检索结果-南通市图书馆

NR4A1 enhances glycolysis in hypoxia-exposed pulmonary artery smooth muscle cells by upregulating HIF-1αexpression

BIOCELL 2023年第11期47卷 2423-2433页

作者： chenyang chen JUAN WEN WEI HUANG JIANG LI Cardiovascular Department The Third Xiangya Hospital of Central South UniversityChangsha410013China Department of Cardiovascular Medicine The Second Xiangya HospitalCentral South UniversityChangsha410011China

Background:Pulmonary arterial hypertension(PAH)is a chronic and progressive disease that is strongly associated with dysregulation of glucose *** in nuclear receptor subfamily 4 group A member 1(NR4A1)activity alter the outcome of *** study aimed to investigate the effects of NR4A1 on glycolysis in PAH and its underlying ***:This study included twenty healthy volunteers and twenty-three PAH patients,and plasma samples were collected from the *** mimic the conditions of PAH in vitro,a hypoxia-induced model of pulmonary artery smooth muscle cell(PASMC)model was *** proliferation of PASMCs was assessed using CCK8 ***:Levels of NR4A1,hypoxia-inducible factor-1α(HIF-1α),and various glycolysis-related enzymes were *** addition,extracellular glucose and lactate production were *** interaction between NR4A1 and HIF-1αwas evaluated by co-immunoprecipitation *** of NR4A1 and HIF-1αwas increased in PAH patients,and exposure to hypoxia resulted in increased levels of NR4A1 and HIF-1αin ***4A1 interacted with HIF-1α.NR4A1 overexpression enhanced hypoxia-induced expression of HIF-1α,GLUT1,PKM2,HK2,and CD36,decreased glucose levels,increased lactate levels and promoted hypoxic PASMC ***,silencing NR4A1 decreased hypoxia-induced expression of HIF-1α,GLUT1,PKM2,HK2,and CD36,promoted glucose production,reduced lactate levels and inhibited hypoxic PASMC ***,overexpression of HIF-1αreversed the regulation of glycolysis caused by NR4A1 ***:NR4A1 enhances glycolysis in hypoxia-induced PASMCs by upregulating HIF-1α.Our findings indicate that the management of NR4A1 activity may be a promising strategy for PAH therapy.

关键词： Pulmonary arterial hypertension NR4A1 HIF-1α Glycolysis Hypoxia Pulmonary arterial smooth muscle cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genome-wide analysis of nuclear factor Y genes and functional investigation of watermelon ClNF-YB9 during seed development

引用

The Crop Journal 2023年第5期11卷 1469-1479页

作者： Qin Feng Ling Xiao Jiafa Wang Jie Wang chenyang chen Jianyang Sun Xixi Wu Man Liu Xian Zhang Shujuan Tian Li Yuan State Key Laboratory of Crop Stress Biology for Arid Areas College of HorticultureNorthwest A&F UniversityYangling 712100ShaanxiChina Shenzhen Research Institute Northwest A&F UniversityShenzhen 518000GuangdongChina

The nuclear factor Y(NF-Y) gene family is a class of transcription factors that are widely distributed in eukaryotes and are involved in various biological processes. However, the NF-Y gene family members in watermelon, a valued and nutritious fruit, remain largely unknown and their functions have not been characterized. In the present study, 22 ClNF-Y genes in watermelon, 29 CsNF-Y genes in cucumber, and 24CmNF-Y genes in melon were identified based on the whole-genome investigation and their protein properties, gene location, gene structure, motif composition, conserved domain, and evolutionary relationship were investigated. ClNF-YB9 from watermelon and its homologs in cucumber and melon were expressed specifically in seeds. Its expression remained low in the early stages of watermelon seed development,increased at 20 days after pollination(DAP), and peaked at 45–50 DAP. Moreover, the knockout mutant Clnf-yb9 exhibited abnormal leafy cotyledon phenotype, implying its critical role during seed ***, protein interaction assays showed that ClNF-YB9 interacts with all ClNF-YCs and the ClNF-YB9-YC4 heterodimer was able to recruit a ClNF-YA7 subunit to assemble a complete NF-Y complex, which may function in seed development. This study revealed the structure and evolutionary relationships of the NF-Y gene family in Cucurbitaceae and the novel function of ClNF-YB9 in regulating seed development in watermelon.

