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Energy & Environmental Materials 2023年第4期6卷 195-202页

作者： chenyang Zhang Yuan Chen Kun fan Guoqun Zhang Jincheng Zou Huichao Dai Yanbo Gao Xiaobo Wang Minglei Mao Chengliang Wang School of Optical and Electronic Information Wuhan National Laboratory for Optoelectronics(WNLO)Optics Valley LaboratoryHuazhong University of Science and TechnologyWuhan 430074China Wenzhou Advanced Manufacturing Technology Research Institute Huazhong University of Science and TechnologyWenzhou 325035China

The pursuit of high-performance electrode materials is highly desired to meet the demand of batteries with high energy and power ***,a deep understanding of the charge storage mechanism is always challenging,which limits the development of advanced electrode ***,high-resolution mass spectroscopy(HR-MS)is employed to detect the evolution of organic electrode materials during the redox process and reveal the charge storage mechanism,by using small molecular oxamides as an example,which have ortho-carbonyls and are therefore potential electrochemical active materials for *** HR-MS results adequately proved that the oxamides could reversibly store lithium ions in the voltage window of 1.5–3.8 *** deeper reduction,the oxamides would decompose due to the cleavage of the C–N bonds in oxamide structures,which could be proved by the fragments detected by HR-MS,^(1)H NMR,and the generation of NH_(3)after the reduction of oxamide by *** work provides a strategy to deeply understand the charge storage mechanism of organic electrode materials and will stimulate the further development of characterization techniques to reveal the charge storage mechanism for developing high-performance electrode materials.

关键词： charge storage mechanism high-resolution mass spectroscopy organic batteries organic electrodes oxamides

A novel numerical simulation method for predicting compressive properties of 3D multiaxial braided composites considering various defects

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Chinese Journal of Aeronautics 2023年第9期36卷 369-379页

作者： Ruixin LEI Hao DOU Yan SUN Tao LIU Wei fan chenyang SONG Shujuan WANG Yao LU Xue YANG Diansen LI School of Textile Science and Engineering Xi’an Polytechnic UniversityXi’an 710048China Key Laboratory of Functional Textile Material and Product(Xi’an Polytechnic University) Ministry of EducationXi’an 710048China School of Chemistry Xi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology Ministry of EducationSchool of ChemistryBeihang UniversityBeijing 100191China

This paper reports a novel manufacturing process of preparing the Three-Dimensional Multiaxial Braided Composites(3DMBCs) and the effects of various defects generated in the manufacturing process on the compressive mechanical properties of 3DMBCs through the experimental and numerical methods. The five-step fabrication process of the 3D multiaxial braided preform was firstly introduced in detail. Then, the influences of various defects such as voids, waviness, and fiber breakage defects on the compressive properties of 3DMBCs were discussed. It is found that the fiber breakage defect and waviness defects were the two primary factors on the decrease of compressive properties of 3DMBCs. However, void defects in the resin and interface had little effect on the composites. When the fiber breakage defect content was 25% and the waviness was 7°, the composite compressive modulus decreased by 51%. The progressive damage process and failure mechanism of the composite under 90° compressive loading confirmed the validity of the numerical model by comparing with the experiments.

关键词： Defects 3-Dimensional reinforcement Mechanical properties Numerical model Stress concentrations

ICU患者呼吸机相关性膈肌功能障碍管理的证据总结

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中华急危重症护理杂志 2025年第1期6卷 100-106页

作者：吉莉吴慧景晨阳岳伟岗汪袁云子汪托红何国宝樊落兰州大学第一医院护理部兰州市730000 兰州大学第一医院重症医学科兰州市730000 兰州大学第一医院心内科兰州市730000 兰州大学第一医院急诊科兰州大学护理学院

目的总结ICU患者呼吸机相关性膈肌功能障碍管理的相关证据,为临床提供实践依据。方法系统检索指南网站、专业协会网站及国内外数据库中关于ICU患者呼吸机相关性膈肌功能障碍管理的相关证据,检索时限为建库至2023年9月20日。纳入证据类... 详细信息

