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Andrographolide protects against atrial fibrillation by alleviating oxidative stress injury and promoting impaired mitochondrial bioenergetics

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第7期24卷 632-649页

作者： Pengcheng YU Jiaru CAO Huaxin SUN Yingchao GONG Hangying YING Xinyu ZHOU Yuxing WANG chenyang qi Hang YANG qingbo LV Ling ZHANG Xia SHENG Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang ProvinceSir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling the First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830011China Department of Cardiology the First School of Clinical Medicine of Zhejiang Chinese Medicine UniversityHangzhou 310006China

Atrial fibrillation(AF)is the most prevalent cardiac arrhythmia seen in clinical settings,which has been associated with substantial rates of mortality and ***,clinically available drugs have limited efficacy and adverse *** aimed to investigate the mechanisms of action of andrographolide(Andr)with respect to *** used network pharmacology approaches to investigate the possible therapeutic effect of *** define the role of Andr in AF,HL-1 cells were pro-treated with Andr for 1 h before rapid electronic stimulation(RES)and rabbits were pro-treated for 1 d before rapid atrial pacing(RAP).Apoptosis,myofibril degradation,oxidative stress,and inflammation were *** sequencing(RNA-seq)was performed to investigate the relevant *** treatment attenuated RAP-induced atrial electrophysiological changes,inflammation,oxidative damage,and apoptosis both in vivo and in ***-seq indicated that oxidative phosphorylation played an important *** electron microscopy and adenosine triphosphate(ATP)content assay respectively validated the morphological and functional changes in *** translocation of nuclear factor erythroid 2-related factor 2(Nrf2)to the nucleus and the molecular docking suggested that Andr might exert a therapeutic effect by influencing the Keap1-Nrf2 *** conclusions,this study revealed that Andr is a potential preventive therapeutic drug toward AF via activating the translocation of Nrf2 to the nucleus and the upregulation of heme oxygenase-1(HO-1)to promote mitochondrial bioenergetics.

关键词： Traditional Chinese medicine Atrial fibrillation Andrographolide Oxidative stress Network pharmacology

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无抗生素纳米抗菌剂:现状、挑战与展望

化学进展 2022年第11期34卷 2540-2560页

作者：漆晨阳涂晶武汉理工大学材料复合新技术国家重点实验室武汉430070

耐药性细菌和生物膜相关的感染性疾病严重威胁全球公众健康。随着纳米技术在抗菌领域的渗透和发展,研发基于无抗生素的新型纳米抗菌剂在避免耐药性产生以及抗菌治疗方式的选择方面提供更多可能性。本文从细菌耐药性的产生机制出发,阐述... 详细信息

耐药性细菌和生物膜相关的感染性疾病严重威胁全球公众健康。随着纳米技术在抗菌领域的渗透和发展,研发基于无抗生素的新型纳米抗菌剂在避免耐药性产生以及抗菌治疗方式的选择方面提供更多可能性。本文从细菌耐药性的产生机制出发,阐述利用纳米材料自身独特的理化性质,实现自体抗菌;作为纳米酶,利用类酶活性催化底物产生活性氧簇(ROS)等抗菌;随后讨论了构建随内源性/外源性环境刺激响应,以及协同多种新型治疗方式的智能纳米抗菌剂,实现高效抗菌。最后,提出了目前面临的挑战及临床应用前景,为开发更加安全、高效的纳米抗菌剂提供借鉴。

关键词：细菌耐药性细菌生物膜纳米材料活性氧簇协同抗菌

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Spatiotemporal characteristics and influencing factors of vegetation water use efficiency on the Tibetan Plateau in 2001–2020

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Journal of Geographical Sciences 2025年第1期 39-64页

作者： HE chenyang WANG Yanjiao YAN Feng LU qi School of Ecological and Environmental Science East China Normal University Institute of Ecological Conservation and Restoration Chinese Academy of Forestry National Climate Center China Meteorological Administration

Water use efficiency （WUE）,as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ***,in the context of global warming,WUE evolution and its primary drivers on the Tibetan Plateau remain *** study employed the ensemble empirical mode decomposition method and the random forest algorithm to decipher the nonlinear trends and drivers of WUE on the Tibetan Plateau in 2001–*** indicated an annual mean WUE of 0.8088 gC/mm·m2across the plateau,with a spatial gradient reflecting decrease from the southeast toward the *** manifesting monotonous trends of increase or decrease in WUE accounted for 23.64%and 9.69%of the total,***,66.67%of the region exhibited trend reversals,i.e.,39.94%of the area of the Tibetan Plateau showed transition from a trend of increase to a trend of decrease,and 26.73%of the area demonstrated a shift from a trend of decrease to a trend of *** factors accounted for 70.79%of the variability in *** leaf area index and temperature served as the major driving forces of WUE variation.