关键词： Watermelon NF-Y gene family Evolution relationship ClNF-YB9 gene function Seed development

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

引用

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang chenyang Zhang Linlin Wu Wei Sun Hongliang Zhang Jianhua chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

采用上行SCMA系统的新型导频结构及信道估计方法

引用

福州大学学报（自然科学版） 2022年第4期50卷 468-474页

作者：陈晨阳郭里婷福州大学物理与信息工程学院福建福州350108

针对在上行稀疏码分多址接入(sparse code multiple access,SCMA)系统中,如果按照多用户共享相同资源的复用形式进行导频结构的设计,会导致正确估计每个用户的信道信息存在较大困难的问题,提出一种适合于上行SCMA系统的新型导频结构.通... 详细信息

针对在上行稀疏码分多址接入(sparse code multiple access,SCMA)系统中,如果按照多用户共享相同资源的复用形式进行导频结构的设计,会导致正确估计每个用户的信道信息存在较大困难的问题,提出一种适合于上行SCMA系统的新型导频结构.通过导频间隔和导频位置的合理设计,保证不同用户在不同的子载波上发送各自的导频,在接收端使用最小二乘法(least square,LS)和线性最小均方误差法(linear minimum mean square error,LMMSE)对导频进行信道估计,最后,通过Cubic内插得到完整的信道估计值.仿真结果表明,基于LS算法的该导频结构更好地平衡了误码率性能和系统复杂度,减少了系统导频开销,并且运算量明显降低.

关键词：稀疏码分多址接入上行信道估计导频结构最小二乘法

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

复杂场景流固耦合的高效模拟

引用

计算机辅助设计与图形学学报 2019年第8期31卷 1358-1367页

作者：赵建旺陈晨阳丰芸芸王章野浙江大学CAD&CG国家重点实验室

大规模复杂流体场景的高效交互模拟技术在灾难仿真、虚拟现实和影视特效制作等领域都有重要的应用价值.针对现有基于物理的流体算法大多只适于尺度较小的场景,难以有效地模拟复杂流体大场景中流固耦合时的固体破碎效果的问题,提出一种... 详细信息

大规模复杂流体场景的高效交互模拟技术在灾难仿真、虚拟现实和影视特效制作等领域都有重要的应用价值.针对现有基于物理的流体算法大多只适于尺度较小的场景,难以有效地模拟复杂流体大场景中流固耦合时的固体破碎效果的问题,提出一种复杂场景的固液耦合高效模拟方法.首先提出一种基于流体隐式粒子法和散度为零的SPH法相混合的计算框架,在确保流体物理属性的同时充分利用细粒度的隐式粒子来丰富流体运动细节,提高场景模拟的真实感;然后采用一种多维度的流固耦合分合计算策略来进一步提高流固耦合效率;为实现流体冲击下的固体破碎效果,采用一种物理与几何相混合的破碎方法:以基于断裂力学中的应变能密度模型来确定固体破碎时碎片的分布,采用基于几何的质心Voronoi方法快速生成碎片,最终实现百万量级粒子参与的复杂流体场景的交互模拟,以及高速流体冲击下的固体破碎效果的高效模拟.

关键词：自然场景仿真复杂场景高效模拟流固耦合

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高电压/宽温域水系碱金属离子电池的研究进展

引用

物理化学学报 2023年第5期39卷 1-24页

作者：陈晨阳赵永智李园园刘金平武汉理工大学化学化工与生命科学学院材料复合新技术国家重点实验室武汉430070 华中科技大学光学与电子信息学院武汉430074

水系储能器件具有固有的高安全性、环境友好性和成本低的优势,在未来智能电网、便携式/可穿戴电子产品等领域显示出巨大的应用潜力。然而水的热力学分解电压低、冰点高,导致水系电解液电化学稳定电压窗口窄以及凝固点高,极大地限制了水... 详细信息

水系储能器件具有固有的高安全性、环境友好性和成本低的优势,在未来智能电网、便携式/可穿戴电子产品等领域显示出巨大的应用潜力。然而水的热力学分解电压低、冰点高,导致水系电解液电化学稳定电压窗口窄以及凝固点高,极大地限制了水系储能器件的能量密度与宽温域应用。因此,设计耐高电压、抗冻的水系电解液,成为水系储能器件大规模、多场景应用的关键。本文系统综述了高电压/宽温域水系碱金属离子电池电解液设计的研究进展,从热力学和动力学角度出发,分别重点介绍提高电解液电压窗口和工作温度范围的各类策略以及相关作用机制。进一步提出宽温域、高压水系电解液的潜在设计思路,并对高性能水系碱金属离子电池的发展方向进行展望。

关键词：碱金属离子电池水系电解液电解液调控高电压宽温域

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

急诊经皮冠状动脉介入治疗急性ST段抬高型心肌梗死患者的住院期间预后分析

引用

中南大学学报（医学版） 2016年第11期41卷 1186-1192页

作者：陈晨阳黄亿源周胜华方臻飞中南大学湘雅二医院心血管内科长沙410011

目的:分析急诊经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗急性心肌梗死(acute myocardial infarction,AMI)患者的病例资料,旨在探讨影响急诊PCI治疗AMI患者住院期间不良预后的相关因素。方法:回顾性分析2010年1月至... 详细信息

