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依折麦布有关物质的合成

中国药物化学杂志 2015年第3期25卷 211-215页

作者：郝晨洲宋帅冯岩程卯生赵冬梅沈阳药科大学基于靶点的药物设计与研究教育部重点实验室辽宁沈阳110016

目的合成4个依折麦布的有关物质。方法在参考依折麦布相关合成报道的基础上,以依折麦布或市售依折麦布中间体1-(4-氟苯基)-3(R)-[3-(4-氟苯基)-3-氧代丙基]-4(S)-(4-苄氧基苯基)-2-氮杂环丁烷酮、(S)-3-[5-(4-氟苯基)-5-羟基-1-氧代戊基... 详细信息

目的合成4个依折麦布的有关物质。方法在参考依折麦布相关合成报道的基础上,以依折麦布或市售依折麦布中间体1-(4-氟苯基)-3(R)-[3-(4-氟苯基)-3-氧代丙基]-4(S)-(4-苄氧基苯基)-2-氮杂环丁烷酮、(S)-3-[5-(4-氟苯基)-5-羟基-1-氧代戊基]-4-苯基-2-口恶唑烷酮为原料,经多步反应分别制得依折麦布的4个有关物质:依折麦布的3'位羟基差向异构体3'-R-依折麦布、脱氟依折麦布,以及两个依折麦布的降解产物。结果与结论目标化合物经1H-NMR、13C-NMR及MS谱确证,纯度均大于99%。设计的合成路线方法简单、条件温和、原料易得。合成的有关物质将为依折麦布原料药质量控制研究提供物质基础。

关键词：依折麦布有关物质合成

Real-time Abnormal Detection of GWAC Light Curve based on Wavelet Transform Combined with GRU-Attention

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Research in Astronomy and Astrophysics 2024年第5期24卷 151-168页

作者： hao Li Qing Zhao Long Shao Tao Liu chenzhou Cui Yunfei Xu College of Artifcial Intelligence Tianjin University of Science and TechnologyTianjin 300457China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China

Nowadays, astronomy has entered the era of Time-Domain Astronomy, and the study of the time-varying light curves of various types of objects is of great significance in revealing the physical properties and evolutionary history of celestial bodies. The Ground-based Wide Angle Cameras telescope, on which this paper is based, has observed more than 10 million light curves, and the detection of anomalies in the light curves can be used to rapidly detect transient rare phenomena such as microgravity lensing events from the massive data. However, the traditional statistically based anomaly detection methods cannot realize the fast processing of massive data. In this paper, we propose a Discrete Wavelet(DW)-Gate Recurrent Unit-Attention(GRU-Attention) light curve warning model. Wavelet transform has good effect on data noise reduction processing and feature extraction, which can provide richer and more stable input features for a neural network, and the neural network can provide more flexible and powerful output model for wavelet transform. Comparison experiments show an average improvement of 61% compared to the previous pure long-short-term memory unit(LSTM) model, and an average improvement of 53.5% compared to the previous GRU model. The efficiency and accuracy of anomaly detection in previous paper work are not good enough, the method proposed in this paper possesses higher efficiency and accuracy,which incorporates the Attention mechanism to find out the key parts of the light curve that determine the anomalies. These parts are assigned higher weights, and in the actual anomaly detection, the star is detected with83.35% anomalies on average, and the DW-GRU-Attention model is compared with the DW-LSTM model, and the detection result f1 is improved by 5.75% on average, while having less training time, thus providing valuable information and guidance for astronomical observation and research.

关键词： methods data analysis-stars variables general-techniques photometric

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国家药品集采对儿童用药供应保障的影响分析

卫生经济研究 2024年第10期41卷 10-14,19页

作者：宋菲陈昊王晨舟张研华中科技大学同济医学院医药卫生管理学院湖北武汉430030 国家医疗保障研究院华科基地湖北武汉430030

国家药品集中带量采购推动新型供求关系和竞争关系,促进药品按值论价;而小剂量、研发不足、基础薄弱的儿童药不符合集采主渠道的治理逻辑,导致儿童药中选较少,带来“劣币驱逐良币”风险,同时,儿童药研发存在同质化、边缘化风险,集采与... 详细信息

国家药品集中带量采购推动新型供求关系和竞争关系,促进药品按值论价;而小剂量、研发不足、基础薄弱的儿童药不符合集采主渠道的治理逻辑,导致儿童药中选较少,带来“劣币驱逐良币”风险,同时,儿童药研发存在同质化、边缘化风险,集采与儿童药发展需求导向错位。儿童用药保障应兼顾有药可用、药物可负担、发展适宜性儿童专用药的多重目标,包容其他价格机制与多元药品选择的存在,如推动儿童专用药单独分组竞争,完善儿童药定价机制,扩大集采儿童药选择范围,从而形成以需求为导向的儿童用药供应保障机制。

关键词：药品集中带量采购儿童专用药儿童用药供应保障

Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan Zhixing Ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang Chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu Yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

