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不同时机的维筋相交针刺法对急性缺血性脑卒中患者负性情绪及睡眠的影响分析

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吉林中医药 2024年第6期44卷 728-732页

作者：郎显兵谭曦黄翔李佳马晨阳刘爔北京市顺义区医院中医科北京101300 北京中医药大学深圳医院<龙岗> 广东深圳518172

目的探讨不同时机介入维筋相交针刺法对急性缺血性脑卒中患者负性情绪及睡眠的影响。方法选择本院于2021年6月-2023年6月收治的急性缺血性脑卒中患者作为样本,共94例。根据维筋相交针刺法不同介入时间将所有患者分为2组,各47例。观察组... 详细信息

目的探讨不同时机介入维筋相交针刺法对急性缺血性脑卒中患者负性情绪及睡眠的影响。方法选择本院于2021年6月-2023年6月收治的急性缺血性脑卒中患者作为样本,共94例。根据维筋相交针刺法不同介入时间将所有患者分为2组,各47例。观察组在发病后10 d内给予维筋相交针刺治疗,对照组在发病后10~30 d给予维筋相交针刺治疗,所有患者均治疗4周。比较患者治疗前后的中医证候评分(口舌歪斜、头晕目眩、半身不遂、肢体麻木)、美国国立卫生研究院卒中量表(NIHSS)评分和血液流变学(血浆黏度、高切全血黏度),分别通过用简化Fugl-Meyer运动功能评分量表和Berg平衡量表(BBS)评估患者的运动功能和平衡能力,采用洼田饮水试验(WST)和吞咽功能评价量表(SSA)评估患者治疗前后的吞咽能力,并通过焦虑自评量表(SAS)、抑郁自评量表(SDS)及匹兹堡睡眠质量指数(PSQI)评估患者治疗前后的负性情绪和睡眠状况。结果观察组患者治疗后的中医证候积分、NIHSS评分和血流动力学指标低于对照组,Fugl-Meyer评分、BBS评分和吞咽能力高于对照组,且SAS评分、SDS评分和PSQI评分更低,均具有统计学意义(P<0.05)。结论早期介入维筋相交针刺法有助于改善缺血性脑卒中患者的负性情绪和睡眠质量。

关键词：维筋相交针刺法缺血性脑卒中运动功能负性情绪睡眠质量

Mixed secondary chromatin structure revealed by modeling radiation-induced DNA fragment length distribution

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Science China(Life Sciences) 2020年第6期63卷 825-834页

作者： Wenzong ma chenyang Gu Lin ma Caoqi Fan Chao Zhang Yujie Sun Cheng Li Gen Yang State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBejing 100871China Radiation Biology Center Graduate School of BiostudiesKyoto UniversityKyoto 606-8501Japan Medical Artificial Intelligence and Automation Department of Radiation OncologyUniversity of Texas Southwestern Medical CenterDallasTX 75390USA Center for Bioinformatics School of Life Sciences and Center for Statistical SciencePeking UniversityBejing 100871China State Key Laboratory of Membrane Biology School of Life Sciencesand Biomedical Pioneering Innovation Center(BIOPIC)Peking UniversityBejing 100871China

Spatial chromatin structure plays fundamental roles in many vital biological processes including DNA replication, transcription,damage and repair. However, the current understanding of the secondary structure of chromatin formed by local nucleosomenucleosome interactions remains controversial, especially for the existence and conformation of 30 nm structure. Since chromatin structure influences the fragment length distribution(FLD) of ionizing radiation-induced DNA strand breaks, a 3D chromatin model fitting FLD patterns can help to distinguish different models of chromatin structure. Here, we developed a novel "30-C" model combining 30 nm chromatin structure models with Hi-C data, which measured the spatial contact frequency between different loci in the genome. We first reconstructed the 3D coordinates of the 25 kb bins from Hi-C heatmaps. Within the25 kb bins, lower level chromatin structures supported by recent studies were filled. Simulated FLD patterns based on the 30-C model were compared to published FLD patterns induced by heavy ion radiation to validate the models. Importantly, the 30-C model predicted that the most probable chromatin fiber structure for human interphase fibroblasts in vivo was 45% zig-zag 30 nm fibers and 55% 10 nm fibers.

