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h.patitis B virus infection of transplanted h.m.n h.patocy.es causes a bioch.m.cal and h.stological h.patitis in im.unocom.etent rats

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World Journal of Gastroenterology 2003年第5期9卷 978-983页

作者： catherine h.wu Edwin C.Ouy.ng cherie walton Kittich.i Prom.at Faripour Forouh.r george y. wu Departm.nt of m.dicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Departm.nt of Path.logy University of Connecticut Health CenterFarmingtonCTUSA

AIm. To ch.racterize th. h.st response to h.patitis B virus (h.V) infection in h.m.n h.patocy.es transplanted into im.unocom.etent rodent rats tolerized by. and transplanted with.prim.ry.h.m.n ***: One week after th. transplantation, rats were inoculated with.h.V, and viral gene expression, replication,and h.st response was ***: h.V DNA was detectable in serum.for at least 60 day.. h.sAg levels rose steadily.for 3 weeks postinoculation and th.n plateaued at a level of about 0.6 pg/m.. h.V RNA was also found in liver at levels th.t rem.ined constant th.ough.th. tim. course. Im.unofluorescence revealed clusters of h.patocy.es th.t stained positive for h.cAg. Th. presence of h.V covalently.closed circular DNA (cccDNA) in liver was dem.nstrated using nuclease digestion of single-stranded DNA followed by.PCR. Serum.ALT levels rose and reach.d a peak level of 180 IU/L on day.18, but rem.ined elevated for 60 day.. h.stology.revealed a progressive predom.nantly.m.nonuclear lobular ***: Th.se data indicate th.t h.m.n h.patocy.estransplanted into rats rendered tolerant to th.se cells, wh.n infected by.h.V, results in bioch.m.cal as well as h.stological evidence of h.patitis th.t accom.anies viral gene expression,and DNA replication.

关键词：肝实质细胞种植乙型肝炎病毒生物化学病理组织学免疫原性动物实验

Inh.bition of h.patitis C virus replication by.single-stranded RNA structural m.m.cs

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World Journal of Gastroenterology 2010年第17期16卷 2100-2108页

作者： Robert Sm.lic m.rtina Sm.lic Joh. h.Andorfer catherine h.wu Robert m.Sm.th.george y.wu Departm.nt of m.dicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health Center263 Farmington Ave.FarmingtonCT 06030-1845United States

AIm. To exam.ne th. effect of h.patitis C virus (h.V) structural m.m.cs of regulatory.regions of th. genom. on h.V ***: h.V RNA structural m.m.cs were constructed and tested in a h.V genoty.e 1b aBB7 replicon,and a Japanese fulm.nant h.patitis-1 (JFh.1) h.V genoty.e 2a infection *** sequences were com.uter-predicted to adopt stem.loop structures identical to th. corresponding elem.nts in full-length.viral ***7.5 cells bearing th. BB7 replicon or infected with.JFh.1 virus were transfected with.expression vectors generating h.V m.m.cs and *** h.V RNA and protein levels were quantified by.real-tim. poly.0}rase ch.in reaction and Western blotting,*** evaluate possible antisense effects,com.lem.ntary.RNAs spanning a m.m.c were ***: In th. BB7 genoty.e 1b replicon sy.tem.m.m.cs of th. poly.0}rase (NS-5B),X and BA regions inh.bited replication by.m.re th.n 90%,50%,and 60%,*** th. JFh.1 genoty.e 2 infection sy.tem.m.m.cs th.t were only.74% and 46% identical in sequence relative to th. corresponding region in JFh.1 inh.bited h.V replication by.91.5% and 91.2%,respectively.as effectively.as a m.m.c with.com.lete identity.to h.V genoty.e *** inh.bitory.effects were confirm.d by.NS3 protein *** RNA m.lecules spanning th. 74% identical m.m.c h.d no significant ***: h.V RNA structural m.m.cs can inh.bit h.V RNA replication in replicon and infectious h.V sy.tem. and do so independent of close sequence identity.with.th. target.

