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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 1037-1047页

作者： Jingwen zhang Liming Yu Yongchang Liu Ran Ding chenxi Liu Zongqing Ma Huijun Li Qiuzhi Gao Hui Wang State Key Lab of Hydraulic Engineering Simulation and Safety Tianjin Key Lab of Composite and Functional MaterialsTianjin UniversityTianjin 300072China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

The infamous type Ⅳ failure within the fine-grained heat-affected zone (FGHAZ) in G115 steel weldments seriously threatens the safe operation of ultra-supercritical (USC) power plants.In this work,the traditional thermo-mechanical treatment was modified via the replacement of hot-rolling with cold rolling,i.e.,normalizing,cold rolling,and tempering (NCT),which was developed to improve the creep strength of the FGHAZ in G115 steel weldments.The NCT treatment effectively promoted the dissolution of preformed M_(23)C_(6)particles and relieved the boundary segregation of C and Cr during welding thermal cycling,which accelerated the dispersed reprecipitation of M_(23)C_(6) particles within the fresh reaustenitized grains during post-weld heat treatment.In addition,the precipitation of Cu-rich phases and MX particles was promoted evidently due to the deformation-induced dislocations.As a result,the interacting actions between precipitates,dislocations,and boundaries during creep were reinforced considerably.Following this strategy,the creep rupture life of the FGHAZ in G115 steel weldments can be prolonged by 18.6%,which can further push the application of G115 steel in USC power plants.

关键词： G115 steel fine-grained heat-affected zone creep strength element segregation nano-sized precipitates

Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

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Signal Transduction and Targeted Therapy 2024年第2期9卷 738-750页

作者： Yun zhang Lijun Du chenxi Wang zhangsheng Jiang Qingchi Duan Yiping Li Zhijun Xie Zhixing He Yi Sun Lin Huang Liwei Lu Chengping Wen Key Laboratory of Chinese medicine rheumatology of Zhejiang Province Research Institute of Chinese Medical Clinical Foundation and ImmunologyCollege of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Chongqing International Institute for Immunology Chongqing 400038China

Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to organs.The dysregulation of double-negative(DN)T cells is considered as a crucial commander during SLE.Neddylation,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune response.However,the function of neddylation in SLE is still unknown.Here,we reported that neddylation inactivation with MLN4924,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of Ube2m in T cells decreased DN T cell accumulation and attenuated murine lupus development.Further investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus mice.Then double knockout(KO)lupus-prone mice(Ube2m-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced Ube2m deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus progression.Our findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus progression.Clinically,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was reduced.Moreover,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation levels.Meantime,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE patients.Altogether,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease.

关键词： inactivation double finding

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基于PASCO系统的数字化开尔文电桥

大学物理实验 2024年第3期37卷 110-114页

作者：董宇杰张晨熙李军颜伟龙杨婷婷周大进陈悦华福建师范大学物理与能源学院福建福州350117

在开尔文电桥法测电阻电路的基础上,结合同轴电阻、PASCO系统、微小信号放大器等仪器,实现了数字化测量。避免繁琐调节步骤的同时,减小了由于待测电阻长时间通电,温度变化所导致的测量误差。使用该方法测量铜的电阻率及电阻率温度系数,... 详细信息

在开尔文电桥法测电阻电路的基础上,结合同轴电阻、PASCO系统、微小信号放大器等仪器,实现了数字化测量。避免繁琐调节步骤的同时,减小了由于待测电阻长时间通电,温度变化所导致的测量误差。使用该方法测量铜的电阻率及电阻率温度系数,与标准值相比,测量误差较小,说明使用该方法减小测量过程中由于温度变化所导致的误差具有可行性。

关键词：数字化测量同轴电阻 PASCO系统微小信号放大器

Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway

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Neural Regeneration Research 2024年第2期19卷 434-439页

