effect of complex inflow distortion on the flow behavior of a contra-rotating *** presence of a low porosity screen reduces the magnitude of axial velocity and generates higher spread of distortion near the localized region of placement of the *** hub-strong complex distortion has a greater effect of presence of this low porosity screen in both circumferential and radial *** leads to higher stagnation pressure variation at the *** the other hand,for the tip-strong complex distortion case,the extent of distortion is observed to be higher in the circumferential direction towards the casing rather than *** localized improvement in the flow(in tip-strong inflow distortion)near the tip region improves the performance both in terms of pressure rise and efficiency of stage compared to hub–strong complex distortion.

关键词： Complex inflow distortion Hub-strong complex distortion Tip-strong complex distortion Contra-rotating fan

In vivo evidence of IGF-I–estrogen crosstalk in mediating the cortical bone response to mechanical strain

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Bone Research 2014年第1期2卷 55-60页

作者： Subburaman Mohan chetan Girijanand Bhat Jon E Wergedal Chandrasekhar Kesavan Musculoskeletal Disease Center VA Loma Linda Healthcare System Department of Medicine Loma Linda University Department of Biochemistry Loma Linda University Department of Physiology Loma Linda University

Although insulin-like growth factor-I （IGF-I） and estrogen signaling pathways have been shown to be involved in mediating the bone anabolic response to mechanical loading, it is not known whether these two signaling pathways crosstalk with each other in producing a skeletal response to mechanical loading. To test this, at 5 weeks of age, partial ovariectomy （pOVX） or a sham operation was performed on heterozygous IGF-I conditional knockout （H IGF-I KO） and control mice generated using a Cre-loxP approach. At 10 weeks of age, a 10 N axial load was applied on the right tibia of these mice for a period of 2 weeks and the left tibia was used as an internal non-non-loaded control. At the cortical site, partial estrogen loss reduced total volumetric bone mineral density （BMD） by 5% in control pOVX mice （P=0.05, one-way ANOVA）, but not in the H IGF-I KO pOVX mice. At the trabecular site, bone volume/total volume （BV/TV） was reduced by 5%-6% in both control pOVX （P〈0.05） and H IGF-I KO pOVX （P=0.05） mice. Two weeks of mechanical loading caused a 7 %-8% and an 11%-13% （P〈0.05 vs. non-loaded bones） increase in cortical BMD and cortical thickness （***）, respectively, in the control sham, control pOVX and H IGF-I KO sham groups. By contrast, the magnitude of cortical BMD （4%, P=0.13） and *** （6%, P〈0.05） responses were reduced by 50% in the H IGF-I KO pOVX mice compared to the other three groups. The interaction between genotype and estrogen deficiency on the mechanical loading-induced cortical bone response was significant （P〈0.05） by two-way ANOVA. Two weeks of axial loading caused similar increases in trabecular BV/TV （13%-17%） and thickness （17%-23%） in all four groups of mice. In conclusion, partial loss of both estrogen and IGF-I significantly reduced cortical but not the trabecular bone response to mechanical loading, providing in vivo evidence of the above crosstalk in mediating the bone response to loading.

关键词： bone IGF estrogen crosstalk in mediating the cortical bone response to mechanical strain

Evaluation of L-dopa,proximate composition with in vitro anti-inflammatory and antioxidant activity of Mucuna macrocarpa beans:A future drug for Parkinson treatment

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1097-1106页

作者： chetan Aware Ravishankar Patil Swaroopsingh Gaikwad Shrirang Yadav Vishwas Bapat Jyoti Jadhav Department of Biotechnology Shivaji UniversityVidyanagarKolhapurMaharashtraIndia Department of Biochemistry Shivaji UniversityVidyanagarKolhapurMaharashtraIndia Department of Botany Shivaji UniversityVidyanagarKolhapurMaharashtraIndia

Objective: To investigate L-3, 4-dihydroxyphenylalanine(L-dopa, anti-Parkinson drug),anti-inflammatory activity, proximate nutritional composition and antioxidant potential of Mucuna macrocarpa(M. macrocarpa) ***: L-dopa content was determined and quantified by high performance thin layer chromatography and reversed phase high-performance liquid chromatography(RPHPLC) methods. Anti-inflammatory activity was performed by in vitro protein denaturation inhibition and human red blood cell membrane stabilisation activity. Proximate composition and elemental analysis were also investigated. The antioxidant potential(2,2-diphenyl-1-picrylhydrazyl, N-N-dimethyl-phenylenediamine and ferric-reducing antioxidant power) of M. macrocarpa beans were evaluated by using different extraction solvents. The RP-HPLC analysis also quantified significant phenolics such as gallic acid, tannic acid, p-hydroxybenzoic acid and p-coumaric ***: RP-HPLC quantification revealed that M. macrocarpa beans contain a high level of L-dopa [(115.41 ± 0.985) mg/g] which was the highest among the Mucuna species from Indian sub-continent. Water extract of seed powder showed strong antiinflammatory and antioxidant potential. Proximate composition of M. macrocarpa beans revealed numerous nutritional and anti-nutritional components. RP-HPLC analysis of major phenolics such as tannic acid(43.795 mg/g), gallic acid(0.864 mg/g), p-coumaric acid(0.364 mg/g) and p-hydroxybenzoic acid(0.036 mg/g) quantified successfully from M. macrocarpa beans ***: This study suggests that M. macrocarpa is a potential source of L-dopa with promising anti-inflammatory, antioxidant and nutritional benefits.

