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Serum prostate-specific antigen value adjusted for non-cancerous prostate tissue volume in patients undergoing radical prostatectomy： a new predictor of biochemical recurrence in localized or locally advanced prostate cancer

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Asian Journal of Andrology 2011年第2期13卷 248-253页

作者： Ja Hyeon Ku Kyung Chul Moon Sung Yong Cho cheol kwak Hyeon Hoe Kim Department of Urology Seoul National University College of Medicine Seoul 1 10-744 Korea Department of Pathology Seeul National University College of Medicine Seoul110-744 Korea

The aim of this study was to investigate the significance of serum prostate-specific antigen （PSA） value adjusted for total tumor volume （PSA/tumor volume） and serum PSA value adjusted for non-cancerous prostate tissue volume （NCPV）（PSA/NCPV） as a predictor of pathological findings and clinical outcome after radical prostatectomy. Clinical and pathological data of 407 patients （median age： 66.5 years; range： 41.8--85.7 years） were reviewed retrospectively. The median follow-up period was 18. I months （range： 1.0- 107.8 months）. Biochemical recurrence was defined as detectable PSA levels （greater than 0.2 ng ml-1） and the time of biochemical recurrence was taken to be the first time PSA became detectable. In the multivariate model, PSA/NCPV was an independent predictor of extracapsular extension and positive surgical margin （P〈O.05）, but PSA/tumor volume was not. Kaplan-Meier curves revealed that PSA/NCPV correlated with biochemical recurrence-free survival （P〈O.O01; log-rank test） but PSA/tumor volume did not （P=0.275; log-rank test）. PSA/NCPV was also a significant independent prognostic factor for biochemical recurrence-free survival on multivariate Cox proportional hazard analysis （P=0.004, relative risk=2.42）. Our findings suggest that PSA/NCPV is associated independently with extracapsular extension and surgical margin status and may be an independent prognostic variable of PSA recurrence after radical prostatectomy.

关键词： prostatectomy prostatic neoplasm PSA treatment outcome tumor volume

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Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

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Asian Journal of Urology 2024年第3期11卷 450-459页

作者： Jung Ki Jo Seong Il Seo MinYong Kang Jinsoo Chung cheol kwak Sung-Hoo Hong Cheryn Song Jae Young Park Chang Wook Jeong Seok Hwan Choi Sung Han Kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(TKI)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progression-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TKIeTKI”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with TKIs,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosine kinase inhibitor Metastatic renal cell carcinoma Overall survival Progression-free survival

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Consensus on safety management of novel hormonal therapy for advanced prostate cancer

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UroPrecision 2023年第2期1卷 53-71,I0005页

作者： Sujun Han Shudong Cheng Degang Ding Jianming Guo Zhisong He Baiye Jin Zhigang Ji Tianxin Lin Yuanjie Niu Weijun Qin Benkang Shi Jinkai Shao Xi'nan Sheng Qiang Wei Xin Wang Xinghuan Wang Shujie Xia Wanhai Xu Qing Zou Xiongbing Zu Renu Eapen Chi‐Fai Ng Hirotsugu Uemura Hiroji Uemura cheol kwak Jae Young Joung Marniza Saad Edmund Chiong Nianzeng Xing National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina The First People's Hospital of Jinzhong JinzhongChina Henan Provincial People's Hospital ZhengzhouChina Zhongshan Hospital Fudan UniversityShanghaiChina Peking University First Hospital BeijingChina The First Affiliated Hospital Zhejiang University School of MedicineHangzhouChina Peking Union Medical College Hospital BeijingChina Sun Yat‐sen Memorial Hospital Sun Yat‐sen UniversityGuangzhouChina The Second Hospital of Tianjin Medical University TianjinChina Xijing Hospital of Air Force Military Medical University Xi'anChina Qilu Hospital of Shandong University JinanChina Shanxi Provincial People's Hospital TaiyuanChina Beijing Cancer Hospital BeijingChina West China Hospital Sichuan UniversityChengduChina Zhongnan Hospital of Wuhan University WuhanChina Shanghai General Hospital ShanghaiChina Fourth Affiliated Hospital of Harbin Medical University HarbinChina Jiangsu Cancer Hospital NanjingChina Xiangya Hospital of Central South University ChangshaChina Peter MacCallum Cancer Centre VictoriaAustralia The Chinese University of Hong Kong Hong KongChina Kindai University Faculty of Medicine Graduate School of Medical Sciences OsakaJapan Yokohama City University Medical Center KanagawaJapan Seoul National University Hospital SeoulKorea National Cancer Center Gyeonggi‐doKorea University of Malaya Medical Centre Wilayah PersekutuanMalaysia National University Hospital SingaporeSingapore

Prostate cancer(PCa)is one of the most prevalent malignant tumors in men,accompanied by high incidence and mortality *** hormonal therapy(NHT)has emerged as the primary treatment for advanced PCa,providing noticeable clinical ***,the diverse range of adverse events(AEs)associated with NHT may influence both treatment efficacy and patients'quality of *** light of the latest international clinical research evidence and recommendations from domestic and foreign guidelines,this consensus aims to provide a comprehensive overview of the common AEs experienced during NHT for advanced PCa ***,it seeks to develop a hierarchical approach to more efficiently manage AEs,presenting valuable insights for clinical medication and adverse reaction management.

