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Science China Chemistry 2025年第1期68卷 257-263页

作者： Jiapian Huang chenxin wang Xu wang Xiaoyu Zhou Wei Xiao Jie Wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

关键词： β-chiral sulfones chiral cyclic sulfinamides sulfur dioxide insertion asymmetric radical cyclization stereoselectivity

LincRNA1230 inhibits the differentiation of mouse ES cells towards neural progenitors

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Science China(Life Sciences) 2016年第5期59卷 443-454页

作者： chenxin wang Guoping Li Yukang Wu Jiajie Xi Jiuhong Kang Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital Shanghai Key Laboratory of Signaling and Disease Research Collaborative Innovation Center for Brain Science School of Life Science and Technology Tongji University Shanghai 200092 China

In vitro, mouse embryonic stem （ES） cells can differentiate into many somatic cell types, including neurons and glial cells. When cultured in serum-free medium, ES cells convert spontaneously and efficiently to a neural fate. Previous studies have shown that the neural conversion of mouse ES cells includes both the participation of neural-specific transcription factors and the regulation of epigenetic modifications. However, the intracellular mechanism underlying this intrinsic transition still re- mains to be further elucidated. Herein, we describe a long intergenic non-coding RNA, LincRNA1230, which participates in the regulation of the neural lineage specification of mouse ES cells. The ectopic forced expression of LincRNAI230 dramatically inhibited mouse ES cells from adopting a neural cell fate, while LincRNA1230 knockdown promoted the conversion of mouse ES cells towards neural progenitors. Mechanistic studies have shown that LincRNA1230 inhibits the activation of early neural genes, such as Pax6 and Soxl, through the modulation of bivalent modifications （tri-methylation of histone3 lysine4 and his- tone3 lysine27） at the promoters of these genes. The interaction of LincRNA1230 with Wdr5 blocked the localization of Wdr5 at the promoters of early neural genes, thereby inhibiting the enrichment of H3K4me3 modifications at these loci. Collectively, these findings revealed a crucial role for LincRNA1230 in the regulation of the neural differentiation of mouse ES cells.

关键词： mouse ES cells neural differentiation long non-coding RNA (IncRNA) bivalent modification Wdr5

Portable visual and electrochemical detection of hydrogen peroxide release from living cells based on dual-functional Pt-Ni hydrogels

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Microsystems & Nanoengineering 2023年第6期9卷 185-194页

作者： Guanglei Li Yao Chen Fei Liu Wenhua Bi chenxin wang Danfeng Lu Dan Wen State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical University(NPU)and Shaanxi Joint Laboratory of GrapheneXi'an 710072P.R.China Interdisciplinary Research Center of Biology&Catalysis School of Life SciencesNPUXi'an 710072P.R.China Faculty of Printing Packaging Engineeringand Digital Media TechnologyXi'an University of TechnologyXi'an 710048P.R.China

It is important to monitor the intra-/extracellular concentration of hydrogen peroxide(H_(2)O_(2))in biological ***,miniaturized devices that enable portable and accurate H_(2)O_(2)measurement are still in their infancy because of the difficulty of developing facile sensing strategies and highly integrated sensing *** this work,portable H_(2)O_(2)sensors based on Pt-Ni hydrogels with excellent peroxidase-like and electrocatalytic activities are ***,simple and sensitive H_(2)O_(2)sensing is achieved through both colorimetric and electrochemical *** as-fabricated H_(2)O_(2)sensing chips exhibit favorable performance,with low detection limits(0.030μM&0.15μM),wide linearity ranges(0.10μM-10.0 mM&0.50μM-5.0 mM),outstanding long-term stability(up to 60 days),and excellent *** the aid of an M5stack development board,portable visual and electrochemical H_(2)O_(2)sensors are successfully constructed without complicated and expensive equipment or professional *** applied to the detection of H_(2)O_(2)released from HeLa cells,the results obtained by the developed sensors are in good agreement with those from an ultraviolet‒visible spectrophotometer(UV‒vis)(1.97μM vs.2.08μM)and electrochemical station(1.77μM vs.1.84μM).

