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Knockdown of SIRT2 Rescues YARS-induced Charcot-Marie-Tooth Neuropathy in Drosophila

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Neuroscience Bulletin 2024年第4期40卷 539-543页

作者： Xuedong Li Mengrong wang Xiang Gao chenyu Li Chunyu Chen Yun Qi Ying Wan Wei Yu State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai200438China School of Basic Medic Science Southwest Medical UniversityLuzhou64600China Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Dear Editor,Charcot-Marie-Tooth disease,the most common inherited peripheral neuropathology,is highly heterogeneous among patients and associated with mutations in~100 different genes at an incidence of at least 1:2,500[1].Over 30 mutated genes have been identified in CMT2,which is characterized by peripheral axon degeneration and distal deficits in motor function[2].The aminoacyl-tRNA synthetase is the largest family in CMT2 and includes tyrosyl-tRNA synthetase(YARS,tyrosyl-tRNA synthetase).

关键词： Marie degeneration pathology

Privacy-preserving integration of multiple institutional data for single-cell type identification with scPrivacy

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Science China(Life Sciences) 2023年第5期66卷 1183-1195页

作者： Shaoqi Chen Bin Duan chenyu Zhu Chen Tang Shuguang wang Yicheng Gao Shaliu Fu Lixin Fan Qiang Yang Qi Liu Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration(Tongji University) Ministry of EducationOrthopaedic Department of Tongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Department of AI WeBankShenzhen 518055China Translational Medical Center for Stem Cell Therapy and Institution for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Shanghai Research Institute for Intelligent Autonomous Systems Shanghai 201210China

The rapid accumulation of large-scale single-cell RNA-seq datasets from multiple institutions presents remarkable opportunities for automatically cell annotations through integrative ***,the privacy issue has existed but being ignored,since we are limited to access and utilize all the reference datasets distributed in different institutions globally due to the prohibited data transmission across institutions by data regulation *** this end,we present scPrivacy,which is the first and generalized automatically single-cell type identification prototype to facilitate single cell annotations in a data privacy-preserving collaboration *** evaluated scPrivacy on a comprehensive set of publicly available benchmark datasets for single-cell type identification to stimulate the scenario that the reference datasets are rapidly generated and distributed in multiple institutions,while they are prohibited to be integrated directly or exposed to each other due to the data privacy regulations,demonstrating its effectiveness,time efficiency and robustness for privacy-preserving integration of multiple institutional datasets in single cell annotations.

关键词： preserving integration utilize

A cylindrical rod ultrasonic motor with 1 mm diameter and its application in endo-scopic OCT

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Chinese Science Bulletin 2005年第8期50卷 826-830页

作者： ZHOUTieying ZHANGKai chenyu wangHuan WUJigang JIANGKaili XUEPing DepartmentofPhysicsandKeyLaboratoryofAtomicandMolecular-Nano-Sciences MinistryofEducationTsinghuaUniversityBeijing100084China

A tiny ultrasonic motor was constructed by using a piezoelectric ceramic cylindrical rod as a vibration generator of the stator. The fabricated tiny motor has a di- ameter of 1 mm, a length of 5 mm and a weight of 36 mg. The resonant frequency is 32 kHz with one fixed boundary or 83 kHz with two free boundaries. Four silver electrodes were deposited on the cylindrical surface. The spacing be- tween two adjacent electrodes was carefully designed. A method was developed for the polarization of the stator. By using the bending vibration mode of the stator, the motor shows a performance with a speed of 1800 rpm and a stalled torque of 4 μ Nm, and can bear a high driving voltage up to 350 Vpp. The motor was used to drive an optical prism for circular scanning in an endoscopic OCT system. The tomo- graphic images of the inner cavities of a plastic tube and a scallion were obtained, and the resolution was of the order of micrometer-scale.