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天文观测数据开放共享政策与策略分析研究

天文研究与技术 2015年第3期12卷 364-373页

作者：万望辉崔辰州乔翠兰赵永恒郝晋新薛艳杰中国科学院国家天文台北京100012 华中师范大学湖北武汉430079 中国科学院北京100864

当代天文学已经进入数据密集型和数据驱动的时代。随着我国天文学研究的不断发展,国内自产的天文观测数据呈现爆炸式增长的趋势。将天文观测数据资源集成并推动数据资源与应用服务的共建共享,建立健全符合科学发展规律的数据资源开放共... 详细信息

当代天文学已经进入数据密集型和数据驱动的时代。随着我国天文学研究的不断发展,国内自产的天文观测数据呈现爆炸式增长的趋势。将天文观测数据资源集成并推动数据资源与应用服务的共建共享,建立健全符合科学发展规律的数据资源开放共享政策与制度,使天文科技资源得到高效有序的管理和使用,对国内天文学研究和科普教育的发展至关重要。在充分调研各国政府、部门和国际组织有关政策的基础上,剖析了国外科学数据"完全与公开"的共享原则,介绍了我国科学数据共享有关的管理规定和当前状况,重点论述国际各大天文望远镜项目和天文数据中心天文观测数据资源开放共享的有关政策。对国内天文观测数据资源和开放共享的现状以及存在的问题进行了分析和总结。对我国天文观测数据资源共享工作发展和政策制定提出了具体建议。

关键词：天文观测数据开放共享政策策略

子宫内膜活检方法对子宫内膜癌手术前后诊断差异的影响

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实用肿瘤杂志 2008年第6期23卷 547-549页

作者：邹果芳胡红波邓郝男汕头大学医学院附属粤北人民医院妇科广东韶关512025 湖南省郴州市第一人民医院妇科湖南郴州423000

目的探讨子宫内膜活检方法对子宫内膜癌手术前后诊断差异的影响。方法回顾性分析136例术前诊断为子宫内膜癌患者的临床资料,包括术前临床分期、手术-病理分期、术后病理诊断。结果单纯分段诊刮术组(A组)70例手术前后病理诊断符合率82.9... 详细信息

目的探讨子宫内膜活检方法对子宫内膜癌手术前后诊断差异的影响。方法回顾性分析136例术前诊断为子宫内膜癌患者的临床资料,包括术前临床分期、手术-病理分期、术后病理诊断。结果单纯分段诊刮术组(A组)70例手术前后病理诊断符合率82.9,子宫腔镜辅助下分段诊刮术组(B组)66例手术前后病理诊断符合率92.4,两组比较差异有统计学意义;A组和B组手术前后分期诊断符合率比较差异有统计学意义。结论子宫腔镜辅助下分段诊刮术诊断子宫内膜癌安全、可靠,优于单纯分段诊刮术。

关键词：子宫内膜肿瘤/诊断子宫内膜/病理学宫腔镜检查活组织检查/仪器和设备刮宫术/方法

Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China

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Biomedical and Environmental Sciences 2023年第2期36卷 127-134页

作者： XI Hui LIU Qin XIE Dong Hua ZHOU Xu TANG Wang Lan TANG De Guo ZENG Chun Yan WANG Qiong NIE Xing Hui PENG Jin Ping GAO Xiao Ya WU Hong Liang ZHANG hao Qing QIU Li FENG Zong Hui WANG Shu Yuan ZHOU Shu Xiang HE Jun ZHOU Shi hao ZHOU Fa Qun ZHENG Jun Qing WANG Shun Yao CHEN Shi Ping ZHENG Zhi Fen MA Xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua NHC Key Laboratory of Birth Defect for Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangsha 410028HunanChina Yongzhou Hospital for Maternal and Child Health Care Yongzhou 425000HunanChina Changde Hospital for Maternal and Child Health Care Changde 415099HunanChina Hengyang Hospital for Maternal and Child Health Care Hengyang 421009HunanChina Shaoyang Hospital for Maternal and Child Health Care Shaoyang 422001HunanChina Yiyang Hospital for Maternal and Child Health Care Yiyang 413099HunanChina Yueyang Hospital for Maternal and Child Health Care Yueyang 414021HunanChina Center of Prenatal Diagnosis Chenzhou No.1 People’s HospitalChenzhou 423099HunanChina Loudi Hospital for Maternal and Child Health Care Loudi 417599HunanChina Huaihua Hospital for Maternal and Child Health Care Huaihua 418099HunanChina Xiangtan Hospital for Maternal and Child Health Care Xiangtan 411104HunanChina Zhuzhou Hospital for Maternal and Child Health Care Zhuzhou 412008HunanChina Changsha Hospital for Maternal and Child Health Care Changsha 410007HunanChina Xiangxi Tujia and Miao Autonomous Prefecture Hospital for Maternal and Child Health Care Jishou 416000HunanChina Zhang Jiajie Centre for maternal and child health family planning services Zhangjiajie 427299HunanChina BGI Genomics BGI-ShenzhenShenzhen 518083GuangdongChina Clinical Laboratory of BGI Health BGI-ShenzhenShenzhen 518083GuangdongChina BGI-Wuhan Clinical Laboratories BGI-ShenzhenWuhan 430074HubeiChina SEBIA Representative Office Shanghai 200001China

Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan *** We recruited 25,946 individuals attending premarital screening from 42 districts and counties in all 14 cities of Hunan *** screening was performed,and molecular parameters were *** The overall carrier rate of thalassemia was 7.1%,including 4.83%forα-thalassemia,2.15%forβ-thalassemia,and 0.12%for bothα-andβ-*** highest carrier rate of thalassemia was in Yongzhou(14.57%).The most abundant genotype ofα-thalassemia andβ-thalassemia was-α^(3.7)/αα(50.23%)andβ^(IVS-Ⅱ-654)/β^(N)(28.23%),***α-globin mutations[CD108(ACC>AAC),CAP+29(G>C),Hb Agrinio and Hb Cervantes]and sixβ-globin mutations[CAP+8(C>T),IVS-Ⅱ-848(C>T),-56(G>C),beta nt-77(G>C),codon 20/21(-TGGA)and Hb Knossos]had not previously been identified in ***,this study provides the first report of the carrier rates of abnormal hemoglobin variants andα-globin triplication in Hunan Province,which were 0.49%and 1.99%,*** Our study demonstrates the high complexity and diversity of thalassemia gene mutations in the Hunan *** results should facilitate genetic counselling and the prevention of severe thalassemia in this region.

关键词： Thalassemia Carrier rate Molecular spectrum Abnormal hemoglobin variants α-globin triplication

Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival

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World Journal of Gastroenterology 2016年第39期22卷 8798-8805页

作者： hao-Jie Yang Jing-Hang Jiang Yu-ting Yang Xiang-Di Yang Zhe Guo Ya-Peng Qi Feng-Hua Zeng Ke-Lan Zhang Neng-Zhi Chen Bang-De Xiang Le-Qun Li Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Department of General Surgery The First People’s Hospital of Changde Department of General Surgery Second People’s Hospital of Jing Men Department of Chemotherapy Affiliated Tumor Hospital of Guangxi Medical University Department of Oncology Chenzhou No.1 People’s Hospital Department of Thyroid and Breast Surgery Central Hospital of Wuhan

AIM to determine whether cyclooxygenase-2(COX-2) and prostaglandin E1 receptor(EP1) contribute to disease and whether they help predict *** We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma(HCC) who underwent surgery between 2008 and 2011 at our hospital. Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffinembedded tissues using polyclonal antibodies. Possible associations between immunohistochemical scores and survival were *** Factors associated with poor overall survival(OS) were alpha-fetoprotein > 400 ng/m L, tumor size ≥ 5 cm, and high EP1 receptor expression, but not high COX-2 expression. Disease-free survival was not significantly different between patients with low or high levels of COX-2 or EP1. COX-2 immunoreactivity was significantly higher in well-differentiated HCC tissues(Edmondson grade Ⅰ-Ⅱ) than in poorly differentiated tissues(Edmondson grade Ⅲ-Ⅳ)(P = 0.003). EP1 receptor immunoreactivity was significantly higher in poorly differentiated tissue than in well-differentiated tissue(P = 0.001).CONCLUSION COX-2 expression appears to be linked to early HCC events(initiation), while EP1 receptor expression may participate in tumor progression and predict survival.

关键词： Cyclooxygenase-2 Hepatocellular carcinoma Liver resection Prognosis Prostaglandin E1 receptor

The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain

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Signal Transduction and Targeted Therapy 2022年第2期7卷 492-501页

作者： Jiajing Wu Jianhui Nie Li Zhang hao Song Yimeng An Ziteng Liang Jing Yang Ruxia Ding Shuo Liu Qianqian Li Tao Li Zhimin Cui Mengyi Zhang Peng He Youchun Wang Xiaowang Qu Zhongyu Hu Qihui Wang Weijin Huang Division of HIV/AIDS and Sex-transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)102629 BeijingChina Research Network of Immunity and Health(RNIH) Beijing Institutes of Life ScienceChinese Academy of Sciences100101 BeijingChina CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of Sciences100101 BeijingChina Division of Hepatitis and Enteric Viral Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)and Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products102629 BeijingChina Translational Medicine Institute First People’s Hospital of ChenzhouUniversity of South ChinaChenzhouChina CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences100101 BeijingChina

Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and *** determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine,the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was *** neutralization activities of Alpha,Beta and Gamma variants’spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant,which were constructed using pseudotyped ***,the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta *** HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–*** results indicate that the antigenicity changes of possible Delta variants were mostly within four folds,whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–*** analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization *** study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain.

关键词： vaccine antigenicity variants