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CORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model via effective CO delivery

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Acta Pharmaceutica Sinica B 2020年第12期10卷 2362-2373,2440页

作者： Gwan-Yeong lee Alam Zeb Eun-Hye Kim Beomseon Suh Young-Jun Shin Donghyun Kim Kyoung-Won Kim Yeong-Hwan Choe ho-Ik Choi cheol-ho lee Omer Salman Qureshi In-Bo Han Sun-Young Chang Ok-Nam Bae Jin-Ki Kim College of Pharmacy Institute of Pharmaceutical Science and TechnologyHanyang UniversityAnsan 15588Republic of Korea Riphah Institute of Pharmaceutical Sciences Riphah International UniversityIslamabad 44000Pakistan Department of Pharmacy Forman Christian CollegeLahore 54600Pakistan Department of Neurosurgery CHA Bundang Medical CenterSchool of MedicineCHA UniversitySeongnam 13496Republic of Korea College of Pharmacy Ajou UniversitySuwon 16499Republic of Korea

The short release half-life of carbon monoxide(CO)is a major obstacle to the effective therapeutic use of carbon monoxide-releasing molecule-2(CORM-2).The potential of CORM-2-entrapped ultradeformable liposomes(CORM-2-UDLs)to enhance the release half-life of CO and alleviate skin inflammation was investigated in the present ***-2-UDLs were prepared by using soy phosphatidylcholine to form lipid bilayers and Tween 80 as an edge *** deformability of CORM-2-UDLs was measured and compared with that of conventional liposomes by passing formulations through a filter device at a constant *** release profile of CO from CORM-2-UDLs was evaluated by myoglobin *** vitro and in vivo anti-inflammatory effects of CORM-2-UDLs were assessed in lipopolysaccharide-stimulated macrophages and TPA-induced ear edema model,*** deformability of the optimized CORM-2-UDLs was 2.3 times higher than conventional ***-2-UDLs significantly prolonged the release half-life of CO from 30 s in a CORM-2 solution to 21.6 ***-2-UDLs demonstrated in vitro anti-inflammatory activity by decreasing nitrite production and pro-inflammatory cytokine ***,CORM-2-UDLs successfully ameliorated skin inflammation by reducing ear edema,pathological scores,neutrophil accumulation,and inflammatory cytokines *** results demonstrate that CORM-2-UDLs could be used as promising therapeutics against acute skin inflammation.

关键词： Carbon monoxide CORM-2 Anti-inflammatory effect Ultradeformable liposomes Skin inflammation Ear edema

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Exploring the relationship between rarity and price of profile picture NFT: A formal concept analysis on the BAYC NFT collection

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BLOCKCHAIN-RESEARCH AND APPLICATIONS 2024年第2期5卷 140-150页

作者： lee, Heejung lee, Geun-cheol Koo, hoon-Young Hanyang Univ Sch Interdisciplinary Ind Studies 222 Wangsimni Ro Seoul 04763 South Korea Konkuk Univ Coll Business Adm 120 Neungdong Ro Seoul 05029 South Korea Chungnam Natl Univ Sch Business 99 Daehak Ro Daejeon 34134 South Korea

Non-fungible token (NFT) is a digital asset whose ownership can be validated and controlled via blockchain technology. The NFT market is a rapidly growing field, and the rarity of NFT is an essential factor that affects its price, as scarcity leads to higher demand. This study focuses on the BAYC NFT collection, which is a successful and representative collection of profile picture NFT, and analyzes how rarity affects NFT prices. This paper investigates the relationship between the rarity and price of the BAYC NFT collection using formal concept analysis (FCA) method. The results show that rarity is a major factor influencing the price of NFT and the effect is more apparent in the medium rarity range. When rarity is very high or very low, other factors become significant determinants, such as the uniqueness and appeal of NFT, and even the naturalness of NFT images. This research highlights the importance of considering rarity when assessing NFT and underscores the need for a comprehensive evaluation of NFT rarity. This study also provides valuable insights into the NFT market and can be useful for NFT investors, creators, and collectors. Furthermore, the usefulness of FCA as a tool for quantifying NFT rarity and evaluating NFT price was demonstrated.