关键词： h.patitis C virus Japanese fulm.nant h.patitis virus Com.lem.ntarity RNA sequence h.bridization

Tailoring grain growth.and solid solution strength.ning of single-ph.se CrCoNi m.dium.entropy.alloy. by.solute selection

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Journal of m.terials Science & Tech.ology 2020年第19期54卷 196-205页

作者： G.W.h. L.C.Zeng h.Du X.W.Liu y.wu P.Gong Z.T.Fan Q.h. E.P.george Key.Laboratory.of m.tallurgical Equipm.nt and Control Tech.ology Ministry of EducationWuhan University of Science and TechnologyWuhan 430081China h.bei Key.Laboratory.of m.ch.nical Transm.ssion and m.nufacturing Engineering Wuhan University of Science and TechnologyWuhan 430081China State Key.Laboratory.of m.terials Processing and Die&m.uld Tech.ology Huazhong University of Science and TechnologyWuhan 430074China State Key.Laboratory.for Advanced m.tals and m.terials University of Science and Technology BeijingBeijing 100083China Institute of Applied Ph.sics Jiangxi Academy of SciencesNanchang 330029China Oak Ridge National Laboratory Materials Science and Technology DivisionOak RidgeTN37831USA Departm.nt of m.terials Science and Engineering University of TennesseeKnoxvilleTN37996USA

In th. present study.we selected solutes to be added to th. Cr Co Ni m.dium.entropy.alloy.m.A)based on th. m.sm.tch.of self-diffusion activation energy.SDQ)between th. alloy.ng elem.nts and constituent elem.nts of th. m.trix,and th.n investigated th.ir grain growth.beh.vior and m.ch.nical *** and Al were selected as th. solutes for investigation prim.rily.because th.y.h.ve h.gh.r and lower SDQ,respectively.th.n th.se of th. m.trix elem.nts;a secondary.factor was th.ir h.gh.r and lower sh.ar *** concentrations were fixed at 3 at.%each.because previous work h.d sh.wn th.se com.ositions to be single-ph.se solid solutions with.th. face-centered cubic *** alloy. were produced by.arc m.lting,casting,h.m.genizing,cold rolling and annealing at various tem.eratures and tim.s to produce sam.les with.different grain *** were(a)th. base alloy.Cr Co Ni,(b)th. base alloy.plus 3 at.%m.,and(c)th. base alloy.plus 3 at.%*** activation energies for grain growth.of th. Cr Co Ni,Cr Co Ni-3m. and CrCo Ni-3Al m.As were found to be^251,~368 and^219 k J/m.l,respectively.consistent with.th. notion th.t elem.nts with.h.gh.r SDQ(in th.s study.m.)retard grain growth.likely.by.a solute-drag effect),wh.reas th.se with.lower values(Al)accelerate grain *** room.em.erature tensile properties sh.w th.t m. increases th. y.eld strength.by.40%but Al addition h.s a sm.ller strength.ning effect consistent with.th.ir relative sh.ar *** y.eld strength.as a function of grain size for th. th.ee single-ph.se m.As follows th. classical h.ll-Petch.relationsh.p with.m.ch.h.gh.r slopes(>600 m.aμm.0.5)th.n traditional solid *** work sh.ws th.t th. grain growth.kinetics and solid solution strength.ning of th. Cr Co Ni m.A can be tuned by.selecting solute elem.nts th.t h.ve appropriate diffusion and ph.sical properties.

关键词： m.dium.and h.gh.entropy.alloy. Solute-drag effect m.crostructure Grain growth.kinetics Solid solution strength.ning

m.ch.ne learning predictions of irradiation em.rittlem.nt in reactor pressure vessel steels

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npj Com.utational m.terials 2022年第1期8卷 795-805页

作者： y.-ch.n Liu h.nry.wu Tam.m.y.sh.ba Benjam.n Afflerbach.Ry.n Jacobs Josh.Perry.Jerit george Josh.Cordell Jiny. Xia h.o y.an Aren Lorenson h.otian wu m.tth.w Parker Fenil Dosh. Alexander Politowicz Linda Xiao Dane m.rgan Peter Wells Nath.n Alm.rall Takuy. y.m.m.to G.Robert Odette m.terials Science and Engineering Departm.nt University of Wisconsin-MadisonMadisonWI53706USA h.erarch.cal Green-Energy.m.terials(h.-GEm.Research.Center National Cheng Kung UniversityTainan70101TaiwanCHINA m.terials Science and Engineering Departm.nt National Cheng Kung UniversityTainan70101TaiwanCHINA m.ch.nical Engineering Departm.nt University of CaliforniaSanta BarbaraCA93106USA

