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休闲性舞蹈防治骨质疏松的临床研究进展

中国骨质疏松杂志 2024年第3期30卷 458-462页

作者：朱琛煜邹军杨珏上海体育大学运动健康学院上海200438 上海体育大学艺术学院上海200438

骨质疏松是一种以骨量减少、骨密度(BMD)和骨矿含量降低以及骨微结构受损为特点的慢性退行性骨代谢疾病,目前骨质疏松已经成为了世界上一个重要的公共卫生问题。近年来休闲性舞蹈成为一种大众休闲运动方式,具有安全且易于学习的运动形式... 详细信息

骨质疏松是一种以骨量减少、骨密度(BMD)和骨矿含量降低以及骨微结构受损为特点的慢性退行性骨代谢疾病,目前骨质疏松已经成为了世界上一个重要的公共卫生问题。近年来休闲性舞蹈成为一种大众休闲运动方式,具有安全且易于学习的运动形式,无时间地点限制、无不良反应的优势,被广泛用于骨质疏松的防治。休闲性舞蹈能够有效维持或增加骨质疏松患者骨量和BMD,延缓骨质疏松的发生发展。本文总结了休闲性舞蹈对中老年骨质疏松患者BMD以及相关骨代谢指标的调节作用及潜在机制,进一步阐明了休闲舞蹈防治骨质疏松的潜在作用机制,为休闲性舞蹈的推广和骨质疏松的临床防治提供一定的理论基础和参考依据。

关键词：骨质疏松休闲性舞蹈骨密度骨代谢

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埋地油气管道磁记忆检测机理及影响因素综述

中国特种设备安全 2024年第2期40卷 8-13页

作者：朱尘宇北京北燃特种设备检验检测有限公司北京100013

金属磁记忆检测技术作为一种新型的埋地油气管道非开挖无损检测手段,具有无须磁化、可预判缺陷等优势。但目前该技术主要围绕小型构件展开探究,且试验以实验室条件居多,服役环境下埋地管道的研究成果不多。鉴于此,本文纵观近年国内外研... 详细信息

金属磁记忆检测技术作为一种新型的埋地油气管道非开挖无损检测手段,具有无须磁化、可预判缺陷等优势。但目前该技术主要围绕小型构件展开探究,且试验以实验室条件居多,服役环境下埋地管道的研究成果不多。鉴于此,本文纵观近年国内外研究进展及现状,概述了效应原理,梳理了基础理论的学说流派,分析了埋地管道工作环境下磁记忆信号的影响因素及作用效果。在此基础上,归纳出目前有待解决的问题,展望了未来的研究方向。

关键词：磁记忆检测应力集中埋地管道油气管道非开挖检测磁记忆信号

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国际黄金价格的影响因素分析及短期预测

建模与仿真 2024年第3期13卷 3482-3490页

作者：吉彦锦朱晨宇上海理工大学理学院上海

黄金被认为是商品价值的尺度、交易的媒介和财富的象征,具有避险和保值增值的重要属性。由于影响黄金价格的因素众多,对黄金的投资存在一定的风险,因此对黄金价格波动规律研究和影响因素分析显得相当必要。本文通过收集数据,建立多元线... 详细信息

黄金被认为是商品价值的尺度、交易的媒介和财富的象征,具有避险和保值增值的重要属性。由于影响黄金价格的因素众多,对黄金的投资存在一定的风险,因此对黄金价格波动规律研究和影响因素分析显得相当必要。本文通过收集数据,建立多元线性回归模型,进行回归分析,对国际黄金价格的影响因素进行探究。本文选取了纽约黄金价格作为被解释变量,美元指数、道格琼斯工业指数、WTI纽约原油价格、美国居民消费价格指数(CPI)作为解释变量,并基于这些实际数据,运用统计分析软件进行多元线性回归分析,研究所选指标与国际黄金价格的影响关系,并建立起多元线性回归模型。结果表明,美元指数、道格琼斯工业指数、WTI纽约原油价格对国际黄金价格呈负相关,美国居民消费价格指数(CPI)对国际黄金价格呈正相关。最后,本文还对国际黄金价格进行了预测。

关键词：国际黄金价格多元线性回归模型回归分析价格预测

Modification strategies for metal-organic frameworks targeting at mem brane-based gas separations

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Green Chemical Engineering 2021年第1期2卷 17-26页

作者： chenyu zhu Yuan Peng Weishen Yang State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing100049China Dalian National Laboratory for Clean Energy Dalian116023China

