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Autoinhibition and cofactors of a helper NLR

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Science China Life Sciences 2024年

作者： Hongyuan Zheng Xuemin Zhou chenyu Zhao Daowen wang Zhengqing Fu College of Agronomy State Key Laboratory of Wheat and Maize Crop Scienceand Center for Crop Genome EngineeringLongzi Lake CampusHenan Agricultural University Department of Biological Sciences University of South Carolina(Columbia)

Plants offer a plethora of benefits to human ***,in the natural world,plants encounter numerous biotic and abiotic pressures,including the presence of various pathogens that cause serious diseases on crops with economic *** guard themselves against infections,plants have developed sophisticated defense *** initial level of plant immunity depends on pattern recognition receptors (PRRs) situated on the surfaces of cells (Zipfel,2014).

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Machine learning in building energy management: A critical review and future directions

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Frontiers of Engineering Management 2022年第2期9卷 239-256页

作者： Qian SHI chenyu LIU Chao XIAO School of Economics and Management Tongji UniversityShanghai 200092China

Over the past two decades,machine learning(ML)has elicited increasing attention in building energy management(BEM)***,the boundary of the ML-BEM research has not been clearly defined,and no thorough review of ML applications in BEM during the whole building life-cycle has been *** study aims to address this gap by reviewing the ML-BEM papers to ascertain the status of this research area and identify future research *** integrated framework of ML-BEM,composed of four layers and a series of driving factors,is ***,based on the hype cycle model,this paper analyzes the current development status of ML-BEM and tries to predict its future development ***,five research directions are discussed:(1)the behavioral impact on BEM,(2)the integration management of renewable energy,(3)security concerns of ML-BEM,(4)extension to other building life-cycle phases,and(5)the focus on fault detection and *** findings of this study are believed to provide useful references for future research on ML-BEM.

关键词： building energy management machine learning integrated framework knowledge evolution

Oxygen-vacancy-anchoring Ni_(x)O_(y) loading towards efficient hydrogen evolution via photo-thermal coupling reaction

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Journal of Energy Chemistry 2021年第10期30卷 77-87,I0003页

作者： Qiliang Wu Zheng Li Xuhan Zhang chenyu Xu Mingjiang Ni Kefa Cen Yanwei Zhang State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou 310027ZhejiangChina Department of Chemical and Materials Engineering University of AlbertaEdmonton ABT6G 1H9Canada

Oxygen vacancy(Vo)is a significant component in defect *** present work reports the anchoring effects of initial Vo for further loading modifications and the reducing capacity of photoinduced Vo for pure water ***,we propose Ni-loaded Cu-doped TiO_(2)(NCT)materials by successive doping and *** continuously added Ni ions should accumulate around the Vos and gradually grow into complete nickel oxide crystals,achieving a higher average valence state of the Ni *** crystals can be detected on a 0.5%NCT sample,while the structure of Ni_(2)O_(3) has been confirmed with a higher nickel mass ***,the introduction of nickel oxide effectively improves the photochemical and electrochemical performance by the interface charge separation,finally reaching an H2 yield of 30.6 pmol/g-cat on 0.5%NCT for Vo-based photo-thermal coupling reaction,which consists of Vo generation in photo and Vo consumption in thermal *** situ infrared spectroscopy further indicated that the presence of high valence state nickel oxide hindered the H2 formation but effectively promoted the conventional oxidizing reaction,with an H2 yield of 20.6 mmol/g-cat in a methanol-water reaction on the 2.0%NCT *** summary,Vo controls the morphological structure of Ni loading and produces diverse effects for reactions with dissimilar mechanisms,which provides a novel way to design modifications for promoting various chemical reactions.