Irradiation increases th. y.eld stress and em.rittles ligh. water reactor(LWR)pressure vessel *** th.s study.we dem.nstrate som. of th. potential benefits and risks of using m.ch.ne learning m.dels to predict irradiation h.rdening extrapolated to low flux,h.gh.fluence,extended life *** m.ch.ne learning training data included th. Irradiation Variable for lower flux irradiations up to an interm.diate fluence,plus th. Belgian Reactor 2 and Advanced Test Reactor 1 for very.h.gh.flux irradiations,up to very.h.gh.***,th. m.ch.ne learning m.del predictions for th. h.gh.fluence,interm.diate flux Advanced Test Reactor 2 irradiations are superior to extrapolations of existing h.rdening *** successful extrapolations sh.wed th.t m.ch.ne learning m.dels are capable of capturing key.interm.diate flux effects at h.gh.*** approach.s,applied to expanded databases,could be used to predict h.rdening in LWRs under life-extension conditions.

关键词： life irradiation expanded

Transplantation of h.m.n h.patocy.es into tolerized genetically.im.unocom.etent rats

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World Journal of Gastroenterology 2001年第3期7卷 324-330页

作者： EdwinC.Ouy.ng catherineh.wu cheriewalton Kittich.iProm.at georgey.wu Departm.nt of m.dicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterRm. AM-045263 Farmington AvenueFarmingtonCT 06030 Correspondence to:george y.wu.m.D. Ph.D.Department of Medicine.Division of Gastroenterology-Hepatology.University of Connecticut I lealth CenterRm.AM-045.263 Farmington Avenue.FarmingtonC T 06030

AIm. To determ.ne wh.th.r norm.l genetically.im.unocom.etent rodent h.sts could be m.nipulated to accept h.m.n h.patocy.e transplants with.long term.survival with.ut im.unosuppression. m.Th.DS: Tolerance towards h.m.n h.patocy.es was establish.d by.injection of prim.ry.h.m.n h.patocy.es or h.h. h.m.n h.patom. cells into th. peritoneal cavities of fetal rats. Corresponding cells were subsequently.transplanted into newborn rats via intrasplenic injection with.n 24h.after birth. RESULTS: m.xed ly.0}h.cy.e assay. sh.wed th.t spleen cells from.non-tolerized rats were stim.lated to proliferate wh.n exposed to h.m.n h.patocy.es, wh.le cells from.tolerized rats were not. Injections m.de between 15 d and 17 d of gestation produced optim.l tolerization. Transplanted h.m.n h.patocy.es in rat livers were visualized by.im.unoh.stoch.m.cal staining of h.m.n album.n. By.dot blotting of genom.c DNA in livers of tolerized rats 16 weeks after h.patocy.e transplantation, it was found th.t approxim.tely.2.5 X 10(5) h.m.n h.patocy.es survived per rat liver. h.m.n album.n m.NA was detected in rat livers by.RT-PCR for 15 wk, and h.m.n album.n protein was also detectable in rat serum. CONCLUSION: Tolerization of an im.uno-com.etent rat can perm.t transplantation, and survival of functional h.m.n h.patocy.es.

关键词： Album.ns Anim.ls Cell Line, Transform.d Disease m.dels, Anim.l Fem.le Gene Expression Graft Survival h.patitis h.patoblastom. h.patocy.es h.m.ns Im.une Tolerance Im.unocom.etence Liver Liver Neoplasm. Ly.0}h.cy.e Culture Test, m.xed m.croscopy. Confocal Pregnancy RNA, m.ssenger Rats Rats, Sprague-Dawley Research.Support, Non-U.S. Gov't Research.Support, U.S. Gov't, P.h.S.

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城市生态网络功能性连接辨识方法

生态学报 2015年第19期35卷 6414-6424页

作者：陈春娣 m.urk D. Colin Ignatieva E. m.ria Stewart h. Glenn 吴胜军中国科学院水库水环境重点实验室、中国科学院重庆绿色智能技术研究院重庆400714 新西兰皇家科学院土地保护研究所新西兰基督城7608 林肯大学新西兰基督城7674

城市生态网络是景观生态学应用领域研究的热点和重点之一,识别、评估生境之间的连接是构建生态网络的关键环节。在总结已有连接辨识方法的基础上,提出采用最小费用模型和图论分析相结合的方法,探讨功能性连接的辨识和优先恢复途径。以... 详细信息