关键词： adverse event novel hormonal therapy prostate cancer safety management

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Dysphagia in patients with isolated pontine infarction

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Neural Regeneration Research 2018年第12期13卷 2156-2159页

作者： Min cheol Chang Sang Gyu kwak Min Ho Chun Department of Rehabilitation Medicine College of Medicine Yeungnam University Department of Medical Statistics College of Medicine Catholic University of Daegu Department of Rehabilitation Medicine Asan Medical Center University of Ulsan College of Medicine

Little is known about dysphagia after pontine infarction. In this study, we evaluated the incidence of dysphagia after isolated pontine infarction and identified the predictive factors for the occurrence of dysphagia. A total of 146 patients were included in this study. All patients underwent clinical testing for dysphagia within 1 day after admission and at the time of discharge. We compared the incidence of dysphagia between patients with unilateral pontine infarction and those with bilateral pontine infarction. To evaluate the functional status of patients, we investigated their initial modified Rankin Scale（mRS） score and initial National Institutes of Health Stroke Scale（NIHSS） score within 1 day of admission. Of 146 patients, 50（34.2%） had dysphagia initially within 1 day after admission. At the second evaluation at the time of discharge, dysphagia was diagnosed in 24 patients（16.4%）. Patients with bilateral pontine infarction were more likely to present with dysphagia. In addition, clinical severity（in terms of mRS and NIHSS scores） was identified as a predictor of dysphagia in patients with cerebral infarction（multiple binary logistic regression analysis, mRS： P = 0.011, NIHSS： P = 0.004）. Dysphagia frequently occurs in patients with isolated pontine infarction. Clinicians should pay particular attention to the occurrence of dysphagia, especially in patients with bilateral pontine infarction or high functional disability.

关键词： dysphagia pons infarction stroke prediction NIHSS score MRS score

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Parameter estimation for building energy models using GRcGAN

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Building Simulation 2023年第4期16卷 629-639页

作者： Hansol Shin cheol-Soo Park Department of Architecture and Architectural Engineering College of EngineeringSeoul National UniversitySeoul08826R.O.Korea Institute of Construction and Environmental Engineering Institute of Engineering ResearchCollege of EngineeringSeoul National UniversitySeoul08826R.O.Korea

Parameter estimation methods can be classified into(1)manual(trial-and-error),(2)numerical optimization(optimization,sampling),(3)Bayesian inference(Bayes filter,Bayesian calibration),and(4)machine learning(generative model).Bayesian calibration has been widely used because it can capture stochastic nature of uncertain ***,the results of Bayesian calibration could be biased by(1)the prior distribution assumed by the expert’s subjective judgment;(2)the likelihood function that cannot always describe the true likelihood;and(3)the posterior distribution approximation method,such as the Markov Chain Monte Carlo,which requires significant computation *** overcome this,a new approach using a generator-regularized continuous conditional generative adversarial network(GRcGAN)is presented in this *** target parameters of the DOE reference building model were *** was trained to estimate uncertain parameters using simulated monthly electricity and gas *** can successfully estimate five uncertain parameters based on 1,000 training data *** proposed approach presents a potential for stochastic parameter estimation.

关键词： generative adversarial networks generative model parameter estimation inverse problem model calibration parameter uncertainty

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Weighted Norm Inequalities of the Maximal Commutator of Quasiradial Bochner-Riesz Operators

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Acta Mathematica Sinica,English Series 2013年第9期29卷 1743-1756页

作者： Yong cheol KIM Department of Mathematics Education Korea University

In this paper, we obtain certain Lpw（Rn）-mapping properties for the maximal operator associated with the commutators of quasiradial Bochner-Riesz means with index δ under certain surface condition on Σed , provided that δ （n-1）/2, b ∈ BMO（Rn）, 1 p ∞ and w ∈ A1 . Moreover, if δ （n-1）/2, then we prove that the above maximal operator admits weak type （H1w（Rn）, L1w（Rn））-mapping properties for b ∈ BMO（Rn） and w ∈ A1 under the surface condition on Σed .