关键词：圆柱杆超声波电机摆动弯度内窥镜检查循环扫描

Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2137-2155页

作者： chenyu Xue Hongpeng Jia Rujing Cao Wenjie Cai Weichen Hong Jianing Tu Songtao wang Qianzhi Jiang Chongpeng Bi Anshan Shan Na Dong The Laboratory of Molecular Nutrition and Immunity College of Animal Science and TechnologyNortheast Agricultural UniversityHarbinP.R.China

Background Infection with pathogenic bacteria during nonantibiotic breeding is one of the main causes of animal intestinal *** acid(OA)is a pentacyclic triterpene that is ubiquitous in *** previous work demonstrated the protective effect of OA on intestinal health,but the underlying molecular mechanisms remain *** study investigated whether dietary supplementation with OA can prevent diarrhea and intestinal immune dysregulation caused by enterotoxigenic Escherichia coli(ETEC)in *** key molecular role of bile acid receptor signaling in this process has also been *** Our results demonstrated that OA supplementation alleviated the disturbance of bile acid metabolism in ETEC-infected piglets(P<0.05).OA supplementation stabilized the composition of the bile acid pool in piglets by regulating the enterohepatic circulation of bile acids and significantly increased the contents of UDCA and CDCA in the ileum and cecum(P<0.05).This may also explain why OA can maintain the stability of the intestinal microbiota structure in ETEC-challenged *** addition,as a natural ligand of bile acid receptors,OA can reduce the severity of intestinal inflammation and enhance the strength of intestinal epithelial cell antimicrobial programs through the bile acid receptors TGR5 and FXR(P<0.05).Specifically,OA inhibited NF-κB-mediated intestinal inflammation by directly activating TGR5 and its downstream c AMP-PKA-CREB signaling pathway(P<0.05).Furthermore,OA enhanced CDCA-mediated MEK-ERK signaling in intestinal epithelial cells by upregulating the expression of FXR(P<0.05),thereby upregulating the expression of endogenous defense molecules in intestinal epithelial *** In conclusion,our findings suggest that OA-mediated regulation of bile acid metabolism plays an important role in the innate immune response,which provides a new diet-based intervention for intestinal diseases caused by pathogenic bacterial infections in pig

关键词： Bile acid receptors Enterotoxigenic Escherichia coli Intestinal innate immunity Oleanolic acid

Preconditioned deconvolution method for high-resolution ghost imaging

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Photonics Research 2021年第6期9卷 1069-1077页

作者： ZHISHEN TONG ZHENTAO LIU chenyu HU JIAN wang SHENSHENG HAN Key Laboratory of Quantum Optics of CAS Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Data Science Fudan UniversityShanghai 200433China ZJLab Shanghai Key Laboratory of Intelligent Information ProcessingShanghai 200433China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

Ghost imaging(GI)can nonlocally image objects by exploiting the fluctuation characteristics of light fields,where the spatial resolution is determined by the normalized second-order correlation function g^(2) .However,the spatial shift-invariant property of g^(2) is distorted when the number of samples is limited,which hinders the deconvolution methods from improving the spatial resolution of *** this paper,based on prior imaging systems,we propose a preconditioned deconvolution method to improve the imaging resolution of GI by refining the mutual coherence of a sampling matrix in *** theoretical analysis shows that the preconditioned deconvolution method actually extends the deconvolution technique to GI and regresses into the classical deconvolution technique for the conventional imaging *** imaging resolution of GI after preconditioning is restricted to the detection *** simulation and experimental results show that the spatial resolution of the reconstructed image is obviously enhanced by using the preconditioned deconvolution *** the experiment,1.4-fold resolution enhancement over Rayleigh criterion is achieved via the preconditioned *** results extend the deconvolution technique that is only applicable to spatial shift-invariant imaging systems to all linear imaging systems,and will promote their applications in biological imaging and remote sensing for high-resolution imaging demands.

关键词： ghost Ghost resolution

Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

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Frontiers of Medicine 2022年第2期16卷 216-226页

作者： Shoubin Zhan Ping Yang Shengkai Zhou Ye Xu Rui Xu Gaoli Liang chenyu Zhang Xi Chen Liuqing Yang Fangfang Jin Yanbo wang Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy State Key Laboratory of Pharmaceutical Biotechnology and Department of PhysiologyJiangsu Engineering Research Center for MicroRNA Biology and BiotechnologyNJU Advanced Institute of Life Sciences(NAILS)School of Life SciencesNanjing UniversityNanjing 210023China Department of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210023China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China Department of Infectious Diseases The First People's Hospital of LianyungangThe First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungang 222000China

Hepatocellular carcinoma(HCC),which makes up the majority of liver cancer,is induced by the infection of hepatitis B/C *** are needed to facilitate the early detection of HCC,which is often diagnosed too late for effective *** tRNA-derived small RNAs(tsRNAs)play vital roles in tumorigenesis and are stable in ***,the diagnostic values and biological functions of circulating tsRNAs,especially for HCC,are still *** this study,we first utilized RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC *** identified tRF-Gln-TTG-006,which was remarkably upregulated in HCC serum(training cohort:24 HCC patients vs.24 healthy controls).In the validation stage,we found that tRF-Gln-TTG-006 signature could distinguish HCC cases from healthy subjects with high sensitivity(80.4%)and specificity(79.4%)even in the early stage(Stage I:sensitivity,79.0%;specificity,74.8%;155 healthy controls vs.153 HCC patients from two cohorts).Moreover,in vitro studies indicated that circulating tRF-Gln-TTG-006 was released from tumor cells,and its biological function was predicted by bioinformatics assay and validated by colony formation and apoptosis *** summary,our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC.

