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Meta-Analysis of the Efficacy of Cimetidine in the Treatment of Mumps

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Journal of Clinical and Nursing Research 2022年第6期6卷 47-56页

作者： Shiwei wang chenyu wang Department of Stomatology The First Affiliated Hospital of Xi’an Medical UniversityXi'an 710077Shaanxi ProvinceChina

Objective:To compare the efficacy of cimetidine and ribavirin in the treatment of mumps by ***:Controlled trials of cimetidine and ribavirin in the treatment of mumps were searched through China National Knowledge Infrastructure(CNKI),Wanfang data,Cqvip,Pubmed,The Cochrane Library and EMBase databases up to September *** effective rate,the time of swelling regression in parotid gland area and the rate of adverse reactions were analyzed by Review Manager 5.3 ***:The final 10 articles included 920 children,including 427 in the trial group and 447 in the control *** analysis showed that the effective rate of cimetidine in the treatment of mumps was higher than that of ribavirin in routine treatment,with a statistically significant difference(odds ratio[OR]=5.2,P1);The time of swelling regression was statistically significant(OR=-1.28,P1);The difference of adverse reaction rate was not statistically significant(OR=0.73,P=0.62).Conclusions:Compared with ribavirin,cimetidine is more effective in the treatment of mumps,with shorter swelling regression time without increases of adverse reactions.

关键词： Cimetidine Ribavirin Mumps Meta-analysis

Effects of fermented sweet potato residue on nutrient digestibility, meat quality, and intestinal microbes in broilers

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Animal Nutrition 2024年第2期17卷 75-86页

作者： Ting Yao chenyu wang Lifen Liang Xuan Xiang Hui Zhou Wentao Zhou Ruoxin Hou Tianli wang Liuqin He Shiyu Bin Yulong Yin Tiejun Li Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of Sciences University of Chinese Academy of Sciences Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal University Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection Ministry of EducationCollege of Life ScienceGuangxi Normal University

This study aimed to investigate the effects of different proportions of dietary fermented sweet potato residue(FSPR) supplementation as a substitute for corn on the nutrient digestibility, meat quality, and intestinal microbes of yellow-feathered broilers. Experiment 1(force-feeding) evaluated the nutrient composition and digestibility of mixtures with different proportions of sweet potato residue(70%, 80%,90%, and 100%) before and after fermentation. In Experiment 2(metabolic growth), a total of 420 oneday-old yellow-feathered broilers were randomly allocated to 4 groups and fed corn-soybean mealbased diets with 0, 5%, 8%, and 10% FSPR as a substitute for corn. The force-feeding and metabolic growth experiments were performed for 9 and 70 d, respectively. The treatment of 70% sweet potato residue(after fermentation) had the highest levels of crude protein, ether extract, and crude fiber and improved the digestibility of crude protein and amino acids(P 10% FSPR increased the serum immunoglobulin M and immunoglobulin G levels in broilers(P 10% FSPR increased the Shannon index and Ruminococcaceae＿UCG-014, Ruminococcaceae＿UCG-010 and Romboutsia abundances and decreased Sutterella and Megamonas abundances(P 14(P 10%FSPR as a substitute for corn can improve the slaughter performance, meat quality

关键词： Fermented sweet potato residue Meat quality Intestinal microbiota Broiler

Evaluation of the antibacterial mechanism and biofilm removal effect of eugenol on Vibrio vulnificus and its application in fresh oysters

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Food Bioscience 2022年第6期50卷 1092-1101页

作者： Kunyao Luo Shengnan Kang Meixian Guo chenyu Shen Lehui wang Xiaodong Xia Xin Lü Chao Shi College of Food Science and Engineering Northwest A&F University22 Xinong RoadYanglingShaanxi712100China School of Food Science and Technology National Engineering Research Center of SeafoodDalian Polytechnic UniversityDalian116304LiaoningChina