关键词： Oxygen vacancy Nickel oxide Water splitting Photo-thermal coupling reaction DFT calculation

The Importance of Food Security from the Perspective of Food Issue of the Roman Empire

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Asian Agricultural Research 2017年第9期9卷 77-80页

作者： Lianjing MA chenyu wang School of Foreign Studies Hefei University of Technology School of History and Philosophy University of Pisa

This paper firstly introduced characteristics of the food production( or grain production) and regulation of the prosperous period of the Roman Empire. Then,it discussed the shortcomings and summarized the experience ... 详细信息

关键词： Roman Empire Food security Regulation Recommendations

MBE:A Music Copyright Depository Framework Incorporating Blockchain and Edge Computing

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Computer Systems Science & Engineering 2023年第12期47卷 2815-2834页

作者： Jianmao Xiao Ridong Huang Jiangyu wang Zhean Zhong chenyu Liu Yuanlong Cao Chuying Ouyang School of Software Jiangxi Normal UniversityNanchang330027China Department of Physics Jiangxi Normal UniversityNanchang330027China

Audio copyright is a crucial issue in the music industry,as it protects the rights and interests of creators and *** paper studies the current situation of digital music copyright certification and proposes a music copyright certification framework based on“blockchain+edge computing mode,”abbreviated as MBE,by integrating edge computing into the Hyperledger Fabric *** framework compresses and splits the audio into small chunks,performs Fast Fourier Transform(FFT)to extract the peak points of each frequency and combines them to obtain unique audio fingerprint *** being confirmed by various nodes on the Fabric alliance chain,audio fingerprint information and copyright owner information are recorded on the chain and broadcast to all *** technology’s characteristics of being tamper-proof and traceable not only reform the trust mechanism of copyright protection but also endow edge computing with the ability to resist tampering and single-point attack,greatly enhancing the robustness of the music copyright certification ***,edge computing mode improves Fabric blockchain’s processing speed and transaction *** results show that MBE’s performance is better than traditional systems regarding efficiency,storage demand and *** to the traditional Fabric system without edge computing mode,MBE exhibits a 53%higher deposition efficiency and a 48%lower storage space requirement.

关键词： Blockchain copyright protection audio fingerprinting smart contracts

High expression of GPR160 in prostate cancer is unrelated to CARTp-mediated signaling pathways

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1467-1471页

作者： chenyu Ye Qingtong Zhou Shi Lin Wensheng Yang Xiaoqing Cai Yiting Mai Yanyan Chen Dehua Yang Ming-Wei wang Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources Sanya 572025China Department of Pharmacy Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghai 201102China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China The National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry School of Sciencethe University of TokyoTokyo 113-0033Japan School of Pharmacy Hainan Medical UniversityHaikou 571199China

To the Editor:G protein-coupled receptors(GPCRs)are the largest group of membrane proteins with over 800 members,characteristic of a seven transmembrane *** playing crucial roles in regulation of various physiological processes,GPCRs have been implicated in many diseases including diabetes,obesity,depression and *** initiate different intracellular responses,GPCRs mainly interact with three families of effector proteins upon agonist binding:the heterotrimeric G proteins,G protein-coupled receptor kinases(GRKs)and arrestins1.

关键词： GPR160 CARTp Prostate cancer Signaling pathway

Oxygen uptake response to switching stairs exercise by non-parametric modeling

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Control Theory and Technology 2024年第2期22卷 315-325页

作者： Hairong Yu chenyu Zhang Kai Cao Hamzah M.Alqudah Steven Weidong Su Key Laboratory of Child Development and Learning Science of Ministry of Education and the School of Biological Science and Medical Engineering Southeast UniversityNanjing210096JiangsuChina College of Artificial Intelligence and Big Data for Medical Science Shandong First Medical University and Shandong Academy of Medical SciencesJinan250117ShandongChina Faculty of Engineering and Information Technology University of Technology SydneyUltimoNSW2007Australia

Oxygen uptake plays a crucial role in the evaluation of endurance performance during exercise and is extensively utilized for metabolic assessment. This study records the oxygen uptake during the exercise phase (i.e., ascending or descending) of the stair exercise, utilizing an experimental dataset that includes ten participants and covers various exercise periods. Based on the designed experiment protocol, a non-parametric modeling method with kernel-based regularization is generally applied to estimate the oxygen uptake changes during the switching stairs exercise, which closely resembles daily life activities. The modeling results indicate the effectiveness of the non-parametric modeling approach when compared to fixed-order models in terms of accuracy, stability, and compatibility. The influence of exercise duration on estimated fitness reveals that the model of the phase-oxygen uptake system is not time-invariant related to respiratory metabolism regulation and muscle fatigue. Consequently, it allows us to study the humans’ conversion mechanism at different metabolic rates and facilitates the standardization and development of exercise prescriptions.

