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Circular RNA: The evolving potential in the disease world

World Journal of Medical Genetics 2024年第1期12卷 1-16页

作者： Aarti Sharma cherry bansal Kiran Lata Sharma Ashok Kumar Department of Research Mayo Clinic ArizonaPhoenixAZ 85054United States Department of Pathology Dr.S Tantia Medical CollegeHospital and Research CenterSri Ganganagar 335002RajasthanIndia Department of Pathology Baylor College of MedicineHoustonTX 77030United States Department of Surgical Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

Circular RNAs(circRNAs),a new star of noncoding RNAs,are a group of endogenous RNAs that form a covalently closed circle and occur widely in the mammalian *** circRNAs are conserved throughout species and fre-quently show stage-specific expression during various stages of tissue *** were a mystery discovery,as they were initially believed to be a product of splicing errors;however,subsequent research has shown that ci-rcRNAs can perform various functions and help in the regulation of splicing and transcription,including playing a role as microRNA(miRNA)*** the application of high throughput next-generation technologies,circRNA hotspots were *** are emerging indications that explain the association of circRNAs with human diseases,like cancers,developmental disorders,and in-flammation,and circRNAs may be a new potential biomarker for the diagnosis and treatment outcome of various diseases,including *** the discoveries of miRNAs and long noncoding RNAs,circRNAs are now acting as a novel re-search entity of interest in the field of RNA disease *** this review,we aim to focus on major updates on the biogeny and metabolism of circRNAs,along with their possible/established roles in major human diseases.

关键词： Circular RNAs Cancer MicroRNA sponges Biomarkers Long noncoding RNA RNA biology

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Updates on“Cancer Genomics and Epigenomics”

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World Journal of Clinical Oncology 2020年第11期11卷 890-897页

作者： Aarti Sharma Kiran Lata Sharma cherry bansal Ashok Kumar Department of Surgical Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India Department of Pathology Baylor College of MedicineHoustonTX 77030United States Department of Pathology Era’s Medical College and HospitalLucknow 226003India

The field of“Cancer Genomics and Epigenomes”has been widely investigated for their involvement in cancer to understand the basic processes of different *** aggregation of genetic and epigenetic alterations also displays a wide range of heterogeneity making it quite necessary to develop personalized treatment *** complex interplay between DNA methylation and chromatin dynamics in malignant cells is one of the major epigenetic mechanisms that lead to gene activation and ***,each tumor needs to be fully characterized to satisfy the ideas of personalized treatment *** present article addresses various aspects of genome characterization methods and their potential role in the field of cancer genomics and epigenomics.

关键词： Genetics Epigenetics Chromatin Cancer Copy number variations Transcription Histone-modifications

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