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Long-term clinical outcomes of lipiodol marking using standard gastroscopy for image-guided radiotherapy of upper gastrointestinal cancers

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World Journal of Gastroenterology 2021年第42期27卷 7387-7401页

作者： Kim Hay Be Richard Khor Daryl lim Joon Ben Starvaggi Michael Chao Sweet ping Ng Michael Ng Leonardo Zorron Cheng Tao Pu Marios Efthymiou Rhys Vaughan Sujievvan Chandran Department of Gastroenterology and Hepatology Austin HealthHeidelberg 3084VictoriaAustralia Department of Radiation Oncology Austin HealthHeidelberg 3084VictoriaAustralia School of Cancer Medicine La Trobe UniversityMelbourne 3086VictoriaAustralia Medicine Dentistry and Health SciencesUniversity of MelbourneParkville 3010VictoriaAustralia Genesis Care East Melbourne 3002VictoriaAustralia

BACKGROUND Image-guided radiotherapy(IGRT)has significantly improved the precision in which radiotherapy is delivered in cancer ***,IGRT uses bony landmarks and key anatomical structures to locate the *** studies have demonstrated the feasibility of peri-tumor fiducials in enabling even more accurate delineation of target and normal *** use of gold coils as fiducials in gastrointestinal tumors has been extensively ***,placement requires expertise and specialized endoscopic ultrasound *** article reports the long-term outcomes of using a standard gastroscopy to inject liquid fiducials for the treatment of oesophageal and gastric tumors with *** To assess the long-term outcomes of liquid fiducial-guided IGRT in a cohort of oesophageal and gastric cancer *** A retrospective cohort study of consecutive adults with Oesophagogastric cancers referred for liquid fiducial placement before definitive/neo-adjuvant or palliative IGRT between 2013 and 2021 at a tertiary hospital in Melbourne,Australia was *** to four liquid fiducials were inserted per patient,each injection consisting of 0.2-0.5mL of a 1:1 mixture of iodized oil(Lipiodol;Aspen Pharmacare)and n-butyl 2-cyanoacrylate(Histoacryl®;***).A 23-gauge injector(Cook Medical)was used for the *** procedures were performed by or under the supervision of a *** fiducial-based IGRT(LF-IGRT)consisted of computer-assisted direct matching of the fiducial region on cone-beam computerised tomography at the time of *** received standard-IGRT(S-IGRT)if fiducial visibility was insufficient,consisting of bone match as a surrogate for tumor *** was delivered to 54Gy in 30 fractions for curative patients and up to 45Gy in 15 fractions for palliative *** 52 patients were referred for liquid fiducial placement within the study period.A total of 51 patients underwent liquid f

关键词： Image-guided radiotherapy Lipiodol Gastroscopy Gastric cancer Oesophageal cancer Fiducial

Hologenomic insights into mammalian adaptations to myrmecophagy

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National Science Review 2023年第4期10卷 24-36页

作者： Shao-Chen Cheng Chun-Bing Liu Xue-Qin Yao Jing-Yang Hu Ting-Ting Yin Burton K.lim Wu Chen Guo-Dong Wang Cheng-Lin Zhang David M.Irwin Zhi-Gang Zhang Ya-ping Zhang Li Yu State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan School of Life SciencesYunnan University State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Department of Natural History Royal Ontario Museum Guangzhou Zoo Center for Excellence in Animal Evolution and Genetics Kunming Institute of ZoologyChinese Academy of Sciences Beijing Zoo Department of Laboratory Medicine and Pathobiology University of Toronto

Highly specialized myrmecophagy(ant-and termite-eating) has independently evolved multiple times in species of various mammalian orders and represents a textbook example of phenotypic evolutionary convergence. We explored the mechanisms involved in this unique dietary adaptation and convergence through multi-omic analyses, including analyses of host genomes and transcriptomes, as well as gut metagenomes, in combination with validating assays of key enzymes’ activities, in the species of three mammalian orders(anteaters, echidnas and pangolins of the orders Xenarthra, Monotremata and Pholidota, respectively) and their relatives. We demonstrate the complex and diverse interactions between hosts and their symbiotic microbiota that have provided adaptive solutions for nutritional and detoxification challenges associated with high levels of protein and lipid metabolisms, trehalose degradation, and toxic substance detoxification. Interestingly, we also reveal their spatially complementary cooperation involved in degradation of ants’ and termites’ chitin exoskeletons. This study contributes new insights into the dietary evolution of mammals and the mechanisms involved in the coordination of physiological functions by animal hosts and their gut commensals.