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石岛湾核电站周边地表γ辐射水平调查及影响因素研究

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中国辐射卫生 2023年第1期32卷 15-20页

作者：齐晨阳张巍张显鹏柳怡凤志慧山东大学公共卫生学院山东济南250012 山东省疾病预防控制中心公共卫生监测评价所山东济南250014

目的对山东省石岛湾核电站运行前周边地表γ辐射累积剂量进行监测,分析剂量水平和影响因素,推算当地居民年有效剂量。方法选择核电站周边30 km内56个监测点,采用热释光剂量片监测法测量环境γ辐射剂量,在2021年4个监测期(第1至4期分别... 详细信息

目的对山东省石岛湾核电站运行前周边地表γ辐射累积剂量进行监测,分析剂量水平和影响因素,推算当地居民年有效剂量。方法选择核电站周边30 km内56个监测点,采用热释光剂量片监测法测量环境γ辐射剂量,在2021年4个监测期(第1至4期分别为2021年1月16日—4月14日、4月15日—7月20日、7月21日—10月21日和10月22日—2022年1月20日)共369天进行γ辐射剂量水平调查,分析其与监测时间、海拔高度和核电站距离之间的关系,并推算地表γ辐射造成的居民年有效剂量,来反映该区域的地表γ辐射本底水平。结果该区域在4个监测期内地表γ辐射剂量率平均值分别为(76.196±3.366)、(81.773±6.144)、(93.554±7.449)和(97.604±9.396)nGy/h,全年地表γ辐射剂量率为(87.282±6.589) nGy/h,对人体造成的有效剂量为0.428 mSv。地表γ辐射水平在2021年7月—2022年1月份较高,距离核电站不同距离组的监测点γ辐射剂量率差异没有统计学意义,本研究结果中未见海拔高度对地表γ辐射剂量的影响。结论石岛湾核电站周边地表2021年地表γ辐射水平处于本底水平。

关键词：地表γ辐射热释光测量剂量率有效剂量核电站

某型航空发动机中介主轴承早期微弱故障诊断研究

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机械与电子 2019年第6期37卷 6-10页

作者：汪伟李军翟旭升齐晨阳空军工程大学航空机务士官学校

针对基于机匣采集的振动信号难以有效提取出航空发动机中介主轴承早期微弱故障特征的问题,提出了基于巴特沃斯低通滤波器降噪和Hilbert包络解调的中介主轴承早期微弱故障诊断方法。该方法依托带涡轮支承和外机匣的新型航空发动机中介主... 详细信息

针对基于机匣采集的振动信号难以有效提取出航空发动机中介主轴承早期微弱故障特征的问题,提出了基于巴特沃斯低通滤波器降噪和Hilbert包络解调的中介主轴承早期微弱故障诊断方法。该方法依托带涡轮支承和外机匣的新型航空发动机中介主轴承试验器,首先,开展某型发动机巡航状态下健康中介主轴承试验,获取基准振动频谱特征;然后,进行外圈剥落预置故障的轴承试验,对采集的振动信号通过低通滤波降噪并进行Hilbert包络分析解调出低频故障信号;最后,对比分析健康主轴承试验与轴承故障试验的时域波形、频谱和包络谱。结果表明,包络谱中转差信号与呈现“山”型边带特征,可用于诊断该型航空发动机中介主轴承外圈的早期剥落故障。

关键词：发动机中介主轴承故障诊断巴特沃斯滤波器微弱故障包络谱分析

燃烧法制备用于甲烷干重整的Ni/TiO2催化剂

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山东化工 2019年第12期48卷 44-45页

作者：李昂漆晨阳韩振兴郭思溪徐艳徐州工程学院化学化工学院

以甲烷和二氧化碳为原料的甲烷干重整反应既有利于实现甲烷资源的合理利用,还可以减轻由二氧化碳导致的温室效应。本文分别采用燃烧法和浸渍法制备了Ni/TiO2催化剂,以甲烷干重整反应评价其催化性能,在800℃,CH4/CO2/N2=9/9/2,空速为48L... 详细信息

以甲烷和二氧化碳为原料的甲烷干重整反应既有利于实现甲烷资源的合理利用,还可以减轻由二氧化碳导致的温室效应。本文分别采用燃烧法和浸渍法制备了Ni/TiO2催化剂,以甲烷干重整反应评价其催化性能,在800℃,CH4/CO2/N2=9/9/2,空速为48L·g^-1·h^-1的条件下,燃烧法制备的Ni/TiO2催化剂具有更高的催化性能,反应6h,甲烷和二氧化碳的转化率分别下降了6%和10%,而常规浸渍法制备的催化剂,相同条件下,甲烷和二氧化碳的转化率分别下降了23%和25%。通过XRD和H2-TPR的表征,可以推测,燃烧法制备的催化剂上Ni的粒径更小、分散度更高,而且具有更强的金属-载体相互作用,因而具有更高的催化性能。

关键词：燃烧法甲烷干重整 Ni/TiO2催化剂

Debris cloud structure and hazardous fragments distribution under hypervelocity yaw impact