目的总结ICU患者呼吸机相关性膈肌功能障碍管理的相关证据,为临床提供实践依据。方法系统检索指南网站、专业协会网站及国内外数据库中关于ICU患者呼吸机相关性膈肌功能障碍管理的相关证据,检索时限为建库至2023年9月20日。纳入证据类型包括临床决策、指南、证据总结、最佳实践、推荐实践、专家共识、系统评价、Meta分析和随机对照试验。由2名研究者独立进行文献质量评价、证据提取和整合。结果共纳入22篇文献,包括1篇指南、1篇临床决策、4篇专家共识、1篇Meta分析、1篇证据总结及14篇随机对照试验。从评估、组建团队、呼吸机管理、药物管理、营养管理、康复训练管理及物理治疗7个维度归纳了共29条证据。结论该研究总结了ICU患者呼吸机相关性膈肌功能障碍管理的最佳证据,具有一定的科学性与全面性,可为临床实践提供参考依据。

关键词：重症监护病房呼吸机相关性膈肌功能障碍证据总结循证护理学

Blue emitting CsPbBr3 perovskite quantum dot inks obtained from sustained release tablets

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Nano Research 2019年第12期12卷 3129-3134页

作者： Hewei Yang Yaqing Feng Zhiyu Tu Kuo Su Xiaozhi fan Bingjie Liu Zhiping Shi Yuzhe Zhang chenyang Zhao Bao Zhan School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China School of Life Sciences Tianjin UniversityTianjin 300072China

Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine(CsPbClxBr3-x,0 详细信息

Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine(CsPbClxBr3-x,0

关键词： sustained release tablet perovskite quantum dot blue emitting perovskite ink polymer gel surface passivation

Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

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Food Science and Human Wellness 2024年第4期13卷 1767-1786页

作者： Yanxin Wang Mingxia Ma Yumeng Huang Siqing fan Jie Peng Shiming Li Xiurong Su Yanbo Wang chenyang Lu State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products and School of Marine Science Ningbo UniversityNingbo 315211China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA College of Life Sciences Huanggang Normal UniversityHuanggang 438000China Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

Hyperuricemia,a metabolic disorder related to uric acid metabolism dysregulation,has become a common metabolic disease worldwide,due to changes in lifestyle and dietary *** recent years,owing to their high activity and few adverse effects,food-derived active peptides used as functional foods against hyperuricemia have attracted increasing *** article aims to focus on the challenge associated with peptide-specific preparation methods development,functional components identification,action mechanism(s)clarification,and bioavailability *** current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting,increased the knowledge about strategies to search antihyperuricemia peptides with definite structure,and emphasized the necessity of combining computer-aided approaches and activity *** addition,novel action mechanism mediated by gut microbiota was discussed,providing different insights from classical ***,considering that little attention was paid previously on the structure-activity relationships of anti-hyperuricemia peptides,we collected the sequences from published studies and make a preliminary summary about the structure-activity relationships,which in turn provided guides for enzymatic hydrolysis optimization and bioavailability ***,this article could promote the development,application and commercialization of food-derived anti-hyperuricemia peptides in the future.

关键词： Hyperuricemia Peptide Enzyme hydrolysis Mechanism Structure-activity relationship Bioavailability

维奈克拉联合用药治疗急性髓细胞白血病作用机制的研究现状

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国际输血及血液学杂志 2021年第5期44卷 376-382页

作者：范晨阳许鑫欣孙维龙施伟鹏陶霞竺佳李帝萱杨向东天津中医药大学第一附属医院国家中医针灸临床医学研究中心300380

B细胞白血病/淋巴瘤(BCL)-2选择性抑制剂维奈克拉(venetoclax)治疗年龄>75岁或者不适宜接受高剂量诱导化疗的急性髓细胞白血病(AML)患者有效。维奈克拉的作用机制为诱导BCL-2依赖的肿瘤细胞凋亡。临床研究结果显示,维奈克拉可与去甲基... 详细信息

B细胞白血病/淋巴瘤(BCL)-2选择性抑制剂维奈克拉(venetoclax)治疗年龄>75岁或者不适宜接受高剂量诱导化疗的急性髓细胞白血病(AML)患者有效。维奈克拉的作用机制为诱导BCL-2依赖的肿瘤细胞凋亡。临床研究结果显示,维奈克拉可与去甲基化药物(HMA)、阿糖胞苷或者小分子抑制剂通过抗耐药、代谢组学、基因组学、抑制拮抗作用等机制发挥协同作用,因此联合用药疗效较单药更为显著。维奈克拉联合用药在临床上应用逐渐普及。为维奈克拉治疗AML的临床用药提供理论基础,笔者拟就维奈克拉联合HMA、小分子抑制剂和细胞毒性药物治疗AML的作用机制及临床疗效的研究现状进行阐述。