关键词： myrmecophagy adaptive evolution hologenome genomics metagenomics convergent evolution

Application of a microscopic optical potential of chiral effective field theory in (p, d) transfer reactions

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Nuclear Science and Techniques 2024年第1期35卷 134-144页

作者： Yi-ping Xu Si-Lu Chen Dan-Yang Pang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China School of Physics Beihang UniversityBeijing 100191China

The microscopic global nucleon–nucleus optical model potential(OMP)proposed by Whitehead,lim,and Holt,the WLH potential(Whitehead et al.,Phys Rev Lett 127:182502,2021),which was constructed in the framework of many-body per-turbation theory with state-of-the-art nuclear interactions from chiral effective field theory(EFT),was tested with(p,d)transfer reactions calculated using adiabatic wave *** target nuclei included both stable and unstable nuclei,and the incident energies reached 200 *** results were compared with experimental data and predictions using the phenomenological global optical potential of Koning and Delaroche,the KD02 ***,we found that the micro-scopic WLH potential described the(p,d)reaction angular distributions similarly to the phenomenological KD02 potential;however,the former was slightly better than the latter for radioactive *** average,the obtained spectroscopic factors(SFs)using both microscopic and phenomenological potentials were similar when the incident energies were below approxi-mately 120 ***,their difference tended to increase at higher incident energies,which was particularly apparent for the doubly magic target nucleus 40Ca.

关键词： Microscopic optical model potential (p,d)transfer Spectroscopic factors

Ultimate generalization to monotonicity for uniform convergence of trigonometric series

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Science China Mathematics 2010年第7期53卷 1849-1858页

作者： Zhou Songping Zhou ping Yu DanSheng Zhejiang Sci Tech Univ Inst Math Hangzhou 310018 Peoples R China St Francis Xavier Univ Dept Math Stat & Comp Sci Antigonish NS B2G 2W5 Canada Hangzhou Normal Univ Dept Math Hangzhou 310036 Zhejiang Peoples R China

Chaundy and Jolliffe proved that if {a n } is a non-increasing (monotonic) real sequence with lim n →∞ a n = 0, then a necessary and sufficient condition for the uniform convergence of the series ∑∞ n=1 a n sin nx is lim n →∞ na n = 0. We generalize (or weaken) the monotonic condition on the coefficient sequence {a n } in this classical result to the so-called mean value bounded variation condition and prove that the generalized condition cannot be weakened further. We also establish an analogue to the generalized Chaundy-Jolliffe theorem in the complex space.

关键词： trigonometric series uniform convergence monotonicity mean value bounded variation

Twelve-week study of moxa smoke: occupational exposure in female rats

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Journal of Traditional Chinese Medicine 2019年第2期39卷 207-212页

作者： Han Li Huang Chang Yang Jia Wang Lei Bai Hua Liu Juntian Jian Huang Liu ping lim MinYee Ju Dahong Lao Lixing Liu Changxi Zhao Baixiao Sun Wen Xu Anping Yang Xiuyan Zhang Cong He Rui Shool of Chinese medicine Beijing University of Chinese MedicineBeijing 100029China Shool of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Department of Acupunture Beijing Dong Fang HospitalBeijing 100078China Healthcare Management Center Beijing Electric Power HospitalBeijing 100073China Medical Experimental Center China Academy of Chinese Medical SciencesBeijing 100700China School of Chinese Medicine The University of Hong KongHong Kong 999077China

OBJECTIVE: To assess the toxicity of moxa smoke in ***: Forty-eight female Wister rats were randomly divided into 4 groups(n = 12/group) to simulate moxa smoke exposure in Chinese medicine clinics(CMCs): the control group, and three moxa-smoke exposed groups of PM10 mass concentrations 3-5, 7-9 and 27-30 mg/m^3, *** concentrations were 1 ×, 2-3 ×, and 7-9 ×fold the concentrations found in CMCs. Exposures continued for 12 weeks(200 min/d, 5 d/week).RESULTS: No deaths were noted. After the exposure, the body weights, ratios of organ weight to body weight, urinary parameters, hematological parameters, clinical chemistry parameters and microscopic examinations revealed no obvious ***: Moxa smoke did not induce toxic effects in female rats in the study. These findings provide new evidence to the toxicity of moxa smoke.