Metal-organic frameworks(MOFs)hold great promises as membrane candidates for highly efficient separation applications,benefiting from the diversified structures,high surface areas and adjustable chemical ***,non-selective defects and framework flexibility are two main concerns which would attenuate the ultimate separation performance and *** helps to orientationally optimize the gas adsorption and diffusion behaviors via manipulation towards framework chemical components,aperture sizes,nanocages,and intercrystalline/intracrystalline defects,consequently promoting membrane separation performance and membrane *** view of recent progresses of modification on MOF-based membranes,two categories of modification strategies were summarized,namely post-synthetic modification and in situ *** the merits and demerits are ***,challenges and opportunities for the current modification strategies were discussed from our perspectives,with an expectation to provide guidelines to the future development of MOF-based membranes which were aspired to reach the commercially attractive performance region.

关键词： Metal-organic framework Modification Membrane Gas separation

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Genomics, Proteomics & Bioinformatics 2022年第5期20卷 1028-1036页

作者： Zhiting Wei Sheng zhu Xiaohan Chen chenyu zhu Bin Duan Qi Liu Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration(Tongji University) Ministry of EducationOrthopaedic Department of Tongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Shanghai Research Institute for Intelligent Autonomous Systems Shanghai 201210China

Transcriptional phenotypic drug discovery has achieved great success,and various compound perturbation-based data resources,such as connectivity map(CMap)and library of integrated network-based cellular signatures(LINCS),have been *** strategies fully mining these resources for phenotypic drug discovery have been *** them,the fundamental issue is to define the proper similarity between transcriptional ***,such similarity has been defined in an unsupervised ***,due to the high dimensionality and the existence of high noise in high-throughput data,similarity defined in the traditional way lacks robustness and has limited *** this end,we present Dr Sim,which is a learning-based framework that automatically infers similarity rather than defining *** evaluated Dr Sim on publicly available in vitro and in vivo datasets in drug annotation and *** results indicated that Dr Sim outperforms the existing *** conclusion,by learning transcriptional similarity,Dr Sim facilitates the broad utility of high-throughput transcriptional perturbation data for phenotypic drug *** source code and manual of Dr Sim are available at https://***/bm2-lab/Dr Sim/.

关键词： Metric learning Transcriptional profile similarity Drug annotation Drug repositioning LINCS

BCL-2抑制剂联合用药治疗老年急性髓系白血病的临床研究

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系统医学 2024年第7期9卷 1-4页

作者：袁晓婧朱晨雨王勇强甘肃省酒钢医院肿瘤血液科甘肃嘉峪关735100 甘肃省酒钢医院骨科甘肃嘉峪关735100

目的探讨B淋巴细胞瘤-2(B-cell Lymphoma-2,BCL-2)抑制剂联合用药在治疗老年急性髓系白血病中的治疗效果,为老年急性髓系白血病的治疗提供实践依据。方法选取甘肃省酒钢医院肿瘤血液科于2020年1月—2023年10月收治的30例老年急性髓系白... 详细信息

目的探讨B淋巴细胞瘤-2(B-cell Lymphoma-2,BCL-2)抑制剂联合用药在治疗老年急性髓系白血病中的治疗效果,为老年急性髓系白血病的治疗提供实践依据。方法选取甘肃省酒钢医院肿瘤血液科于2020年1月—2023年10月收治的30例老年急性髓系白血病患者作为研究对象,按照随机数表法分为对照组(15例)和干预组(15例)。干预组采用BCL-2抑制剂联合用药治疗,对照组采用常规治疗方法。比较两组治疗后的效果和不良反应发生率。结果治疗后,干预组的好转率(86.67%)显著高于对照组(46.67%),差异有统计学意义(χ^(2)=5.400,P<0.05)。治疗后,干预组的血液学指标显著优于对照组,差异有统计学意义(P<0.05);干预组的免疫学指标优于对照组,差异有统计学意义(P<0.05);干预组不良反应总发生率显著低于对照组,差异有统计学意义(P<0.05)。结论BCL-2抑制剂联合用药在治疗老年急性髓系白血病患者中,能有效改善患者的血液学指标和免疫学指标,促进疾病的好转,降低不良反应发生率。

关键词： BCL-2抑制剂老年急性髓系白血病维奈克拉

Polyimide Aerogel Fibers with Controllable Porous Microstructure for Super‑Thermal Insulation Under Extreme Environments

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Advanced Fiber Materials 2022年第5期4卷 1118-1128页

作者： Tiantian Xue chenyu zhu Xueling Feng Qamar Wali Wei Fan Tianxi Liu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University2999 North Renmin RoadShanghai 201620People’s Republic of China Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122People’s Republic of China School of Applied Sciences and Humanities National University of TechnologyIslamabad 42000Pakistan