关键词： tsRNA biomarker hepatocarcinoma

Contributions of Cs and Rb on Inhibiting Photo-induced Phase Segregation and En-hancement Optoelectronic Performances of MA_(1-y)XyPbI_(1.8)Br_(1.2)(X=Cs,Rb)Single Crystals

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Chinese Journal of Structural Chemistry 2022年第5期41卷 77-84页

作者： Qing Yao Kaiyu wang Jie Zhang Changqian Li chenyu Shang Feitong Chen Qi Huang Qiqi Zhao Weiwei Zhang Xiaoyuan Zhan Jianxu Ding College of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

Introducing inorganic cation into hybrid organic-inorganic perovskites(HOIPs)has attracted great attention because of the enhancement stabilities without sacrificing their excellent optoelectronic ***,we introduce Cs and Rb into MAPbI_(1.8)Br_(1.2)single crystals(SCs)to dig out the mixed cation effect on optoelectronic performances and phase *** Rb and Cs can increase the lattice capacity,which is sufficient to relieve the lattice stress caused by photon energy,thus achieving the purpose of stabilizing the lattice structure and inhibiting migration of halide ions,compared with MAPbI_(1.8)Br_(1.2)*** the other hand,the smaller polarity of Rb and Cs reduces the electron-phonon coupling,thus significantly inhibiting the migration of halide ***,through planar photo-detectors,MA_(0.9)Cs_(0.1)PbI_(1.8)Br_(1.2)-based device behaves much excellent optoelectronic performance(R=0.170 A/W,EQE=51.39%,D^(*)=4.42×10^(12)Jones,on/off ratio:~522).

关键词： perovskite single crystal photo-induced phase segregation mixed A-cation optoelectronic performances

基于系统动力学的物流园区与产业园区服务功能联动

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系统工程理论与实践 2017年第10期37卷 2660-2671页

作者：陶经辉王陈玉南京财经大学营销与物流管理学院南京210046 江苏省现代物流重点实验室(南京财经大学) 南京210046

运用系统动力学理论,通过因果反馈分析图确定了模型的界限,设计了系统流图,并结合变量之间量化公式的构造,构建了"ILSD"模型,在模型的仿真模拟过程中用GDP、第三产业产值以及进口交易额和出口交易额四个状态变量的模拟值与真实值的误差... 详细信息

运用系统动力学理论,通过因果反馈分析图确定了模型的界限,设计了系统流图,并结合变量之间量化公式的构造,构建了"ILSD"模型,在模型的仿真模拟过程中用GDP、第三产业产值以及进口交易额和出口交易额四个状态变量的模拟值与真实值的误差值检验了模型的有效性.研究结果表明:产业园区的功能转型升级影响物流园区的功能转型升级,二者在功能上有较强的联动关系.物流园区在未来功能建设中将强化增值服务功能和配套服务功能,而弱化基本服务功能,至2017年左右,我国物流园区的增值服务额将超过基本服务额,成为主要服务功能,至2020年左右,我国物流园区的增值服务额的增速分别约是配套服务额增速的2倍和基本服务额增速的3倍左右.

关键词：产业园区物流园区系统动力学联动发展

Dark Spatial Solitary Wave Due to Cascaded x^（2） Nonlinearity

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Communications in Theoretical Physics 2004年第1X期42卷 110-112页

作者： GAOGuan-Qie CHENXian-Feng chenyu-Ping wangFei-Yu XIAYu-Xing InstituteofOpticsandPhotonics DepartmentofPhysicsShanghaiJiaoTongUniversityShanghai200240China

The formation of the dark spatial solitary wave in cascaded second harmonic generation processes is numerically studied based on the nonlinear-coupled equations. It is shown that the solitary wave exists when the effe... 详细信息

关键词：级联非线性非线性薛定谔方程计算物理空间孤立子量子光学