作者： chenxi Zhao Tiangang Zhou Ming Li Jie Liu Xiaoqing Zhao Yilin Pang Xinjie Liu Jiawei zhang Lei Ma Wenxiang Li Xue Yao Shiqing Feng Department of Orthopedics Tianjin Medical University General HospitalTianjinChina International Science and Technology Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of OrthopedicsTianjin Medical University General HospitalTianjinChina Orthopedic Research Center of Shandong University Cheeloo College of MedicineDepartment of OrthopedicsQilu Hospital of Shandong UniversityJinanShandong ProvinceChina

Argatroban is a synthetic thrombin inhibitor approved by U.S.Food and Drug Administration for the treatment of thrombosis.However,whether it plays a role in the repair of spinal cord injury is unknown.In this study,we established a rat model of T10 moderate spinal cord injury using an NYU Impactor ModerⅢand performed intraperitoneal injection of argatroban for 3 consecutive days.Our results showed that argatroban effectively promoted neurological function recovery after spinal cord injury and decreased thrombin expression and activity in the local injured spinal cord.RNA sequencing transcriptomic analysis revealed that the differentially expressed genes in the argatroban-treated group were enriched in the JAK2/STAT3 pathway,which is involved in astrogliosis and glial scar formation.Western blotting and immunofluorescence results showed that argatroban downregulated the expression of the thrombin receptor PAR1 in the injured spinal cord and the JAK2/STAT3 signal pathway.Argatroban also inhibited the activation and proliferation of astrocytes and reduced glial scar formation in the spinal cord.Taken together,these findings suggest that argatroban may inhibit astrogliosis by inhibiting the thrombin-mediated PAR1/JAK2/STAT3 signal pathway,thereby promoting the recovery of neurological function after spinal cord injury.

关键词： argatroban astrogliosis JAK/STAT signaling pathway protease-activated receptor-1 spinal cord injury thrombin vimentin

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微腔光频梳研究进展:从均匀到非均匀泵浦

仪器仪表学报 2023年第9期44卷 1-13页

作者：张晨希殷科江天国防科技大学前沿交叉学科学院长沙410073 国防科技大学理学院量子信息研究所长沙410073

光频梳光谱在频域呈梳状等间距分布,兼具宽光谱、高相干、低相噪等特点,因此在光钟、测距、光谱检测、相干通信等诸多领域具有良好应用前景。微腔为光频梳产生提供了小型集成化平台,使得微腔光频梳,尤其是高相干的耗散克尔孤子光梳,在... 详细信息

光频梳光谱在频域呈梳状等间距分布,兼具宽光谱、高相干、低相噪等特点,因此在光钟、测距、光谱检测、相干通信等诸多领域具有良好应用前景。微腔为光频梳产生提供了小型集成化平台,使得微腔光频梳,尤其是高相干的耗散克尔孤子光梳,在近年备受研究者们关注。绝大多数微腔光频梳的实现依赖于均匀连续光泵浦,然而非均匀泵浦,如相位调制与脉冲泵浦,因其在孤子重频控制与能量转化效率方面具有特定优势,逐步进入研究者视野。本文回顾了微腔光频梳研究进展,具体综述了关于非均匀驱动场下耗散克尔孤子的产生及其动力学研究,并对其未来发展趋势进行了分析和展望。非均匀泵浦能够提高耗散克尔孤子的可控性及能量转化效率,将为更多微腔光频梳应用铺平道路。

关键词：光频梳微腔孤子相位调制泵浦脉冲泵浦

第二十七届当代中国建筑创作论坛·学生代表“成长”感悟

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世界建筑导报 2024年第2期39卷 54-57页

作者：吕炟麟朱显珺陈思马咏薇张晨曦李佳颖郝云起梁芷清张宇涵施忱希牛嘉琪刘蓓陈卓禧黄忻玥何子熙不详

01-清华大学-吕炟麟-《在深圳,我看见活力城市》(节选)作为在北京生长二十年的地道北方人,此次深圳之行为我打开了观察体验迥异城市风貌的视窗。于我眼中,北京与深圳作为当今中国的“龙头城市”,都具有相当的城市活力。然而,北京的活“... 详细信息