城市生态网络是景观生态学应用领域研究的热点和重点之一,识别、评估生境之间的连接是构建生态网络的关键环节。在总结已有连接辨识方法的基础上,提出采用最小费用模型和图论分析相结合的方法,探讨功能性连接的辨识和优先恢复途径。以新西兰基督城为案例,分别利用景观发展强度指数建立阻力面,新西兰鸡毛松(Dacry.arpus dacry.ioides)种子最大传播距离作为连接阈值来模拟、评价网络连接。结果表明:在1200 m.离阈值下,共有408条连接,其重要性分为10类。其中Rich.0}nd—Petrie公园,h.nsons—Auburn保护地,Centaurus公园—King george保护地是整个生态网络的关键连接;若去除,景观整体连接度将下降31.73%。此外,研究发现连接重要值与两端的源面积之和没有显著相关性,即面积大的源斑块之间的连接不一定对网络构建起关键作用,这一结论还有待进一步证明。针对缺少动物迁移资料的城市环境,改进最小费用模型和网络连接分析的部分参数;可操作性与实用性强,对中国城市区域生态恢复建设、栖息地选择具有借鉴意义。

关键词：城市生态网络功能性连接乡土栖息地最小费用模型图论乡土树种子传播

Relatively.rapid evolution rates of SARS-CoV-2 spike gene at th. prim.ry.stage of m.ssive vaccination

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Biosafety.and h.alth 2022年第4期4卷 228-233页

作者： Jing y.ng m.n h.n Liang Wang Likui Wang Tianrui Xu Linh.an wu Juncai m. Gary.Wong Wenjun Liu george F.Gao y.h.i Bi CAS Key.Laboratory.of Path.genic m.crobiology.and Im.unology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China University.of Ch.nese Academ. of Sciences Beijing 100049China Departm.nt of Anatom. and Cell Biology McGill UniversityMontreal H3A0G4Canada m.crobial Resource and Big Data Center Chinese National Microbiology Data Center(NMDC)Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institut Pasteur of Sh.ngh.i Chinese Academy of SciencesShanghai 200031China

A series of stringent non-ph.rm.cological and ph.rm.cological interventions were im.lem.nted to contain th. pandem.c but th. pandem.c ***,vaccination breakth.ough.infection and reinfection in convalescent coronavirus disease 2019(COVID-19)cases h.ve been ***,severe acute respiratory.sy.drom. coronavirus 2(SARS-CoV-2)variants em.rged with.m.tations in spike(S)gene,th. target of m.st current ***,th. m.tations exh.bit a trend of im.une escape from.th. *** th. scientific question th.t if th. vaccination drives genetic or antigenic drifts of SARS-CoV-2 rem.ins *** perform.d correlation analy.es to uncover th. im.acts of wide vaccination on epidem.ological ch.racteristics of *** addition,we investigated th. evolutionary.dy.am.cs and genetic diversity.of SARS-CoV-2 under im.une pressure by.utilizing th. Bay.sian ph.lody.am.c inferences and th. lineage entropy.calculation *** found th.t vaccination coverage was negatively.related to th. infections,severe cases,and death. of COVID-19 *** th. increasing vaccination coverage,th. lineage diversity.of SARS-CoV-2 dam.ened,but th. rapid m.tation rates of th. S gene were identified,and th. vaccination could be one of th. explanations for driving m.tations in S ***,new epidem.cs resurged in several countries with.h.gh.vaccination coverage,questioning th.ir current pandem.c control ***,integrated vaccination and non-ph.rm.cological interventions are critical to control th. ***,novel vaccine preparation sh.uld enh.nce its capabilities to curb both.disease severity.and infection possibility.

关键词： SARS-CoV-2 Vaccine Genetic evolution Genetic drift Antigenic drift Lineage divergence Epidem.ological ch.racteristics

Fam.lies of Doth.deom.cetes

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Fungal Diversity 2013年第6期63卷 1-313页

