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Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion

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Neural Regeneration Research 2019年第7期14卷 1230-1236页

作者： Min cheol Chang Chae Ri Park Seung Hwa Rhie Woo Hyun shim Dae Yul Kim Department of Rehabilitation Medicine College of MedicineYeungnam University Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of Medicine Department of Rehabilitation Medicine Asan Medical CenterUniversity of Ulsan College of Medicine Department of Radiology Asan Medical CenterUniversity of Ulsan College of Medicine

The neuroprotective function of macrophage migration inhibitory factor(MIF) in ischemic stroke was rarely *** study aimed to investigate the effects of early treadmill exercise on recovery from ischemic stroke and to determine whether these effects are associated with the expression levels of MIF and brain-derived neurotrophic factor(BDNF) in the ischemic area.A total of 40 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group [middle cerebral artery occlusion(MCAO)-Ex,n = 10),ischemia and sedentary group(MCAO-St,n = 10),sham-surgery and exercise group(Sham-Ex,n= 10),or sham-surgery and sedentary group(Sham-St,n = 10).The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 minutes,whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without *** in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 minutes once a day for 5 consecutive *** reperfusion,the hanging time tested by the wire hang test was longer and the relative fractional anisotropy determined by MRI was higher in the peri-infarct region of the MCAO-Ex group compared with the MCAO-St *** expression levels of MIF and BDNF in the peri-infarct region were upregulated in the MCAO-Ex *** MIF and BDNF levels were positively correlated with relative fractional anisotropy changes in the peri-infarct *** was no significant difference in the levels of MIF and BDNF in the peri-infarct region between the Sham-Ex and Sham-St *** study demonstrated that early exercise(initiated 48 hours after the MCAO) could improve motor and neuronal recovery after ischemic ***,the increased levels of MIF and BDNF in the peri-infarct region(penumbra) may be one of the mechanisms of enhanced neurological function *** experiments were approved by the Institutional Animal Care and Use Committee in Asan Medical Center in South Korea(2016-12-126).

关键词： ischemic stroke early exercise macrophage migration inhibitory factor brain-derived neurotrophic factor motor recovery neural regeneration

Ultra-flexible graphene/nylon/PDMS coaxial fiber-shaped multifunctional sensor

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Nano Research 2023年第4期16卷 5541-5547页

作者： Peddathimula Puneetha Siva Pratap Reddy Mallem Sung cheol Park Seoha Kim Dong Hun Heo cheol Min Kim Jaesool shim Sung Jin An Dong-Yeon Lee Kwi-Il Park Department of Robotics and Intelligent Machine Engineering/College of Mechanical and IT Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Advanced Material Research Center Kumoh National Institute of TechnologyGumi 39177Republic of Korea School of Mechanical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Materials Science and Engineering Kumoh National Institute of TechnologyGumi 39177Republic of Korea

The development of flexible and wearable devices is mainly required for tactile sensing;as such devices can adapt to complicated nonuniform surfaces,they can be applied to the human ***,it remains necessary to simultaneously achieve small-scale,portable,and stable developments in such ***,this work aims at fabricating a novel,lightweight,ultra-flexible,and fiber-shaped coaxial structure with a diameter of 0.51 mm using polydimethylsiloxane/graphene/nylon material,based on piezoresistive and triboelectric *** piezoresistive-based robotic-hand-controlled sensor thus realized exhibits a response time of 120 ms and a fast recovery time of 55 ***,the piezoresistive-based sensors effectively feature whisker/joystick-guided behaviors and also sense the human finger *** to the triboelectric-based selfpowered nanogenerator behavior,the resulting sensor can convert mechanical motion into electrical energy,without adversely affecting human ***,this triboelectric-based human finger sensor can be operated under different bending modes at specific ***,this multifunctional sensor is cost-effective and suitable for various applications,including robotichand-controlled operations in medical surgery,whisker/joystick motions in lightweight drone technology,and navigation with highsensitivity components.

