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解决预防高血压的社会决定因素(RESTORE)网络:预防高血压的健康公平研究网络概述

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中华高血压杂志(中英文) 2024年第1期32卷 100-100页

作者： Spruill TM Muntner P Popp CJ Shimbo D Cooper LA Moran AE Penko J Bibbins-Domingo K Ibe C Nnodim OI Howard G Bellows BK Spoer BR Ravenell J cherrington al Levy P Commodore-Mensah Y Juraschek SP Molello N Dietz KB Brown D Bartelloni A Ogedegbe G 刘青

美国心脏协会资助了一个预防高血压的健康公平研究网络(addressing social determinants to prevent hypertension,RESTORE Network),作为其在所有社区实现健康公平的一部分,本文将概述RESTORE网络。方法:RESTORE网络包括五项独立的随...

美国心脏协会资助了一个预防高血压的健康公平研究网络(addressing social determinants to prevent hypertension,RESTORE Network),作为其在所有社区实现健康公平的一部分,本文将概述RESTORE网络。方法:RESTORE网络包括五项独立的随机试验,测试实施非药物干预措施的方法,这些干预措施已被证实可以降低血压。这些试验以社区为基础,地点包括阿拉巴马州农村的教堂、密歇根州的流动医疗中心、

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中华高血压杂志(中英文) 2023年第1期 100-100页

作者： Akinyelure OP Hubbard D Sakhuja S Hardy ST Oparil S cherrington al Reynolds K Wozniak G Muntner P 林沁郑武洪

在过去1年中未就诊的高血压患者血压失控的可能性更大。本研究人员使用2013—2018年美国国家健康和营养调查数据(n=5985),检查了过去1年美国成人高血压患者未就诊的相关因素。高血压定义为收缩压≥140和/或舒张压≥90mm Hg(1mm Hg=0.133... 详细信息

在过去1年中未就诊的高血压患者血压失控的可能性更大。本研究人员使用2013—2018年美国国家健康和营养调查数据(n=5985),检查了过去1年美国成人高血压患者未就诊的相关因素。高血压定义为收缩压≥140和/或舒张压≥90mm Hg(1mm Hg=0.133k Pa)或使用抗高血压药物。通过自我报告获取受试者过去1年的就诊情况,发现7.0%的美国成年高血压患者在过去1年中未曾就诊。与过去1年曾就诊的患者相比,

关键词：成人高血压国家健康

Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in nonalcoholic steatohepatitis patients

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Acta Pharmaceutica Sinica B 2023年第1期13卷 1-28页

作者： Solène Marie Kayla L.Frost Raymond K.Hau Lucy Martinez-Guerrero Jailyn M.Izu Cassandra M.Myers Stephen H.Wright Nathan J.cherrington College of Pharmacy Department of Pharmacology&ToxicologyUniversity of ArizonaTucsonAZ 85721USA College of Medicine Department of PhysiologyUniversity of ArizonaTucsonAZ 85724USA

The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing enzymes and ***-alcoholic steatohepatitis(NASH)causes disease-specific alterations to the absorption,distribution,metabolism,and excretion(ADME)processes,including a decrease in protein expression of basolateral uptake transporters,an increase in efflux transporters,and modifications to enzyme *** can result in increased drug exposure and adverse drug reactions(ADRs).Our goal was to predict drugs that pose increased risks for ADRs in NASH *** research identified 71 drugs with reported ADRs in patients with liver disease,mainly non-alcoholic fatty liver disease(NAFLD),54 of which are known substrates of transporters and/or metabolizing *** NASH is the progressive form of NAFLD but is most frequently undiagnosed,we identified other drugs at risk based on NASH-specific alterations to ADME ***,we present another list of 71 drugs at risk of pharmacokinetic disruption in NASH,based on their transport and/or metabolism *** encompasses drugs from various pharmacological classes for which ADRs may occur when used in NASH patients,especially when eliminated through multiple pathways altered by the ***,these results may inform clinicians regarding the selection of drugs for use in NASH patients.