关键词： Anti-inflammatory Antioxidants L-dopa Mucuna macrocarpa Oxidative stress Parkinson’s disease

One pot three component synthesis of spiro [indolo-3,10’-indeno[1,2-b]quinolin]-2,4,11’-triones as a new class of antifungal and antimicrobial agents

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Chinese Chemical Letters 2017年第1期28卷 136-142页

作者： Kalawati Meena Sudesh Kumari Jitender M.Khurana Amita Malik chetan Sharma Harsh Panwar Department of Chemistry University of Delhi Delhi 110007 India Dyal Singh College University of Delhi Lodhi Road Delhi 110003 India Department of Dairy Microbiology College of Dairy Science and Technology Guru Angad Dev Veterinary and Animal Science UniversityLudhiana 141004 India

A simple and efficient three component procedure has been developed for the synthesis of highly substituted spiro[indolo-3,100-indeno[1,2-b]quinolin]-2,4,11＇-triones by one pot three component condensation of enaminones, isatin and indane-1,3-dione in ethanol：water（1：1） in presence of ceric ammonium nitrate（CAN） as catalyst. This method provides several advantages such as lesser reaction time, high yield of products and operational simplicity. The antimicrobial activity of some of the compounds has been investigated against six microbial strains, some of the tested compounds showed good antimicrobial activity.

关键词： Multicomponent reactions Isatin Spirooxindole Heterocycles Antimicrobial activity

Multicomponent domino process for the synthesis of some novel 5-(arylidene)-3-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-thiazolidine-2,4-diones using PEG-400 as an efficient reaction medium and their antimicrobial evaluation

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Chinese Chemical Letters 2015年第1期26卷 50-54页

作者： Jayant Sindhu Harjinder Singh J.M.Khurana chetan Sharma K.R.Aneja Department of Chemistry Delhi University Department of Microbiology Kurukshetra University

A series of novel thiazolidinedione-triazole hybrids were synthesized by one pot reaction between thiazolidine-2.4-dione,substituted aryl aldehydes,piopargyl bromide and substituted aryl azides using piperidine,CuSO4· 5H2O and sodium ascorbate as catalysts in PEG-400 as a highly efficient and green *** thiazolidinedione-triazole hybrids were subjected to in vitro antibacterial activity against four strains *** *** subtilis,Escherichia coli,Pseudomonas aeruginosa and antifungal activity against two fungal strains namely,Aspergillus niger and Aspergillus flavus.

关键词： Multicomponent AntibacterialAntifungal 1,2,3-Triazoles thiazolidine-2,4-diones

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结构宏观计量经济学

Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review

作者： (美)德容 chetan·Dave

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Frontiers of Environmental Science & Engineering 2019年第3期13卷 3-11页

作者： Virender K.Sharma Xin Yu Thomas J.McDonald chetan Jinadatha Dionysios D.Dionysiou Mingbao Feng Department of Environmental and Occupational Health School of Public Health Texas A&M University College Station TX 77843 USA Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China Central Texas Veterans Health Care System Temple TX 76504 USA College of Medicine Texas A&M Health Science Center Bryan TX 77807 USA Environmental Engineering and Science Program Department of Chemical and Environmental Engineering (DChEE) 705 Engineering Research Center University of Cincinnati Cincinnati OH 45221 USA

Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have been recognized as one of the biggest public health issues of the 21 st century. Both ARB and ARGs have been determined in water after treatment with conventional disinfectants. Ultraviolet (UV) technology has been seen growth in application to disinfect the water. However, UV method alone is not adequate to degrade ARGs in water. Researchers are investigating the combination of UV with other oxidants (chlorine, hydrogen peroxide (H2O2), peroxymonosulfate (PMS), and photocatalysts) to harness the high reactivity of produced reactive species (C1-, C1O -, Cl2-,-OH, and SO4-_) in such processes with constituents of cell (e.g., deoxyribonucleic acid (DNA) and its components) in order to increase the degradation efficiency of ARGs. This paper briefly reviews the current status of different UV-based treatments (UV/chlorination, UV/H2O2, UV/PMS, and UV-photocatalysis) to degrade ARGs and to control horizontal gene transfer (HGT) in water. The review also provides discussion on the mechanism of degradation of ARGs and application of q-PCR and gel electrophoresis to obtain insights of the fate of ARGs during UV-based treatment processes.

关键词： Antibiotic resistance bacteria Advanced oxidation processes Disinfection Reactive chlorine species Sulfate radicals Reactive oxygen species

A Numerical Approach on Reduction of Young’s Modulus During Deformation of Sheet Metals

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Modeling and Numerical Simulation of Material Science 2012年第1期2卷 1-13页

作者： chetan Nikhare Mechanical Engineering Department University of New Hampshire

The paper investigates the elastic behavior of the metal after unloading. For this purpose the strip of metal with tensile gauge length was simulated with high and low strength material. Further the channel forming was modeled for combination of materials to predict the spring-back and compared the results. It is observed that the Young’s modulus (E-value) decreases with the increase in plastic strain. The strength of the material has no effect on the decrease in the E-value after unloading during tension test. However in channel forming the E-value after unloading depends on the starting E-value, spring-back angle and maximum strain achieved in the channel. The proposed mathematical equations to determine the E-value after unloading from the tension test and channel forming test gives very good prediction with each other. It is also found that the lowest spring-back occurred in the channel with the composite Hard-Soft material.

关键词： Elasticity Spring-Back Channel Forming Optimization Deformation