关键词：白血病,髓样,急性药物疗法,联合原癌基因蛋白质c-bcl-2 药理作用分子作用机制维奈克拉

High lithiophilic nitrogen-doped carbon nanotube arrays prepared by in-situ catalyze for lithium metal anode

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Chinese Chemical Letters 2021年第7期32卷 2254-2258页

作者： chenyang Zhao Xiaoju Yin Zhikun Guo Dan Zhao Guiye Yang Aosai Chen Lishuang fan Yu Zhang Naiqing Zhang State Key Laboratory of Urban Water Resource and Environment School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Academy of Fundamental and Interdisciplinary Sciences Harbin Institute of TechnologyHarbin 150001China

Lithium metal has a very outstanding theoretical capacity(3860 mAh/g)and is one of the most superior anode materials for high energy density ***,the uncontrollable dendrite growth and the fo rmation of"dead lithium"are the important hidden dangers of short cycle life and low ***,the uncontrollable dendrite growth and the fo rmation of dead lithium leads to short cycle life and hidden dange r,which hinder its practical *** the nucleation and growth process of lithium is an effective strategy to inhibit lithium ***,a simple in situ self-catalytic method is used to construct nitrogen doped carbon nanotube arrays on stainless steel mesh(N-CNT@SS)as a lithium composite *** N-doped CNTs provide a great number of N-functional groups,which enhance the lithiophilic of anode and provide a large number of uniform nucleation sites,hence it has excellent structural stability for *** arrays provide neat lithium-ion transport channels to uniform lithiumion flux and inhibits dendrite generation,revealed by the COMSOL multi-physics concentration field *** N-CNT@SS composite anode sustain stable at 98.9%over 300 cycles at 1 mA/***@SS as the anode is coupled LiFePO_(4)(LFP)as the cathode construct a full battery,demonstrating excellent cycling stability with a capacity of 152.33 mAh/g and capacity retaining ratio of 95.4%after 100 cycles at 0.5 C.

关键词： Lithium metal batteries Nitrogen doped carbon nanotubes Stainless steel mesh COMSOL multi-physics concentration field Simulation Lithiophilic anode

补肾解毒通络方阻止白血病复发机制的网络药理学分析

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中医药信息 2021年第6期38卷 1-9页

作者：孙维龙许鑫欣陶霞施伟鹏竺佳范晨阳李帝萱杨向东天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津300381

目的:探讨补肾解毒通络方(BSJDTLF)的作用机制。方法:使用网络药理与蛋白组学相结合的研究方法,对其靶点与作用通路进行了分析、预测。将补肾解毒通络方进行液相色谱质谱分析,对质谱结果中的化合物通过TCMSP与CTD数据库进行分析,得到对... 详细信息

目的:探讨补肾解毒通络方(BSJDTLF)的作用机制。方法:使用网络药理与蛋白组学相结合的研究方法,对其靶点与作用通路进行了分析、预测。将补肾解毒通络方进行液相色谱质谱分析,对质谱结果中的化合物通过TCMSP与CTD数据库进行分析,得到对应化合物的作用靶点,再通过NCBI和GENE CARD数据库筛选与白血病相关的作用靶点基因。分选给药小鼠的间充质干细胞进行高通量蛋白组学分析筛选出差异蛋白。将差异蛋白与靶点基因进行比对,经GO、KEGG和K核分析得到BSJDTLF作用机制通路。结果:共筛选到潜在靶点50个,关键靶点10个,包括Mmp2、Stmn1、Icam1等。主要涉及慢性白血病、急性白血病、VEGF信号等通路。结论:预测了补肾解毒通络方作用于间充质干细胞的具体机制。

关键词：补肾解毒通络方白血病复发网络药理学蛋白质组学中药复方

正常睡眠—觉醒节律被干预的再生障碍性贫血小鼠外周血细胞数量、MT、NE水平变化观察

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山东医药 2023年第15期63卷 43-48页

作者：施伟鹏张伟锋杨福军陶霞范晨阳竺佳李蒂萱杨向东天津中医药大学第一附属医院血液科天津300381 国家中医针灸临床医学研究中心天津中医药大学第一附属医院中国医学科学院放射医学研究所辐射损伤效应研究室