关键词： electrochemical peroxide ultraviolet

Extrusion-base d 3D-printe d“rolle d-up”composite scaffolds with hierarchical pore structure for bone growth and repair

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Journal of Materials Science & Technology 2024年第4期171卷 222-234页

作者： Yufan Li Li Chen Yijing Stehle Mingyue Lin chenxin wang Rui Zhang Min Huang Yubao Li Qin Zou Research Center for Nano Biomaterials Analytical&Testing CenterSichuan UniversityChengdu 610064China Analytical&Testing Center Sichuan UniversityChengdu 610064China Department of mechanical engineering Union College807 Union St.SchenectadyNY 12308USA Sichuan Institute of Atomic Energy Chengdu 610101China

Three-dimensional(3D)bioprinting,specifically direct ink writing(DIW)capable of printing biologically active substances such as growth factors or drugs under low-temperature conditions,is an emerging di-rection in bone tissue ***,limited by the bio-ink mobility and the poor resolution of this printing technology,the lateral pores of current crisscross-stacked scaffolds printed through DIW tend to clog and are inimical to bone ***,it is critical to develop DIW printed biologi-cal scaffold structure with high mechanical strength,porosity,and biocompatibility ***,patterned polylactic acid(PLA)/polycaprolactone(PCL)/nano-hydroxyapatite(n-HA)based scaffold was printed through DIW technological and rolled-up for properties characterization,cytocompatibility test,and bone repair *** result not only shows that the hexagonal patterned scaffolds are me-chanically strong with porosity,but also demonstrated that the hierarchical pore structure formed during rolled-up has the potential to address the clogging problem and stimulates bone growth and repair.

关键词： Direct ink writing(DIW) Bone repair scaffold,Micro-CT Bio composites

Classification of Villages in Wan’an County under the Background of Rural Revitalization

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Journal of Landscape Research 2023年第5期15卷 98-100页

作者： wang chenxin College of City Construction Jiangxi Normal UniversityNanchangJiangxi 330022China

Rural revitalization strategy is an important strategic layout of rural development in the new era of the CPC Central Committee,and scientific and reasonable determination of village types is an important measure to promote rural revitalization by *** villages of Wan’an County were selected as the research ***,the factors that have a key impact on the development of the villages were extracted and qualitatively analyzed to preliminarily screen and judge their ***,the evaluation index system of development potential of the villages was constructed to quantitatively evaluate and reasonably classify the ***,the spatial distribution characteristics and quantity of different villages were revealed,and differentiated development strategies were proposed.

关键词： Rural revitalization Village classification Development potential evaluation system Wan’an County

Individual blastomeres of 4-and 8-cell embryos have ability to develop into a full organism in mouse

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Journal of Genetics and Genomics 2018年第12期45卷 677-680页

作者： Xinxin Zhang Tianda Li Linlin Zhang Liyuan Jiang Tongtong Cui Xuewei Yuan chenxin wang Zhonghua Liu Ying Zhang Wei Li Qi Zhou College of Life Science Northeast Agricultural University of China Harbin 150030China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Following fertilization in mammals, the zygote initiates the developmental program, which has a transient capacity to generate cell types of both embryonic and extraembryonic lineages, which is defined as totipotency (Condic, 2014). In mice,only zygotes and blastomeres of 2-cell stage embryos are considered totipotent, since they have the ability to develop into a full

关键词： and 8-cell embryos have ability to develop into a full organism in mouse

良性阵发性位置性眩晕耳石复位后复发危险因素的Meta分析

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临床耳鼻咽喉头颈外科杂志 2018年第17期32卷 1298-1303页

作者：王晨欣王建明山西医科大学第一临床医学院太原030001 山西医科大学第一医院耳鼻咽喉头颈外科

目的:应用Meta分析法探讨良性阵发性位置性眩晕(BPPV)行耳石复位后复发的相关危险因素。方法:检索PubMed、Embase、OVID、Springer、Proquest等数据库,筛选BPPV复发危险因素的相关文献,采用Revman 5.3软件对纳入的文献进行Meta分析。结... 详细信息

目的:应用Meta分析法探讨良性阵发性位置性眩晕(BPPV)行耳石复位后复发的相关危险因素。方法:检索PubMed、Embase、OVID、Springer、Proquest等数据库,筛选BPPV复发危险因素的相关文献,采用Revman 5.3软件对纳入的文献进行Meta分析。结果:最终纳入的文献共15篇,累计样本量共4 477例。Meta分析结果表明:伴有高脂血症较不伴有高脂血症患者(OR=1.74,95%CI 1.14～2.65,P=0.01),伴有梅尼埃病较不伴有梅尼埃病患者(OR=4.57,95%CI2.78～7.52,P0.05)和伴有偏头痛较不伴有偏头痛患者(OR=0.99,95%CI0.66～1.47,P>0.05)BPPV耳石复位后复发差异无统计学意义。结论:伴有高脂血症、梅尼埃病为BPPV耳石复位后复发的危险因素。