01-清华大学-吕炟麟-《在深圳,我看见活力城市》(节选)作为在北京生长二十年的地道北方人,此次深圳之行为我打开了观察体验迥异城市风貌的视窗。于我眼中,北京与深圳作为当今中国的“龙头城市”,都具有相当的城市活力。然而,北京的活“力”更多表现为“影响力”,而深圳的活“力”则是一种“生命力”。

关键词：城市风貌活力城市龙头城市城市活力观察体验当代中国建筑影响力生命力

Sound insulation measurement of building components combining diffuse acoustic field excitation and near-field acoustic holography reconstruction

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Chinese Journal of Acoustics 2024年第2期43卷 248-273页

作者： WANG Hongwei XIONG Wei WANG Qiaochu zhang Guangyao YANG chenxi School of Architecture South China University of TechnologyGuangzhou 510640 State Key Laboratory of Subtropical Building Science South China University of TechnologyGuangzhou 510640

A method for measuring the airborne sound insulation of building components combining diffuse acoustic field(DAF) excitation and near-field acoustic holography(NAH)radiation intensity reconstruction is proposed. In this method, the DAF is first used to excite the vibration of the component and obtain the incident sound power, then the normal sound intensity distribution with high spatial resolution on the surface of the component is reconstructed from the radiation sound pressure field using the NAH, and finally, according to the sound intensity distribution, the radiated sound power is calculated and the radiation heat areas are located, so as to realize the measurement of sound insulation and sound insulation defects of components. The experimental research in a sound insulation room shows that under the condition that the test distance and sampling interval are both0.04 m, the error of the sound insulation measured by this method compared to the sound pressure method is less than 3.3 d B in the 100–5000 Hz frequency band and less than1.3 d B in the 250–3150 Hz frequency band, and the positioning accuracy of round holes(diameter: 8 mm) and rectangular slots(length: 80 mm, width: 3 mm) is up to the centimeter level. At the same time, the method has strong stability under the influence of certain amount of reverberation and background noise. When reverberation time in the receiving room increases from 1.0 s to 3.4 s(step size: 0.6 s), and the signal-to-noise ratio decreases from 10 d B to 0 d B(step size: 5 d B), the sound volume measurement errors are within 0.8 d B and 0.3 d B, and the defect location errors are within 0.037 m and 0.035 m.The proposed method helps to improve the measurement capability of sound insulation characteristics of building components in the laboratory, and it is robust to the receiving room test environment.

关键词： insulation excitation field

磷酸酯化聚乙烯亚胺阻燃粘胶织物的制备与性能

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纺织学报 2023年第6期44卷 161-167页

作者：蒋之铭张超张晨曦朱平青岛大学功能纺织品与先进材料研究院山东青岛266071 青岛大学纺织服装学院山东青岛266071 青岛大学新型防火阻燃材料开发与应用国家地方联合工程研究中心山东青岛266071 省部共建生物多糖纤维成形与生态纺织国家重点实验室山东青岛266071

为降低多元羧酸交联剂的强酸性对阻燃粘胶织物的强力损伤,以多氨基磷酸酯化聚乙烯亚胺(BPEI-DP)为阻燃剂,在1,2,3,4-丁烷四羧酸(BTCA)的交联作用下得到阻燃粘胶织物,研究了其表面化学组成、阻燃性能、热降解稳定性能和热释放行为,分析了... 详细信息