关键词： Hi-C DNA strand break ionizing radiation chromatin structure

Diversity and sub-functionalization of TaGW8 homoeologs hold potential for genetic yield improvement in wheat

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The Crop Journal 2019年第6期7卷 830-844页

作者： Lin ma chenyang Hao Hongxia Liu Jian Hou Tian Li Xueyong Zhang Key Laboratory of Crop Gene Resources and Germplasm Enhancement Ministry of Agriculture/Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Institute of Animal Sciences Chinese Academy of Agricultural SciencesBeijing 100193China

Grain Weight 8(GW8) in rice is a SQUAMOSA Promoter-Binding Protein-Like(SPL) family transcription factor with multiple biological functions. In this study, three GW8 homoeologs were cloned from homoeologous group 7 chromosomes of wheat. Subcellular localization and trans-activation activity assays suggested that Ta GW8 is a transcriptional *** GW8 genes were preferentially expressed in young spikes and developing grains. Ectopic expressions of Ta GW8 in Arabidopsis and rice resulted in enhanced vegetative growth,earlier flowering and larger seeds. Ta GW8-7 A was the most highly variable of the three homoeologs with four haplotypes(Hap-1/2/3/4). Ta GW8-7 B had two haplotypes(Hap-L/H).Ta GW8-7 A-Hap-2 was associated with high thousand-grain weight(TGW) and large kernel length and showed higher transcriptional levels and binding activity than the other haplotypes. The high frequency of Ta GW8-7 A-Hap-2 in Chinese wheat populations suggested that it had been extensively selected in breeding. This haplotype showed a high potential for exploitation in global wheat breeding because its frequency was low in exotic germplasm. Ta GW8-7 B-Hap-H produced abundant transcripts and was associated with early heading and maturity, less tiller number and high TGW. This haplotype might be suitable for multiple cropping systems due to short wheat season. In this study we identified sub-functionalization among Ta GW8 homoeologs and obtained functional molecular markers that can be used in breeding for high grain yield.

关键词： Grain yield Haplotype association marker assisted breeding Thousand grain weight Triticum aestivum

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机械陀螺漂移量检测系统设计

长春理工大学学报（自然科学版） 2023年第4期46卷 91-98页

作者：马晨阳白素平闫钰锋韩佳昊康世勋长春理工大学光电工程学院长春130022

机械陀螺检测中漂移量是最主要的被测参数,其直接反映陀螺综合性能的优劣。为了实现对陀螺漂移量自动化、高精度的测量,建立陀螺漂移量检测系统。首先,运用光学知识分析光束的路径并建立多次反射式增程光路数学模型。其次,建立图像处理... 详细信息

机械陀螺检测中漂移量是最主要的被测参数,其直接反映陀螺综合性能的优劣。为了实现对陀螺漂移量自动化、高精度的测量,建立陀螺漂移量检测系统。首先,运用光学知识分析光束的路径并建立多次反射式增程光路数学模型。其次,建立图像处理检测系统,对陀螺反射光斑进行识别处理,其主要工作为光斑跟踪和光斑中心定位。最后通过实验并根据实验结果调整检测系统。实验结果表明,在最佳检测条件下,机械陀螺漂移量的检测范围为±2°,其实验精度最高可达11″,符合陀螺漂移量检测稳定可靠、高精度的要求。

关键词：机械陀螺陀螺漂移量检测系统光斑检测

CO_(2) hydrogenation to methanol over the copper promoted In_(2)O_(3) catalyst

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Journal of Energy Chemistry 2024年第6期93卷 135-145,I0004页

作者： Rui Zou chenyang Shen Kaihang Sun Xinbin ma Zhuoshi Li maoshuai Li Chang-Jun Liu School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China Collaborative Innovation Center of Chemical Science&Engineering Tianjin UniversityTianjin 300072China

The metal promoted In_(2)O_(3) catalysts for CO_(2) hydrogenation to methanol have attracted wide attention because of their high activity with high methanol ***,there was still no experimental confirmation if copper could be a good promoter for In_(2)O_(3).Herein,the Cu promoted In_(2)O_(3) catalyst was prepared using a deposition-precipitation *** prepared Cu/In_(2)O_(3) catalyst shows significantly higher CO_(2) conversion and space time yield(STY)of methanol,compared to the un-promoted In_(2)O_(3) *** loading of Cu facilitates the activation of both H_(2) and CO_(2) with the interface between the Cu cluster and defective In_(2)O_(3) as the active *** Cu/In_(2)O_(3) catalyst takes the CO hydrogenation pathway for methanol synthesis from CO_(2) *** exhibits a unique size effect on the CO *** temperatures below 250℃,CO adsorption on Cu/In_(2)O_(3) is stronger than that on In_(2)O_(3),causing higher methanol *** increasing temperatu res,the Cu catalyst aggregates,which leads to the formation of weak CO adsorption site and causes a decrease in the methanol *** with other metal promoted In_(2)O_(3) catalysts,it can be concluded that the catalyst with stronger CO adsorption possesses higher methanol selectivity.