关键词： extremely lightweight ultra-flexible piezoresistive/triboelectric sensor human-machine whisker

Guaranteeing almost fault-free tracking performance from transient to steady-state:a disturbance observer approach

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Science China(Information Sciences) 2018年第7期61卷 227-243页

作者： Gyunghoon PARK Hyungbo shim ASRI Department of Electrical and Computer Engineering Seoul National University

In this paper, we propose an output-feedback fault-tolerant controller(FTC) for a class of uncertain multi-input single-output systems under float and lock-in-place actuator faults. Of particular interest is to recover a fault-free tracking performance of a(pre-defined) nominal closed-loop system, during the entire time period including the transients due to abrupt actuator faults. As a key component, a highgain disturbance observer(DOB) is employed to rapidly compensate the lumped disturbance, a compressed expression of all the effect of actuator faults(as well as model uncertainty and disturbance) on the *** implement this high-gain approach, a fixed control allocation(CA) law is presented in order to keep an extended system with a virtual scalar input to remain of minimum phase under any patterns of faults. It is shown via the singular perturbation theory that the proposed FTC, consisting of the high-gain DOB and the CA law, resolves the problem in an approximate but arbitrarily accurate sense. Simulations with the linearized lateral model of Boeing 747 are performed to verify the validity of the proposed FTC scheme.

关键词： disturbance observer fault-tolerant control robust control performance recovery actuator fault

Estimation of vegetative mercury emissions in China

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Journal of Environmental Sciences 2008年第9期20卷 1070-1074页

作者： Shang Gyoo shim Korea Institute of Science and Technology

Vegetative mercury emissions were estimated within the framework of Biogenic Emission Inventory System (BEIS3 V3.11). In this estimation, the 19 categories of U.S. Geological Survey landcover data were incorporated to generate the vegetation-specific mercury emissions in a 81-km Lambert Conformal model grid covering the total Chinese continent. The surface temperature and cloud-corrected solar radiation from a Mesoscale Meteorological model (MM5) were retrieved and used for calculating the diurnal variation...

关键词： mercury emission Biogenic Emission Inventory System (BEIS3) natural source

Overlooked impact of precursor mixing:Implications in the electrochemical performance of battery electrode materials

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Journal of Energy Chemistry 2023年第7期82卷 56-65,I0003页

作者： JinHa shim Jin Ho Bang Department of Applied Chemistry Center for Bionano Intelligence Education and ResearchHanyang University55 Hanyangdaehak-roSangnok-guAnsanGyeonggi-do 15588Republic of Korea Department of Chemical and Molecular Engineering Hanyang University55 Hanyangdaehak-roSangnok-guAnsanGyeonggi-do 15588Republic of Korea

Solid-state reactions are an essential part of the synthesis of various cathode materials for lithium-ion batteries(LIBs).Despite the simplicity and effectiveness for mass production,a subtle variation in synthesis conditions can often give rise to unexpectedly different physical properties,significantly affecting the electrochemical performance of electrode ***,this aspect has long been overlooked in the LIB community,which should focus on advancement in understanding the influence of synthesis *** solid-state reactions occur only at the interface of precursor materials,maximizing the interfacial contact area between mixed precursor powders is *** milling and/or mixing are common practices that have been performed in both academia and industry for this *** the common belief that this pre-treatment before calcination would be of great benefit for the preparation of high-performance LIB materials,we revealed in this work that this practice is not always successful for this *** our case study of the preparation of LiCoO_(2),we demonstrated that mechanical mixing-a routinely implemented process for homogeneous mixing of precursors-can be harmful if it is performed without assuring optimal working conditions for *** underlying reasons for this surprising result are elucidated in this work,and we hope that this new insight can help avoid the potential pitfall of routine implementations performed for LIB materials.

关键词： LiCoO_(2) Solid-state reaction Mechanical mixing Cathode material Lithium-ion battery

Acceleration Workspace of Cooperating Multi-Finger Robot Systems

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Journal of Bionic Engineering 2008年第2期5卷 103-110页

作者： Hyungwon shim Jihong Lee BK21 Mechatronics Group Chungnam National University

We present a mathematical method for acceleration workspace analysis of cooperating multi-finger robot systems using a model of point-contact with friction. A new unified formulation from dynamic equations of cooperating multi-finger robots is derived considering the force and acceleration relationships between the fingers and the object to be handled. From the dynamic equation, maximum translational and rotational acceleration bounds of an object are calculated under given constraints of contact conditions, configurations of fingers, and bounds on the torques of joint actuators for each finger. Here, the rotational acceleration bounds can be applied as an important manipulability index when the multi-finger robot grasps an object. To verify the proposed method, we used a set of case studies with a simple multi-finger mechanism system. The achievable acceleration boundary in task space can be obtained successfully with the proposed method and the acceleration boundary depends on the configurations of fingers.