关键词： Moxibustion Artemisia Smoki ng,non-tobacco products Toxicity tests

Contour Based Path Planning with B-Spline Trajectory Generation for Unmanned Aerial Vehicles (UAVs) over Hostile Terrain

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Journal of Intelligent Learning Systems and Applications 2011年第3期3卷 122-130页

作者： Ee-May Kan Meng-Hiot lim Swee-ping Yeo Jiun-Sien Ho Zhenhai Shao 不详

This research focuses on trajectory generation algorithms that take into account the stealthiness of autonomous UAVs;generating stealthy paths through a region laden with enemy radars. The algorithm is employed to estimate the risk cost of the navigational space and generate an optimized path based on the user-specified threshold altitude value. Thus the generated path is represented with a set of low-radar risk waypoints being the coordinates of its control points. The radar-aware path planner is then approximated using cubic B-splines by considering the least radar risk to the destination. Simulated results are presented, illustrating the potential benefits of such algorithms.

关键词： Unmanned Aerial Vehicles (UAVs) Radar Path Planning B-Splines

Credit Card Fraud Detection on Original European Credit Card Holder Dataset Using Ensemble Machine Learning Technique

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Journal of Cyber Security 2023年第1期5卷 33-46页

作者： Yih Bing Chu Zhi Min lim Bryan Keane ping Hao Kong Ahmed Rafat Elkilany Osama Hisham Abusetta Department of Electrical and Electronic Engineering FETBEUCSI UniversityKuala Lumpur56000Malaysia

The proliferation of digital payment methods facilitated by various online platforms and applications has led to a surge in financial fraud,particularly in credit card *** technologies such as machine learning have been widely employed to enhance the early detection and prevention of losses arising frompotentially fraudulent ***,a prevalent approach in existing literature involves the use of extensive data sampling and feature selection algorithms as a precursor to subsequent *** sampling techniques can significantly reduce computational time,the resulting dataset relies on generated data and the accuracy of the pre-processing machine learning models *** datasets often lack true representativeness of realworld data,potentially introducing secondary issues that affect the precision of the *** instance,undersampling may result in the loss of critical information,while over-sampling can lead to overfitting machine learning *** this paper,we proposed a classification study of credit card fraud using fundamental machine learning models without the application of any sampling techniques on all the features present in the original *** results indicate that Support Vector Machine(SVM)consistently achieves classification performance exceeding 90%across various evaluation *** discovery serves as a valuable reference for future research,encouraging comparative studies on original dataset without the reliance on sampling ***,we explore hybrid machine learning techniques,such as ensemble learning constructed based on SVM,K-Nearest Neighbor(KNN)and decision tree,highlighting their potential advancements in the *** study demonstrates that the proposed machine learning models yield promising results,suggesting that pre-processing the dataset with sampling algorithm or additional machine learning technique may not always be *** research contributes to the fi

关键词： Machine learning credit card fraud ensemble learning non-sampled dataset hybrid AI models European credit card holder

Studies of Characterization of Microstructures for Low Dimensional Materials

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Journal of Iron and Steel Research International 1994年第1期1卷 25-38页

作者： ZHU Jing lim Xi Wei XU Hai Gang HU Jin Sheng LU Hong Xiu Guo Wei ZHAO Xiang Rong JIA Li ping YE Heng Qiang andNIHG Xiao Guang Central Iron & Steel Research Institute MMI Lab of Atomic Imaging of Solids Institute of Metal Research Academia Sinica

The characterization of microstructure for three kinds of typical low dimensional materials,such as ultrafine particle(zero- dimension),whisker(one- dimension)and thin film(two-dimensions),has been carried *** methods and criteria for the characterization are investigated and *** interesting results of the characterization are reported.

关键词： microstructure ultrafine-particle whisker thin film low dimensional material

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聚己酸内酯纳米纤维的拉伸试验及表面表征

高分子材料科学与工程 2008年第11期24卷 126-129页

作者：原波王珺韩平畴林水德复旦大学力学与工程科学系复旦大学材料科学系上海200433 北京大学工学院北京100871 新加坡国立大学生物工程部与机械工程系新加坡117576

文中采用静电纺丝法制备了纳米聚己酸内酯纤维,对单根纤维进行了单向拉伸试验,研究了单根纤维在纳米尺度的基本力学性能;并通过原子力显微镜研究了纤维表面结构特征对纤维力学性能的影响。结果表明,在拉伸载荷作用下,随着纤维直径的减小... 详细信息

文中采用静电纺丝法制备了纳米聚己酸内酯纤维,对单根纤维进行了单向拉伸试验,研究了单根纤维在纳米尺度的基本力学性能;并通过原子力显微镜研究了纤维表面结构特征对纤维力学性能的影响。结果表明,在拉伸载荷作用下,随着纤维直径的减小,纤维的杨氏模量没有显著的变化;纤维表面特征对纤维的拉伸强度有重要影响,但对纤维的杨氏模量影响不大。

关键词：纳米纤维静电纺丝法拉伸试验表面特征