关键词： Non-parametric modeling Interval stair training exercise Kernel method.Cardiorespiratory response Oxygen uptake

In Situ Scattering Studies of Crystallization Kinetics in a Phase-Separated Zr-Cu-Fe-Al Bulk Metallic Glass

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Acta Metallurgica Sinica(English Letters) 2022年第1期35卷 103-114页

作者： Sinan Liu Jiacheng Ge Huiqaing Ying chenyu Lu Dong Ma Xun-Li wang Xiaobing Zuo Yang Ren Tao Feng Jun Shen Horst Hahn Si Lan Herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and Technology200 Xiaolingwei AvenueNanjing210094China Department of Physics City University of Hong Kong83 Tat Chee AvenueKowloon999077Hong Kong SARChina Neutron Sciences Platform Songshan Lake Materials LaboratoryDongguan523000China Neutron Sciences Directorate Oak Ridge National Laboratory1 Bethel Valley RoadOak RidgeTN37830USA Center of Neutron Scattering City University of Hong Kong Shenzhen Research InstituteShenzhen518057China X-Ray Science Division Argonne National LaboratoryLemontIL60439USA College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen518060China Institute for Nanotechnology Karlsruhe Institute of Technology76344Eggenstein-LeopoldshafenGermany

Thermal stability and the crystallization kinetics of a phase-separated Zr-Cu-Fe-Al bulk metallic glass were investigated using in situ high-energy synchrotron X-ray and neutron diffraction,as well as small-angle synchrotron X-ray *** was revealed that this glass with excellent glass-forming ability possesses a two-step crystallization *** crystalline products and their evolution sequence are more complicated than a homogeneous Zr-Cu-Al glass with average glass-forming *** experimental results indicate that a finely distributed nanometer-sized cubic Zr_(2)Cu phase forms first and then transforms to a tetragonal Zr_(2)Cu phase,while the matrix transforms to an orthorhombic Zr_(3)Fe *** strength of the Zr-Cu-Fe-Al composite containing cubic Zr_(2)Cu phase and glass matrix increases,and the plasticity also improves compared to the as-cast Zr-Cu-Fe-Al bulk metallic *** results suggest that the formation of multiple and complex crystalline products would be the characteristics of the Zr-Cu-Fe-Al glass with better glass-forming *** study may shed light on the synthesis of bulk-sized glass-nanocrystals composites of high strength and good plasticity.

关键词： Bulk metallic glass Crystallization kinetics Synchrotron and neutron scattering Phase separation

Unveiling size-fluorescence correlation of organic nanoparticles and its use in nanoparticle size determination

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Aggregate

Aggregate 2024年第1期5卷 331-336页

作者： Wu-Jie Guo Shixiang Ma Hui wang Lu Qiao Lei Chen chenyu Hong Bin Liu Xiaoyan Zheng Hui-Qing Peng State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijingChina Key Laboratory of Cluster Science of Ministry of Education Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion MaterialsKey Laboratory of Medicinal Molecule Science and Pharmaceutics Engineering of Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijingChina

Quantitatively establishing the correlation between nanoparticle size and fluorescence is essential for understanding the behavior and functionality of fluorescent nanoparticles(FNPs).However,such exploration focusing on organic FNPs has not been achieved to ***,we employ the use of supramolecular polymeric FNPs prepared from tetraphenylethylene-based bis-ureidopyrimidinone monomers(bis-UPys)to relate the size to the fluorescence of organic *** an equal concentration of bis-UPys,a logarithmic relationship between them is built with a correlation coefficient higher than *** calculations indicate that variations in fluorescence intensity among FNPs of different sizes are attributed to the distinct molecular packing environments at the surface and within the interior of the *** leads to different nonradiative decay rates of the embedded and exposed bis-UPys and thereby changes the overall fluorescence quantum yield of nanoparticles due to their different specific surface *** established fluorescence intensity-size correlation possesses fine universality and reliability,and it is successfully utilized to estimate the sizes of other nanoparticles,including those in highly diluted dispersions of *** work paves a new way for the simple and real-time determination of nanoparticle sizes and offers an attractive paradigm to optimize nanoparticle functionalities by the size effect.

关键词： aggregation-induced emission fluorescence detection fluorescent nanoparticle nanoparticle size supramolecular polymer