Eugenol is a natural active substance with high antibacterial activity,but its antibacterial activity against Vibrio vulnificus has not been extensively *** purpose of this study was to investigate the antibacterial and biofilm-clearing abilities and potential mechanisms of eugenol against ***,and to provide knowledge for the use of eugenol to prevent oyster *** was found that eugenol had an encouraging antibacterial effect on *** with a minimum inhibitory concentration(MIC)of 0.2 mg/*** accumulation of reactive oxygen species(ROS)and the increase of malondialdehyde(MDA)content suggest that oxidative stress is involved in the bactericidal ***,cell membrane hyperpolarization,changes in cell membrane integrity and morphology suggest that eugenol can reduce the permeability and integrity of cell membranes in *** addition,eugenol produced a significant biofilm clearance effect on ***,as evidenced by the reduced amount of biofilm and the reduction of polysaccharides and viable cells in the ***,eugenol was able to effectively inhibit the activity of *** in artificially contaminated oyster at 4°C and 25°*** sensory analysis showed that 0.10%eugenol was most acceptable to trained *** of these highlight the great promise of eugenol as a natural bacteriostatic agent for the food industry.

关键词： Eugenol Vibrio vulnificus Antibacterial mechanism Biofilm removal Reactive oxidative species Oyster

TurboID Proximity Labeling of a Protocadherin Protein to Characterize Interacting Protein Complex

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American Journal of Molecular Biology 2023年第4期13卷 213-226页

作者： chenyu wang Laidong Yu Hunan Key Laboratory of Molecular Precision Medicine Xiangya Hospital Central South University Changsha China Shanghai United International School Gubei Campus Shanghai China Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life Sciences Central South University Changsha China

The study of the neuron has always been a fundamental aspect when it came to studying mental illnesses such as autism and depression. The protein protocadherin-9 (PCDH9) is an important transmembrane protein in the development of the neuron synapse. Hence, research on its protein interactome is key to understanding its functionality and specific properties. A newly discovered biotin ligase, TurboID, is a proximity labeler that is designed to be able to label and observe transmembrane proteins, something that previous methods struggled with. The TurboID method is verified in HEK293T cells and primary cultured mouse cortical neurons. Results have proven the validity of the TurboID method in observing PCDH9-interacting proteins.

关键词： TurboID PCDH9 Proximity Labeling Protein Interactome Synapse Development

Axon-like aligned conductive CNT/GelMA hydrogel fibers combined with electrical stimulation for spinal cord injury recovery

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Bioactive Materials 2024年第5期35卷 534-548页

作者： Shenglian Yao Yongdong Yang chenyu Li Kaitan Yang Xin Song Chuanhong Li Zheng Cao He Zhao Xing Yu Xiumei wang Lu-Ning wang School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Key Laboratory of Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Department of Orthopedics Dongzhimen HospitalBeijing University of Chinese Medicine5 Hai Yun CangBeijing100700China

Rehabilitation and regenerative medicine are two promising approaches for spinal cord injury(SCI)recovery,but their combination has been *** biomaterials could bridge regenerative scaffolds with electrical stimulation by inducing axon regeneration and supporting physiological electrical signal ***,we developed aligned conductive hydrogel fibers by incorporating carbon nanotubes(CNTs)into methacrylate acylated gelatin(GelMA)hydrogel via rotating liquid bath *** electrospun CNT/GelMA hydrogel fibers mimicked the micro-scale aligned structure,conductivity,and soft mechanical properties of neural *** in vitro studies,CNT/GelMA hydrogel fibers supported PC12 cell proliferation and aligned adhesion,which was enhanced by electrical stimulation(ES).Similarly,the combination of aligned CNT/GelMA hydrogel fibers and ES promoted neuronal differentiation and axon-like neurite sprouting in neural stem cells(NSCs).Furthermore,CNT/GelMA hydrogel fibers were transplanted into a T9 transection rat spinal cord injury model for in vivo *** results showed that the incorporating CNTs could remain at the injury site with the GelMA fibers biodegraded and improve the conductivity of regenerative *** aligned structure of the hydrogel could induce the neural fibers regeneration,and the ES enhanced the remyelination and axonal *** assessments and electrophysiological results suggest that the combination of aligned CNT/GelMA hydrogel fibers and ES could significantly restore motor function in *** study demonstrates that conductive aligned CNT/GelMA hydrogel fibers can not only induce neural regeneration as a scaffold but also support ESto promote spinal cord injury *** conductive hydrogel fibers enable merging regenerative medicine and rehabilitation,showing great potential for satisfactory locomotor recovery after SCI.