目的:分析急诊经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗急性心肌梗死(acute myocardial infarction,AMI)患者的病例资料,旨在探讨影响急诊PCI治疗AMI患者住院期间不良预后的相关因素。方法:回顾性分析2010年1月至2014年12月中南大学湘雅二医院行急诊PCI治疗AMI的患者资料,根据是否发生心血管不良事件分为事件组及非事件组,比较两组间可能引起心血管不良事件发生的相关因素。结果:不良事件的发生率为22%(67/304);通过t检验或χ2检验发现:肌酐,脑钠肽(brain natriuretic peptide,BNP),红细胞比容,白细胞、年龄>75岁,Killip分级≥2级,术后心肌梗死溶栓治疗(thrombolysis in myocardial infarction,TI MI)血流≤2级,术前发生心律失常、多支病变,术后2 h ST段回落率<50%,长就诊至球囊扩张(door-to-balloon,D2B)时间差异具有统计学意义(P<0.05),进一步进行logistic回归分析,其结果显示:红细胞比容(red blood cell specific volume,HCT)、N端脑钠肽激素原前体(N-terminal pro-brain natriuretic peptide,NTpro BNP)、Ki l lip分级≥2级、术后TI MI血流≤2级、术后2 h ST段回落率<50%、长D2B时间是心血管不良事件发生的重要影响因素。结论:HCT,NT-pro BNP,Killip分级≥2级,术后TIMI血流≤2级,术后2 h ST段回落率<50%、长D2B时间是心血管不良事件发生的重要影响因素,对上述高危患者进行积极的监测与处理,能够有效改善AMI患者急诊PCI术后的预后,减少住院期间不良事件的发生。

关键词：急性ST段抬高型心肌梗死急诊经皮冠状动脉介入治疗心血管不良事件影响因素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

固态锂电池界面优化策略的研究进展

引用

物理化学学报 2023年第8期39卷 39-55页

作者：赵永智陈晨阳刘文燚胡伟飞刘金平武汉理工大学化学化工与生命科学学院材料复合新技术国家重点实验室武汉430070

固态锂电池具有安全性好、能量密度高等优点,在新能源汽车和智能电子等领域具有广泛的应用前景。然而,由化学/电化学和物理因素引起的界面副反应与高界面阻抗问题制约了其进一步发展。先前的综述已对解决化学/电化学界面问题的方法有了... 详细信息

固态锂电池具有安全性好、能量密度高等优点,在新能源汽车和智能电子等领域具有广泛的应用前景。然而,由化学/电化学和物理因素引起的界面副反应与高界面阻抗问题制约了其进一步发展。先前的综述已对解决化学/电化学界面问题的方法有了相对全面的阐述,但并未细致讨论不同结构固态电池中物理界面的影响及应对策略。本文将简要介绍化学/电化学界面问题及其解决方案;重点按结构特点将固态锂电池分为三明治结构、粉末复合结构和3D一体化结构,细致地分析不同电池结构的物理界面特点与优化策略,并对各种策略的优缺点进行比较分析;最后,对固态锂电池电极/电解质界面的未来研究方向进行展望。

关键词：固态锂电池界面阻抗化学/电化学界面物理界面优化策略

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

经导管主动脉瓣膜置入术后瓣周漏的研究进展

引用

心血管病学进展 2015年第1期36卷 18-22页

作者：陈晨阳方臻飞中南大学湘雅二医院心内科湖南长沙410011

重度主动脉瓣狭窄是老年人中发病率及病死率较高的疾病,经导管主动脉瓣置入术(TAVI)已经成为具有手术禁忌及高风险患者的替代治疗。然而相比于外科瓣膜置换术,TAVI术后更容易发生瓣周漏。研究显示,超过70%的TAVI术后患者会出现不同程度... 详细信息

重度主动脉瓣狭窄是老年人中发病率及病死率较高的疾病,经导管主动脉瓣置入术(TAVI)已经成为具有手术禁忌及高风险患者的替代治疗。然而相比于外科瓣膜置换术,TAVI术后更容易发生瓣周漏。研究显示,超过70%的TAVI术后患者会出现不同程度的瓣周漏,与此同时,术后瓣周漏被认为是近、远期死亡的独立危险因素,即使轻度瓣周主动脉反流也会严重影响患者生存率。现通过综合分析文献,对TAVI术后瓣周漏的评估方式、发病机理、处理方法及相关进展做一综述。

关键词：主动脉狭窄经导管主动脉瓣膜置入术瓣周漏

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

引用

Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang Jun Lin chenyang Wu Yuhua Gao chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan chen Ying Huang Jinpeng Sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：