关键词： NFT valuation Formal concept analysis Rarity

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Chemical and mechanical properties of stainless, environment-friendly, and nonflammable Mg alloys (SEN alloys): A review

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Journal of Magnesium and Alloys 2024年第3期12卷 841-872页

作者： Jong Un lee Hyun Ji Kim Sang-cheol Jin Ye Jin Kim Young Min Kim Bong Sun You Jun ho Bae Sung Hyuk Park Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Metallurgical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Missile Research Institute Agency for Defense DevelopmentDaejeon 34060Republic of Korea

This review article provides overall understanding of stainless,environment-friendly,and nonflammable Mg alloys(SEN alloys)recently developed at the Korea Institute of Materials *** alloys are produced by adding small amounts of Ca and Y(eachhose of commercial AZ91 alloys.(5)Simultaneous introduction of Ca and Y suppresses the formation of Mg17Al12 discontinuous precipitates during aging,leading to the enhanced elongation of aged SEN alloys.(6)Adding mischmetal into the SEN9 alloy leads to a six-fold enhancement in ***,the studies conducted on SEN alloys demonstrate their excellent ignition and corrosion resistances and mechanical properties,which broaden the industrial applications of Mg alloys by addressing their inherent weaknesses.

关键词： SEN magnesium alloy Corrosion resistance Ignition resistance Mechanical properties Extrudability.

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Revealing the influence of in-situ formed LiCl on garnet/Li interface for dendrite-free solid-state batteries

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Journal of Energy Chemistry 2024年第5期92卷 394-403页

作者： Seoyoon Shin Jinuk lee Tae ho Shin Seokhee lee Hydrogen Energy Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju-siGyeongsangnam-do 52851Republic of Korea Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea

Inadequate interfacial contact between lithium and solid-state electrolytes(SSEs)leads to elevated impedance and the growth of lithium dendrites,presenting significant obstacles to the practical viability of solid-state batteries(SSBs).To ameliorate interfacial contact,optimizing the surface treatment of SSEs has been widely ***,the formation of LiCl through acid treatment,an equally crucial factor impacting SSB performance,has received limited attention,leaving its underlying mechanism *** study aims to shed light on SSE characteristics following LiCl formation and the removal of Li_(2)CO_(3) through acid *** seek to establish quantifiable links between SSE surface structure and SSB performance,focusing on interfacial resistance,current distribution,critical current density(CCD),and lithium *** formation of LiCl,occurring as Li_(2)CO_(3) is removed through acid treatment,effectively mitigates lithium dendrite formation on SSE *** action inhibits electron injection and reduces the diffusion rate of Li ***,acid treatment transforms the SSE surface into a lithiophilic state by eliminating surface Li_(2)CO_(3).Consequently,the interfacial resistance between lithium and SSEs substantially decreases from 487.67 to 35.99Ωcm^(2) at 25°*** leads to a notably high CCD of 1.3 mA cm^(-2) and a significantly extended cycle life of 1,000 ***,in full SSBs incorporating LiCoO_(2)cathodes and acid-treated garnet SSEs,we observe exceptional cyclability and rate *** findings highlight that acid treatment not only establishes a fundamental relationship between SSE surfaces and battery performance but also offers an effective strategy for addressing interfacial challenges in SSBs.

关键词： Solid-statebatteries Acidtreatment Interfacial stability LiCl Surface modification

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The association between C-reactive protein to albumin ratio and 6-month neurological outcome in patients with in-hospital cardiac arrest

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World Journal of Emergency Medicine 2024年第3期15卷 223-228页

作者： Ji ho lee Dong Hun lee Byung Kook lee Seok Jin Ryu Department of Emergency Medicine Chonnam National University HospitalGwangju 61469Republic of Korea Department of Emergency Medicine Chonnam National University Medical SchoolGwangju 61469Republic of Korea

The global incidence rates of in-hospital cardiac arrest(IHCA)range from1.2 to 9.0 per1,000 hospitalized patients,as per the National Cardiac Arrest Database.[1] While IHCAs tend to exhibit superior 30-day survival rates relative to out-of-hospital cardiac arrests (OHCA) due to situational advantages,such as immediate access to medical personnel and treatments.