关键词： Conductive hydrogel fibers CNT/GelMA Electrical stimulation NSCs differentiation Spinal cord injury

Reflection on the equitable attribution of responsibility for artificial intelligence-assisted diagnosis and treatment decisions

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Intelligent Medicine 2023年第2期3卷 139-143页

作者： Antian Chen chenyu wang Xinqing Zhang Department of Cardiology Peking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100730China Department of Computer Science College of Natural SciencesUniversity of Texas at AustinTXUSA Echocardiography Medical Center Maternal-Fetal Medicine center in Fetal Heart DiseaseBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China School of Humanities and Social Sciences Peking Union Medical College&Chinese Academy of Medical SciencesBeijing 100005China

Artificial intelligence(AI)is developing rapidly and is being used in several medical capacities,including assisting in diagnosis and treatment *** a result,this raises the conceptual and practical problem of how to distribute responsibility when AI-assisted diagnosis and treatment have been used and patients are harmed in the *** on this issue have not yet been *** would be beneficial to tackle responsibility attribution prior to the development of biomedical AI technologies and ethical *** general,human doctors acting as superiors need to bear responsibility for their clinical ***,human doctors should not bear responsibility for the behavior of an AI doctor that is practicing medicine *** to the degree of fault-which includes internal institutional ethics,the AI bidding process in procurement,and the medical process-clinical institutions are required to bear corresponding *** manufacturers are responsible for creating accurate algorithms,network security,and insuring patient privacy ***,the AI itself should not be subjected to legal evaluation since there is no need for it to bear *** responsibility should be borne by the employer,in this case the medical institution.

关键词： Artificial intelligence Diagnosis Ethics Responsibility attribution

Identification of a novel MYO1D variant associated with laterality defects,congenital heart diseases,and sperm defects in humans

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Frontiers of Medicine 2024年第3期18卷 558-564页

作者： Zhuangzhuang Yuan Xin Zhu Xiaohui Xie chenyu wang Heng Gu Junlin Yang Liangliang Fan Rong Xiang Yifeng Yang Zhiping Tan Department of Cardiovascular Surgery The Second Xiangya Hospital of Central South UniversityChangsha410011China Clinical Center for Gene Diagnosis and Therapy The Second Xiangya Hospital of Central South UniversityChangsha410011China Department of Cell Biology School of Life SciencesCentral South UniversityChangsha410013China Department of Gynecology and Obstetrics Xiangya Hospital of Central South UniversityChangsha410008China

The establishment of left–right asymmetry is a fundamental process in animal *** with this process leads to a range of disorders collectively known as laterality defects,which manifest as abnormal arrangements of visceral *** patients with laterality defects,congenital heart diseases(CHD)are *** multiple model organisms,extant research has established that myosin-Id(MYO1D)deficiency causes laterality *** study investigated over a hundred cases and identified a novel biallelic variant of MYO1D(NM_015194:c.1531G>A;p.D511N)in a consanguineous family with complex CHD and laterality *** examination of the proband revealed asthenoteratozoospermia and shortened ***,the effects of the D511N variant and another known MYO1D variant(NM_015194:c.2293C>T;p.P765S)were *** assessment showed that both enhance the interaction withβ-actin and ***,this study revealed the genetic heterogeneity of this rare disease and found that MYO1D variants are correlated with laterality defects and CHD in ***,this research established a connection between sperm defects and MYO1D *** offers guidance for exploring infertility and reproductive health *** findings provide a critical basis for advancing personalized medicine and genetic counseling.