关键词： Non-alcoholic steatohepatitis Hepatic elimination Transporter Enzyme Pharmacokinetics Drug-drug interaction Liver Adverse drug reaction

altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3869-3878页

作者： Joseph L.Jilek Kayla L.Frost Kevyn A.Jacobus Wenxi He Erica L.Toth Michael Goedken Nathan J.cherrington Department of Pharmacology&Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85724USA Rutgers Translational Sciences Rutgers UniversityPiscatawayNJ 08901USA

Disease-mediated alterations to drug disposition constitute a significant source of adverse drug ***(CDDP)elicits nephrotoxicity due to exposure in proximal tubule cells during renal *** to renal drug transporter expression have been discovered during nonalcoholic steatohepatitis(NASH),however,associated changes to substrate toxicity is *** test this,a methionine-and choline-deficient diet-induced rat model was used to evaluate NASH-associated changes to CDDP pharmacokinetics,transporter expression,and *** rats administered CDDP(6 mg/kg,i.p.)displayed 20%less nephrotoxicity than healthy ***,CDDP renal clearance decreased in NASH rats from 7.39 to 3.83 mL/min,renal secretion decreased from 6.23 to 2.80 mL/min,and renal CDDP accumulation decreased by 15%,relative to healthy *** copper transporter-1 expression decreased,and organic cation transporter-2 and ATPase copper transporting protein-7 b increased slightly,reducing CDDP *** CDDP accumulation increased 250%in NASH rats relative to healthy *** organic cation transporter-1 induction and multidrug and toxin extrusion protein-1 and multidrug resistance-associated protein-4 reduction may contribute to hepatic CDDP sequestration in NASH rats,although no drug-related toxicity was *** data provide a link between NASH-induced hepatic and renal transporter expression changes and CDDP renal clearance,which may alter nephrotoxicity.

关键词： Nonalcoholic steatohepatitis NASH Cisplatin Drug transporter Nephrotoxicity

糖尿病:过去、现在和将来——2005年第65届ADA年会主席致辞

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国外医学（内分泌学分册） 2005年第5期25卷 i0003-i0005页

作者： alan D.cherrington 朱鋐达 Department of Molecular Physiology and Biophysics Vander bilt Vnivesity School of Medicine Nashville USA 上海第二医科大学附属瑞金医院

在2005年第65届美国糖尿病学会(ADA)年会上,ADA年会主席cherrington教授对美国糖尿病研究的过去、现在和将来作了全面的阐述。

关键词：美国糖尿病学会 ADA年会 2005年

Regulation of drug metabolism and toxicity by multiple factors of genetics,epigenetics,lncRNAs,gut microbiota,and diseases:a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations(MDO)

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Acta Pharmaceutica Sinica B 2017年第2期7卷 241-248页

作者： Ai-Ming Yu Magnus Ingelman-Sundberg Nathan J.cherrington Lauren M.aleksunes Ulrich M.Zanger Wen Xie Hyunyoung Jeong Edward M.Morgan Peter J.Turnbaugh Curtis D.Klaassen Aadra P.Bhatt Matthew R.Redinbo Pengying Hao David J.Waxman Li Wang Xiao-bo Zhong Department of Biochemistry and Molecular Medicine School of MedicineUniversity of California at Davis Department of Physiology and Pharmacology Karolinska Institutet Department of Pharmaceutical Sciences College of PharmacyUniversity of Arizona Department of Pharmacology and Toxicology School of PharmacyRutgers University Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology Eberhard Karls University Center of Pharmacogenomics and Department of Pharmaceutical Sciences School of PharmacyUniversity of Pittsburgh Department of Pharmacy Practice School of PharmacyUniversity of Illinois at Chicago Department of Pharmacology School of MedicineEmory University Department of Microbiology and Immunology and the George William Hooper Research Foundation University of California at San Francisco Department of Environmental and Occupational Health Sciences University of Washington Department of Chemistry University of North Carolina at Chapel Hill Department of Biology and Bioinformatics Program Boston University Department of Physiology and Neurobiology University of Connecticut Department of Pharmaceutical Sciences School of PharmacyUniversity of Connecticut

Variations in drug metabolism may alter drug efficacy and cause toxicity;better understanding of the mechanisms and risks shall help to practice precision *** the 21 st International Symposium on Microsomes and Drug Oxidations held in Davis,California,USA,in October 2-6,2016,a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity,and discussed potential implications to personalized medications.A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption,distribution,metabolism,and excretion(ADME) and drug *** drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were *** addition,the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were *** findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research.

关键词： Drug metabolism and toxicity Genetics Epigenetics Gut microbiota Long non-coding RNAs Disease Personalized medication