关键词： CO_(2)hydrogenation Methanol Cu In_(2)O_(3) CO Selectivity DFT

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pT1期结直肠癌淋巴结转移危险因素分析

浙江医学 2024年第16期46卷 1692-1697页

作者：邓科李博马晨阳李琪赵逸斌沈杰杨少辉崔巍宁波市医疗中心李惠利医院结直肠外科 315040 宁波市医疗中心李惠利医院急诊科 315040

目的探讨p_(T1)期结直肠癌(CRC)患者淋巴结转移(LNM)的危险因素。方法回顾性选取2017年1月至2023年6月在宁波市医疗中心李惠利医院行一期局部切除+二期补救性根治切除手术或一次性根治切除手术且经术后病理检查证实为p_(T1)期CRC的342... 详细信息

目的探讨p_(T1)期结直肠癌(CRC)患者淋巴结转移(LNM)的危险因素。方法回顾性选取2017年1月至2023年6月在宁波市医疗中心李惠利医院行一期局部切除+二期补救性根治切除手术或一次性根治切除手术且经术后病理检查证实为p_(T1)期CRC的342例患者为研究对象,其中接受一期局部切除+二期补救性根治切除手术148例。采用多因素logistic回归模型分析p_(T1)期CRC患者和接受一期局部切除+二期补救性根活切除手术的CRC患者LNM的独立影响因素,并构建与验证p_(T1)期CRC患者LNM风险预测模型;比较LNM阳性与阴性患者的5年总体生存率。结果p_(T1)期CRC患者LNM率为13.2%(45/342),肿大淋巴结直径>5 mm(OR=6.751)、组织低分化(OR=4.439)、脉管侵犯(OR=10.395)均是其LNM的独立危险因素(均P<0.05)。接受一期局部切除+二期补救性根治切除手术的CRC患者LNM率为11.5%(17/148),女性(OR=4.274,P=0.023)是其LNM的独立危险因素,深部黏膜下浸润(DSI)不是其LNM的独立危险因素(P=0.067)。LNM阳性与阴性的p_(T1)期CRC患者5年总体生存率比较差异无统计学意义(94.0%比98.0%,P=0.681)。基于肿大淋巴结直径、肿瘤部位、组织分化程度、黏液腺癌、脉管侵犯等5个因素构建的p_(T1)期CRC患者LNM风险预测模型的C指数为0.808,其预测p_(T1)期CRC患者LNM风险的总体正确率为90.6%。结论基于肿大淋巴结直径、肿瘤部位、组织分化程度、黏液腺癌、脉管侵犯等5项因素构建的p_(T1)期CRC患者LNM风险预测模型能为患者后续治疗决策提供一定的帮助,对于接受一期局部切除+二期补救性根治切除手术的患者,应注意DSI可能不是LNM的独立危险因素。

关键词：结直肠癌淋巴结转移危险因素列线图

Total phenolic, flavonoid content, and antioxidant activity of flour, noodles, and steamed bread made from different colored wheat grains by three milling methods

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The Crop Journal 2015年第4期3卷 328-334页

作者： Yaoguang Li Dongyun ma Dexiang Sun chenyang Wang Jian Zhang Yingxin Xie Tiancai Guo Agronomy College National Engineering Research Center for Wheat Henan Agricultural University The Collaborative Innovation Center of Henan Food Crops Henan Agricultural University Institute of Food Science and Technology Henan Agricultural University

The objective of this study was to evaluate the effects of wheat variety, food processing, and milling method on antioxidant properties. Black wheat variety Heibaoshi 1 had the highest total phenolic content(659.8 μg gallic acid equivalents g-1), total flavonoid content(319.3 μg rutin equivalents g-1), and antioxidant activity, whereas light purple wheat variety Shandongzimai 1 had the lowest total flavonoid content(236.2 μg rutin equivalents g-1) and antioxidant activity. Whole wheat flour and partially debranned grain flour had significantly higher total phenolic contents, total flavonoid contents, and antioxidant activity than refined flour(P ma assay) of steamed bread made from whole wheat flour, partially debranned grain flour, and refined flour were 23.5%, 21.1%, and 31.6% lower, respectively, than the corresponding values of flour. These results suggested that black whole wheat flour and partially debranned grain flour are beneficial to human health.

