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Gallbladder lymphangioma:A case report and review of the literature

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World Journal of Gastroenterology 2007年第2期13卷 320-323页

作者： Jwa-Kyung Kim Kyo-Sang Yoo Joon Ho Moon Kwang Hyuk park Yong Woo Chung Kyoung Oh Kim cheol hee park Taeho Hahn Sang Hoon park Jong Hyeok Kim Jang Yeong Jeon Min Jung Kim Kwang Seon Min Department of Pathology Hallym University College of Medicine Anyang Korea Choong Kee park Department of Gastroenterology and Hepatology Hallym University College of Medicine Anyang Korea Department of Surgery Hallym University College of Medicine Anyang Korea Department of Diagnostic Radiology Hallym University College of Medicine Anyang Korea

Lymphangiomas are rare, benign tumors of the lymphatic system, usually present in children aged 5 years and younger. Because they are asymptomatic until the mass enlarges to cause symptoms, most lymphangiomas are diagnosed at adulthood incidentally. We experienced a case of a 60-year-old man diagnosed with a cystic lymphangioma of the gallbladder, which was successfully resected without any complication. Magnetic resonance imaging and magnetic resonance cholangiopancreatography were very helpful for the diagnosis of the cystic lesion around the gallbladder as were ultrasonography and computed tomography scan. These showed a multi-lobulated cystic mass with intact cystic duct and bile duct in the gallbladder fossa. The patient underwent an open cholecystectomy and the histological findings were consistent with a cystic lymphangioma of the gallbladder. We here report the case of cystic lymphangioma of the gallbladder with a review of the literature.

关键词： Lymphangioma Gallbladder Cholecystectomy

Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO KYUNG park MINSUK KWON MINAE AN JUNG YONG HONG JOON OH park SUNG hee LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol Lee Won-hee park Su-hwan Yun Tae-Soon Kwon Duckhee Lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

(Y,Gd)BO_3∶Eu的真空紫外光谱特性

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高等学校化学学报 2000年第11期21卷 1658-1660页

作者：吴雪艳洪广言曾小青尤洪鹏金昌弘卞锺洪裴淑贤庾炳容权一亿朴哲熙中国科学院长春应用化学研究所稀土化学与物理开放实验室长春130022 韩国科学技术研究院应用化学部

The (Y,Gd)BO 3∶Eu phosphor was synthesized by solid state reaction. The UV spectra showed that in a certain range of Gd 3+ concentration, more Gd 3+ absorbed energy and transferred it to Eu 3+ with its increasing concentration. From the spectra in VUV region, it was observed that both the doping and the concentrations of Gd 3+ , Eu 3+ greatly affected the absorption of the host lattice. The absorbances at 147 nm and 170 nm increased when the Gd 3+ was doped which can be explained as that Gd 3+ transferred energy to BO 4. The optical properties of (Y,Gd)BO 3∶Eu were the best when the concentration of Eu 3+ was about 0.04.

关键词： VUV光谱基质吸收带稀土发光材料荧光粉

Parameter estimation for building energy models using GRcGAN

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Building Simulation 2023年第4期16卷 629-639页

作者： Hansol Shin cheol-Soo park Department of Architecture and Architectural Engineering College of EngineeringSeoul National UniversitySeoul08826R.O.Korea Institute of Construction and Environmental Engineering Institute of Engineering ResearchCollege of EngineeringSeoul National UniversitySeoul08826R.O.Korea

Parameter estimation methods can be classified into(1)manual(trial-and-error),(2)numerical optimization(optimization,sampling),(3)Bayesian inference(Bayes filter,Bayesian calibration),and(4)machine learning(generative model).Bayesian calibration has been widely used because it can capture stochastic nature of uncertain ***,the results of Bayesian calibration could be biased by(1)the prior distribution assumed by the expert’s subjective judgment;(2)the likelihood function that cannot always describe the true likelihood;and(3)the posterior distribution approximation method,such as the Markov Chain Monte Carlo,which requires significant computation *** overcome this,a new approach using a generator-regularized continuous conditional generative adversarial network(GRcGAN)is presented in this *** target parameters of the DOE reference building model were *** was trained to estimate uncertain parameters using simulated monthly electricity and gas *** can successfully estimate five uncertain parameters based on 1,000 training data *** proposed approach presents a potential for stochastic parameter estimation.

关键词： generative adversarial networks generative model parameter estimation inverse problem model calibration parameter uncertainty

Differentiation of hepatocellular carcinoma from its variousmimickers in liver magnetic resonance imaging:What arethe tips when using hepatocyte-specific agents?