为降低多元羧酸交联剂的强酸性对阻燃粘胶织物的强力损伤,以多氨基磷酸酯化聚乙烯亚胺(BPEI-DP)为阻燃剂,在1,2,3,4-丁烷四羧酸(BTCA)的交联作用下得到阻燃粘胶织物,研究了其表面化学组成、阻燃性能、热降解稳定性能和热释放行为,分析了BPEI-DP/BTCA体系对粘胶织物力学性能的影响。结果表明:阻燃粘胶织物的极限氧指数(LOI)提升至28.9%,垂直燃烧测试中阻燃织物离火自熄,无续燃和阴燃现象,损毁长度为9.9 cm;相比于纯粘胶织物,阻燃粘胶织物的成炭性显著提升,热释放明显降低,最大热释放速率下降了34%;其耐水洗性能与N-羟甲基-3-(二甲氧基膦酰基)丙酰胺阻燃粘胶织物相当,20次标准水洗后LOI值从28.9%下降至24.9%;该阻燃体系有效保留了粘胶织物的断裂强力,保留率可达70%左右,为高品质阻燃纺织品的设计制备提供了思路。

关键词：粘胶织物磷酸酯化聚乙烯亚胺 1,2,3,4-丁烷四羧酸阻燃整理力学性能

Corrigendum to“Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material”[Journal of Materials Science&Technology 146(2023)211-220]

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Journal of Materials Science & Technology 2024年第3期170卷 255-257页

作者： chenxi Dou Mingyang zhang Dechun Ren Haibin Ji Zhe Yi Shaogang Wang Zengqian Liu Qiang Wang Yufeng Zheng Zhefeng zhang Rui Yang Liaoning Provincial Key Laboratory of Oral Diseases School and Hospital of StomatologyChina Medical UniversityShenyang 110001China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Peking UniversityBeijing 100871China Center for Adaptive System Engineering School of Creativity and ArtShanghaiTech UniversityShanghai 201210China

The authors are very sorry for their carelessness that there are some problems with Fig.3 in the original manuscript.

关键词： composite phase partially

Constructing efficient bacterial cell factories to enable one-carbon utilization based on quantitative biology:A review

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Quantitative Biology 2024年第1期12卷 1-14页

作者： Yazhen Song chenxi Feng Difei Zhou Zengxin Ma Lian He Cong zhang Guihong Yu Yan Zhao Song Yang Xinhui Xing School of Life Sciences Shandong Province Key Laboratory of Applied Mycologyand Qingdao International Center on Microbes Utilizing BiogasQingdao AgriculturalUniversityQingdaoChina Department of Chemical Engineering University of WashingtonSeattleWashingtonUSA Key Laboratory of Systems Bioengineering Ministry of EducationTianjin UniversityTianjinChina Key Laboratory of Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijingChina Center for Synthetic and Systems Biology Tsinghua UniversityBeijingChina Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate Schooland Insttute of Biomedical Health Technology and EngineeringShenzhen Bay LaboratoryShenzhenChina

Developing methylotrophic cell factories that can efficiently catalyze organic one-carbon(C1)feedstocks derived from electrocatalytic reduction of carbon dioxide into bio-based chemicals and biofuels is of strategic significance for building a carbon-neutral,sustainable economic and industrial system.With the rapid advancement of RNA sequencing technology and mass spectrometer analysis,researchers have used these quantitative microbiology methods extensively,especially isotope-based metabolic flux analysis,to study the metabolic processes initiating from C1 feedstocks in natural C1-utilizing bacteria and synthetic C1 bacteria.This paper reviews the use of advanced quantitative analysis in recent years to understand the metabolic network and basic principles in the metabolism of natural C1-utilizing bacteria grown on methane,methanol,or formate.The acquired knowledge serves as a guide to rewire the central methylotrophic metabolism of natural C1-utilizing bacteria to improve the carbon conversion efficiency,and to engineer non-C1-utilizing bacteria into synthetic strains that can use C1 feedstocks as the sole carbon and energy source.These progresses ultimately enhance the design and construction of highly efficient C1-based cell factories to synthesize diverse high value-added products.The integration of quantitative biology and synthetic biology will advance the iterative cycle of understand–design–build–testing–learning to enhance C1-based biomanufacturing in the future.

关键词： ^(13)C-metabolic flux analysis methylotrophic cell factories one-carbon feedstock quantitative biology