关键词： acceleration workspace multi-finger robots point-contact with friction model unified dynamic equation acceleration boundary

Characterization of flexible copper laminates fabricated by Cu electro-plating process

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中国有色金属学会会刊：英文版 2009年第4期19卷 965-969页

作者： Chang-Min LEE Jun-Hyung LIM Soo-Min HWANG Eui-cheol PARK Jong-Hyun shim Jin-Hyun PARK Jinho JOO Seung-Boo JUNG School of Advanced Materials Science and Engineering Sungkyunkwan University

Flexible copper clad laminates(FCCLs) were fabricated using the electro-plating process and the combined effect of the current density and plating time on their surface morphology,texture,hardness,electrical resistivity and folding behavior was *** achieve Cu layers with similar thicknesses,the current density was varied in the range of 0.2-3 A/dm2 and the plating time was controlled in the range of 0.5-7.5 h to compensate for the variation of the current *** surface morphology,hardness,and folding behavior were characterized by atomic force microscopy,nanoindentation technique and Massachusett Institute of Technology folding endurance test,*** X-ray diffraction patterns indicated that the Cu phase was formed without any secondary phases;however,the preferred orientation changed from(220) to(111) as the current density increased over 1 A/*** addition,it was observed that the root-mean-square and hardness values decreased when the current density increased and the plating time decreased *** electrical resistivity was as low as approximately 21 nΩ·m and the number of cycles without failure in the folding test was over 15 000,which were comparable to those of commercial FCCLs.

关键词：电镀工艺层压板铜层制备表征电流密度原子力显微镜纳米压痕技术

Multi-channel electromyography pattern classification using deep belief networks for enhanced user experience

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Journal of Central South University 2015年第5期22卷 1801-1808页

作者： shim Hyeon-min LEE Sangmin Institute for Information and Electronic Research Inha University 100 Inharo Incheon 402-751 Korea Department of Electronic Engineering Inha University 100 Inharo Incheon 402-751 Korea

An enhanced algorithm is proposed to recognize multi-channel electromyography(EMG) patterns using deep belief networks(DBNs). It is difficult to classify the EMG features because an EMG signal has nonlinear and time-varying ***, in several previous studies, various machine-learning methods have been applied. A DBN is a fast, greedy learning algorithm that can find a fairly good set of weights rapidly, even in deep networks with a large number of parameters and many hidden layers. To evaluate this model, we acquired EMG signals, extracted their features, and then compared the model with the DBN and other conventional classifiers. The accuracy of the DBN is higher than that of the other algorithms. The classification performance of the DBN model designed is approximately 88.60%. It is 7.55%(p=9.82×10-12) higher than linear discriminant analysis(LDA) and 2.89%(p=1.94×10-5) higher than support vector machine(SVM). Further, the DBN is better than shallow learning algorithms or back propagation(BP), and this model is effective for an EMG-based user-interfaced system.

关键词： electromyography(EMG) pattern classification feature extraction deep learning deep belief network(DBN)

Land suitability assessment for apple(Malus domestica)in the Republic of Korea using integrated soil and climate information,MLCM,and AHP

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International Journal of Agricultural and Biological Engineering 2018年第2期11卷 139-144页

作者： Hojung Kim Kyomoon shim Department of Agricultural Environment National Institute of Agricultural ScienceIseo-myeonWanju-gunRepublic of Korea

Apples(Malus domestica)are one of the major fruits cultivated in South Korea and *** both sustain the productivity of apple trees and preserve the land,a land suitability assessment has been *** methods were used to analyze land suitability,a Most-Limiting Characteristic Method(MLCM)and an Analytic Hierarchy Process(AHP)with integrated soil and climate information based on the FAO classification *** most-limiting characteristic analysis showed that almost all areas were classified as marginally suitable(S3)or not suitable(N),which together accounted for 94.54%of the land in the Republic of *** the contrary,AHP showed that S1(34.1%)and S2(44.17%)account for the majority of the land.

关键词： land suitability evaluation biophysical modeling GIS land use planning multi-criteria analysis Republic of Korea