Application of aerogel fibers in thermal insulating garments have sparked a substantial ***,achieving a high porosity and low thermal conductivity for aerogel fibers remain challenging,despite the innovative designs of porous ***,we fabricated lightweight and super-thermal insulating polyimide(PI)aerogel fibers via freeze-spinning by using polyvinyl alcohol(PVA)as a pore *** high affinity of PVA with water enables it to accelerate the ice crystal nucleation,adjust pore formation,and construct a controllable porous structure of PI aerogel *** as-fabricated PI aerogel fiber has a considerable reduced pore size,high porosity(95.6%),improved flexibility and mechanical strength,and can be woven into *** PI aerogel fabric exhibits low thermal conductivity and excellent thermal insulation in a wide range of temperature(from-196 to 300℃).Furthermore,the PI aerogel fabrics can be easily functionalized to expand their applications,such as in intelligent temperature regulation and photothermal *** results demonstrate that the aerogel fibers/fabric are promising materials for next-generation textile materials for personal thermal management.

关键词： Polyimide Aerogel fiber Pore regulation Thermal insulation Thermal management

Different response of bacterial community to the changes of nutrients and pollutants in sediments from an urban river network

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Frontiers of Environmental Science & Engineering 2020年第2期14卷 161-172页

作者： Fang Zhang Hao Zhang Ying Yuan Dun Liu chenyu zhu Di Zheng Guanghe Li Yuquan Wei Dan Sun School of Environment and State Key Joint Laboratory of Environment Simulation and Pollution Control Tsinghua UniversityBeijing 100084China College of Resource and Environmental Science China Agricultural UniversityBeijing 100193China Ocean College Zhejiang UniversityZhoushan 316021China

Microbial communities in sediment are an important indicator linking to environmental pollution in urban river ***,how the diversity and structure of bacterial communities in sediments from an urban river network respond to different environmental factors has not been well *** goal of this study was to understand the patterns of bacterial communities in sediments from a highly dense urbanized river network in the lower Yangtze River Delta by Illumina MiSeq *** correlations between bacterial communities,the environmental gradient and geographical distance were analyzed by redundancy analysis(RDA)and network *** diversity and richness of bacterial community in sediments increased from upstream to downstream consistently with the accumulation of nutrient in the urban river *** community composition and structure showed obvious spatial changes,leading to two distinct groups,which were significantly related to the characteristics of nutrient and heavy metal in *** substance,available nitrogen,available phosphorus,Zn,Cu,Hg and As were selected as the key environmental factors shaping the bacterial community in sediments based on *** co-occurrence patterns of bacterial networks showed that positive interaction between bacterial communities increased but the connectivity among bacterial genera and stability of sediment ecosystem reduced under a higher content of nutrient and heavy metal in *** sensitive and ubiquitous taxa with an overproportional response to key environmental factors were detected as indicator species,which provided a novel method for the prediction of the pollution risk of sediment in an urban river network.

关键词： Sediment Urban river network Bacterial community Network analysis Indicator species

Systematic Exploration of Optimized Base Editing gRNA Design and Pleiotropic Effects with BExplorer

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Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1237-1245页

作者： Gongchen Zhang chenyu zhu Xiaohan Chen Jifang Yan Dongyu Xue Zixuan Wei Guohui Chuai Qi Liu Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Base editing technology is being increasingly applied in genome engineering,but the current strategy for designing guide RNAs(gRNAs)relies substantially on empirical experience rather than a dependable and efficient in silico ***,the pleiotropic effect of base editing on disease treatment remains unexplored,which prevents its further clinical ***,we presented BExplorer,an integrated and comprehensive computational pipeline to optimize the design of gRNAs for 26 existing types of base editors in *** BExplorer,we described its results for two types of mainstream base editors,BE3 and ABE7.10,and evaluated the pleiotropic effects of the corresponding base editing *** revealed 524 and 900 editable pathogenic single nucleotide polymorphism(SNP)loci in the human genome together with the selected optimized gRNAs for BE3 and ABE7.10,*** addition,the impact of 707 edited pathogenic SNP loci following base editing on 131 diseases was systematically explored by revealing their pleiotropic effects,indicating that base editing should be carefully utilized given the potential pleiotropic ***,the systematic exploration of optimized base editing gRNA design and the corresponding pleiotropic effects with BExplorer provides a computational basis for applying base editing in disease treatment.

关键词： Gene editing Base editing Pleiotropy CRISPR/Cas9 gRNAdesign