关键词： Total phenolic content Total flavonoid content Milling method Antioxidant activity Colored wheat

A haplotype block associated with thousand-kernel weight on chromosome 5DS in common wheat(Triticum aestivum L.)

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Journal of Integrative Plant Biology 2015年第8期57卷 662-672页

作者： Yuquan Wang chenyang Hao Jun Zheng Hongmei Ge Yang Zhou Zhengqiang ma Xueyong Zhang Crop Genomics and Bioinformatics Center and National Key Lab of Crop Genetics and Germplasm Enhancement College of Agricultural SciencesNanjing Agricultural University Key Laboratory of Crop Gene Resources and Germplasm Enhancement Ministry of Agriculture/Institute of Crop Science the Chinese Academy of Agricultural Sciences

Spike number per unit area, number of grains per spike, and thousand-kernel weight（TKW） are important yield components for wheat（Triticum aestivum L.）. TKW has the highest heritability among the three components. We validated 27 simple sequence repeat（SSR） loci associated with TKW in an F2：5breeding population grown in four environments. A cfd78265 bpmarker on chromosome 5DS showed the strongest association with TKW and had a significantly positive effect on TKW compared to allele cfd78259 bp, with mean increases of 5.17, 3.63, 4.11, and 5.16 g in the four environments. markers cfd67 and cfd40 flanking cfd78 also showed significantly positive associations with TKW with increases of 5.11, 3.29, 4.31, and 4.50 g for cfd67205, and4.98, 3.49, 4.06, and 4.84 g for cfd40187 compared with cfd67203 and cfd40190in the four environments, respectively. A major quantitative trait locus for TKW spanning 2.94 c M on chromosome 5DS was detected by association *** linkage disequilibrium（LD）（r2〉 0.2） was detected Resear among the three linked markers, which formed three haplotype blocks in the F2：5breeding population. Mean TKW differences between Hap B-I and Hap B-II were 5.80, 4.41, 4.02,and 5.06 g in the four environments, respectively. Moreover,significant LD was detected only between cfd78 and cfd67 and between cfd67 and cfd40 in a germplasm collection. This study provides a base for cloning genes related to TKW on chromosome 5DS.

关键词： Association mapping haplotype thousand-kernel weight Triticum oestivum

中国南方丘陵地区农机社会化服务现状与发展分析

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农机使用与维修 2023年第1期 48-52页

作者：康丽春马琛洋龙乐艾子卿何权许赛文颜玄洲江西农业大学工学院南昌330045

在我国的农业发展中,农业机械一直扮演着不可替代的角色,在农机市场蓬勃发展的同时,农机应用与服务仍存在问题。在农忙之后,规模化种植农户的农机基本闲置,而小型农户却购机用机难。为此,一种新型农机使用方式悄然兴起,即农机社会化服务... 详细信息

在我国的农业发展中,农业机械一直扮演着不可替代的角色,在农机市场蓬勃发展的同时,农机应用与服务仍存在问题。在农忙之后,规模化种植农户的农机基本闲置,而小型农户却购机用机难。为此,一种新型农机使用方式悄然兴起,即农机社会化服务,将耕整地、种植(播种或移栽)、施肥、灌溉、植保、收获、秸秆还田等环节中一个或者多个环节的作业交给农机专业户或农机合作组织,由农机组织使用相应的农业机械来完成作业,并收取一定费用。以水稻、小麦机械收获为主的“跨区作业”现象是我国典型的农机社会化服务。目前,我国农机社会化服务组织越来越壮大,服务重点逐渐从耕地、收获环节向耕、种、灌溉、植保、收获全生产周期发展。如何规范农机社会化服务,使农机所有者与农机使用者达到利益最大化,成为下一步值得深思的问题。因此,分析了我国农机社会化服务的现状与发展趋势,对农机社会化规范服务、提高经济效益与社会效益提出了建议与意见。

关键词：农机社会化服务农机服务