关键词： Commutator quasiradial Bochner–Riesz operators weighted norm inequalities

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The electronic structure and intervalley coupling of artificial and genuine graphene superlattices

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Nano Research 2016年第4期9卷 1101-1115页

作者： Pilkwang Kim cheol-Hwan Park Department of Physics and Astronomy Seoul National University Seou108826 Republic of Korea

The so-called artificial graphene is an artificial material whose low-energy carriers are described by the massless Dirac equation. Applying a periodic potential with triangular symmetry to a two-dimensional electron gas is one approach to make such a material. According to recent experimental results, it is now possible to realize artificial graphene in the lab and to even apply an additional lateral, one-dimensional periodic potential to it. We name the latter system an artificial graphene superlattice in order to distinguish it from a genuine graphene superlaedce made from graphene. In this study, we investigate the electronic structure of artificial graphene superlattices, which exhibit the emergence of energy band gaps, merging and splitting of the Dirac points, etc. Then, from a similar investigation on genuine graphene superlattices, we show that many of these features originate from the coupling between Dirac fermions residing in two different valleys--the intervaUey coupling. Furthermore, contrary to previous studies, we find that the effects of intervalley coupling on the electronic structure cannot be ignored, irrespective of the length of the spatial period of the superlattice.

关键词： graphene artificial graphene graphene superlattice intervaUey coupling

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The Role of Elytra in Beetle Flight: Ⅰ.Generation of Quasi-Static Aerodynamic Forces

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Journal of Bionic Engineering 2010年第4期7卷 354-363页

作者： Patar Ebenezer Sitorus Hoon cheol Park Doyoung Byun Nam Seo Goo cheol Heui Han National Research Laboratory for Biomimetics and Intelligent Microsystems Konkuk University Department of Advanced Technology Fusion Konkuk University Department of Aerospace Information System Engineering Konkuk University Department of Aeronautical and Mechanical Design Chungju National University

We conducted a comprehensive study to investigate the aerodynamic characteristics and force generation of the elytra of abeetle,Allomyrina *** analysis included wind tunnel experiments and three-dimensional computational fluiddynamics simulations using ANSYS-CFX *** first approach was a quasi-static study that considered the effect ofinduced flapping flow due to the flapping motion of the fore-wings (elytra) at a frequency of around 30 Hz to 40 *** dihedralangle was varied to represent flapping motion during the upstroke and *** found that an elytron producespositive lift at 0° geometric angle of attack,negative lift during the upstroke,and always produces drag during both the upstrokeand *** also found that the lift coefficient of an elytron does not drop even at a very high geometric angle of *** a beetle with a body weight of 5 g,based on the quasi-static method,the fore-wings (elytra) can produce lift of less than 1%of its body weight.

关键词： elytra angle of attack dihedral angle CFD wind tunnel test

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Ungraded Matrix Factorizations as Mirrors of Non-orientable Lagrangians

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Acta Mathematica Sinica,English Series 2024年第1期40卷 26-42页

作者： Lino AMORIM cheol-Hyun CHO Department of Mathematics Kansas State University138 Cardwell Hall1228 N.17th StreetManhattanKS 66506USA Department of Mathematical Sciences Research Institute of MathematicsSeoul National UniversitySan 56-1ShinrimdongGwanakguSeoul 47907South Korea

We introduce the notion of ungraded matrix factorization as a mirror of non-orientable Lagrangian *** ungraded matrix factorization of a polynomial W,with coefficients in a field of characteristic 2,is a square matrix Q of polynomial entries satisfying Q^(2)=W·*** then show that non-orientable Lagrangians correspond to ungraded matrix factorizations under the localized mirror functor and illustrate this construction in a few *** main example is the Lagrangian submanifold RP^(2)⊂CP^(2)and its mirror ungraded matrix factorization,which we construct and *** particular,we prove a version of Homological Mirror Symmetry in this setting.

关键词： Mirror symmetry non-orientable Lagrangian submanifold matrix factorization

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Design and Demonstration of a Locust-Like Jumping Mechanism for Small-Scale Robots

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Journal of Bionic Engineering 2012年第3期9卷 271-281页

作者： Quoc-Viet Nguyen Hoon cheol Park Department of Advanced Technology Fusion Konkuk University Seoul 143-701 Republic of Korea

A jumping mechanism can be an efficient mode of motion for small robots to overcome large obstacles on the ground and rough terrain. In this paper, we present a 7 g prototype of locust-inspired jumping mechanism that uses springs, wire, reduction gears, and a motor as the actuation components. The leg structure and muscles of a locust or grasshopper were mimicked using springs and wire, springs for passive extensor muscles, and a wire as a flexor muscle. A small motor was used to slowly charge the spring through a lever and gear system, and a cam with a special profile was used as a clicking mechanism for quick release of elastic energy stored in the springs to create a sudden kick for a quick jump. Performance analysis and experiments were conducted for comparison and performance estimation of the jumping mechanism prototype. Our prototype could produce standing jumps over obstacles that were about 14 times its own size （approximate to 71 cm） and a jumping distance of 20 times its own size （approximate to 100 cm）.

关键词： biomimetics locust jumping mechanism passive tibia extensor muscle

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