目的观察正常睡眠—觉醒节律被干预的再生障碍性贫血小鼠外周血细胞数量、昼夜节律调节因子(MT、NE)水平变化,以探讨睡眠—觉醒节律干预对再生障碍性贫血小鼠血细胞的影响及可能的作用机制。方法C57BL/6雄性小鼠随机分为实验组[睡眠—... 详细信息

目的观察正常睡眠—觉醒节律被干预的再生障碍性贫血小鼠外周血细胞数量、昼夜节律调节因子(MT、NE)水平变化,以探讨睡眠—觉醒节律干预对再生障碍性贫血小鼠血细胞的影响及可能的作用机制。方法C57BL/6雄性小鼠随机分为实验组[睡眠—觉醒节律干预组(睡眠干预组、觉醒干预组、睡眠—觉醒干预组)和睡眠—觉醒节律未干预组]和正常对照组,实验组建立再生障碍性贫血小鼠模型,正常对照组未建立再生障碍性贫血小鼠模型。睡眠—觉醒节律未干预组及正常对照组保持正常睡眠—觉醒节律,睡眠干预组、觉醒干预组分别给予光照24 h、睡眠24 h干预,睡眠—觉醒干预组前3 d日间睡眠夜间觉醒,后3 d相反。各组共干预9天,在干预前1天和干预后第6天分别测量各组小鼠外周血细胞数。干预前采用ELISA法检测实验组和对照组小鼠血浆和骨髓中MT、NE、OX、PGE2。干预前1天和干预后3、6、9天分别测量各组小鼠血浆MT、NE。结果(1)各组干预前后血细胞比较:干预前,与正常对照组比较,实验组WBC、RBC、PLT数量及HGB水平低(P均睡眠—觉醒节律未干预组>正常对照组的规律。干预第3天,与正常对照组比较,睡眠—觉醒干预组血浆NE水平高(P<0.05);与睡眠—觉醒节律未干预组、睡眠干预组、觉醒干预组比较,睡眠—觉醒干预组血浆NE水平高(P均<0.05);干预第6天,与正常对照组比较,觉醒干预组血浆NE水平高(P<0.05);与睡眠—觉醒节律未干预组比较,睡眠—觉醒干预组血浆NE水平低(P<0.05);干预第9天:与正常对照组及睡眠干预组比较,睡眠—觉醒干预组NE水平高(P均<0.05)。结论正常睡眠—觉醒节律被干预的再生障碍性贫血小鼠外周血细胞数量升高,血浆MT及NE均升高,以睡眠、觉醒节律均被干预为著;紊乱的睡眠—觉醒节律干预可能通过调节MT、NE水平促使再生障碍性贫血小鼠血细胞数量升高。

关键词：睡眠—觉醒节律外周血细胞节律调节因子褪黑素去甲肾上腺素再生障碍性贫血

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Microtubule actin crosslinking factor 1 functions as a novel therapeutic target in lung metastasis of osteosarcoma

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Genes & Diseases 2023年第2期10卷 325-328页

作者： Chaofei Yang Ye Tian fan Zhao Qian Huang Zhiyong Liu chenyang He Hui Li Yu li Zhiping Miao Airong Qian Lab for Bone Metabolism Xi'an Key Laboratory of Special Medicine and Health EngineeringKey Lab for Space Biosciences and BiotechnologyResearch Center for Special Medicine and Health Systems EngineeringNPU-UAB Joint Laboratory for Bone MetabolismSchool of Life SciencesNorthwestern Polytechnical UniversityXi'anShaanxi 710072China Department of Oncology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710004China Honghui Hospital Xi'anShaanxi 710054China

Lung metastasis is the primary cause of death in osteosarcoma(OS)patients.1 A better understanding of the molecular mechanisms underlying OS tumorigenesis and metastasis is urgently needed to identify therapeutic *** actin crosslinking factor 1(MACF1),which belongs to the spectraplakin family of cytoskeletal crosslinking proteins,2 is critical for cell migration and polarization due to its regulation of the ***,MACF1 was indicated to be involved in the metastatic invasion of some human cancers,3 but the function of MACF1 in OS is still unclear.

关键词： metastasis osteosarcoma therapeutic