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Defence Technology（防务技术） 2023年第9期27卷 169-183页

作者： chenyang Wu qi-Guang He Xiaowei Chen Chunbo Zhang Zebin Shen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyHaidian DistrictBeijing100081China School of Mechatronical Engineering Beijing Institute of TechnologyHaidian DistrictBeijing100081China Institute of Systems Engineering China Academy of Engineering PhysicsMianyangSichuan621999China

This study investigates how the debris cloud structure and hazardous fragment distribution vary with attack angle by simulating a circular cylinder projectile hypervelocity impinging on a thin plate using the finite element-smoothed particle hydrodynamics(FE-SPH)adaptive *** on the comparison and analysis of the experimental and simulation results,the FE-SPH adaptive method was applied to address the hypervelocity yaw impact problem,and the variation law of the debris cloud structure with the attack angle was *** screening criterion of the hazardous fragment at yaw impact is given by analyzing the debris formation obtained by the FE-SPH adaptive method,and the distribution characteristics of hazardous fragments and their relationship with the attack angle are ***,the velocity space was used to evaluate the distribution range and damage capability of asymmetric hazardous *** maximum velocity angle was extended from fully symmetrical working conditions to asymmetrical cases to describe the asymmetrical debris cloud distribution *** this range,the energy density was calculated to quantitatively analyze how much damage hazardous fragments inflict on the rear *** results showed that the number of hazardous fragments generated by the case near the 35°attack angle was the largest,the distribution range was the smallest,and the energy density was the *** results suggest that in this case,debris cloud generated by the impact had the strongest damage to the rear plate.

关键词： Debris cloud Hypervelocity yaw impact FE-SPH adaptive method Velocity space Hazardous fragments distribution

Responsive Polymers with Contraction-arisen Helicity and Biomimetic Membrane-spanning Transport Functions

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Chemical Research in Chinese Universities 2022年第3期38卷 803-808页

作者： MIN Jing ZHANG chenyang qi Shuaiwei WANG Liyan DONG Zeyuan State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012P.R.China

Responsive polymers have attracted increasing attention for prospective design of smart *** development of multifunctional responsive materials is very dependent on polymeric structures that can be manipulated with the change of microenvironment at the molecular ***,we report a type of responsive coordination polymers(RCPs)consisting of dual phenanthroline-oxadiazole(DPO)units and metal Zn^(2+)ions,which can contract from linear structure into topologically helical structure driven by hydrophobic effect while changing the microenvironment from nonpolar solvent to aqueous *** symmetry breaking of RCPs was confirmed by circular dichroism(CD)spectra and atomic force microscope(AFM)images,clearly demonstrating the intramolecularly contraction-arisen ***,RCPs can intelligently adapt different microenvironments by changing their conformations,as evidenced by a demonstration of biomimetic lipid bilayer-based vesicle ***,RCPs show significant concentration-dependent transmembrane transport functions,implying that RCPs are able to span cellular membranes to form channels inside the hydrophobic lipid *** the same time,the electrophysiological conductance experiments further underpin the biomimetic transport functions and channel-based conduction mechanism of *** study demonstrates an important paradigm of responsive polymers performing microenvironment-induced conformational change and thereof unique functions,and thus provides valuable insights on the development of functional responsive materials.

关键词： Responsive polymer Molecular contraction Symmetry breaking Helicity Transmembrane transport

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慢性心力衰竭治疗口服药物的临床研究进展

心脑血管病防治 2023年第3期23卷 37-40页

作者：潘加欢赵博文胡罗霞祁晨阳毛威浙江中医药大学附属第一医院杭州310003 浙江医院杭州310013 浙江省中西医结合循环系统疾病诊治重点实验室杭州310053

慢性心力衰竭是心血管疾病终末阶段,严重威胁人们生命健康,作为引起人类尤其是老年人死亡原因受到广泛关注。临床中对慢性心力衰竭治疗,主要是选择西医药物治疗方法,治疗药物包括强心苷类药物、利尿剂、血管扩张药物等,随着临床研究的... 详细信息

慢性心力衰竭是心血管疾病终末阶段,严重威胁人们生命健康,作为引起人类尤其是老年人死亡原因受到广泛关注。临床中对慢性心力衰竭治疗,主要是选择西医药物治疗方法,治疗药物包括强心苷类药物、利尿剂、血管扩张药物等,随着临床研究的不断深入,近年来出现的钠-葡萄糖共转运蛋白2(SGLT2)抑制剂、If通道阻滞剂、可溶性鸟苷酸环化酶(sGC)刺激剂等为心力衰竭患者带来了希望。不同的药物对于疾病干预作用存在差异,它们显示出一些积极的效果。本文针对治疗慢性心力衰竭药物研究及常用治疗药物的类型进行综述及评价,以指导临床中的合理用药参考。

关键词：慢性心力衰竭治疗口服药物临床评价