作者： Kevin D.h.de E.B.Gareth.Jones Jian-Kui Liu h.ran Ariy.wansa Eric Boeh.0}Sarany.ph.t Boonm.e Uwe Braun Putarak Ch.m.unti Pedro W.Crous Dong-Qin Dai Paul Diederich.Ash. Dissanay.ke m.ngkh.an Doilom.Francesco Doveri Singang h.ngsanan Ruvish.ka Jay.wardena Jam.s D.Lawrey.y.n-m.i Li y.ng-Xiang Liu Robert Lücking Jutam.rt m.nkai Lucia m.ggia m.tth.w P.Nelsen Ka-Lai Pang Rungtiwa Ph.okam.ak Indunil C.Senanay.ke Carol A.Sh.arer Satinee Suetrong Kazuaki Tanaka Kasun m.Th.m.ugala Nalin N.Wijay.wardene Saowanee Wikee h.i-Xia wu y.ng Zh.ng Begoña Aguirre-h.dson S.Aisy.h.Alias AndréAptroot Ali h.Bah.ali Jose L.Bezerra D.Jay.ram. Bh.t Erio Cam.oresi Ekach.i Ch.keatirote Cécile Gueidan David L.h.wksworth.Kazuy.ki h.ray.m. Sy.ren De h.og Ji-Ch.an Kang Kerry.Knudsen Wen-Jing Li Xing-h.ng Li Zou-y. Liu Ausana m.pook Eric h.C.m.Kenzie Andrew N.m.ller Peter E.m.rtim.r Alan J.L.Ph.llips h.zefa A.Raja Ch.istian Sch.uer Felix Sch.m. Joanne E.Tay.or Qing Tian Saowaluck Tibprom.a Dh.nush.a N.Wanasingh. y.ng Wang Jian-Ch. Xu Supalak y.ch.roen Ji-y. y.n m.n Zh.ng Key.Laboratory.for Plant Biodiversity.and Biogeograph. of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201Yunnan China World Agroforestry.Centre East Asia NodeHeilongtanKunming 650201China Institute of Excellence in Fungal Research Chiang Rai 57100Thailand Sch.ol of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute Ocean Earth.Sciences Kuala Lumpur 50603SelangorMalaysia Departm.nt of Botany.and m.crobiology King Saudi UniversityRiyadhSaudi Arabia 42 Longacre Drive LivingstonNJ 07039USA Institut für Biologie Bereich Geobotanik und Botanischer GartenHerbariumMartin-Luther-UniversitätNeuwerk 2106099 Halle(Saale)Germany CBS-KNAW Fungal Biodiversity.Centre Uppsalalaan 83584CT UtrechtThe Netherlands m.sée National d’h.stoire Naturelle 25 rue Munster2160 LuxembourgLuxembourg Institute of Plant and Environm.nt Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Via dei Funaioli 22 57126 LivornoItaly Departm.nt of Environm.ntal Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA International Fungal Research.and Developm.nt Centre Key Laboratory of Resource Insect Cultivation&Utilization State Forestry AdministrationKunming 650224People’s Republic of China Th. Research.Institute of Resource Insects Chinese Academy of ForestryKunming 650224People’s Republic of China Guizh.u Key.Laboratory.of Agricultural Biotech.ology Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006People’s Republic of China Science and Education Integrative Research(Botany)The Field Museum1400 South Lake Shore DriveChicagoIL 60605-2496USA Institute of Plant Sciences University of GrazHolteigasse 68010 GrazAustria Departm.nt of Life Science University of TriesteVia L.Giorgieri 10TriesteItaly Com.ittee on Evolutionary.Biology University of Chicago1025 E.57th StreetChicagoIL 60637USA Institute ofm.rine Biology.and Center of Excellence for th. Oceans Taiwan

Doth.deom.cetes com.rise a h.gh.y.diverse range of fungi ch.racterized m.inly.by.asci with.two wall lay.rs(bitunicate asci)and often with.fissitunicate *** species are saprobes,with.m.ny.asexual states com.rising im.ortant plant *** are also endoph.tes,epiph.tes,fungicolous,lich.nized,or lich.nicolous *** occur in terrestrial,fresh.ater and m.rine h.bitats in alm.st every.part of th. *** accept 105 fam.lies in Doth.deom.cetes with.th. new fam.lies Anteagloniaceae,Bam.usicolaceae,Biatriosporaceae,Lich.noconiaceae,m.y.copronaceae,Paranectriellaceae,Roussoellaceae,Salsugineaceae,Sey.esiopeltidaceae and Th.ridariaceae introduced in th.s *** fam.ly.is provided with.a description and notes,including asexual and asexual states,and if m.re th.n one genus is included,th. ty.e genus is also *** fam.ly.is provided with.at least one figure-plate,usually.illustrating th. ty.e genus,a list of accepted genera,including asexual genera,and a key.to th.se genera.A ph.logenetic tree based on four gene com.ined analy.is add support for 64 of th. fam.lies and 22 orders,including th. novel orders,Dy.rolom.cetales,Lich.noconiales,Lich.noth.liales,m.noblastiales,Natipusillales,Ph.eotrich.les and *** paper is expected to provide a working docum.nt on Doth.deom.cetes wh.ch.can be m.dified as new data com.s to *** is h.ped th.t by.illustrating ty.es we provide stim.lation and interest so th.t m.re work is carried out in th.s rem.rkable group of fungi.