关键词：良性阵发性位置性眩晕复发危险因素

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新课程改革二十年来中小学师生关系的变迁

教育研究 2022年第10期43卷 118-130页

作者：雷浩王晨馨教育部人文社会科学重点研究基地华东师范大学课程与教学研究所上海200062

随着新课程改革的深入推进,我国中小学师生关系的变迁受到广泛关注。通过运用横断历史元分析的方法对新课程改革以来的师生关系研究报告进行分析,研究发现,随着新课程改革的推进,我国中小学师生关系的依恋性和友善性在逐年增强,冲突性... 详细信息

随着新课程改革的深入推进,我国中小学师生关系的变迁受到广泛关注。通过运用横断历史元分析的方法对新课程改革以来的师生关系研究报告进行分析,研究发现,随着新课程改革的推进,我国中小学师生关系的依恋性和友善性在逐年增强,冲突性和回避性则逐年下降。新课程历时能够正向预测依恋性和友善性的变迁,负向预测冲突性和回避性的变迁;生均教育经费支出能正向预测依恋性的变迁,负向预测冲突性和回避性的变迁;生师比能正向预测冲突性和回避性变迁;专任教师职称情况对冲突性和回避性变迁有显著的负向预测作用。与初中和高中相比较,小学阶段师生关系的依恋性、友善性、冲突性和回避性变化更为明显。与男生相比较,女生感知的师生关系依恋性和友善性上升、冲突性和回避性下降均更明显。建构良好师生关系,需要促进中小学师生关系的依恋性和友善性提升,减少师生关系的冲突性和回避性;增加教育改革供给,促进师生关系更好发展;尊重学生群体特征,提供针对性的策略以促进师生关系良性变迁。

关键词：基础教育新课程改革师生关系

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构建和谐社会的法治分析

法学杂志 2005年第3期26卷 9-11页

作者：王称心中国政法大学法学院北京100088

和谐社会不仅是人与人之间、人与社会之间在经济、政治、文化等各个领域的和谐,也是人和自然的和谐,在市场经济体制下以法治为基本方策来构建和谐社会应是最佳选择。法治理论为我国市场经济体制下构建和谐社会提供了方式选择的必然性和... 详细信息

和谐社会不仅是人与人之间、人与社会之间在经济、政治、文化等各个领域的和谐,也是人和自然的和谐,在市场经济体制下以法治为基本方策来构建和谐社会应是最佳选择。法治理论为我国市场经济体制下构建和谐社会提供了方式选择的必然性和实践的可行性。

关键词：和谐社会法治建设中国市场经济法律文化

基于自动化方法的教育人工智能系统设计与应用

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中国电化教育 2020年第6期 7-15页

作者：王萍王陈欣朱璇上海外国语大学国际教育学院上海201620 上海外国语大学语言研究院上海201620

教育人工智能系统设计与应用研究的目标是推动教育与人工智能深度融合,促进人工智能在教育领域的落地,加速教育迈向智能化时代。文章从文献分析、地平线报告分析、技术成熟度模型分析三个方面梳理了当前教育人工智能应用研究的现状。接... 详细信息

教育人工智能系统设计与应用研究的目标是推动教育与人工智能深度融合,促进人工智能在教育领域的落地,加速教育迈向智能化时代。文章从文献分析、地平线报告分析、技术成熟度模型分析三个方面梳理了当前教育人工智能应用研究的现状。接着,分析了教育人工智能系统的主要功能模块,归纳了系统设计开发中存在的问题与面临的困难。在此基础上提出了基于自动化思想和学习理论支持的新型教育人工智能系统设计方法与模型,并进行了案例实践研究。基于自动化方法的教育人工智能系统设计有助于帮助教师实现智能教育应用,降低人工智能应用门槛,扩展教育应用场景,提高开发与更新效率。

关键词：自动化教育人工智能系统设计学习理论