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World Journal of Gastroenterology 2016年第1期22卷 284-299页

作者： Yang Shin park Chang hee Lee Jeong Woo Kim Sora Shin cheol Min park Department of Radiology Korea University Guro HospitalKorea University College of MedicineSeoul 152-703South Korea Korea University College of Medicine Anam-dong 5-gaSeongbuk-GuSeoul 136-701South Korea

Hepatocellular carcinoma is the most common primary hepatic malignant *** widespread use of liver imaging,various cirrhosis-related nodules are frequently detected in patients with chronic liver disease,while diverse hypervascular hepatic lesions are incidentally detected but undiagnosed on dynamic computed tomography and magnetic resonance imaging(MRI).However,use of hepatocyte-specific MR contrast agents with combined perfusion and hepatocyte-selective properties have improved diagnostic performance in detection and characterization of focal liver ***,the enhancement patterns observed during dynamic phases using hepatocyte-specific agents may be different from those observed during MRI using conventional extracellular fluid agents,leading to confusion in ***,we discuss useful tips for the differentiation of hepatocellular carcinoma from similar lesions in patients with and without chronic liver disease using liver MRI with hepatocyte-specific agents.

关键词： Hepatocellular carcinoma Gadoxetic acid Magnetic resonance imaging Liver cirrhosis

Reduced micro RNA 375 in colorectal cancer upregulates metadherin-mediated signaling

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World Journal of Gastroenterology 2019年第44期25卷 6495-6507页

作者： Seol-hee Han Ji-Su Mo Won-cheol park Soo-Cheon Chae Department of Pathology School of MedicineWonkwang UniversityIksanChonbuk 54538South Korea Digestive Disease Research Institute Wonkwang UniversityIksanChonbuk 54538South Korea

BACKGROUND The human microRNA 375(MIR375)is significantly downregulated in human colorectal cancer(CRC)and we have previously shown that MIR375 is a CRCassociated *** metadherin(MTDH)is a candidate target gene of *** To investigate the interaction and function between MIR375 and MTDH in human *** A luciferase reporter system was used to confirm the effect of MIR375 on MTDH *** expression levels of MIR375 and the target genes were evaluated by quantitative RT-PCR(qRT-PCR),western blotting,or *** MTDH expression was found to be upregulated in human CRC tissues compared to that in healthy *** show that MIR375 regulates the expression of many genes involved in the MTDH-mediated signal transduction pathways[BRAF-MAPK and phosphatidylinositol-4,5-biphosphate-3-kinase catalytic subunit alpha(PIK3CA)-AKT]in CRC *** MTDH expression levels were found to inhibit NF-κB inhibitor alpha,which further upregulated NFKB1 and RELA expression in CRC *** Our findings suggest that suppressing MIR375 expression in CRC regulates cell proliferation and angiogenesis by increasing MTDH ***,MIR375 may be of therapeutic value in treating human CRC.

关键词： MicroRNA 375 Metadherin Mitogen-activated protein kinase Angiogenesis Cell proliferation Colorectal cancer

The electronic structure and intervalley coupling of artificial and genuine graphene superlattices

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Nano Research 2016年第4期9卷 1101-1115页

作者： Pilkwang Kim cheol-Hwan park Department of Physics and Astronomy Seoul National University Seou108826 Republic of Korea

The so-called artificial graphene is an artificial material whose low-energy carriers are described by the massless Dirac equation. Applying a periodic potential with triangular symmetry to a two-dimensional electron gas is one approach to make such a material. According to recent experimental results, it is now possible to realize artificial graphene in the lab and to even apply an additional lateral, one-dimensional periodic potential to it. We name the latter system an artificial graphene superlattice in order to distinguish it from a genuine graphene superlaedce made from graphene. In this study, we investigate the electronic structure of artificial graphene superlattices, which exhibit the emergence of energy band gaps, merging and splitting of the Dirac points, etc. Then, from a similar investigation on genuine graphene superlattices, we show that many of these features originate from the coupling between Dirac fermions residing in two different valleys--the intervaUey coupling. Furthermore, contrary to previous studies, we find that the effects of intervalley coupling on the electronic structure cannot be ignored, irrespective of the length of the spatial period of the superlattice.

关键词： graphene artificial graphene graphene superlattice intervaUey coupling

Segregation of voiced and unvoiced components from residual of speech signal

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Journal of Central South University 2012年第2期19卷 496-503页

作者： JO cheol-woo KIM Jae-hee School of Mechatronics Changwon National University

In conventional source-filter models, voiced and unvoiced components were considered independently. However, in practice it was difficult to separate the source into two parts. An actual source consists of a mixture of two sources and the ratio varies according to the content or the intention of speaker. It had been investigated to separate the voiced and unvoiced components for different source models. Source signals were modeled based on the residual signal measured from inverse filtering. Three different source models were assumed. The parameters of each model were optimized for the original speech signal using a genetic algorithm. The resulting parameters were compared in terms of the mel-cepstral distance to the original signal, the spectrogram and the spectral envelope from the synthesized signal. The optimization method achieves an improvement of 15% for the Klatt model, but there is little improvement in the modified residual case.

关键词： voice source model synthesis optimization genetic algorithm