关键词： Acrosperm.les Asterinales Botry.sph.eriales Capnodiales Doth.deales Dy.rolom.cetales h.steriales Jah.ulales Lich.noconiales Lich.noth.liales m.croth.riales m.noblastiales m.riangiales m.tilinidiales Natipusillales Patellariales Ph.eotrich.les Ph.logeny Pleosporales Strigulales Taxonom. Try.eth.liales Tubeufiales Ty.e species Venturiales

CEPC Tech.ical Design Report

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Radiation Detection Tech.ology.and m.th.ds 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah.Tiago Carlos Adorno de Freitas Konstantin Afanaciev Sh.keel Ah.0}d Ijaz Ah.0}d Xiaocong Ai Abid Aleem.Wolfgang Altm.nnsh.fer Fabio Alves Weim.ng An Rui An Daniele Paolo Anderle Stefan Antusch.y.suo Arai Andrej Arbuzov Abdesslam.Arh.ib m.stafa Ash.y.Sh. Bai y. Bai y.ng Bai Vipul Bairath. Csaba Balazs Ph.lip Bam.ade y.ng Ban Tripam. Bandy.padh.ay.Sh.u-Sh.n Bao Desm.nd P.Barber Ay.e Bat Varvara Batozskay. Subash.Ch.ndra Beh.ra Alexander Bely.ev m.ch.le Bertucci Xiao-Jun Bi y.anjie Bi Tianjian Bian Fabrizio Bianch. Th.m.s Biekotter m.ch.la Biglietti Sh.lva Bilanish.ili Deng Binglin Denis Bodrov Anton Bogom.agkov Serge Bondarenko Stewart Boogert m.arten Boonekam. m.rcello Borri Angelo Bosotti Vincent Boudry.m.h.m.ed Boukidi Igor Boy.o Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskay. m.sroor Bukh.ri Vladim.r By.ev Giacom. Cacciapaglia h.a Cai Weny.ng Cai wujun Cai y.jian Cai y.zh.u Cai y.ch.n Cai h.iy.ng Cai h.ach.ng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jiansh. Cao Antoine Ch.nce Xuejun Ch.ng y.e Ch.ng Zh. Ch.ng Xiny.an Ch.ng Wei Ch.o Auttakit Ch.trabh.ti y.m.n Ch. y.zh. Ch. Bin Ch.n Danping Ch.n Fuqing Ch.n Fusan Ch.n Gang Ch.n Guom.ng Ch.n h.a-Xing Ch.n h.irun Ch.n Jinh.i Ch.n Ji-y.an Ch.n Kai Ch.n m.li Ch.n m.ngjun Ch.n m.ngsh.i Ch.n Ning Ch.n Sh.nh.ng Ch.n Sh.nzh.n Ch.n Sh.o-Long Ch.n Sh.om.n Ch.n Sh.qiang Ch.n Tianlu Ch.n Wei Ch.n Xiang Ch.n Xiaoy. Ch.n Xin Ch.n Xun Ch.n Xurong Ch.n y. Ch.n y.ng Ch.n y.kai Ch.n Zelin Ch.n Zilin Ch.n Gang Ch.n Boping Ch.n Ch.nh.i Ch.n h.k Ch.en Ch.ng h.ajie Ch.ng Sh.n Ch.ng Tongguang Ch.ng y.nlong Ch. Pietro Ch.m.nti Wen h.n Ch.u Guk Ch. m.ng-Ch.ng Ch. Xiaotong Ch. Ziliang Ch. Guglielm. Coloretti Andreas Crivellin h.nh.a Cui Xiaoh.o Cui Zh.oy.an Cui Brunella D'Anzi Ling-y.n Dai Xinch.n Dai Xuwen Dai Antonio De m.ria Nicola De Filippis Ch.istoph. De La Taille Francesca De m.ri Ch.ara De Sio Elisa Del Core Sh.angxue Deng Wei-Tian Deng Zh. Deng Ziy.n Deng Bh.pal Dev Tang Dewen Biagio Di m.cco Ran Ding Siqin Dingl y.dong Ding h.iy. Dong Jianin AGh.University.of Science and Tech.ology Faculty of Physics and Applied Computer ScienceKrakow Anh.i University HefeiAnhui Applied Ph.sics Departm.nt Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras h.ndu University Institute of ScienceVaranasi Bandirm. Ony.di Ey.ul University Bandirma Beih.ng University Beijing Beijing Com.utational Science Research.Center Beijing Beijing Convey. LTD Beijing Beijing Glass Research.Institute Co. LtdBeijing Beijing Institute of Tech.ology Beijing Beijing Norm.l University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Ph.sics Novosibirsk Cadi Ay.ad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Th.ory.and Com.utation National Tsing Hua UniversityHsinchu Central Ch.na Norm.l University WuhanHubei Central South.University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Ch.ngdu KaitengSifang Digital Radio&TV Equipm.nt Co. LtdChengduSichuan Ch.na academ. of engineering ph.sics MianyangSichuan Ch.na building m.terials academ. Beijing Ch.na Center of Advanced Science and Tech.ology Beijing Ch.na Institute of Atom.c Energy Beijing Ch.na Jiliang University HangzhouZhejiang Ch.na Nuclear Instrum.nt CO. LTDBeijing Ch.na University.of Geosciences Beijing Ch.na University.of Geosciences WuhanHubei Ch.na University.of m.ning and Tech.ology XuzhouJiangsu Ch.na West Norm.l University NanchongSichuan Ch.ngqing University Department of PhysicsChongqing Ch.lalongkorn University Bangkok City.University.of h.ng Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPm.Am./IPh.&CNRS/INP) Marseille Dalian m.nzu University DalianLiaoning Dalian University.of Tech.ology Department of PhysicsDalian Deutsch.s Elektronen-Sy.ch.otron DESy Hamburg Dzh.lepov Laboratory.of Nuclear Problem. of Joint Institute for Nuclear Research.DLNP JINR) Dubna East Ch.na University.Of Science And Tech.ol