关键词： patients cardiac IHC

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Development of vehicle-recognition method on water surfaces using LiDAR data:SPD^(2)(spherically stratified point projection with diameter and distance)

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Defence Technology（防务技术） 2024年第6期36卷 95-104页

作者： Eon-ho lee Hyeon Jun Jeon Jinwoo Choi Hyun-Taek Choi Sejin lee The Department of Mechanical Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea Ocean System Engineering Research Division Korea Research Institute of Ships and Ocean Engineering(KRISO)Daejeon 34103Republic of Korea The Division of Mechanical&Automotive Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea

Swarm robot systems are an important application of autonomous unmanned surface vehicles on water *** monitoring natural environments and conducting security activities within a certain range using a surface vehicle,the swarm robot system is more efficient than the operation of a single object as the former can reduce cost and save *** is necessary to detect adjacent surface obstacles robustly to operate a cluster of unmanned surface *** this purpose,a LiDAR(light detection and ranging)sensor is used as it can simultaneously obtain 3D information for all directions,relatively robustly and accurately,irrespective of the surrounding environmental *** the GPS(global-positioning-system)error range exists,obtaining measurements of the surface-vessel position can still ensure stability during platoon *** this study,a three-layer convolutional neural network is applied to classify types of surface *** aim of this approach is to redefine the sparse 3D point cloud data as 2D image data with a connotative meaning and subsequently utilize this transformed data for object classification ***,we have proposed a descriptor that converts the 3D point cloud data into 2D image *** use this descriptor effectively,it is necessary to perform a clustering operation that separates the point clouds for each *** developed voxel-based clustering for the point cloud ***,using the descriptor,3D point cloud data can be converted into a 2D feature image,and the converted 2D image is provided as an input value to the *** intend to verify the validity of the proposed 3D point cloud feature descriptor by using experimental data in the ***,we explore the feasibility of real-time object classification within this framework.

关键词： Object classification Clustering 3D point cloud data LiDAR(light detection and ranging) Surface vehicle

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Construction of a High‑Performance Composite Solid Electrolyte Through In‑Situ Polymerization within a Self‑Supported Porous Garnet Framework

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Nano-Micro Letters 2024年第5期16卷 56-70页

作者： An‑Giang Nguyen Min‑ho lee Jaekook Kim Chan‑Jin Park Department of Materials Science and Engineering Chonnam National University77 Yongbong‑roBuk‑guGwangju 61186South Korea

Composite solid electrolytes(CSEs)have emerged as promising candidates for safe and high-energy–density solid-state lithium metal batteries(SSLMBs).however,concurrently achieving exceptional ionic conductivity and interface compatibility between the electrolyte and electrode presents a significant challenge in the development of high-performance CSEs for *** overcome these challenges,we present a method involving the in-situ polymerization of a monomer within a self-supported porous Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZT)to produce the *** synergy of the continuous conductive LLZT network,well-organized polymer,and their interface can enhance the ionic conductivity of the CSE at room ***,the in-situ polymerization process can also con-struct the integration and compatibility of the solid electrolyte–solid electrode *** synthesized CSE exhibited a high ionic conductivity of 1.117 mS cm^(-1),a significant lithium transference number of 0.627,and exhibited electrochemical stability up to 5.06 V ***/Li+at 30℃.Moreover,the Li|CSE|LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cell delivered a discharge capacity of 105.1 mAh g^(-1) after 400 cycles at 0.5 C and 30℃,corresponding to a capacity retention of 61%.This methodology could be extended to a variety of ceramic,polymer electrolytes,or battery systems,thereby offering a viable strategy to improve the electrochemical properties of CSEs for high-energy–density SSLMBs.

关键词： Scalable tape-casting method Self-supported porous Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) Composite solid electrolyte LiF-and B-rich interphase layers

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Enhanced prediction of anisotropic deformation behavior using machine learning with data augmentation

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Journal of Magnesium and Alloys 2024年第1期12卷 186-196页

作者： Sujeong Byun Jinyeong Yu Seho Cheon Seong ho lee Sung Hyuk Park Taekyung lee School of Mechanical Engineering Pusan National UniversityBusan 46241South Korea School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566South Korea