关键词： MYO1D laterality defect congenital heart disease sperm defect β-actin SPAG6

Probing the Interfacial Forces and Surface Interaction Mechanisms in Petroleum Production Processes

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Engineering 2022年第11期18卷 49-61页

作者： Diling Yang Xuwen Peng Qiongyao Peng Tao wang chenyu Qiao Ziqian Zhao Lu Gong Yueliang Liu Hao Zhang Hongbo Zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada College of Petroleum Engineering China University of PetroleumBeijing 102249China

Despite the advances that have been made in renewable energy over the past decade,crude oil or petroleum remains one of the most important energy resources to the *** production presents many challenging issues,such as the destabilization of complex oil-water emulsions,fouling phenomena on pipelines and other facilities,and water *** problems are influenced by the molecular forces at the oil/water/solid/gas interfaces involved in relevant ***,we present an overview of recent advances on probing the interfacial forces in several petroleum production processes(e.g.,bitumen extraction,emulsion stabilization and destabilization,fouling and antifouling phenomena,and water treatment)by applying nanomechanical measurement technologies such as a surface forces apparatus(SFA)and an atomic force microscope(AFM).The interaction forces between bitumen and mineral solids or air bubbles in the surrounding fluid media determine the bitumen liberation and flotation efficiency in oil sands *** stability of complex oil/water emulsions is governed by the forces between emulsion drops and particularly between interface-active species(e.g.,asphaltenes).Various oil components(e.g.,asphaltenes)and emulsion drops interact with different substrate surfaces(e.g.,pipelines or membranes),influencing fouling phenomena,oil-water separation,and wastewater *** these intermolecular and interfacial forces has advanced the mechanistic understanding of these interfacial interactions,facilitating the development of advanced materials and technologies to solve relevant challenging issues and improve petroleum production *** challenges and suggestions on future research directions in the field are also presented.

关键词： Intermolecular and surface forces Interface Emulsion Colloids Fouling and antifouling Water treatment

A bHLH transcription factor,CsSPT,regulates high-temperature resistance in cucumber

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Horticultural Plant Journal 2024年第2期10卷 503-514页

作者： Yonggui Liang chenyu Yang Fangyan Ming Bingwei Yu Zhihua Cheng Yixi wang Zhengkun Qiu Xiaolan Zhang Bihao Cao Shuangshuang Yan Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(South China) Ministry of Agriculture and Rural AffairsGuangdong Vegetable Engineering and Technology Research CenterCollege of HorticultureSouth China Agricultural UniversityGuangzhouGuangdong 510642China State Key Laboratories of Agrobiotechnology Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable CropsMOE Joint Laboratory for International Cooperation in Crop Molecular BreedingChina Agricultural UniversityBeijing 100193China

High-temperature stress threatens the growth and yield of crops. Basic helix-loop-helix(bHLH) transcription factors(TFs) have been shown to play important roles in regulating high-temperature resistance in plants. However, the bHLH TFs responsible for high-temperature tolerance in cucumbers have not been identified. We used transcriptome profiling to screen the high temperature-responsive candidate bHLH TFs in cucumber. Here, we found that the expression of 75 CsbHLH genes was altered under high-temperature stress. The expression of the CsSPT gene was induced by high temperatures in TT(Thermotolerant) cucumber plants. However, the Csspt mutant plants obtained by the CRISPR-Cas9 system showed severe thermosensitive symptoms, including wilted leaves with brown margins and reduced root density and cell *** Csspt mutant plants also exhibited elevated H_(2)O_(2) levels and down-regulated photosystem-related genes under normal ***, there were high relative electrolytic leakage(REC), malondialdehyde(MDA), glutathione(GSH), and superoxide radical(O_(2)^(·-)) levels in the Csspt mutant plants, with decreased Proline content after the high-temperature treatment. Transcriptome analysis showed that the photosystem and chloroplast activities in Csspt mutant plants were extremely disrupted by the high-temperature stress compared with wildtype(WT) plants. Moreover, the plant hormone signal transduction, as well as MAPK and calcium signaling pathways were activated in Csspt mutant plants under high-temperature stress. The HSF and HSP family genes shared the same upregulated expression patterns in Csspt and WT plants under high-temperature conditions. However, most bHLH, NAC, and bZIP family genes were significantly down-regulated by heat in Csspt mutant plants. Thus, these results demonstrated that CsSPT regulated the high-temperature response by recruiting photosynthesis components, signaling pathway molecules, and transcription factors. Our results pro

关键词： Cucumber bHLH CsSPT Photosynthesis High temperature