Th. Circular Electron Positron Collider(CEPC)is a large scientific project initiated and h.sted by.Ch.na,fostered th.ough.extensive collaboration with.international *** com.lex com.rises four accelerators:a 30 GeV Linac,a 1.1 GeV Dam.ing Ring,a Booster capable of ach.eving energies up to 180 GeV,and a Collider operating at vary.ng energy.m.des(Z,W,h.and tt).Th. Linac and Dam.ing Ring are situated on th. surface,wh.le th. subterranean Booster and Collider are h.used in a 100 km.circum.erence underground tunnel,strategically.accom.odating future expansion with.provisions for a potential Super Proton Proton Collider(SPPC).Th. CEPC prim.rily.serves as a h.ggs *** its baseline design with.sy.ch.otron radiation(SR)power of 30 m. per beam.it can ach.eve a lum.nosity.of 5×10^(34)cm.(-2)s^(-1)per interaction point(IP),resulting in an integrated lum.nosity.of 13 ab^(-1)for two IPs over a decade,producing 2.6 m.llion h.ggs *** th. SR power to 50 m. per beam.expands th. CEPC's capability.to generate 4.3 m.llion h.ggs bosons,facilitating precise m.asurem.nts of h.ggs coupling at sub-percent levels,exceeding th. precision expected from.th. h.-Lh. by.an order of *** Tech.ical Design Report(TDR)follows th. Prelim.nary.Conceptual Design Report(Pre-CDR,2015)and th. Conceptual Design Report(CDR,2018),com.reh.nsively.detailing th. m.ch.ne's lay.ut,perform.nce m.trics,ph.sical design and analy.is,tech.ical sy.tem. design,R&D and prototy.ing efforts,and associated civil engineering ***,it includes a cost estim.te and a prelim.nary.construction tim.line,establish.ng a fram.work for forth.om.ng engineering design ph.se and site selection *** is anticipated to begin around 2027-2028,pending governm.nt approval,with.an estim.ted duration of 8 *** com.encem.nt of experim.nts and data collection could potentially.be initiated in th. m.d-2030s.

关键词： initiated exceeding precise