Mg alloys possess an inherent plastic anisotropy owing to the selective activation of deformation mechanisms depending on the loading *** characteristic results in a diverse range of flow curves that vary with a deformation *** study proposes a novel approach for accurately predicting an anisotropic deformation behavior of wrought Mg alloys using machine learning(ML)with data *** developed model combines four key strategies from data science:learning the entire flow curves,generative adversarial networks(GAN),algorithm-driven hyperparameter tuning,and gated recurrent unit(GRU)*** proposed model,namely GAN-aided GRU,was extensively evaluated for various predictive scenarios,such as interpolation,extrapolation,and a limited dataset *** model exhibited significant predictability and improved generalizability for estimating the anisotropic compressive behavior of ZK60 Mg alloys under 11 annealing conditions and for three loading *** GAN-aided GRU results were superior to those of previous ML models and constitutive *** superior performance was attributed to hyperparameter optimization,GAN-based data augmentation,and the inherent predictivity of the GRU for *** a first attempt to employ ML techniques other than artificial neural networks,this study proposes a novel perspective on predicting the anisotropic deformation behaviors of wrought Mg alloys.

关键词： Plastic anisotropy Compression Annealing Machine learning Data augmentation

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Strengthening mechanisms analysis and tailoring of bimodal grain structures for enhanced strength in CoCrFeMnNi high-entropy alloys

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Rare Metals 2024年第8期43卷 3893-3903页

作者： Jaesoung lee Seulgi Kim Taehyun Kwon Young II Kim Suyeon Kim Sung ho Song Bin lee Dongju lee Department of Urban Energyand Environmental EngineeringChungbuk National UniversityCheongju 28644Republic of Korea Division of Advanced Materials Engineering Kongju National UniversityChungnam 330-717Republic of Korea Department of Advanced Materials Engineering for Information and Electronics Integrated-Education Institute for Frontier Science and Technology(BK21 Four)Kyung Hee UniversityYongin17104Republic of Korea

The CoCrFeMnNi high-entropy alloys(HEAs)with a(face-centered cubic) FCC structure has garnered considerable attention for its exceptional ductility and strain hardening ***,its yield strength is insufficient for structural *** this study,strengthening mechanisms in these HEAs were investigated to gain insight into the mechanical properties according to alloy powder ***,we present a novel approach to achieve both high strength and high ductility through the creation of a bimodal structure consisting of both coarse and fine grains via gas atomization and spark plasma sintering processes.A bimodally structured HEA prepared with a mass ratio of 2:8 between coarse particles(75-106 μm) and fine particles(≤25 μm)yielded optimal results,with a strength of 491.95 MPa and elongation of 19.64%.This strength value represents an~41% increase compared with the sample that displayed a fine single microstructure(347.08 MPa for yield strength).The strength enhancement was attributed to the prevention of plastic deformation initiation from the fine particles during *** innovative approach to the creation of HEAs with bimodal structures shows promise for various applications,such as structural components that require a combination of high strength and high ductility.

关键词： High-entropy alloys CrCoFeMoNi Bimodal Gas atomization Mechanical properties

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A dose-dependent bimodal switch by homologous Aux/IAA transcriptional repressors

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Molecular Plant 2024年第9期17卷 1407-1422页

作者： Hyung-Taeg Cho Minsu lee Hee-Seung Choi Kwang-ho Maeng Kyeonghoon lee Ha-Yeon lee Anindya Ganguly hoonyoung Park Chang-hoi ho Department of Biological Sciences Seoul National UniversitySeoulKorea School of Earth and Environmental Sciences Seoul National UniversitySeoulKorea Department of Climate and Energy Systems Engineering Ewha Womans UniversitySeoulKorea

Combinatorial interactions between different regulators diversify and enrich the chance of transcriptional regulation in eukaryotic ***,a dose-dependent functional switch of homologous transcriptional repressors has rarely been ***,we show that SHY2,an auxin/indole-3-acetic acid(Aux/IAA)repressor,exhibits a dose-dependent bimodal role in auxin-sensitive root-hair growth and gene transcrip-tion in Arabidopsis,whereas other Aux/lAA homologs consistently repress the auxin *** co-repressor(TOPLESS[TPL])-binding affinity of a bimodal Aux/IAA was lower than that of a consistently re-pressing Aux/*** switch of a single amino acid residue in the TPL-binding motif between the bimodal form and the consistently repressing form switched their TPL-binding affinity and transcriptional and bio-logical roles in auxin *** on these data,we propose a model whereby competition between homologous repressors with different co-repressor-binding affinities could generate a bimodal output at thetranscriptional anddevelopmental levels.

关键词： auxin Aux/IAA dose-dependent regulation root hair transcription TOPLESS(TPL)

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