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Environmental cues determine the fate of astrocytes after spinal cord injury

Neural Regeneration Research 2017年第12期12卷 1964-1970页

作者： Fatima M.nathan Shuxin Li Shriners Hospitals Pediatric Research Center Department of Anatomy and Cell Biology Lewis Katz School of Medicine at Temple UniversityPhiladelphia PA USA

Reactive astrogliosis occurs after central nervous system（CNS） injuries whereby resident astrocytes form rapid responses along a graded continuum. Following CNS lesions, na？ve astrocytes are converted into reactive astrocytes and eventually into scar-forming astrocytes that block axon regeneration and neural repair. It has been known for decades that scarring development and its related extracellular matrix molecules interfere with regeneration of injured axons after CNS injury, but the cellular and molecular mechanisms for controlling astrocytic scar formation and maintenance are not well known. Recent use of various genetic tools has made tremendous progress in better understanding genesis of reactive astrogliosis. Especially, the latest experiments demonstrate environment-dependent plasticity of reactive astrogliosis because reactive astrocytes isolated from injured spinal cord form scarring astrocytes when transplanted into injured spinal cord, but revert in retrograde to naive astrocytes when transplanted into naive spinal cord. The interactions between upregulated type I collagen and its receptor integrin β1 and the N-cadherin-mediated cell adhesion appear to play major roles for local astrogliosis around the lesion. This review centers on the environment-dependent plasticity of reactive astrogliosis after spinal cord injury and its potential as a therapeutic target.

关键词： astrogliosis astrocyte fate scar formation spinal cord injury axon regeneration environmentcue collagen I integrin β1

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Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease

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Biomedical Engineering Frontiers 2021年第1期2卷 44-54页

作者： Alicia Megia-Fernandez Adam Marshall Ahsan R.Akram Bethany Mills Sunay V.Chankeshwara Emma Scholefield Amy Miele Bruce C.McGorum ches.ey michaels.nathan knighton Tom Vercauteren Francois Lacombe Veronique Dentan Annya M.Bruce Joanne Mair Robert Hitchcock Nik Hirani Chris Haslett Mark Bradley Kevin Dhaliwal EaStCHEM The University of Edinburgh School of ChemistryJoseph Black BuildingWest Mains RoadEdinburghUK EH93FJ Translational Healthcare Technologies Group Centre for Inflammation ResearchQueen’s Medical Research InstituteUniversity of Edinburgh47 Little France CrescentEdinburgh BioQuarterEdinburghUK EH164TJ The Roslin Institute and Royal(Dick)School of Veterinary Studies University of EdinburghEaster BushMidlothianUK EH259RG Department of Biomedical Engineering University of Utah36 S Wasatch DrSalt Lake CityUT 84112USA School of Biomedical Engineering&Imaging Sciences King’s College LondonLondonUK SE17EH Mauna Kea Technologies 9Rue d’EnghienParisFrance 75010

Objective and Impact *** is a need to develop platforms delineating inflammatory biology of the distal human *** describe a platform technology approach to detect in situ enzyme activity and observe drug inhibition in the distal human lung using a combination of matrix metalloproteinase(MMP)optical reporters,fibered confocal fluorescence microscopy(FCFM),and a bespoke delivery *** development of new therapeutic agents is hindered by the lack of in vivo in situ experimental methodologies that can rapidly evaluate the biological activity or drug-target engagement in *** optimised a novel highly quenched optical molecular reporter of enzyme activity(FIB One)and developed a translational pathway for in-human *** demonstrate the specificity for matrix metalloproteases(MMPs)2,9,and 13 and probe dequenching within physiological levels of MMPs and feasibility of imaging within whole lung models in preclinical ***,in a first-in-human exploratory experimental medicine study of patients with fibroproliferative lung disease,we demonstrate,through FCFM,the MMP activity in the alveolar space measured through FIB One fluorescence increase(with pharmacological inhibition).*** translational in situ approach enables a new methodology to demonstrate active drug target effects of the distal lung and consequently may inform therapeutic drug development pathways.

关键词： Lung lung specificity

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Erratum to “Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease”

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Biomedical Engineering Frontiers 2023年第1期4卷 30-30页

作者： Alicia Megia-Fernandez Adam Marshall Ahsan R.Akram Bethany Mills Sunay V.Chankeshwara Emma Scholefield Amy Miele Bruce C.McGorum ches.ey michaels.nathan knighton Tom Vercauteren Francois Lacombe Veronique Dentan Annya M.Bruce Joanne Mair Robert Hitchcock Nik Hirani Chris Haslett Mark Bradley Kevin Dhaliwal EaStCHEM The University of Edinburgh School of ChemistryJoseph Black BuildingWest Mains RoadEdinburgh EH93FJUK Translational Healthcare Technologies Group Centre for Inflammation ResearchQueen’s Medical Research InstituteUniversity of Edinburgh47 Little France CrescentEdinburgh BioQuarterEdinburgh EH164TJUK The Roslin Institute and Royal(Dick)School of Veterinary Studies University of EdinburghEaster BushMidlothian EH259RGUK Department of Biomedical Engineering University of Utah36 S Wasatch DrSalt Lake CityUT 84112USA School of Biomedical Engineering&Imaging Sciences King’s College LondonLondon SE17EHUK Mauna Kea Technologies 9Rue d’EnghienParis 75010France

In the research article“Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease”[1],the data availability statement was inadvertently omitted by the *** has now been corrected in the PDF ... 详细信息

关键词： HTML Human Optical

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Responses of Arctic sea ice to stratospheric ozone depletion

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Science Bulletin 2022年第11期67卷 1182-1190页

作者： Jiankai Zhang Wenshou Tian John A.Pyle James Keeble nathan Luke Abraham Martyn P.Chipperfield Fei Xie Qinghua Yang Longjiang Mu Hong-Li Ren Lin Wang Mian Xu College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Department of Chemistry University of CambridgeCambridge CB21EWUK National Centre for Atmospheric Science Cambridge CB21EWUK School of Earth and Environment University of LeedsLeeds LS29JTUK College of Global Change and Earth System Science Beijing Normal UniversityBeijing 100875China School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 519082China Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao 266237China State Key Laboratory of Severe Weather Institute of Tibetan Plateau&Polar MeteorologyChinese Academy of Meteorological SciencesBeijing 100081China Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

The Arctic has experienced several extreme springtime stratospheric ozone depletion events over the past four decades,particularly in 1997,2011 and ***,the impact of this stratospheric ozone depletion on the climate system remains poorly *** we show that the stratospheric ozone depletion causes significant reductions in the sea ice concentration(SIC)and the sea ice thickness(SIT)over the Kara Sea,Laptev Sea and East Siberian Sea from spring to *** is partially caused by enhanced ice transport from Barents-Kara Sea and East Siberian Sea to the Fram Strait,which is induced by a strengthened and longer lived polar vortex associated with stratospheric ozone ***,cloud longwave radiation and surface albedo feedbacks enhance the melting of Arctic sea ice,particularly along the coast of the Eurasian *** study highlights the need for realistic representation of stratosphere-troposphere interactions in order to accurately predict Arctic sea ice loss.

关键词：平流层臭氧东西伯利亚海北极海冰地表反照率喀拉海长波辐射拉普捷夫海海冰密集度

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